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A recent study conducted at Temple University Health System in Philadelphia, Pennsylvania, explored the role of polyunsaturated fatty acid biosynthesis in acute myeloid leukemia (AML). The research found that elevated expression of fatty acid desaturase 1 (FADS1) in AML patients correlated with worse overall survival. Inhibition of FADS1 led to AML cell growth reduction and delayed leukemia onset in a mouse model, suggesting potential therapeutic implications for targeting PUFA metabolism in AML treatment. The study highlights the complex interplay between lipid metabolism and immune signaling pathways in AML progression and provides insights into potential treatment strategies. [Extracted from the article]

A study conducted by researchers at Washington University explores the relationship between obesity, cellular senescence, and osteoarthritis. The research suggests that gene therapy targeting the fat-1 gene can mitigate metabolic dysfunction, cellular senescence, and joint degeneration induced by obesity and joint injury. The findings support the potential for fat-1 gene therapy to be used clinically in treating obesity- and/or injury-induced osteoarthritis. The study was funded by Shriners Hospitals for Children and the National Institutes of Health (NIH) in the United States. [Extracted from the article]

A recent study conducted at Cairo University focused on non-alcoholic fatty liver disease (NAFLD) and its treatment using Cicer arietinum polyunsaturated fatty acids (CAP) and C. arietinum polyunsaturated fatty acids phytosome (CAPP) in male albino rats. The study found that CAP and CAPP treatments helped alleviate hepatosteatosis by downregulating fatty acid synthase (FAS), stearoyl-CoA desaturase 1 (SCD-1), and oxidative stress. The research suggests that these treatments may have a potential role in managing NAFLD. [Extracted from the article]

A study conducted at Nanjing Medical University in China explored the role of FADS3 in head and neck squamous cell carcinoma (HNSCC). The research found that FADS3 expression was higher in HNSCC compared to normal tissues and was associated with poor clinical outcomes. FADS3 was identified as a potential prognostic marker for HNSCC, impacting tumor progression, immune infiltration, and response to immunotherapy. The study suggests that targeting FADS3 could be a potential treatment strategy for HNSCC. [Extracted from the article]

A study conducted by Guizhou Medical University in Guiyang, China, explored the use of exogenous hydrogen peroxide (H2O2) to improve secondary metabolites in post-harvest fresh Ginkgo leaves. The research found that applying H2O2 led to increased levels of antioxidants, osmolytes, flavonoids, and ginkgolides, resulting in a significant enhancement of secondary metabolites in the leaves. This discovery has implications for the pharmaceutical industry and offers a new method for enhancing secondary metabolites in medicinal crops during post-harvest processing. [Extracted from the article]

A recent study from Shanghai Ocean University in China explores the potential of microalgae for precision nutrition and sustainable diets through metabolic engineering. By manipulating metabolic pathways and key metabolites, researchers aim to enhance the production of bioactive compounds like omega-3 fatty acids and antioxidants. The tailored microalgal strains developed could serve as cost-effective and sustainable sources of nutrition for human consumption and aquaculture, addressing the demand for functional foods and environmentally friendly feed alternatives. This research has been peer-reviewed and offers insights into the potential impact of microalgal precision nutrition on human health and food production systems. [Extracted from the article]

Researchers at the First Hospital of China Medical University conducted a study on bladder cancer, focusing on the role of stearoyl-CoA desaturase (SCD) in the disease. The study aimed to analyze the SCD transcription start site and explore the impact of SCD inhibitors on cancer stem cells. The research also highlighted the significance of nervonic acid in altering the proliferative capacity of bladder cancer cell lines. This study provides valuable insights into potential treatment strategies for bladder cancer. [Extracted from the article]

A recent study conducted at Chongqing Medical University in China explored the use of 6-gingerol, an active compound in ginger, to alleviate fructose-induced hepatic steatosis in rats. The research found that 6-gingerol reduced hyperlipidemia and inhibited de novo lipogenesis, targeting stearoyl-CoA desaturase (SCD) to decrease fatty acid desaturation levels. The study suggests that 6-gingerol may be a potential therapeutic option for metabolic-associated fatty liver disease. For more information, the full article can be accessed through the International Journal of Molecular Sciences. [Extracted from the article]

