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Your search keyword '"Jouda, Jean-Bosco"' showing total 19 results
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19 results on '"Jouda, Jean-Bosco"'

1. LC-MS Identification and Preliminary Pharmacological Study of the Aqueous and Ethanol Extracts from Combretum glutinosum Perr ex DC. (Combretaceae)

Author

Toklo, Placide Mahougnan, Ahomadegbe, Mathias Amour, Dah-Nouvlessounon, Durand, Jouda, Jean-Bosco, Tchegnitegni, Billy Toussie, Wouamba, Steven Collins Njonte, Ahoton, Djidénou, Assogba, Mahoudo Fidèle, Tchamgoue, Joseph, Lenta, Bruno Ndjakou, Kouam, Simeon Fogue, Baba-Moussa, Lamine, Ladekan, Eléonore Chikani Yayi, and Gbenou, Joachim Djimon

Published
2023
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5. Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae)

Author

Leutcha, Bosco Peron, primary, Dzoyem, Jean Paul, additional, Jouda, Jean-Bosco, additional, Sema, Denis Kehdinga, additional, Tsague Tankeu, Virginie Flaure, additional, Bitchagno, Gabin Thierry Mbahbou, additional, Tchegnitegni, Billy Toussie, additional, Essoung, Flaure Rosette Ehawa, additional, Ndjakou Lenta, Bruno, additional, Fogue Kouam, Siméon, additional, Delie, Florence, additional, Meli Lannang, Alain, additional, and Sewald, Norbert, additional

Published
2022
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6. Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae)

Author

Leutcha, Bosco Peron, Dzoyem, Jean Paul, Jouda, Jean-Bosco, Sema, Denis Kehdinga, Tsague Tankeu, Virginie Flaure, Bitchagno, Gabin Thierry Mbahbou, Tchegnitegni, Billy Toussie, Essoung, Flaure Rosette Ehawa, Ndjakou Lenta, Bruno, Fogue Kouam, Siméon, Delie, Florence, Meli Lannang, Alain, and Sewald, Norbert

Subjects
carbamide, Albizia lebbeck, cytotoxici, antimicrobial activity, flavonoids, Acacia, Fabaceae
Abstract

Twenty-two compounds were isolated from the fruit of Albizia lebbeck including one unprecedented, rare amino acid-derived zwitterionic and one new flavone derivative. The isolation was performed on repeated column chromatography over silica gel and their structures were determined by 1D-, 2D-NMR and HR-ESI-MS spectra together with reported data in the literature. The chemophenetic significance is also discussed. Some isolated compounds were reported for the first time to be found in the species. Additionally, compound 2 showed antibacterial activity and compounds 1 and 2 revealed moderate cytotoxic activity against the Raw 264.7 cancer cell line with IC50 values of 37.19 µM and 29.36 µM, respectively. Furthermore, a proposed biosynthetic pathway of compound 1 is described.

Published
2022

7. In Vitro Antilipidic and Antithrombotic Activities of Plectranthus glandulosus (Lamiaceae) Leaves Extracts and Fractions

Author

Zouheira, Djamila, primary, Ngnokam, Sylvie Lea Wansi, additional, Kamani, Sylviane Laure Poualeu, additional, Tchegnitegni, Billy Toussie, additional, Jouda, Jean Bosco, additional, Mba, Jean Romuald, additional, Nchouwet, Moïse Legentil, additional, Nfor, Njini Gael, additional, Nyirimigabo, Alain K., additional, Kowa, Théodora Kopa, additional, and Agbor, Gabriel A., additional

Published
2022
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8. A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf

Author

Laura, Gertrude Foudjo Melacheu, Njoya, Emmanuel Mfotie, Jouda, Jean-Bosco, Kweka, Brussine Nadege Wakeu, Mbazoa, Céline Djama, Wang, Fei, Seguin, Elisabeth, and Wandji, Jean

Abstract

One new indole alkaloid derivative, 5,6-dioxo-11-hydroxy voacangine (1) together with four known compounds (2-5), were isolated from the fruits of Tabernaemontana inconspicua Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR, HRESI-MS, and a comparison with the literature. The new compound was found to be cytotoxic on human breast cancer MDA-MB 231 cells with IC50 values of 3.35 µM and 2.19 µM after 24 and 48 hours, respectively.

