β-Scorpion toxin induces the release of γ-3Haminobutyric acid in rat brain slices

Authors :: Fernandes, V. M. V.
Nicolato, R.
Moraes-Santos, T.
Gomez, R. S.
Prado, M. A. M.
Romano-Silva, M. A.
Gomez, M. V.
Source :: NeuroReport; September 2001, Vol. 12 Issue: 13 p2911-2913, 3p
Publication Year :: 2001
Abstract: The effect of the β-scorpion toxin, TiTX γ on the release of 3HGABA from rat brain cortical slices is described. The stimulatory effect of TiTX γ on the release of 3HGABA was dependent on incubation time and TiTX γ concentration with an EC50of 0.19 μM. The scorpion toxin effect was calcium dependent and was completely inhibited by tetrodotoxin. β-Alanine also induced the release of 3HGABA and this effect was not inhibited by tetrodotoxin but was additive in the presence of TiTX γ. The data suggest a neuronal origin for the release of 3HGABA by TiTX γ.

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