1. DPPH-Scavenging Activities and Structure-Activity Relationships of Phenolic Compounds
- Author
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Zheng, Cheng-Dong, Li, Gang, Li, Hu-Qiang, Xu, Xiao-Jing, Gao, Jin-Ming, and Zhang, An-Ling
- Abstract
Thirty-eight phenolic compounds (including 31 flavonoids) were examined for their DPPH radical-scavenging activities, and structure-activity relationships were evaluated. Specifically, the presence of an Ortho-dihydroxyl structure in phenolics is largely responsible for their excellent antiradical activity. 3-Hydroxyl was also essential to generate a high radical-scavenging activity. An increasing number of hydroxyls on flavones with a 3′,4′-dihydroxyl basic structure, the presence of a third hydroxyl group at C-5′, a phloroglucinol structure, glycosylation and methylation of the hydroxyls, and some other hydroxyls, for example 5-, and 7-hydroxyl in ring A, decreased the radical-scavenging activities of flavonoids and other phenolics.
- Published
- 2010
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