70 results on '"Van Zon, A."'
Search Results
2. Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study
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Ballering, Aranka V, van Zon, Sander K R, olde Hartman, Tim C, and Rosmalen, Judith G M
- Abstract
Patients often report various symptoms after recovery from acute COVID-19. Previous studies on post-COVID-19 condition have not corrected for the prevalence and severity of these common symptoms before COVID-19 and in populations without SARS-CoV-2 infection. We aimed to analyse the nature, prevalence, and severity of long-term symptoms related to COVID-19, while correcting for symptoms present before SARS-CoV-2 infection and controlling for the symptom dynamics in the population without infection.
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- 2022
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3. Automated video chain optimization
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van Zon, Kees and Ali, Walid
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Television sets -- Research ,Business ,Electronics and electrical industries ,Engineering and manufacturing industries - Abstract
Video processing algorithms found in complex video appliances such as television sets and set top boxes exhibit an interdependency that makes it is difficult to predict the picture quality of an end product before it is actually built. This quality is likely to improve when algorithm interaction is explicitly considered. Moreover, video algorithms tend to have many programmable parameters, which are traditionally tuned in manual fashion. Tuning these parameters automatically rather than manually is likely to speed up product development. We present a methodology that addresses these issues by means of a genetic algorithm that, driven by a novel objective image quality metric, finds high-quality configurations of the video processing chain of complex video products.
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- 2001
4. Bright horizons
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Van Zon, Carla
- Published
- 2001
5. 'Ik wil graag meer balans'
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van Zon, Daan P.M.W, Krabbe, Tess S., and Damstra, M.S.
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- 2022
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6. Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation
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He, Gui-Wei, Lin, Lin, DeMartino, Jeff, Zheng, Xuan, Staliarova, Nadzeya, Dayton, Talya, Begthel, Harry, van de Wetering, Willine J., Bodewes, Eduard, van Zon, Jeroen, Tans, Sander, Lopez-Iglesias, Carmen, Peters, Peter J., Wu, Wei, Kotlarz, Daniel, Klein, Christoph, Margaritis, Thanasis, Holstege, Frank, and Clevers, Hans
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- 2022
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7. Transitioning out of work and metabolic syndrome incidence: a longitudinal study among 13 303 older workers from the Lifelines Cohort Study and Biobank
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Runge, Katharina, van Zon, Sander K. R., Bu¨ltmann, Ute, and Henkens, Kène
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BackgroundThis study investigates (1) whether different employment transition types (ie, unemployment, work disability, early retirement and regular retirement) are associated with metabolic syndrome (MetS) incidence among older workers (50–64 years) and (2) whether occupational group moderates the association between employment transition type and MetS incidence.MethodsA sample of 13 303 older Dutch workers from the Lifelines Cohort Study and Biobank was examined using longitudinal data from two comprehensive measurement waves with a mean follow-up time of 3.7 years. MetS components were based on physical measures, blood markers and medication use. Employment transitions were determined using questionnaires. Logistic regression analysis was performed to examine the association between employment transition type and MetS incidence.ResultsOlder workers who transitioned from employment to unemployment (adjusted OR 1.39, 95% CI 1.05 to 1.82) or work disability (adjusted OR 1.89, 95% CI 1.15 to 3.10) had a significantly higher MetS incidence than the working control group. No association between early retirement or regular retirement with MetS incidence was found after adjusting for sociodemographic, educational and occupational factors. Occupational group did not moderate the association between employment transition type and MetS incidence.ConclusionThe results suggest that older workers who transition from employment to unemployment or work disability are at risk for developing MetS. More awareness among occupational physicians and general practitioners about MetS incidence in late working life is needed in general and more specific among older workers who transition into unemployment or work disability.
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- 2022
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8. Do chronic diseases moderate the association between psychosocial working conditions and work exit? Longitudinal results from 55 950 Dutch workers
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van Zon, Sander K R, Ots, Patricia, Robroek, Suzan J W, Burdorf, Alex, Oude Hengel, Karen M, and Brouwer, Sandra
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BackgroundThis study aims to examine whether the presence of chronic diseases or multimorbidity moderates the associations between psychosocial working conditions and work exit through unemployment, work disability or early retirement.MethodsData from Lifelines (n=55 950), a prospective population-based cohort study, were enriched with monthly information on employment status from Statistics Netherlands. Working conditions were measured with the Copenhagen Psychosocial Questionnaire. Work exit was defined as unemployment, work disability and early retirement. Participants were classified as having no chronic disease, one chronic disease or multimorbidity. Cause-specific Cox proportional hazard regression models, adjusted for age, gender, education and partnership status, were used to analyse associations between working conditions and work exit. Interaction terms were used to examine moderation by chronic disease status.ResultsHigher social support decreased the risk for unemployment, work disability and early retirement. Higher meaning of work decreased the risk of unemployment, and more possibilities for development decreased the risk for work disability. Chronic disease status did generally not moderate associations between working conditions and work exit. Only among workers without a chronic disease, more possibilities for development was associated with a lower risk for unemployment (HR: 0.89; 95% CI: 0.85 to 0.94).ConclusionWhile efforts to retain workers with chronic diseases in the labour market should continue, favourable psychosocial working conditions are important for all workers.
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- 2022
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9. Cartilage-derived cells display heterogeneous pericellular matrix synthesis in agarose microgels
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van Mourik, Marloes, Tiemeijer, Bart M., van Zon, Maarten, Abinzano, Florencia, Tel, Jurjen, Foolen, Jasper, and Ito, Keita
- Abstract
•Cartilage-derived cells can produce a pericellular matrix within 10 days.•Flow cytometry and microscopy suggest that matrix synthesis is a sequential process.•Chondroprogenitors show more heterogeneity between individual cells.•A chondroprogenitor subset could have a high potential for functional tissue repair.
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- 2024
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10. Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing
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Artegiani, Benedetta, Hendriks, Delilah, Beumer, Joep, Kok, Rutger, Zheng, Xuan, Joore, Indi, Chuva de Sousa Lopes, Susana, van Zon, Jeroen, Tans, Sander, and Clevers, Hans
- Abstract
CRISPR–Cas9 technology has revolutionized genome editing and is applicable to the organoid field. However, precise integration of exogenous DNA sequences into human organoids is lacking robust knock-in approaches. Here, we describe CRISPR–Cas9-mediated homology-independent organoid transgenesis (CRISPR–HOT), which enables efficient generation of knock-in human organoids representing different tissues. CRISPR–HOT avoids extensive cloning and outperforms homology directed repair (HDR) in achieving precise integration of exogenous DNA sequences into desired loci, without the necessity to inactivate TP53 in untransformed cells, which was previously used to increase HDR-mediated knock-in. CRISPR–HOT was used to fluorescently tag and visualize subcellular structural molecules and to generate reporter lines for rare intestinal cell types. A double reporter—in which the mitotic spindle was labelled by endogenously tagged tubulin and the cell membrane by endogenously tagged E-cadherin—uncovered modes of human hepatocyte division. Combining tubulin tagging with TP53knock-out revealed that TP53 is involved in controlling hepatocyte ploidy and mitotic spindle fidelity. CRISPR–HOT simplifies genome editing in human organoids.