A study conducted at the Birla Institute of Technology and Science Pilani in India focused on Montelukast Therapy and its potential as a treatment for non-alcoholic fatty liver disease (NAFLD). The research identified Montelukast as a potential inhibitor of the SCD1 enzyme, which plays a role in fat accumulation in the liver. The study utilized virtual screening, molecular docking, and molecular dynamics simulations to identify potential inhibitors, with Montelukast showing promising results in reducing hepatic fat accumulation and oxidative stress. The findings suggest that Montelukast could be a valuable treatment option for metabolic disorders involving SCD1. [Extracted from the article]

The article discusses the role of fatty acid desaturases, specifically SCD1 and FADS2, in promoting the proliferation of Epstein-Barr virus-infected B cells. It highlights how the upregulation of these enzymes by EBV is crucial for B cell proliferation and how inhibiting both enzymes leads to a significant reduction in cell growth. The study also reveals the metabolic pathways linking SCD1 and FADS2 to cell proliferation, suggesting potential targets for future anti-lymphoma therapies. [Extracted from the article]

Researchers from the Royal Netherlands Academy of Arts and Sciences have made advancements in studying Non-Alcoholic Fatty Liver Disease (NAFLD) using human fetal hepatocyte organoids. These organoid models help in target discovery and drug screening for steatosis, the first stage of NAFLD. The study identified compounds effective at resolving steatosis and highlighted the importance of FADS2 in hepatic steatosis. This research provides valuable insights into the etiology of steatosis and potential drug targets for NAFLD. [Extracted from the article]

Researchers from the Institute for Molecular and Cellular Biology in Rosario, Argentina have developed a high-resolution 13C NMR approach for profiling fatty acid unsaturation in lipid extracts and in live Caenorhabditis elegans. Unsaturated fatty acids (UFA) play a crucial role in cellular processes and disruptions in UFA homeostasis can contribute to various disorders. The researchers used NMR spectroscopy to analyze C. elegans and identified differences in lipid compositions and fatty acid unsaturation levels between wild-type and mutant strains. This method provides a nondestructive and nontargeted technique for studying lipid storage in intact worms and can be used for future investigations of fatty acid regulation. [Extracted from the article]

A recent study conducted at the University of Wisconsin Madison has provided new insights into liver cancer. The research focused on the role of the enzyme Stearoyl-CoA desaturase-1 (SCD1) in liver damage, including fibrosis and hepatocellular carcinoma (HCC). The study found that deficiency of SCD1 in the liver led to increased saturation of liver lipid species and hepatic fibrosis. The research highlights the connection between monounsaturated fatty acid (MUFA) insufficiency and the development of fibrosis, cirrhosis, and HCC. [Extracted from the article]

Researchers from the Institute of Molecular and Cellular Biology in Rosario, Argentina have conducted a study on lipid research, specifically focusing on unsaturated fatty acids (UFA) and their role in cellular processes in animals. The researchers used a high-resolution 13C NMR spectroscopy technique to analyze the lipid compositions and fatty acid unsaturation levels in live Caenorhabditis elegans, a type of roundworm. The study found notable differences in lipid extracts between wild-type worms and mutant worms with impaired fatty acid desaturation. This research provides a benchmark for future investigations of fatty acid regulation in live C. elegans using NMR spectroscopy. [Extracted from the article]

The article reports on research from the University of Leeds examining how the fatty acid desaturase insertion-deletion polymorphism rs66698963 affects colorectal polyp prevention with eicosapentaenoic acid (EPA). Topics discussed include the impact of the FADS Indel polymorphism on polyp prevention, the interaction between EPA use and genetic markers, and the implications for personalized medicine in colorectal cancer prevention.

A study conducted by researchers at Jiangnan University in Wuxi, China, has found that two enzymes, stearoyl-coenzyme A desaturase (SCD) and fatty acid desaturase 2 (FADS2), play significant roles in the development of breast invasive carcinoma (BRCA). The study used bioinformatic analysis and experimental validation to investigate the potential functions of SCD and FADS2 in BRCA. The researchers found that the expression of SCD and FADS2 genes was positively linked to worse overall survival and disease-free survival in patients with BRCA. Additionally, the expression of SCD was correlated with the abundance of CD8+ T cells and macrophage cell infiltration, while the expression of FADS2 was correlated with the abundance of B cells. The study suggests that SCD and FADS2 may serve as potential therapeutic targets for BRCA treatment. [Extracted from the article]

