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A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf
- Publication Year :
- 2021
- Publisher :
- Taylor & Francis, 2021.
-
Abstract
- One new indole alkaloid derivative, 5,6-dioxo-11-hydroxy voacangine (1) together with four known compounds (2-5), were isolated from the fruits of Tabernaemontana inconspicua Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR, HRESI-MS, and a comparison with the literature. The new compound was found to be cytotoxic on human breast cancer MDA-MB 231 cells with IC50 values of 3.35 µM and 2.19 µM after 24 and 48 hours, respectively.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....7a88cfe37a532a9ccc693d5475374436
- Full Text :
- https://doi.org/10.6084/m9.figshare.8870465