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- 2020
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11. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
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Sawhney, Jitendra PS., Kothiwale, Veerappa A., Bisne, Vikas, Durgaprasad, Rajashekhar, Jadhav, Praveen, Chopda, Manoj, Vanajakshamma, Velam, Meena, Ramdhan, Vijayaraghavan, Govindan, Chawla, Kamaldeep, Allu, Jagan, Pieper, Karen S., John Camm, A., Kakkar, Ajay K., Kakkar, Ajay K., Bassand, Jean-Pierre, John Camm, A., Fitzmaurice, David A., Goldhaber, Samuel Z., Goto, Shinya, Haas, Sylvia, Hacke, Werner, Mantovani, Lorenzo G., Misselwitz, Frank, Pieper, Karen S., Turpie, Alexander G.G., van Eickels, Martin, Verheugt, Freek W.A., John Camm, A., Bassand, Jean-Pierre, Goldhaber, Samuel Z., Haas, Sylvia, Kayani, Gloria, Mantovani, Lorenzo G., Fox, Keith A.A., Gersh, Bernard J., Luciardi, Hector Lucas, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Barretto, Antonio Carlos Pereira, Connolly, Stuart J., Spyropoulos, Alex, Eikelboom, John, Corbalan, Ramon, Hu, Dayi, Jansky, Petr, Nielsen, Jørn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Le Heuzey, Jean-Yves, Darius, Harald, Keltai, Matyas, Kakkar, Sanjay, Sawhney, Jitendra Pal Singh, Agnelli, Giancarlo, Ambrosio, Giuseppe, Koretsune, Yukihiro, Sánchez Díaz, Carlos Jerjes, Ten Cate, Hugo, Atar, Dan, Stepinska, Janina, Panchenko, Elizaveta, Lim, Toon Wei, Jacobson, Barry, Oh, Seil, Viñolas, Xavier, Rosenqvist, Marten, Steffel, Jan, Angchaisuksiri, Pantep, Oto, Ali, Parkhomenko, Alex, Al Mahmeed, Wael, Fitzmaurice, David, Goldhaber, Samuel Z., Hu, D.Y., Chen, K.N., Zhao, Y.S., Zhang, H.Q., Chen, J.Z., Cao, S.P., Wang, D.W., Yang, Y.J., Li, W.H., Yin, Y.H., Tao, G.Z., Yang, P., Chen, Y.M., He, S.H., Wang, Ying, Wang, Yong, Fu, G.S., Li, X., Wu, T.G., Cheng, X.S., Yan, X.W., Zhao, R.P., Chen, M.S., Xiong, L.G., Chen, P., Jiao, Y., Guo, Y., Xue, L., Wang, F.Z., Li, H., Yang, Z.M., Bai, C.L., Chen, J., Chen, J.Y., Chen, X., Feng, S., Fu, Q.H., Gao, X.J., Guo, W.N., He, R.H., He, X.A., Hu, X.S., Huang, X.F., Li, B., Li, J., Li, L., Li, Y.H., Liu, T.T., Liu, W.L., Liu, Y.Y., Lu, Z.C., Luo, X.L., Ma, T.Y., Peng, J.Q., Sheng, X., Shi, X.J., Sun, Y.H., Tian, G., Wang, K., Wang, L., Wu, R.N., Xie, Q., Xu, R.Y., Yang, J.S., Yang, L.L., Yang, Q., Yang, Y.J., Ye, Y., Yu, H.Y., Yu, J.H., Yu, T., Zhai, H., Zhan, Q., Zhang, G.S., Zhang, Q., Zhang, R., Zhang, Y., Zheng, W.Y., Zhou, B., Zhou, Z.H., Zhu, X.Y., Kakkar, S., Sawhney, J.P.S., Jadhav, P., Durgaprasad, R., Ravi Shankar, A.G., Rajput, R.K., Bhargava, K., Sarma, R., Srinivas, A., Roy, D., Nagamalesh, U.M., Chopda, M., Kishore, R., Kulkarni, G., Chandwani, P., Pothiwala, R.A., Padinhare Purayil, M., Shah, S., Chawla, K., Kothiwale, V.A., Raghuraman, B., Vijayaraghavan, G., Vijan, V.M., Bantwal, G., Bisne, V., Khan, A., Gupta, J.B., Kumar, S., Jain, D., Abraham, S., Adak, D., Barai, A., Begum, H., Bhattacharjee, P., Dargude, M., Davies, D., Deshpande, B., Dhakrao, P., Dhyani, V., Duhan, S., Earath, M., Ganatra, A., Giradkar, S., Jain, V., Karthikeyan, R., Kasala, L., Kaur, S., Krishnappa, S., Lawande, A., Lokesh, B., Madarkar, N., Meena, R., More, P., Naik, D., Prashanth, K., Rao, M., Rao, N.M., Sadhu, N., Shah, D., Sharma, M., Shiva, P., Singhal, S., Suresh, S., Vanajakshamma, V., Panse, S.G., Koretsune, Y., Kanamori, S., Yamamoto, K., Kumagai, K., Katsuda, Y., Sadamatsu, K., Toyota, F., Mizuno, Y., Misumi, I., Noguchi, H., Ando, S., Suetsugu, T., Minamoto, M., Oda, Hiroshi, Shiraishi, K., Adachi, S., Chiba, K., Norita, H., Tsuruta, M., Koyanagi, T., Yamamoto, K., Ando, H., Higashi, T., Okada, K., Azakami, S., Komaki, S., Kumeda, K., Murayama, T., Matsumura, J., Oba, Y., Sonoda, R., Goto, K., Minoda, K., Haraguchi, Y., Suefuji, H., Miyagi, H., Kato, H., Nakamura, Tadashi, Nakamura, Tsugihiro, Nandate, H., Zaitsu, R., Fujiura, Yoshihisa, Yoshimura, A., Numata, H., Ogawa, J., Tatematsu, H., Kamogawa, Y., Murakami, K., Wakasa, Y., Yamasawa, M., Maekawa, H., Abe, S., Kihara, H., Tsunoda, S., Saito, Katsumi, Saito, Kazuyuki, Fudo, T., Obunai, K., Tachibana, H., Oba, I., Kuwahata, T., Higa, S., Gushiken, M., Eto, T., Yoshida, H., Ikeda, D., Fujiura, Yoshitake, Ishizawa, M., Nakatsuka, M., Murata, K., Ogurusu, C., Shimoyama, M., Akutsu, M., Takamura, I., Hoshino, F., Yokota, N., Iwao, T., Tsuchida, K., Takeuchi, M., Hatori, Y., Kitami, Y., Nakamura, Yoichi, Oyama, R., Ageta, M., Oda, Hiroyuki, Go, Y., Mishima, K., Unoki, T., Morii, S., Shiga, Yuhei, Sumi, H., Nagatomo, T., Sanno, K., Fujisawa, K., Atsuchi, Y., Nagoshi, T., Seto, T., Tabuchi, T., Kameko, M., Nii, K., Oshiro, K., Takezawa, H., Nagano, S., Miyamoto, N., Iwaki, M., Nakamura, Yuichiro, Fujii, M., Okawa, M., Abe, Masahiko, Abe, Masatake, Abe, Mitsunori, Saito, T., Mito, T., Nagao, K., Minami, J., Mita, T., Sakuma, I., Taguchi, T., Marusaki, S., Doi, H., Tanaka, M., Fujito, T., Matsuta, M., Kusumoto, T., Kakinoki, S., Ashida, K., Yoshizawa, N., Agata, J., Arasaki, O., Manita, M., Ikemura, M., Fukuoka, S., Murakami, H., Matsukawa, S., Hata, Y., Taniguchi, T., Ko, T., Kubo, H., Imamaki, M., Akiyama, M., Inagaki, M., Odakura, H., Ueda, T., Katsube, Y., Nakata, A., Watanabe, H., Techigawara, M., Igarashi, M., Taga, K., Kimura, T., Tomimoto, S., Shibuya, M., Nakano, M., Ito, K., Seo, T., Hiramitsu, S., Hosokawa, H., Hoshiai, M., Hibino, M., Miyagawa, K., Horie, Hajime, Sugishita, N., Shiga, Yukio, Soma, A., Neya, K., Yoshida, Tetsuro, Yoshida, Tomoki, Mizuguchi, M., Ishiguro, M., Minagawa, T., Wada, M., Mukawa, H., Okuda, F., Nagasaka, S., Abe, Y., Adachi, Sen, Adachi, Susumu, Adachi, T., Akahane, K., Amano, T., Aoki, K., Aoyama, T., Arai, H., Arima, S., Arino, T., Asano, H., Asano, T., Azuma, J., Baba, T., Betsuyaku, T., Chibana, H., Date, H., Doiuchi, J., Emura, Y., Endo, M., Fujii, Y., Fujiki, R., Fujisawa, A., Fujisawa, Y., Fukuda, T., Fukui, T., Furukawa, N., Furukawa, T., Furumoto, W., Goto, T., Hamaoka, M., Hanazono, N., Hasegawa, K., Hatsuno, T., Hayashi, Y., Higuchi, K., Hirasawa, K., Hirayama, H., Hirose, M., Hirota, S., Honda, M., Horie, Hideki, Ido, T., Iiji, O., Ikeda, H., Ikeda, K., Ikeoka, K., Imaizumi, M., Inaba, H., Inoue, T., Iseki, F., Ishihara, A., Ishioka, N., Ito, N., Iwase, T., Kakuda, H., Kamata, J., Kanai, H., Kanda, H., Kaneko, M., Kano, H., Kasai, T., Kato, T., Kato, Y., Kawada, Y., Kawai, K., Kawakami, K., Kawakami, S., Kawamoto, T., Kawano, S., Kim, J., Kira, T., Kitazawa, H., Kitazumi, H., Kito, T., Kobayashi, T., Koeda, T., Kojima, J., Komatsu, H., Komatsu, I., Koshibu, Y., Kotani, T., Kozuka, T., Kumai, Y., Kumazaki, T., Maeda, I., Maeda, K., Maruyama, Y., Matsui, S., Matsushita, K., Matsuura, Y., Mineoi, K., Mitsuhashi, H., Miura, N., Miyaguchi, S., Miyajima, S., Miyamoto, H., Miyashita, A., Miyata, S., Mizuguchi, I., Mizuno, A., Mori, T., Moriai, O., Morishita, K., Murai, O., Nagai, Sho, Nagai, Shunichi, Nagata, E., Nagata, H., Nakagomi, A., Nakahara, S., Nakamura, M., Nakamura, R., Nakanishi, N., Nakayama, T., Nakazato, R., Nanke, T., Nariyama, J., Niijima, Y., Niinuma, H., Nishida, Y., Nishihata, Y., Nishino, K., Nishioka, H., Nishizawa, K., Niwa, I., Nomura, K., Nomura, S., Nozoe, M., Ogawa, T., Ohara, N., Okada, M., Okamoto, K., Okita, H., Okuyama, M., Ono, H., Ono, T., Onuki