This document is a patent application for a new method of treating Parkinson's disease. The application describes the use of a double stranded ribonucleic acid (dsRNA) agent that targets the Stearoyl-CoA Desaturase 5 (Scd5) gene. The dsRNA agent consists of a sense strand and an antisense strand, with the antisense strand being complementary to the target gene. The patent application provides detailed information on the specific nucleotide sequences, modifications, and conjugations that can be used in the dsRNA agent. The application also mentions the potential use of the dsRNA agent in treating Parkinson's disease and other movement disorders. [Extracted from the article]

A recent study conducted by researchers at Southwest University in Chongqing, China, explores the genetic factors that regulate food intake in domesticated silkworms. The study found that a specific gene, fatty acid desaturase, which is responsible for regulating food intake, is suppressed in domesticated silkworms but expressed in the salivary glands of wild silkworms. The researchers also discovered that a specific catalytic product of this gene, called -vaccenic acid, functions as a satiation signal, regulating food intake and growth in silkworms. This study sheds light on the role of satiety in silkworm domestication and provides new insights into the potential involvement of salivary glands in the regulation of satiety in animals. [Extracted from the article]

A recent study conducted by researchers at Nihon University School of Medicine explored the mechanisms of resistance to Stearoyl-CoA desaturase 1 (SCD1) inhibition in cancer cells. The study found that cancer cells resistant to SCD1 inhibitors did not undergo cell death induced by endoplasmic reticulum (ER) stress, unlike SCD1 inhibitor-sensitive cells. This resistance was attributed to the presence of fatty acid desaturase 2 (FADS2), which prevented the accumulation of palmitic acid. The researchers suggest that combination therapy targeting both SCD1 and FADS2 could be a potential strategy for cancer treatment. [Extracted from the article]

A recent report from Capital Medical University in Beijing, China explores the role of fatty acid desaturase (FADS) genes in atherosclerosis. The study specifically investigates the impact of hepatic FADS1 on aortic and peripheral vessel atherosclerosis in ApoE-/- mice. The findings suggest that knockdown of hepatic FADS1 exacerbates aortic atherosclerosis and non-alcoholic fatty liver disease (NAFLD), but does not affect peripheral atherosclerosis induced by vascular cuff combined with tandem stenosis. This research provides new insights into the association between FADS and atherosclerosis. [Extracted from the article]

Researchers at the University of Kentucky have presented data on cancer research, specifically focusing on the determination of fatty acid uptake and desaturase activity in mammalian cells using NMR-based stable isotope tracing. The study found that mammalian cells both import exogenous fatty acids and synthesize them de novo, with desaturase enzymes playing a role in introducing double bonds into fatty acyl-CoA substrates. The researchers developed an NMR method to determine the uptake of C-13-palmitate and its incorporation into complex lipids in human colorectal cancer cells. The NMR approach is non-destructive and provides direct information about the level of saturation and incorporation of fatty acids into complex lipids. [Extracted from the article]

A study conducted by researchers at Tabriz University of Medical Sciences examined the expression and activity of the enzyme stearoyl-CoA desaturase 1 (SCD1) in different breast cancer cell lines. The study found that the luminal A/B and triple-negative subtypes of breast cancer showed higher SCD1 expression and activity compared to the HER2-enriched subtype. These findings suggest differences in lipid metabolism among breast cancer subclasses and identify potential therapeutic targets for managing breast cancer. The study provides valuable insights into the unique conditions of the tumor microenvironment and the role of fatty acids in cancer cell energy supply. [Extracted from the article]

Researchers at Capital Medical University in Beijing, China, have conducted a study on the role of the D-5 fatty acid desaturase (FADS1) gene in atherosclerosis. The study found that knockdown of hepatic Fads1 in mice with atherosclerosis exacerbated the disease and non-alcoholic fatty liver disease (NAFLD), leading to weight loss. However, the knockdown did not affect peripheral atherosclerosis induced by vascular cuff combined with tandem stenosis. The findings suggest that FADS1 may play a role in the development and progression of atherosclerosis. [Extracted from the article]

