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DPPH-Scavenging Activities and Structure-Activity Relationships of Phenolic Compounds
- Source :
- Natural Product Communications; November 2010, Vol. 5 Issue: 11
- Publication Year :
- 2010
-
Abstract
- Thirty-eight phenolic compounds (including 31 flavonoids) were examined for their DPPH radical-scavenging activities, and structure-activity relationships were evaluated. Specifically, the presence of an Ortho-dihydroxyl structure in phenolics is largely responsible for their excellent antiradical activity. 3-Hydroxyl was also essential to generate a high radical-scavenging activity. An increasing number of hydroxyls on flavones with a 3′,4′-dihydroxyl basic structure, the presence of a third hydroxyl group at C-5′, a phloroglucinol structure, glycosylation and methylation of the hydroxyls, and some other hydroxyls, for example 5-, and 7-hydroxyl in ring A, decreased the radical-scavenging activities of flavonoids and other phenolics.
Details
- Language :
- English
- ISSN :
- 1934578X and 15559475
- Volume :
- 5
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Natural Product Communications
- Publication Type :
- Periodical
- Accession number :
- ejs49639196
- Full Text :
- https://doi.org/10.1177/1934578X1000501112