Pearce, Y., Oriso, S., Ota, A., Otaki, E., Saito, Y., Sakai, H., Sakamoto, N., Sakamoto, Y., Samejima, Y., Sasagawa, Y., Sasaguri, H., Sasaki, A., Sasaki, T., Sato, Kazuki, Sato, Kiyoharu, Sawano, M., Seki, S., Sekine, Y., Seta, Y., Sezaki, K., Shibata, N., Shiina, Y., Shimono, H., Shimoyama, Y., Shindo, T., Shinohara, H., Shinohe, R., Shinozuka, T., Shirai, T., Shiraiwa, T., Shozawa, Y., Suga, T., Sugimoto, C., Suzuki, Kazuo, Suzuki, Keita, Suzuki, Shu, Suzuki, Shunji, Suzuki, Susumu, Suzuki, Y., Tada, M., Taguchi, A., Takagi, T., Takagi, Y., Takahashi, K., Takahashi, S., Takai, H., Takanaka, C., Take, S., Takeda, H., Takei, K., Takenaka, K., Tana, T., Tanabe, G., Taya, K., Teragawa, H., Tohyo, S., Toru, S., Tsuchiya, Y., Tsuji, T., Tsuzaki, K., Uchiyama, H., Ueda, O., Ueda, T., Ueyama, Y., Wakaki, N., Wakiyama, T., Washizuka, T., Watanabe, M., Yamada, T., Yamagishi, T., Yamaguchi, H., Yamamoto, Kenichi, Yamamoto, Kentaro, Yamamoto, Kunihiko, Yamamoto, T., Yamaura, M., Yamazoe, M., Yasui, K., Yokoyama, Y., Yoshida, K., Lim, T.W., Ching, C.K., Foo, C.G., Chow, J.H., Chen, D.D., Jaufeerally, F.R., Lee, Y.M., Li, H., Lim, G., Lim, W.T., Thng, S., Yap, S.Y., Yeo, C., Oh, S., Pak, H.N., Kim, J.-B., Kim, J.H., Jang, S.-W., Kim, D.H., Kim, J., Ryu, D.R., Park, S.W., Kim, D.-K., Choi, D.J., Oh, Y.S., Cho, M.-C., Kim, S.-H., Jeon, H.-K., Shin, D.-G., Park, J.S., Park, H.K., Han, S.-J., Sung, J.H., Cho, J.-G., Nam, G.-B., On, Y.K., Lim, H.E., Kwak, J.J., Cha, T.-J., Hong, T.J., Park, S.H., Yoon, J.H., Kim, N.-H., Kim, K.-S., Jung, B.C., Hwang, G.-S., Kim, C.-J., Park, J.S., Kim, D.B., Ahn, J.J., An, H.J., Bae, H., Baek, A.L., Chi, W.J., Choi, E.A., Choi, E.H., Choi, H.K., Choi, H.S., Han, S., Heo, E.S., Her, K.O., Hwang, S.W., Jang, E.M., Jang, H.-S., Jang, S., Jeon, H.-G., Jeon, S.R., Jeon, Y.R., Jeong, H.K., Jung, I.-A., Kim, Hyeon Jeong, Kim, Hyun Ju, Kim, Ji Seon, Kim, Jung Sook, Kim, J.A., Kim, K.T., Kim, M.S., Kim, Sang Hee, Kim, Sang Hyun, Kim, Y.-I., Lee, C.S., Lee, E.H., Lee, G.H., Lee, H.Y., Lee, H.-Y., Lee, K.H., Lee, K.R., Lee, M.S., Lee, M.-Y., Lee, R.W., Lee, S.E., Lee, S.H., Lee, S., Lee, W.Y., Noh, I.K., Park, A.R., Park, B.R., Park, H.N., Park, J.H., Park, M., Park, Y., Seo, S.-Y., Shim, J., Sim, J.H., Sohn, Y.M., Son, W.S., Son, Y.S., Song, H.J., Wi, H.K., Woo, J.J., Ye, S., Yim, K.H., Yoo, K.M., Yoon, E.J., Yun, S.Y., Angchaisuksiri, P., Chawanadelert, S., Mongkolwongroj, P., Kanokphatcharakun, K., Cheewatanakornkul, S., Laksomya, T., Pattanaprichakul, S., Chantrarat, T., Rungaramsin, S., Silaruks, S., Wongcharoen, W., Siriwattana, K., Likittanasombat, K., Katekangplu, P., Boonyapisit, W., Cholsaringkarl, D., Chatlaong, B., Chattranukulchai, P., Santanakorn, Y., Hutayanon, P., Khunrong, P., Bunyapipat, T., Jai-Aue, S., Kaewsuwanna, P., Bamungpong, P., Gunaparn, S., Hongsuppinyo, S., Inphontan, R., Khattaroek, R., Khunkong, K., Kitmapawanont, U., Kongsin, C., Naratreekoon, B., Ninwaranon, S., Phangyota, J., Phrommintikul, A., Phunpinyosak, P., Pongmorakot, K., Poomiphol, S., Pornnimitthum, N., Pumprueg, S., Ratchasikaew, S., Sanit, K., Sawanyawisuth, K., Silaruks, B., Sirichai, R., Sriwichian, A., Suebjaksing, W., Sukklad, P., Suttana, T., Tangsirira, A., Thangpet, O., Tiyanon, W., Vorasettakarnkij, Y., Wisaratapong, T., Wongtheptien, W., Wutthimanop, A., Yawila, S., Oto, A., Altun, A., Ozdogru, I., Ozdemir, K., Yilmaz, O., Aydinlar, A., Yilmaz, M.B., Yeter, E., Ongen, Z., Cayli, M., Pekdemir, H., Ozdemir, M., Sucu, M., Sayin, T., Demir, M., Yorgun, H., Ersanli, M., Okuyan, E., Aras, D., Abdelrahman, H., Aktas, O., Alpay, D., Aras, F., Bireciklioglu, M.F., Budeyri, S., Buyukpapuc, M., Caliskan, S., Esen, M., Felekoglu, M.A., Genc, D., Ikitimur, B., Karaayvaz, E.B., Kılıç Karataş, S., Okutucu, S., Ozcelik, E., Quisi, A., Sag, H., Sahiner, L., Sayin, B.Y., Seker, T., Uzun Alkan, D., Yildirim, E., Yildirim, R., Yilmaz, F., Yuksekdag, V., Luciardi, H.L., Vensentini, N., Ingaramo, A.C., Sambadaro, G.A., Fernandez Caputi, V., Berman, S.G., Dragotto, P., Kleiban, A.J., Centurion, N., Giacomi, G., Ahuad Guerrero, R.A., Conde, D., Zapata, G., Di Paola, L.A., Ramos, J.L., Dran, R.D., Egido, J., Fernandez, A.A., Fosco, M.J., Sassone, S., Sinisi, V.A., Cartasegna, L.R., Berli, M.A., Gomez Vilamajo, O.A., Ferroni, F., Alaguibe, E.D., Alvarez D'Amelio, A., Arabetti, C., Arias, L., Belardi, J.A., Bergesio, L., Berli, F., Berli, M., Borchowiec, S., Buzzetti, C., Cabrini, R., Campisi, V., Cappi, A.L., Carrizo, R., Colombo Berra, F., Costabel, J.P., Costamagna, O.J.A., Damonte, A.A., De Urquiza, I.N., Diez, F., Edén, M.F., Fanuele, M., Fernandez Voena, F., Foa Torres, M., Funosas, C., Giacomi, M.P., Gimenez, C.H., Gurfinkel, E.P., de L.M. Had, M., Hansen, V., Hrabar, A.D., Ingratta, M., Lopez, A., Maehara, G., Maffei, L., Martinelli, A., Martinelli, C., Matkovich, J., Mautner, B., Meirino, A., Munguia, R., Navarro, A., Novas, V., Perez Prados, G., Pontoriero, J., Potito, R.N., Ricotti, C., Rodriguez, M.A., Rolandi, F., Said Palladino, M.E., Salinger, M., Sanziani, L.S., Schygiel, P.O., Sossich, A., Tinto, J.F., Tonelli, L., Tufare, A.L., Vallejo, M., Yunis, M.E., Zillo, M., Zurbrigk, F.J., Barretto, A.C.P., Sobral Filho, D.C., Jaber, J., Armaganijan, D., Faria Neto, J., Steffens, A., Kunz Sebba Barroso de Souza, W., de Souza Neto, J.D., Ribeiro, J.M., Silveira Teixeira, M., Ferreira Rossi, P.R., Pires, L., Moreira, D., Moura Jorge, J.C., Menezes Lorga Filho, A., Bodanese, L.C., Westerlund Montera, M., Del Carlo, C.H., Da Rocha Rodrigues, T., Alves da Costa, F.A., Lopes, A., Lopes, R., Araújo, G.R., Fernandes Manenti, E.R., Kerr Saraiva, J.F., Ferreira Braga, J.C., Negri, A., Souto, L., Moncada, C., Bertolim Precoma, D., 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Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
- Abstract
The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry.