A recent report from Capital Medical University in Beijing, China discusses the relationship between polyunsaturated fatty acid metabolism and atherosclerosis. The study highlights the complexity of atherosclerosis and the various factors that contribute to its development. It emphasizes the importance of polyunsaturated fatty acids in mammalian growth and development, and how their levels and fatty acid desaturase activity can impact the progression of atherosclerosis. The research also explores the role of genetic variants in the fatty acid desaturase gene cluster in atherosclerotic cardiovascular disease. For more information, readers can refer to the original article published in Reviews in Cardiovascular Medicine. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the microbial community structure and functions of a bacteria-dominated microbiome in the boiling vent-water of a sulfur-borax spring called Lotus Pond, located in the Puga valley of eastern Ladakh. The study reveals that Aquificae is the most numerically dominant phylum in the microbiome, accounting for 80% of all 16S rRNA-encoding reads. The metagenomic analysis also identifies several bacterial genera, including Fervidobacterium, Halomonas, Hydrogenobacter, Paracoccus, Sulfurihydrogenibium, Tepidimonas, Thermus, and Thiofaba, which are present in the vent-water. Aquificae is not only numerically dominant but also potentially acts as the main primary producer in the ecosystem. The study suggests that further exploration is needed to understand how Aquificae overcomes competition with other thermophiles and the bioenergetic costs of thermal endurance for mesophilic intruders. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of cis-vaccenic acid (cVA) in prostate cancer. The study found that cVA, a monounsaturated fatty acid, is produced by the enzyme stearoyl CoA desaturase 1 (SCD1), which is frequently dysregulated in cancer. The researchers discovered that cVA promotes cell growth and rescues reductions in cell viability caused by SCD1 inhibition. This study highlights the importance of understanding the lipidome of cancer cells to better comprehend the molecular pathology of the disease. Please note that this preprint has not undergone peer review. [Extracted from the article]

A recent study conducted at Lovely Professional University in Punjab, India, explores the potential of targeting the enzyme stearoyl-CoA desaturase (SCD) as a novel approach for diabetes therapy. The research suggests that lipid metabolism plays a crucial role in the development of insulin resistance, particularly in type 2 diabetes. By inhibiting SCD, it may be possible to manage diabetes more effectively. The study highlights the therapeutic potential of SCD inhibitors in the treatment of diabetes. [Extracted from the article]

A recent study explored the relationship between sleep disturbances, astrocytes, and lipid metabolism in Alzheimer's disease (AD). The study focused on the inhibition of stearoyl-CoA desaturase (SCD), an enzyme involved in lipid metabolism, and its effects on sleep and astrocytic function in a mouse model of AD. The results showed that while SCD inhibition did not restore sleep disturbances in the mice, it did reverse changes in astrocytes in the hippocampus. These findings contribute to our understanding of the pathophysiology of AD and its associated sleep disturbances. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]

A report from the University of Cambridge discusses the long-term effects of childhood malnutrition on adult health. The researchers studied 278 Afro-Caribbean adults who had experienced severe malnutrition in childhood. They found that certain desaturase activities, which are involved in lipid metabolism, were associated with markers of non-communicable disease risk, particularly adiposity. The study suggests that weight gain during nutritional rehabilitation after childhood malnutrition may influence the associations between desaturase activities and adult metabolic parameters. [Extracted from the article]

A recent preprint study found that there is a conserved transcriptomic signature of reduced fatty acid and lipid metabolism gene expression in human post-mortem ALS spinal cord and a Drosophila model of FTD/ALS. The study also revealed a common and specific reduction in phospholipid species containing polyunsaturated fatty acids (PUFAs). Increasing PUFA levels specifically in neurons led to a substantial extension of lifespan and suppressed stressor-induced neuronal death in patient iPSC-neurons. The study suggests that interventions to increase PUFA levels specifically within neurons may be beneficial in the treatment of FTD/ALS. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

Keywords: Breast Cancer; Breast Diseases and Conditions; Breast Tumors; Cancer; Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Genetics; Health and Medicine; Oncology; Oxidoreductases; Oxygenases; Stearoyl-CoA Desaturase; Women's Health EN Breast Cancer Breast Diseases and Conditions Breast Tumors Cancer Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Genetics Health and Medicine Oncology Oxidoreductases Oxygenases Stearoyl-CoA Desaturase Women's Health 1620 1620 1 11/06/23 20231109 NES 231109 2023 NOV 7 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Research findings on breast tumors are discussed in a new report. Understanding the role of adipose tissue (AT), as the main component of the breast tumor microenvironment (TME) in the development of cancer, is crucial for the early detection of breast cancer (BC).". [Extracted from the article]