Published
2021
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9. Asperpyrone, a rare α-pyrone metabolite produced by an endophytic fungus Aspergillus sp. isolated from Garicinia smeathmannii (Planch. & Triana) Oliv

Author

Jouda, Jean-Bosco, Njoya, Emmanuel Mfotie, Nguengang, Ruland Tchuinkeu, Tankeu, Virginie Flaure Tsague, Stammler, Hans-Georg, Shiono, Yoshihito, Sewald, Norbert, and Lannang, Alain Meli

Abstract

A new α-pyrone, asperpyrone (1) and two known compounds, stigmasterol (2) and 7-hydroxy-3-(2,3-dihydroxybutyl)-1(3H)-Isobenzofuranone (3) were isolated from the solid rice culture of the endophytic fungus Aspergillus sp., an endophytic fungus isolated from the fresh inner tissue of the barks of Garicinia smeathmannii. Their structures were determined by extensive spectral analysis including 1 D and 2 D NMR, HRESIMS and single-crystal X-ray crystallographic analysis. Asperpyrone (1) was tested against an axenic culture of Entamoeba moshkovskii, but did not exhibit any significant amoebicidal activity.

Published
2021
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11. A New Chromene Derivative and a New Polyalcohol Isolated From the Fungus Xylaria sp. 111A Associated With Garcinia polyantha Leaves

Author

Tegha, Hycienth Fung, primary, Jouda, Jean-Bosco, additional, Dzoyem, Jean Paul, additional, Sema, Denis Kehdinga, additional, Leutcha, Bosco Peron, additional, Allémann, Eric, additional, Delie, Florence, additional, Shiono, Yoshihito, additional, Sewald, Norbert, additional, and Lannang, Alain Meli, additional

Published
2021
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12. Heptacyclosordarianone, a New Polyketide From Sordaria sp., an Endophytic Fungus From Garcinia polyantha

Author

Tsague Tankeu, Virginie Flaure, primary, Sema, Denis Kehdinga, additional, Jouda, Jean-Bosco, additional, Tatsimo, Simplice Joel N., additional, Ntonga, Patrick Akono, additional, Wansi, Jean Duplex, additional, Fogue, Simeon Kouam, additional, Loura, Benoît, additional, Shiono, Yoshihito, additional, Sewald, Norbert, additional, and Lannang, Alain Meli, additional

Published
2020
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16. Antibacterial and cytotoxic cytochalasins from the endophytic fungus sp. Phomopsis harbored in Garcinia kola (Heckel) nut.

Author

Jouda, Jean-Bosco, Tamokou, Jean-de-Dieu, Mbazoa, Céline Djama, Douala-Meli, Clovis, Sarkar, Prodipta, Bag, Prasanta Kumar, and Wandji, Jean

Subjects
ERYTHROCYTES, ANTI-infective agents, ANTINEOPLASTIC agents, CELL culture, CHROMATOGRAPHIC analysis, FUNGI, MICROBIOLOGICAL techniques, MOLECULAR structure, RESEARCH funding, SPECTROPHOTOMETRY, STATISTICS, PLANT extracts, DATA analysis, DATA analysis software, CYTOTOXINS, INDOLE compounds, DESCRIPTIVE statistics, CANCER cell culture, IN vitro studies, ONE-way analysis of variance
Abstract

Background: The continuous emergence of multidrug-resistant (MDR) bacteria drastically reduced the efficacy of our antibiotic armory and consequently, increased the frequency of therapeutic failure. The search for bioactive constituents from endophytic fungi against MDR bacteria became a necessity for alternative and promising strategies, and for the development of novel therapeutic solutions. We report here the isolation and structure elucidation of antibacterial and cytotoxic compounds from Phomopsis sp., an endophytic fungus associated with Garcinia kola nuts. Methods: The fungus Phomopsis sp. was isolated from the nut of Garcinia kola. The crude extract was prepared from mycelium of Phomopsis sp. by maceration in ethyl acetate and sequentially fractionated by column chromatography. The structures of isolated compounds were elucidated on the basis of spectral studies and comparison with published data. The isolated compounds were evaluated for their antibacterial and anticancer properties by broth microdilution and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide methods respectively. The samples were also tested spectrophotometrically for their hemolytic properties against human red blood cells. Results: The fractionation of the crude extract afforded three known cytochalasins including 18-metoxycytochalasin J (1), cytochalasins H (2) and J (3) together with alternariol (4). The cytochalasin compounds showed different degrees of antibacterial activities against the tested bacterial pathogens. Shigella flexneri was the most sensitive microorganism while Vibrio cholerae SG24 and Vibrio cholerae PC2 were the most resistant. Ampicillin did not show any antibacterial activity against Vibrio cholerae NB2, Vibrio cholerae PC2 and Shigella flexneri at concentrations up to 512 µg/mL, but interestingly, these multi-drug resistant bacterial strains were sensitive to the cytochalasin metabolites. These compounds also showed significant cytotoxic properties against human cancer cells (LC50 = 3.66-35.69 µg/mL) with low toxicity to normal non-cancer cells. Conclusion: The three cytochalasin compounds isolated from the Phomopsis sp. crude extract could be a clinically useful alternative for the treatment of cervical cancer and severe infections caused by MDR Shigella and Vibrio cholerae. [ABSTRACT FROM AUTHOR]