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- 2018
- Full Text
- View/download PDF
12. The Interaction of Genetic Predisposition and Socioeconomic Position With Type 2 Diabetes Mellitus: Cross-Sectional and Longitudinal Analyses From the Lifelines Cohort and Biobank Study
- Author
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van Zon, Sander K.R., Reijneveld, Sijmen A., van der Most, Peter J., Swertz, Morris A., Bültmann, Ute, and Snieder, Harold
- Abstract
Supplemental digital content is available in the text.
- Published
- 2018
- Full Text
- View/download PDF
13. 'Vergeet Mij Niet': Hoe ruziënde ouders in een virtuele omgeving de emoties van plegers van partnergeweld beïnvloeden.
- Author
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Henskens, Renée, Wondergem, Bernd, Mooij, Jolanda, van Zon, Christel, and Schoutens, Lisette
- Abstract
Copyright of PROCES is the property of Boom uitgevers Den Haag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
14. The impact of low education and poor health on unemployment varies by work life stage
- Author
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van Zon, Sander, Reijneveld, Sijmen, Mendes de Leon, Carlos, and Bültmann, Ute
- Abstract
The aim of this study is to examine associations and interactions of education, and physical and mental health with unemployment in early, mid, and late work life. This cross-sectional study uses data from 69,118 respondents from Lifelines. Health status was measured with the RAND-36, education was self-reported, and participants working <12 h per week or indicating to be unemployed were considered unemployed. The relative excess risk due to interaction (RERI) was calculated to measure interaction on the additive scale. Interactions of low education and poor mental health were found in early [RERI: 2.14; 95% confidence interval (CI): 0.63, 3.65], mid (1.41; 0.61, 2.20) and late (0.63; 0.09, 1.17) work life. Interaction between low education and poor physical health was only found in mid-work life (1.27; 0.61, 1.93). Low education and poor physical and mental health exacerbate each other’s impact on unemployment varying by work life stage. Policies addressing unemployment may become more effective if they better account for the physical and mental health status of adults in certain stages of their work life.
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- 2017
- Full Text
- View/download PDF
15. Objective and Subjective Measures of Simultaneous vs Sequential Bilateral Cochlear Implants in Adults: A Randomized Clinical Trial
- Author
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Kraaijenga, Véronique J. C., Ramakers, Geerte G. J., Smulders, Yvette E., van Zon, Alice, Stegeman, Inge, Smit, Adriana L., Stokroos, Robert J., Hendrice, Nadia, Free, Rolien H., Maat, Bert, Frijns, Johan H. M., Briaire, Jeroen J., Mylanus, E. A. M., Huinck, Wendy J., Van Zanten, Gijsbert A., and Grolman, Wilko
- Abstract
IMPORTANCE: To date, no randomized clinical trial on the comparison between simultaneous and sequential bilateral cochlear implants (BiCIs) has been performed. OBJECTIVE: To investigate the hearing capabilities and the self-reported benefits of simultaneous BiCIs compared with those of sequential BiCIs. DESIGN, SETTING, AND PARTICIPANTS: A multicenter randomized clinical trial was conducted between January 12, 2010, and September 2, 2012, at 5 tertiary referral centers among 40 participants eligible for BiCIs. Main inclusion criteria were postlingual severe to profound hearing loss, age 18 to 70 years, and a maximum duration of 10 years without hearing aid use in both ears. Data analysis was conducted from May 24 to June 12, 2016. INTERVENTIONS: The simultaneous BiCI group received 2 cochlear implants during 1 surgical procedure. The sequential BiCI group received 2 cochlear implants with an interval of 2 years between implants. MAIN OUTCOMES AND MEASURES: First, the results 1 year after receiving simultaneous BiCIs were compared with the results 1 year after receiving sequential BiCIs. Second, the results of 3 years of follow-up for both groups were compared separately. The primary outcome measure was speech intelligibility in noise from straight ahead. Secondary outcome measures were speech intelligibility in noise from spatially separated sources, speech intelligibility in silence, localization capabilities, and self-reported benefits assessed with various hearing and quality of life questionnaires. RESULTS: Nineteen participants were randomized to receive simultaneous BiCIs (11 women and 8 men; median age, 52 years [interquartile range, 36-63 years]), and another 19 participants were randomized to undergo sequential BiCIs (8 women and 11 men; median age, 54 years [interquartile range, 43-64 years]). Three patients did not receive a second cochlear implant and were unavailable for follow-up. Comparable results were found 1 year after simultaneous or sequential BiCIs for speech intelligibility in noise from straight ahead (difference, 0.9 dB [95% CI, –3.1 to 4.4 dB]) and all secondary outcome measures except for localization with a 30° angle between loudspeakers (difference, –10% [95% CI, –20.1% to 0.0%]). In the sequential BiCI group, all participants performed significantly better after the BiCIs on speech intelligibility in noise from spatially separated sources and on all localization tests, which was consistent with most of the participants’ self-reported hearing capabilities. Speech intelligibility-in-noise results improved in the simultaneous BiCI group up to 3 years following the BiCIs. CONCLUSIONS AND RELEVANCE: This study shows comparable objective and subjective hearing results 1 year after receiving simultaneous BiCIs and sequential BiCIs with an interval of 2 years between implants. It also shows a significant benefit of sequential BiCIs over a unilateral cochlear implant. Until 3 years after receiving simultaneous BiCIs, speech intelligibility in noise significantly improved compared with previous years. TRIAL REGISTRATION: trialregister.nl Identifier: NTR1722
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- 2017
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16. Investigating young adults’ mental health and early working life trajectories from a life course perspective: the role of transitions
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Bu¨ltmann, Ute, Arends, Iris, Veldman, Karin, McLeod, Christopher B., van Zon, Sander K.R., and Amick III, Benjamin C.
- Abstract
BackgroundMany young adults leave the labour market because of mental health problems or never really enter it, through early moves onto disability benefits. Across many countries of the Organisation for Economic Co-operation and Development, between 30% and 50% of all new disability benefit claims are due to mental health problems; among young adults this moves up to 50%–80%.OutlineWe propose a research agenda focused on transitions in building young adults’ mental health and early working life trajectories, considering varying views for subgroups of a society. First, we briefly review five transition characteristics, then we elaborate a research agenda with specific research questions.Research agendaOur research agenda focuses on transitions as processes, in time and place and as sensitive periods, when examining young adults’ mental health and early working life trajectories from a life course perspective. As more and more childhood and adolescent cohorts mature and facilitate research on later life labour market, work and health outcomes, transition research can help guide policy and practice interventions.Future cross-disciplinary researchIn view of the many challenges young adults face when entering the changing world of work and labour markets, future research on transitions in young adults related to their mental health and early working life trajectories will provide ample opportunities for collaborative cross-disciplinary research and stimulate debate on this important challenge.