Keywords: Warsaw; Poland; Europe; Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Gastroenterology; Health and Medicine; Oxidoreductases; Oxygenases; Pancreas; Stearoyl-CoA Desaturase EN Warsaw Poland Europe Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Gastroenterology Health and Medicine Oxidoreductases Oxygenases Pancreas Stearoyl-CoA Desaturase 182 182 1 10/03/23 20231003 NES 231003 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- A new study on Enzymes and Coenzymes - Fatty Acid Desaturases is now available. Stearoyl-CoA desaturase 1 (SCD1) is critical for producing unsaturated fatty acyl moieties for fluent storage into and out of LDs, likely affecting the overall rate of beta-cell survival. [Extracted from the article]

The expression of various fatty acid metabolizing enzymes such as stearoyl-CoA desaturase 1 (SCD1) was altered in early-stage ovarian cancer tissue compared with that in normal ovarian tissue. Keywords: Biomarkers; Cancer; Desaturase; Diagnostics and Screening; Enzymes and Coenzymes; Fatty Acid Desaturases; Gynecology; Health and Medicine; Oncology; Ovarian Cancer; Oxidoreductases; Oxygenases; Stearoyl-CoA Desaturase; Women's Health EN Biomarkers Cancer Desaturase Diagnostics and Screening Enzymes and Coenzymes Fatty Acid Desaturases Gynecology Health and Medicine Oncology Ovarian Cancer Oxidoreductases Oxygenases Stearoyl-CoA Desaturase Women's Health 1184 1184 1 09/11/23 20230912 NES 230912 2023 SEP 12 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Researchers detail new data in ovarian cancer. [Extracted from the article]

The recombinant Auxenochlorella protothecoides of claim 14, wherein recombinant Auxenochlorella protothecoides has an upregulated ACCase enzyme to boost levels of Malonyl CoA in the cytosol. Keywords: Acyltransferases; Biological Factors; Biological Pigments; Carotenoids; Choline; Desaturase; Diet and Nutrition; Enzymes and Coenzymes; Ethanolamines; Genetics; Health and Medicine; Micronutrient; Patent Application; Phosphotransferases; Quaternary Ammonium Compounds; Transferases; Trimethyl Ammonium Compounds EN Acyltransferases Biological Factors Biological Pigments Carotenoids Choline Desaturase Diet and Nutrition Enzymes and Coenzymes Ethanolamines Genetics Health and Medicine Micronutrient Patent Application Phosphotransferases Quaternary Ammonium Compounds Transferases Trimethyl Ammonium Compounds 3240 3240 1 08/14/23 20230814 NES 230814 2023 AUG 18 (NewsRx) -- By a News Reporter-Staff News Editor at Pharma Business Week -- A patent application by the inventors Bhat, Riyaz (Fremont, CA, US); IM, Chungsoon (Fremont, CA, US); KIM, Jane (Fremont, CA, US); Moseley, Jeffrey (Fremont, CA, US), filed on December 12, 2022, was made available online on July 27, 2023, according to news reporting originating from Washington, D.C., by NewsRx correspondents. First, the DAG moiety of PC can be liberated (by hydrolysis) by the reversible action of CDP-choline: 1,2-sn-diacylglycerol choline phosphotransferase (CPT or DAG-CPT), thus becoming available for TAG assembly by diacylglycerol acyltransferase (DGAT). "Both CDP-choline: 1,2-sn-diacylglycerol choline phosphotransferase (CPT and/or DAG-CPT) and phosphatidylcholine: 1,2-sn-diacylglycerol choline phosphotransferase (PDCT) enzyme activities, described in FIG. [Extracted from the article]

Preliminary small animal PET/CT imaging study showedhigh specific uptake and block of [C-11]SSI-4 uptake withco-injection of cold SSI-4 in high SCD1-expressing organs includinglacrimal gland, brown fat, liver, and tumor. Keywords: Jacksonville; State:Florida; United States; North and Central America; Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Oxidoreductases; Oxygenases; Stearoyl-CoA Desaturase EN Jacksonville State:Florida United States North and Central America Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Oxidoreductases Oxygenases Stearoyl-CoA Desaturase 321 321 1 08/07/23 20230812 NES 230812 2023 AUG 7 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Current study results on Enzymes and Coenzymes - Fatty Acid Desaturases have been published. [Extracted from the article]

