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1. β-Scorpion toxin induces the release of γ-3Haminobutyric acid in rat brain slices

Author

Fernandes, V. M. V., Nicolato, R., Moraes-Santos, T., Gomez, R. S., Prado, M. A. M., Romano-Silva, M. A., and Gomez, M. V.

Abstract

The effect of the β-scorpion toxin, TiTX γ on the release of 3HGABA from rat brain cortical slices is described. The stimulatory effect of TiTX γ on the release of 3HGABA was dependent on incubation time and TiTX γ concentration with an EC50of 0.19 μM. The scorpion toxin effect was calcium dependent and was completely inhibited by tetrodotoxin. β-Alanine also induced the release of 3HGABA and this effect was not inhibited by tetrodotoxin but was additive in the presence of TiTX γ. The data suggest a neuronal origin for the release of 3HGABA by TiTX γ.

Published
2001

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