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- 2020
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17. Arts : Dare to leap into the unknown
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Van Zon, Carla
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- 1987
18. New life and growth
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Van Zon, Carla
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- 1986
19. The role of low educational attainment on the pathway from adolescent internalizing and externalizing problems to early adult labour market disconnection in the Dutch TRAILS cohort
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Minh, Anita, McLeod, Christopher B., Reijneveld, Sijmen A., Veldman, Karin, van Zon, Sander K.R., and Bültmann, Ute
- Abstract
Mental health challenges in adolescence may affect labour market transitions in young adulthood. Policies addressing early labour market disconnection largely focus on early school-leaving and educational attainment; however, the role of low educational attainment on the path from adolescent mental health to labour market disconnection is unclear. Using the TRacking Adolescents' Individual Lives Survey from the Netherlands (n = 1,197), we examined the extent to which achieving a basic educational qualification (by age 22) in the contemporary Dutch education system, mediates the effect of adolescent mental health (age 11–19) on early adult labour market disconnection, defined as ‘not in education, employment, or training’ (NEET, age 26). We estimated the total effect, the natural direct and indirect effects, and the controlled direct effects of internalizing and externalizing symptoms on NEET by gender. Among young men, clinical levels of adolescent externalizing symptoms were associated with a 0.093 higher probability of NEET compared with no symptoms (95% confidence interval, CI: 0.001, 0.440). The indirect effect through educational attainment accounted for 15.1% of the total effect. No evidence of mediation was observed for the relationship between externalizing symptoms and NEET in young women. No evidence of mediation was observed for the relationship between adolescent internalizing symptoms and NEET in either gender. The findings imply that adolescent externalizing symptoms disrupts the achievement of a basic educational qualification, leading to a higher probability of NEET in young men. This mechanism may play a smaller role in the risk of NEET associated with internalizing symptoms and in young women.
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- 2023
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20. Development of a Squelch Effect in Adult Patients After Simultaneous Bilateral Cochlear Implantation
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Kraaijenga, Véronique J. C., van Zon, Alice, Smulders, Yvette E., Ramakers, Geerte G. J., Van Zanten, Gijsbert A., Stokroos, Robert J., Huinck, Wendy J., Frijns, Johan H. M., Free, Rolien H., and Grolman, Wilko
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- 2016
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21. Comparison of Bilateral and Unilateral Cochlear Implantation in Adults: A Randomized Clinical Trial
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Smulders, Yvette E., van Zon, Alice, Stegeman, Inge, Rinia, Albert B., Van Zanten, Gijsbert A., Stokroos, Robert J., Hendrice, Nadia, Free, Rolien H., Maat, Bert, Frijns, Johan H. M., Briaire, Jeroen J., Mylanus, Emmanuel A. M., Huinck, Wendy J., Smit, Adriana L., Topsakal, Vedat, Tange, Rinze A., and Grolman, Wilko
- Abstract
IMPORTANCE: The cost of bilateral cochlear implantation (BCI) is usually not reimbursed by insurance companies because of a lack of well-designed studies reporting the benefits of a second cochlear implant. OBJECTIVE: To determine the benefits of simultaneous BCI compared with unilateral cochlear implantation (UCI) in adults with postlingual deafness. DESIGN, SETTING, AND PARTICIPANTS: A multicenter randomized clinical trial was performed. The study took place in 5 Dutch tertiary referral centers: the University Medical Centers of Utrecht, Maastricht, Groningen, Leiden, and Nijmegen. Forty patients eligible for cochlear implantation met the study criteria and were included from January 12, 2010, through November 2, 2012. The main inclusion criteria were postlingual onset of hearing loss, age of 18 to 70 years, duration of hearing loss of less than 20 years, and a marginal hearing aid benefit. Two participants withdrew from the study before implantation. Nineteen participants were randomized to undergo UCI and 19 to undergo BCI. INTERVENTIONS: The BCI group received 2 cochlear implants during 1 surgery. The UCI group received 1 cochlear implant. MAIN OUTCOMES AND MEASURES: The primary outcome was the Utrecht Sentence Test with Adaptive Randomized Roving levels (speech in noise, both presented from straight ahead). Secondary outcomes were consonant-vowel-consonant words in silence, speech-intelligibility test with spatially separated sources (speech in noise from different directions), sound localization, and quality of hearing questionnaires. Before any data were collected, the hypothesis was that the BCI group would perform better on the objective and subjective tests that concerned speech intelligibility in noise and spatial hearing. RESULTS: Thirty-eight patients were included in the study. Fifteen patients in the BCI group used hearing aids before implantation compared with 19 in the UCI group. Otherwise, there were no significant differences between the groups’ baseline characteristics. At 1-year follow-up, there were no significant differences between groups on the Utrecht Sentence Test with Adaptive Randomized Roving levels (9.1 dB, UCI group; 8.2 dB, BCI group; P = .39) or the consonant-vowel-consonant test (median percentage correct score 85.0% in the UCI group and 86.8% in the BCI group; P = .21). The BCI group performed significantly better than the UCI group when noise came from different directions (median speech reception threshold in noise, 14.4 dB, BCI group; 5.6 dB, BCI group; P <.001). The BCI group was better able to localize sounds (median correct score of 50.0% at 60°, UCI group; 96.7%, BCI group; P <.001). These results were consistent with the patients’ self-reported hearing capabilities. CONCLUSIONS AND RELEVANCE: This randomized clinical trial demonstrates a significant benefit of simultaneous BCI above UCI in daily listening situations for adults with postlingual deafness. TRIAL REGISTRATION: trialregister.nl Identifier: NTR1722
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- 2016
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22. Development and Validation of a Prediction Model for Unemployment and Disability Benefits: Results from the Longitudinal Population-Based Lifelines Cohort Study and Biobank
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Ots, Patricia, Oude Hengel, Karen M., Burdorf, Alex, Robroek, Suzan J.W., Nieboer, Daan, Schram, Jolinda L.D., van Zon, Sander K.R., and Brouwer, Sandra
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- 2022
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23. Cost–Utility of Bilateral Versus Unilateral Cochlear Implantation in Adults: A Randomized Controlled Trial
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Smulders, Yvette E., van Zon, Alice, Stegeman, Inge, van Zanten, Gijsbert A., Rinia, Albert B., Stokroos, Robert J., Free, Rolien H., Maat, Bert, Frijns, Johan H. M., Mylanus, Emmanuel A. M., Huinck, Wendy J., Topsakal, Vedat, and Grolman, Wilko
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- 2016
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24. Wage divergence and asymmetries in unemployment in a model with biased technical change
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Muysken, Joan, Sanders, Mark, and Van Zon, Adriaan
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Workers -- Effect of technological innovations on ,Labor supply -- Effect of technological innovations on ,Skilled labor -- Compensation and benefits ,Unemployment -- Economic aspects ,Unskilled labor -- Compensation and benefits ,Wages -- Social aspects ,Banking, finance and accounting industries ,Business, international ,Economics - Abstract
Research is presented on how decreasing demand for low-skilled labour has affected wages and unemployment in Europe and the United States, and includes a model showing two classes of goods and two skill levels. Two different labour market regimes are examined with regard to their response to skill-biased technical change.
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- 2001
25. Cochlear Implantation for Patients With Single-Sided Deafness or Asymmetrical Hearing Loss
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van Zon, Alice, Peters, Jeroen P. M., Stegeman, Inge, Smit, Adriana L., and Grolman, Wilko
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A systematic review of the literature to evaluate the clinical outcome of cochlear implantation for patients with single-sided deafness (SSD) or asymmetrical hearing loss (AHL).
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- 2015
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26. Fusion of optical flow based motion pattern analysis and silhouette classification for person tracking and detection
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Burgess, Douglas, Owen, Gari, Rana, Harbinder, Zamboni, Roberto, Kajzar, François, Szep, Attila A., Tangelder, Johan W. H., Lebert, Ed, Burghouts, Gertjan J., van Zon, Kasper, and den Uyl, Marten J.