Keywords: Cancer; Genetics; Health and Medicine; Oncology; Prostate Cancer; Prostatic Neoplasms EN Cancer Genetics Health and Medicine Oncology Prostate Cancer Prostatic Neoplasms 709 709 1 08/07/23 20230808 NES 230808 2023 AUG 8 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- Fresh data on prostate cancer are presented in a new report. Keywords for this news article include: National Cancer Institute (NCI), Genetics, Oncology, Prostate Cancer, Health and Medicine, Prostatic Neoplasms. [Extracted from the article]

Desaturase, Enzymes and Coenzymes, Fatty Acid Desaturases, Mixed Function Oxygenases, Oxidoreductases Keywords: Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Mixed Function Oxygenases; Oxidoreductases EN Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Mixed Function Oxygenases Oxidoreductases 988 988 1 08/07/23 20230807 NES 230807 2023 AUG 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on mixed function oxygenases is the subject of a new report. [Extracted from the article]

To assess the functional relevance of SCD2 in the macrophage response to infection, we challenged SCD2-deficient macrophages with uropathogenic Escherichia coli and found that there was impaired clearance of intracellular bacteria. Keywords: Connective Tissue Cells; Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Health and Medicine; Immunology; Inflammation; Macrophages; Mononuclear Phagocyte System; Myeloid Cells; Oxidoreductases; Oxygenases; Phagocytes; Stearoyl-CoA Desaturase EN Connective Tissue Cells Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Health and Medicine Immunology Inflammation Macrophages Mononuclear Phagocyte System Myeloid Cells Oxidoreductases Oxygenases Phagocytes Stearoyl-CoA Desaturase 1032 1032 1 07/24/23 20230728 NES 230728 2023 JUL 28 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on fatty acid desaturases is now available. [Extracted from the article]

Keywords: Urbana; State:Illinois; United States; North and Central America; Life Science; Desaturase; Enzymes and Coenzymes EN Urbana State:Illinois United States North and Central America Life Science Desaturase Enzymes and Coenzymes 4976 4976 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Life Science have been published. Urbana, State:Illinois, United States, North and Central America, Life Science, Desaturase, Enzymes and Coenzymes. [Extracted from the article]

We investigated the effect of external and internal osmotic stress on the profile of long-chain polyunsaturated fatty acids (LC-PUFA) in euryhaline eels Anguilla japonica. Freshwater (FW) fish were transferred to seawater (SW) for external osmotic stress or subjected to internal stress through injection with hypertonic saline. FW eels injected with isotonic saline served as controls. Plasma osmolality, Na+ concentration, and gill Na+/K+-ATPase activity increased, but hematocrit decreased compared with controls in eels exposed to external or internal osmotic stress. The expression of two major transporter genes for SW adaptation, the Na+ -K+ -2Cl- co-transporter 1a (NKCC1a) in the gill and NKCC2b in the intestine, was up-regulated only in SW-transferred eels, suggesting a direct impact of SW on the gill and intestine via SW ingestion. Total LC-PUFA contents and DHA (22:6 n-3) increased in the gill and liver of SW-transferred eels and in the intestine of hypertonic saline-injected eels. However, total LC-PUFA content in plasma decreased after both external and internal osmotic stimuli. In contrast, the gene expression of two key enzymes involved in the LC-PUFA biosynthesis, Δ6 fatty acid desaturase and elongase, did not change in the gill, intestine and liver of osmotically stressed eels. These results indicate that LC-PUFA is possibly involved in osmoregulation and the increased LC-PUFA contents of osmoregulatory organs might be a result of LC-PUFA transport via circulation, rather than through de novo biosynthesis. [ABSTRACT FROM AUTHOR]

Keywords: Aurora; State:Colorado; United States; North and Central America; Acute Myeloid Leukemia; Antineoplastics; BCL-2 Inhibitors; Cancer; Drugs and Therapies; Health and Medicine; Hematology; Leukemia; Myeloid Leukemia; Oncology; Pharmaceuticals; Stem Cell Research; Venetoclax Therapy EN Aurora State:Colorado United States North and Central America Acute Myeloid Leukemia Antineoplastics BCL-2 Inhibitors Cancer Drugs and Therapies Health and Medicine Hematology Leukemia Myeloid Leukemia Oncology Pharmaceuticals Stem Cell Research Venetoclax Therapy 2411 2411 1 06/12/23 20230616 NES 230616 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators publish new report on Oncology - Acute Myeloid Leukemia. For more information on this research see: Therapy-resistant Acute Myeloid Leukemia Stem Cells Are Resensitized To Venetoclax. [Extracted from the article]