Published
2016
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17. Anti-mycobacterial activity of polyketides from Penicilliumsp. endophyte isolated from Garcinia nobilisagainst Mycobacteriumsmegmatis

Author

Jouda, Jean Bosco, Mawabo, Isabelle Kamga, Notedji, Augustin, Mbazoa, Céline Djama, Nkenfou, Jean, Wandji, Jean, and Nkenfou, Céline Nguefeu

Abstract

According to estimates by the World Health Organization, there were 9.6 million new tuberculosis (TB) cases in 2014: 5.4 million among men, 3.2 million among women, and 1.0 million among children. There were also 1.5 million TB deaths. Although there are potent anti-TB molecules, the misuse of these drugs in addition to inconsistent or partial treatment have led to the development of multidrug-resistant TB and extensively drug-resistant TB. It is established that plants harbor microorganisms, collectively known as endophytes, which also produce metabolites. Exploring the as-yet untapped natural products from the endophytes increases the chances of finding novel and active compounds. The present study was aimed to investigate the antimycobacterial activity of the crude extract and compounds isolated from Penicilliumsp. endophyte associated with Garcinia nobilisagainst Mycobacterium smegmatis.

Published
2016
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18. A New Chromene Derivative and a New Polyalcohol Isolated From the Fungus Xylariasp. 111A Associated With Garcinia polyanthaLeaves

Author

Tegha, Hycienth Fung, Jouda, Jean-Bosco, Dzoyem, Jean Paul, Sema, Denis Kehdinga, Leutcha, Bosco Peron, Allémann, Eric, Delie, Florence, Shiono, Yoshihito, Sewald, Norbert, and Lannang, Alain Meli

Abstract

From the crude extract of the plant-associated fungus Xylariasp. collected in Cameroon, a new 2H-chromene derivative, hexacycloxylariolone (1), and a new polyalcohol, xylatriol (2), were isolated, in addition to 3 known compounds, 2,3-furandiol (3), 1,8-dimethoxynaphthalene (4), and 1-palmitoyl-rac-glycerol (5). Their chemical structures were established on the basis of the interpretation of spectroscopic data. Hexacycloxylariolone (1), 1,8-dimethoxynaphthalene (4), and 1-palmitoyl-rac-glycerol (5) showed antiproliferative activity by inhibiting the growth of Raw 264.7 and THP-1 cancer cell lines.

Published
2021
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19. Heptacyclosordarianone, a New Polyketide From Sordariasp., an Endophytic Fungus From Garcinia polyantha

Author

Tsague Tankeu, Virginie Flaure, Sema, Denis Kehdinga, Jouda, Jean-Bosco, Tatsimo, Simplice Joel N., Ntonga, Patrick Akono, Wansi, Jean Duplex, Fogue, Simeon Kouam, Loura, Benoît, Shiono, Yoshihito, Sewald, Norbert, and Lannang, Alain Meli

Abstract

One new polyketide derivative, heptacyclosordarianone (1), together with 2 known compounds, heptacyclosordariolone (2) and sordariol (3), were isolated from an extract of Sordariasp. AM-71, an endophytic fungus inhabiting Garcinia polyantha. The structures of these compounds were elucidated based on intensive nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry and by comparison with literature data. All compounds were assayed for their antimicrobial and cytotoxic properties. Only compound 2showed antimicrobial activities against Bacillus subtilisDSMZ 704, Pseudomonas agariciDSMZ 11810, and Micrococcus luteusDSMZ 1605 with minimum inhibitory concentration values of 9.3, 15.5, and 16.9 µg/mL respectively. None of the isolated compounds showed a significant cytotoxic property.

Published
2020
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