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- 2014
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27. Inefficient degradation of cyclin B1 re-activates the spindle checkpoint right after sister chromatid disjunction
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Clijsters, Linda, van Zon, Wouter, Riet, Bas ter, Voets, Erik, Boekhout, Michiel, Ogink, Janneke, Rumpf-Kienzl, Cornelia, and Wolthuis, Rob MF
- Abstract
Sister chromatid separation creates a sudden loss of tension on kinetochores, which could, in principle, re-activate the spindle checkpoint in anaphase. This so-called “anaphase problem” is probably avoided by timely inactivation of cyclin B1-Cdk1, which may prevent the spindle tension sensing Aurora B kinase from destabilizing kinetochore–microtubule interactions as they lose tension in anaphase. However, exactly how spindle checkpoint re-activation is prevented remains unclear. Here, we investigated how different degrees of cyclin B1 stabilization affected the spindle checkpoint in metaphase and anaphase. Cells expressing a strongly stabilized (R42A) mutant of cyclin B1 degraded APC/CCdc20substrates normally, showing that checkpoint release was not inhibited by high cyclin B1-Cdk1 activity. However, after this initial wave of APC/CCdc20activity, the spindle checkpoint returned in cells with uncohesed sister chromatids. Expression of a lysine mutant of cyclin B1 that is degraded only slightly inefficiently allowed a normal metaphase-to-anaphase transition. Strikingly, however, the spindle checkpoint returned in cells that had not degraded the cyclin B1 mutant 10–15 min after anaphase onset. When cyclin B1 remained in late anaphase, cytokinesis stalled, and translocation of INCENP from separated sister chromatids to the spindle midzone was blocked. This late anaphase arrest required the activity of Aurora B and Mps1. In conclusion, our results reveal that complete removal of cyclin B1 is essential to prevent the return of the spindle checkpoint following sister chromatid disjunction. Speculatively, increasing activity of APC/CCdc20in late anaphase helps to keep cyclin B1 levels low.
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- 2014
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28. WPSS: watching people security services
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Zamboni, Roberto, Kajzar, Francois, Szep, Attila A., Burgess, Douglas, Owen, Gari, Bouma, Henri, Baan, Jan, Borsboom, Sander, van Zon, Kasper, Luo, Xinghan, Loke, Ben, Stoeller, Bram, van Kuilenburg, Hans, and Dijk, Judith
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- 2013
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29. Evaluation of Concordance Between the Microorganisms Detected in the Nasopharynx and Middle Ear of Children With Otitis Media
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Dongen, Thijs M. A. van, Heijden, Geert J. M. G. van der, van Zon, Alice, Bogaert, Debby, Sanders, Elisabeth A. M., and Schilder, Anne G. M.
- Abstract
Studies of microorganisms involved in otitis media in children often use a nasopharyngeal sample as a proxy for the middle ear fluid to test for bacteria and viruses. The question is whether such studies provide an accurate estimate of the prevalence of microorganisms involved in otitis media. We performed a systematic review of the literature reporting on the concordance between test results of nasopharyngeal and middle ear fluid samples for the most prevalent microorganisms in children with otitis media. Our findings show that the concordances vary from 68 to 97 per microorganism. For the most prevalent microbes, positive predictive values are around 50. Most negative predictive values are moderate to high, with a range from 68 up to 97. These results indicate that test results from nasopharyngeal samples do not always provide an accurate proxy for those of the middle ear fluid. It is important to interpret and use results of such studies carefully.
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- 2013
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30. Diffusion of Transcription Factors Can Drastically Enhance the Noise in Gene Expression
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van Zon, Jeroen S., Morelli, Marco J., Tǎnase-Nicola, Sorin, and ten Wolde, Pieter Rein
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We study by Green's Function Reaction Dynamics the effect of the diffusive motion of repressor molecules on the noise in mRNA and protein levels for a gene that is under the control of a repressor. We find that spatial fluctuations due to diffusion can drastically enhance the noise in gene expression. After dissociation from the operator, a repressor can rapidly rebind to the DNA. Our results show that the rebinding trajectories are so short that, on this timescale, the RNA polymerase (RNAP) cannot effectively compete with the repressor for binding to the promoter. As a result, a dissociated repressor molecule will on average rebind many times, before it eventually diffuses away. These rebindings thus lower the effective dissociation rate, and this increases the noise in gene expression. Another consequence of the timescale separation between repressor rebinding and RNAP association is that the effect of spatial fluctuations can be described by a well-stirred, zero-dimensional, model by renormalizing the reaction rates for repressor-DNA (un) binding. Our results thus support the use of well-stirred, zero-dimensional models for describing noise in gene expression. We also show that for a fixed repressor strength, the noise due to diffusion can be minimized by increasing the number of repressors or by decreasing the rate of the open complex formation. Lastly, our results emphasize that power spectra are a highly useful tool for studying the propagation of noise through the different stages of gene expression.
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- 2006
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31. A generic tool for biotinylation of tagged proteins in transgenic mice
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Driegen, Siska, Ferreira, Rita, van Zon, Arend, Strouboulis, John, Jaegle, Martine, Grosveld, Frank, Philipsen, Sjaak, and Meijer, Dies
- Abstract
Abstract The remarkable high affinity (Kd ~ 10−15 M) of avidin/streptavidin for biotin has been extensively exploited in purification methodologies. Recently a small peptide sequence (Avi-tag) has been defined that can be specifically and efficiently biotinylated by the bacterial BirA biotin ligase. Fusion of this small peptide sequence to a protein of interest and co-expression with the BirA gene in mammalian cells allowed purification of the biotinylated protein together with its associated proteins and other molecules. Ideally, one would like to apply these technologies to purify tagged proteins directly from mouse tissues. To make this approach feasible for a large variety of proteins we developed a mouse strain that expresses the BirA gene ubiquitously by inserting it in the ROSA26 locus. We demonstrate that the BirA protein is indeed expressed in all tissues tested. In order to demonstrate functionality we show that it biotinylates the transgene-encoded Avi-tagged Gata1 and Oct6 transcription factors in erythroid cells of the foetal liver and Schwann cells of the peripheral nerve respectively. Therefore, this mouse can be crossed to any transgenic mouse to obtain efficient biotinylation of an Avi-tagged protein for the purpose of protein (complex) purification.
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- 2005
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32. Book Review: The Rhine: An Eco-Biography 1815–2000
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van Zon, Henk
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- 2003
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33. Reform of Ukraine's energy complex as precondition for eliminating its energy dependence
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van Zon, H.
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More than half of the energy consumed in the Ukraine is imported and most energy imports originate in Russia. This energy dependence provides a major lever for the Russian government to influence Ukrainian politics, especially given the fact that not all imported energy is paid for. It is argued that economic reform, and in particular reform of the energy complex, could greatly diminish the Ukraine's energy dependence. Economic reform would lead to more efficient energy use in the world's most energy intensive economy. Reform of the energy sector would result in higher collection rates, less rent seeking behaviour and more investments in the energy sector that could in turn diminish energy loss during distribution and lead to more and cheaper domestic energy.
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- 2003
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34. Front Propagation Techniques to Calculate the Largest Lyapunov Exponent of Dilute Hard Disk Gases
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van Zon, R. and van Beijeren, Henk
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A kinetic approach is adopted to describe the exponential growth of a small deviation of the initial phase space point, measured by the largest Lyapunov exponent, for a dilute system of hard disks, both in equilibrium and in a uniform shear flow. We derive a generalized Boltzmann equation for an extended one-particle distribution that includes deviations from the reference phase space point. The equation is valid for very low densities n, and requires an unusual expansion in powers of 1/|ln n|. It reproduces and extends results from the earlier, more heuristic clock model and may be interpreted as describing a front propagating into an unstable state. The asymptotic speed of propagation of the front is proportional to the largest Lyapunov exponent of the system. Its value may be found by applying the standard front speed selection mechanism for pulled fronts to the case at hand. For the equilibrium case, an explicit expression for the largest Lyapunov exponent is given and for sheared systems we give explicit expressions that may be evaluated numerically to obtain the shear rate dependence of the largest Lyapunov exponent.
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- 2002
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35. Multiple Human Vault RNAs
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van Zon, Arend, Mossink, Marieke H., Schoester, Martijn, Scheffer, George L., Scheper, Rik J., Sonneveld, Pieter, and Wiemer, Erik A.C.