Keywords: Biomarkers; Cancer; Desaturase; Diagnostics and Screening; Drugs and Therapies; Enzymes and Coenzymes; Fatty Acid Desaturases; Genetics; Health and Medicine; Oncology; Oxidoreductases; Oxygenases; Pharmaceuticals; Stearoyl-CoA Desaturase; Stem Cell Research EN Biomarkers Cancer Desaturase Diagnostics and Screening Drugs and Therapies Enzymes and Coenzymes Fatty Acid Desaturases Genetics Health and Medicine Oncology Oxidoreductases Oxygenases Pharmaceuticals Stearoyl-CoA Desaturase Stem Cell Research 481 481 1 06/05/23 20230609 NES 230609 2023 JUN 6 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- New research on cancer is the subject of a new report. According to the news reporters, the research concluded: "In addition, the involvement of SCD1 in cancer stem cells has been observed in various types of cancer. [Extracted from the article]

Keywords: Acute Myeloid Leukemia; Antineoplastics; Aza Compounds; Azacitidine; Azacitidine Therapy; BCL-2 Inhibitors; Cancer; Drugs and Therapies; Enzymes and Coenzymes; Fatty Acid Desaturases; Health and Medicine; Hematology; Leukemia; Mixed Function Oxygenases; Myeloid Leukemia; Oncology; Oxidoreductases; Pharmaceuticals; Stem Cell Research; Venetoclax Therapy EN Acute Myeloid Leukemia Antineoplastics Aza Compounds Azacitidine Azacitidine Therapy BCL-2 Inhibitors Cancer Drugs and Therapies Enzymes and Coenzymes Fatty Acid Desaturases Health and Medicine Hematology Leukemia Mixed Function Oxygenases Myeloid Leukemia Oncology Oxidoreductases Pharmaceuticals Stem Cell Research Venetoclax Therapy 348 348 1 04/10/23 20230413 NES 230413 2023 APR 14 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- New study results on acute myeloid leukemia have been published. This study includes the largest lipidomic profile of LSC-enriched primary AML patient cells to date and indicates that inhibition of fatty acid desaturation is a promising therapeutic target for relapsed AML.". [Extracted from the article]

Keywords: Cardiology; Cardiovascular; Cardiovascular Research; Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Health and Medicine; Oxidoreductases; Oxygenases; Stearoyl-CoA Desaturase EN Cardiology Cardiovascular Cardiovascular Research Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Health and Medicine Oxidoreductases Oxygenases Stearoyl-CoA Desaturase 245 245 1 04/03/23 20230403 NES 230403 2023 APR 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on fatty acid desaturases is the subject of a new report. According to news originating from Warsaw, Poland, by NewsRx editors, the research stated, "Stearoyl-CoA desaturase is a rate-limiting enzyme in the synthesis of monounsaturated fatty acids." The loss of stearoyl-CoA desaturase 1 reduces fatty acid oxidation and increases glucose oxidation in the heart. [Extracted from the article]

Keywords: Bariatrics; Cardiology; Cardiovascular; Cardiovascular Research; Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Genetics; Health and Medicine; Mixed Function Oxygenases; Nutritional and Metabolic Diseases and Conditions; Obesity; Oxidoreductases; Peptide Hormones; Peptide Proteins; Proinsulin; Risk and Prevention EN Bariatrics Cardiology Cardiovascular Cardiovascular Research Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Genetics Health and Medicine Mixed Function Oxygenases Nutritional and Metabolic Diseases and Conditions Obesity Oxidoreductases Peptide Hormones Peptide Proteins Proinsulin Risk and Prevention 2023 MAR 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New study results on obesity have been published. Bariatrics, Cardiology, Cardiovascular, Cardiovascular Research, Desaturase, Enzymes and Coenzymes, Fatty Acid Desaturases, Genetics, Health and Medicine, Mixed Function Oxygenases, Nutritional and Metabolic Diseases and Conditions, Obesity, Oxidoreductases, Peptide Hormones, Peptide Proteins, Proinsulin, Risk and Prevention. [Extracted from the article]