Research on Atherosclerosis Discussed by Researchers at Capital Medical University (Targeted Knockdown of Hepatic D-5 Fatty Acid Desaturase FADS1 Aggravates Atherosclerosis in ApoE-/- Mice).

Researchers at Capital Medical University in Beijing, China, have conducted a study on the role of the D-5 fatty acid desaturase (FADS1) gene in atherosclerosis. The study found that knockdown of hepatic Fads1 in mice with atherosclerosis exacerbated the disease and non-alcoholic fatty liver disease (NAFLD), leading to weight loss. However, the knockdown did not affect peripheral atherosclerosis induced by vascular cuff combined with tandem stenosis. The findings suggest that FADS1 may play a role in the development and progression of atherosclerosis. [Extracted from the article]