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Human vaults are intracellular ribonucleoprotein particles believed to be involved in multidrug resistance. The complex consists of a major vault protein (MVP), two minor vault proteins (VPARP and TEP1), and several small untranslated RNA molecules. Three human vault RNA genes (HVG1–3) have been described, and a fourth was found in a homology search (HVG4). In the literature only the association of hvg1 with vaults was shown in vivo. However, in a yeast three-hybrid screen the association of hvg1, hvg2, and hvg4 with TEP1 was demonstrated. In this study we investigated the expression and vault association of different vault RNAs in a variety of cell lines, including pairs of drug-sensitive and drug-resistant cells. HVG1–3are expressed in all cell lines examined, however, none of the cell lines expressedHVG4. This probably is a consequence of the absence of essential external polymerase III promoter elements. The bulk of the vault RNA associated with vaults was hvg1. Interestingly, an increased amount of hvg3 was bound to vaults isolated from multidrug-resistant cell lines. Our findings suggest that vaults bind the RNA molecules with different affinities in different situations. The ratio in which the vault RNAs are associated with vaults might be of functional importance.
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- 2001
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36. The digital economy: Challenges for Central European Industry
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van Zon, Hans
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The trajectory of beneficial use of information and communication technologies (ICT) in Hungary, Poland, Lithuania and Ukraine is analysed, especially in industry. With respect to telecom access, availability, affordability and uptake indicators, the four countries are generally behind EU cohesion countries. Between the four countries, there are huge differences in development of information society services. In industry, the use of information technologies usually has not attained the phase in which they are most rewarding. Among the most important barriers to a beneficial use of computer networking in industry are the attitude of management, lack of financial resources and a lack of facilitative environment for enterprises. ICT usage is rarely part of a long-term development stratery of the firm.
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- 2001
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37. Neo-Patrimonialism as an Impediment to Economic Development: The Case of Ukraine
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van Zon, H.
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Since the abolition of communism anti-modern tendencies have come to the fore in Ukrainian society. The vicious circle of underdevelopment in which Ukraine finds itself nowadays can be seen in the context of the incompatibility of neo-patrimonial society with the requirements of modern economic development. The deficiencies of a paralysing state should be seen in the context of a specific mode of interaction between state and society that allowed a patrimonial and predatory state to develop. Ukraine's economic decline and redistribution of resources brought about a revolution in social stratification that contributed further to the de-modernization of the country. Ukraine's development problem can be compared with that of typical Third World countries although Ukraine has some features that aggravates the situation, such as an over-powerful state.
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- 2001
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38. Structural relaxation in poly(ethylene oxide)-salt solutions
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van Zon, A, Bel, G.-J, Mos, B, Verkerk, P, and de Leeuw, S.W
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We present the results of molecular dynamics simulations of PEOxNaI polymer electrolytes, performed to study the influence of NaI on the dynamics of PEO. By calculating the mean square displacement of the CH2groups we observe that the Rouse-like motion, typical for short polymer chains, is slowed down under the influence of NaI. This slowing down is also observed in the self part of the intermediate scattering function Fs(k,t), as an increase in the relaxation time. By using the Gaussian approximation it is shown that the stretched exponential relaxation in the small k-limit of Fs(k,t) is a result of the Rouse-like motion of the polymers. We find that our results are in good agreement with neutron spin-echo experiments.
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- 2000
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39. Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+T cells
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Matas-Rico, Elisa, Frijlink, Elselien, van der Haar Àvila, Irene, Menegakis, Apostolos, van Zon, Maaike, Morris, Andrew J., Koster, Jan, Salgado-Polo, Fernando, de Kivit, Sander, Lança, Telma, Mazzocca, Antonio, Johnson, Zoë, Haanen, John, Schumacher, Ton N., Perrakis, Anastassis, Verbrugge, Inge, van den Berg, Joost H., Borst, Jannie, and Moolenaar, Wouter H.
- Abstract
Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA promotes tumor cell migration and metastasis via LPAR1 and T cell motility via LPAR2, yet its actions in the tumor immune microenvironment remain unclear. Here, we show that ATX secreted by melanoma cells is chemorepulsive for tumor-infiltrating lymphocytes (TILs) and circulating CD8+T cells ex vivo, with ATX functioning as an LPA-producing chaperone. Mechanistically, T cell repulsion predominantly involves Gα12/13-coupled LPAR6. Upon anti-cancer vaccination of tumor-bearing mice, ATX does not affect the induction of systemic T cell responses but, importantly, suppresses tumor infiltration of cytotoxic CD8+T cells and thereby impairs tumor regression. Moreover, single-cell data from melanoma tumors are consistent with intratumoral ATX acting as a T cell repellent. These findings highlight an unexpected role for the pro-metastatic ATX-LPAR axis in suppressing CD8+T cell infiltration to impede anti-tumor immunity, suggesting new therapeutic opportunities.
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- 2021
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40. Metabolic syndrome incidence in an aging workforce: Occupational differences and the role of health behaviors
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Runge, Katharina, van Zon, Sander K.R., Bültmann, Ute, and Henkens, Kène
- Abstract
This study investigates whether the incidence of metabolic syndrome (MetS), and its components, differs by occupational group among older workers (45–65 years) and whether health behaviors (smoking, leisure-time physical activity, diet quality, and alcohol consumption) can explain these differences. A sample of older workers (N = 34,834) from the North of the Netherlands was investigated. We analyzed data from two comprehensive measurement waves of the Lifelines Cohort Study and Biobank. MetS components were determined by physical measurements, blood markers, medication use, and self-reports. Occupational group and health behaviors were assessed by questionnaires. The association between occupational groups and MetS incidence was examined using logistic regression analysis. Health behaviors were subsequently added to the model to examine whether they can explain differences in MetS incidence between occupational groups. Low skilled white-collar (OR: 1.24; 95 % CI: 1.12, 1.37) and low skilled blue-collar (OR: 1.37; 95 % CI: 1.18, 1.59) workers had a significantly higher MetS incidence risk than high skilled white-collar workers. Similar occupational differences were observed on MetS component level. Combinations of unhealthy behaviors were more prevalent among blue-collar workers. MetS incidence in older workers differs between occupational groups and health behaviors explain a substantial part of these differences. Health promotion tailored to occupational groups may be beneficial specifically among older low skilled blue-collar workers. Research into other factors that contribute to occupational differences is needed as well as studies spanning the entire working life course.
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- 2021
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41. Enkele aspecten van de schilderspraktijk in het atelier van Pieter Aertsen natuurwetenschappelijk nader bekeken
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Boreel, Jacqueline M. C. and van Zon-Christoffels, Francis W. H.
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- 1989
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42. The course of a Plasmodium berghei infection in six different mouse strains
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Eling, W., van Zon, A., and Jerusalem, C.
- Abstract
Summary Experiments were carried out to study common and strain specific features of malaria (P. berghei) in mice. In the various mouse strains infection with 10
5 P.E. results in four different mortality patterns, with frequent secondary infections among all long surviving mice. A prepatent period of four days, proliferation in oxyphilic erythrocytes, a first peak of parasitaemia on day 7/8 and crisis occur in all strains. The magnitude of peak parasitaemia, however, and the ability to develop polychromatocytosis which coincides with survival beyond crisis are strain specific. Transient variations in number of erythrocytes and s.g.o.t. activity shortly after infection are the earliest noticeable changes, but do not predict later ones. The inception of definitive anaemia is on day 6 in all strains, and thus just before the first peak of parasitaemia but independent of its magnitude. Anaemia further develops at a strain specific rate. In general, parasite proliferation, peak infection, crisis, and polychromatocytosis are followed by changes in s.g.o.t. activity chronologically but not quantitatively. Extensive thymic involution occurs in all strains, but develops in a strain specific pattern. Initial changes in spleen weight can reflect R.E.S. activity and an ongoing immunological process which collapses, however, around peak infection. Subsequent increases in spleen weight may in particular depend on proliferation of erythropoietic tissue, especially in instances of distinct polychromatocytosis. There is no quantitative correlation between changes in liver weight and s.g.o.t. activity, but focal liver cell necrosis may account for high s.g.o.t. activity.- Published
- 1977
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43. Influence of platinum-based electrodes on the microstructure of sol-gel and MOD prepared lead zirconate titanate films
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Spierings, G. A. C. M., Van Zon, J. B. A., Larsen, P. K., and Klee, M.
- Abstract
The microstructure and preferred orientation of PZT films deposited by spin-coating techniques are shown to depend on the morphology of the Ti/Pt bottom electrode. Annealing of the as-deposited Ti/Pt electrodes results in the formation of hillocks. These hillocks serve as nucleation sites for perovskite formation and thus determine the microstructure and preferred orientation of the crystallized PZT films. The microstructure features are investigated by X-ray diffraction analyses and scanning and transmission electron microscopies.
- Published
- 1993
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44. Educational Television Programmes for Infants. The First Projects: Results of Research
- Author
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van Zon, Dick
- Abstract
In the summer of 1975 NOT (Dutch Foundation for Educational Television) started educational television programmes for infants by way of experiment. There are about 6,500 infant schools for children between four and six in Holland; about 90 per cent of this age group receive this kind of education. Before the television programmes started none of these schools possessed a television set. Two questionnaires sent out to kindergarten teachers supplied the necessary information about participation in and evaluation of the experimental programmes. From the questionnaires emerged also the opinions of the teachers about ETV for infant school pupils in general and a set of characteristics of infant schools. It appeared among other things that 15 to 20 per cent of the schools in question had made use of the programmes and that 83 per cent of the teachers were in favour of ETV for infant school pupils.
- Published
- 1977
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45. A standardized method for testing the side effects of pesticides on the predacious mite, Amblyseius potentillae [Acarina: Phytoseiidae]
- Author
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Overmeer, W. and van Zon, A.
- Abstract
Abstract: A method is described for testing adverse effects of pesticides on the predacious miteAmblyseius potentillae Garman in the laboratory. It complies with the terms of the W.P.R.S./I.O.B.C. Working Group “Pesticides and Beneficial Arthropods” with respect to such methods. Twenty commercial pesticides were tested on the predator as part of a joint pesticide test programme of the Working Group.
- Published
- 1982
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46. A comparative study of the effect of some pesticides on three predacious mite species: Typhlodromus pyri, Amblyseius potentillae and A. bibens [ Acarina: Phytoseiidae ]
- Author
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Overmeer, W. and van Zon, A.
- Abstract
Abstract: Toxicological responses to 10 different pesticides were determined for 3 species of typhlodromid mites,Typhlodromus pyri Scheuten,Amblyseius potentillae Garman, andA. bibens Blommers, in order to investigate whether or notA. bibens might be used as a substitute for the 2 other species as a testing object for measuring adverse effects of pesticides. T. pyri andA. potentillae are important predators in orchards on phytophagous mites. These species can be reared on the common spider mite,Tetranychus urticae Koch, but they seem averse to the webbing of the spider mite. When placed on detached bean leaves on moist cotton wool withT. urticae present as prey, these typhlodromids tend to run off the leaves, especially when in addition such leaves have been treated with pesticides.A. bibens on the other hand will stay on the leaves when prey is present; it seems to be attracted by the webbing of the spider mite. This makesA. bibens an attractive testing object. In the present study the 3 species mentioned were tested comparatively in closed cells to see whether or not there might be differences in intrinsic susceptibility to pesticides. Mortality of adults, the effect on reproduction, and the mortality of eggs and juveniles were determined. It was found thatA. bibens can reasonably well replace other typhlodromids as a testing objeot for obtaining information on adverse effects of pesticides in orchards.
- Published
- 1981
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47. Corticosterone regulation of the effector function of malarial immunity during pregnancy
- Author
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van Zon, A A, Eling, W M, Hermsen, C C, and Koekkoek, A A
- Abstract
In the experimental Plasmodium berghei mouse model, as in human malaria, reduced maternal responsiveness and even loss of immunity were observed during pregnancy. Loss of immunity in the second half of pregnancy occurred during a period of elevated plasma corticoid levels. Further analysis showed that plasma corticoid levels were significantly higher in immunodepressed mice than in mice that remained immune throughout pregnancy. Plasma corticosterone levels differed increasingly from those in mice with persistent immunity towards recrudescence. In nonimmune infected controls, however, only a slight increase in plasma corticosterone, already present during the subpatent period, was measured. Blocking the maternal corticoid production by adrenalectomy delayed the increase of plasma corticosterone (fetoplacental origin) and reduced the number of mice that lost immunity during pregnancy considerably. The role of various plasma corticoid levels in the regulation of effector function of immunity during pregnancy is discussed.
- Published
- 1982
- Full Text
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48. Molecular Genotyping of Staphylococcus aureusStrains: Comparison of Repetitive Element Sequence-Based PCR with Various Typing Methods and Isolation of a Novel Epidemicity Marker
- Author
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van der Zee, Anneke, Verbakel, Harold, van Zon, Johan-Carlo, Frenay, Ine, van Belkum, Alex, Peeters, Marcel, Buiting, Anton, and Bergmans, Anneke
- Abstract
ABSTRACTRepetitive sequence-based (Rep)-PCR genotyping as described here is based on the presence of homologues of Mycoplasma pneumoniaerepeat-like elements in Staphylococcus. In this study we comparatively evaluated the usefulness of rep-PCR typing with two sets of well-defined collections of Staphylococcus aureusstrains. Rep-PCR analysis of the first collection ofS. aureusstrains (n= 59) and oneStaphylococcus intermediusstrain showed 14 different rep-PCR patterns, with each pattern harboring 6 to 15 DNA fragments. The discriminatory power of rep-PCR typing compared well to those of arbitrarily primed PCR (average of 20 types) and pulsed-field gel electrophoresis (11 types). S. aureusstrain collection I comprised four outbreak-related groups of isolates. The isolates in only one group were found to have identical rep-PCR profiles. However, in an analysis of isolates from three additional independent local outbreaks (nfor outbreaks 1 and 2 = 5, nfor outbreak 3 = 12), identical rep-PCR types were found among strains isolated during each outbreak. Therefore, we conclude that rep-PCR genotyping may be an easy and fast method for monitoring of the epidemiology of nosocomial Staphylococcusinfections. Rep-PCR analysis of strain collection II, which consisted of epidemic and nonepidemic methicillin-resistant S. aureus(MRSA) strains, revealed that a cluster of similar rep-PCR profiles was found among MRSA isolates which were more frequently isolated and which were most often associated with outbreaks.
- Published
- 1999
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49. The effect of some fungicides on Phytoseiulus persimilis [Acarina: Phytoseiidae]
- Author
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van Zon, A. and Wysoki, M.
- Abstract
Abstract: The effect of 11 fungicides on different developmental stages of the predator mitePhytoseiulus persimilis A.-H. was investigated. Special attention was paid to the effect that these compounds may have on the survival of adult females and juveniles, on the hatching of eggs and on the fecundity of the females. The experiments were conducted in the laboratory in climatic chambers at a temperature of 25°C±1°C, a relative humidity of at least 80% and a photoperiod of 16 h light per day. The fungicides were tested at 3 different concentrations: the concentration advised by the manufacturer and the double and half of that concentration. It appeared possible to group the fungicides in 3 classes, based on their effect in residue tests on females and newly hatched juveniles: a) with very low effect (Pallinal M, Nimrod, Plondrel, Asepta Funginex, Morestan, Fungaflor and Karathane); b) with low effect on females at the advised concentration and with moderate effect on the juveniles (SM55, Goldion, and Malonoben) and c) with high effect on females (100% mortality) in the advised concentration (Curamil). Only 2 classes could be recognized, when the effect of the direct application of fungicides on eggs and juveniles were taken into account: one class without or with very little effect (Fungaflor, Asepta Funginex, Plondrel, Morestan, Pallinal M and Nimrod) and the other one with a very high effect (Malonoben, Goldion, SM55, Karathane and Curamil).
- Published
- 1978
- Full Text
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50. Perpendicular giant magnetoresistance of Co/Cu multilayers on V-grooved substrates: Dependence on deposition method
- Author
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Oepts, W., Gijs, M.A.M., Reinders, A., Jungblut, R.M., Kerkhof, J.M., van Zon, A.M.A., and de Jonge, W.J.M.
- Abstract
The perpendicular giant magnetoresistance of Co/Cu multilayers grown at an angle onto V-grooved InP substrates is studied using two different deposition techniques. Samples are grown both at ultra-high vacuum in a molecular beam epitaxy system and in a classical high vacuum electron beam evaporation system. Using the two spin-channel model for electron transport, the spin-asymmetry parameters were determined. The absolute value and temperature behavior of the spin-asymmetry parameters of the Co bulk scattering and the interface scattering are comparable for both series. We find that the interface scattering of the e-beam evaporated multilayers is relatively less spin-dependent.
- Published
- 1997
- Full Text
- View/download PDF
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