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Purpose: This study aims to introduce a vision-based model to generate droplets with auto-tuned parameters. The model can auto-adjust the inherent uncertainties and errors involved with the fabrication and operating parameters in microfluidic platform, attaining precise size and frequency of droplet generation. Design/methodology/approach: The photolithography method is utilized to prepare the microfluidic devices used in this study, and various experiments are conducted at various flow-rate and viscosity ratios. Data for droplet shape is collected to train the artificial intelligence (AI) models. Findings: Growth phase of droplets demonstrated a unique spring back effect in droplet size. The fully developed droplet sizes in the microchannel were modeled using least absolute shrinkage and selection operators (LASSO) regression model, Gaussian support vector machine (SVM), long short term memory (LSTM) and deep neural network models. Mean absolute percentage error (MAPE) of 0.05 and R2 = 0.93 were obtained with a deep neural network model on untrained flow data. The shape parameters of the droplets are affected by several uncontrolled parameters. These parameters are instinctively captured in the model. Originality/value: Experimental data set is generated for varying viscosity values and flow rates. The variation of flow rate of continuous phase is observed here instead of dispersed phase. An automated computation routine is developed to read the droplet shape parameters considering the transient growth phase of droplets. The droplet size data is used to build and compare various AI models for predicting droplet sizes. A predictive model is developed, which is ready for automated closed loop control of the droplet generation. [ABSTRACT FROM AUTHOR]

The article discusses three books that explore the challenges and limitations of addressing complex problems through engineering and scientific approaches. The first book, "Wicked Problems" by Guru Madhavan, argues for a more civic-minded approach to engineering in order to tackle the growing number of complex social problems. The second book, "Rational Accidents" by John Downer, examines the paradox of the aviation industry's safety and reliability, highlighting the unique factors that contribute to its success. The third book, "Systems Ultra" by Georgina Voss, takes a more experiential approach to understanding complex systems, exploring their structure, behavior, and power dynamics. Overall, the books emphasize the need for a broader and more inclusive perspective in addressing complex problems. [Extracted from the article]

Organ-on-a-chip technology is gaining popularity as an alternative to animal testing in drug development and other areas. These "organs on chips" are small plastic devices lined with human tissues that mimic the functions of organs. They are being used to study diseases, test new drugs, and explore personalized treatments. The development of this technology has the potential to revolutionize medicine by providing safer and more effective drugs. Recent changes in FDA regulations have supported the use of non-animal-based testing in preclinical trials. A 2022 study using liver chips successfully identified issues with drugs that had previously passed animal testing but caused harm to humans. While organs on chips have the potential to improve research for rare diseases and increase the success rate of clinical trials, there are challenges such as cost, sourcing human cells, and lack of standardization among different companies producing these devices. However, this technology could help address health inequities in research and reduce the need for animal testing. [Extracted from the article]

A University of Lille researcher's study on the genetics of Alzheimer's disease (AD) focused on the presynaptic toxicity of the AD susceptibility gene BIN1. The research found that the BIN1 isoform1 (BIN1iso1) induced neurodegeneration in Drosophila retina by accumulating early endosome vesicles, leading to synaptic loss. The study suggests that BIN1iso1 has an isoform-specific deleterious effect on synaptic integrity, potentially contributing to early synaptic loss in AD. The findings were published in Alzheimer's & Dementia and can be accessed for free online. [Extracted from the article]

A patent application titled "Parallel Microfluidic Device for High Throughput Cell Assays in Microdroplets" was published online by inventors Wenjing KANG, Tania Konry, and Saheli Sarkar. The technology described in the patent application allows for the analysis of single cell characteristics through a multiplex microfluidic system that integrates parallel devices and switches for high-throughput screening of different cells, cell combinations, and assay conditions. The system enables the encapsulation of single cells or groups of cells for analysis, drug screening, and real-time monitoring, providing a more efficient alternative to traditional methods. [Extracted from the article]

A study published in Health & Medicine Week discusses the development of a non-invasive method to assess the mechanical properties of mouse oocytes using a microfluidic device. The device can differentiate between healthy and mechanically aberrant oocyte groups based on their deformability under controlled pressure. This research has the potential to improve the quality of embryos and success rates in assisted reproduction procedures by selecting oocytes based on their mechanical properties. The study proposes that deformability measurements can provide insights into oocyte tension and elasticity, with elasticity being the most significant factor in this context. [Extracted from the article]

Researchers Tania Konry and Giovanni Ugolini have submitted a patent application for a "Single Cell Isolation and Processing System With Reversible Well Shape" to the USPTO. The technology involves microwells with variable shapes that aid in cell manipulation and recovery, controlled by vacuum applied beneath a deformable membrane. This system allows for the isolation, analysis, and processing of individual cells or cell groups, with potential applications in immunotherapy, single cell proteomics, and rapid screening. The patent application details the design and functionality of the microwell device, highlighting its potential for automated single cell analyses and cell recovery processes. [Extracted from the article]

A recent study conducted by Massachusetts General Hospital and Harvard Medical School introduced a new method for analyzing circulating tumor cells (CTCs) in blood samples, which can provide valuable insights into cancer progression. By utilizing a high-throughput microfluidic device, researchers were able to enrich CTCs from large blood volumes, revealing significant intra-patient heterogeneity and subclonal patterns of aneuploidy and distinct signaling pathways within CTCs. This innovative approach enables comprehensive monitoring of cancer through cell-based liquid biopsy, offering potential benefits for cancer diagnosis and treatment. [Extracted from the article]

The patent application by Sethi, Rakesh, assigned to TDK U.S.A. Corporation, focuses on a system and method for clustering and deconvolution of particle phenotype. The invention aims to quantify cell plasticity and detect fine phenotypic changes in diseased cells at a single-cell level without the need for labeling. By utilizing impedance probing, the system provides faster and more accurate classification of cells compared to existing optical-based methods, allowing for the identification and distinction between normal and diseased cells. The system also offers advantages such as low latency, high accuracy, and real-time anomaly detection for individual particles or single biological cells. [Extracted from the article]

Researchers at the Indian Institute of Technology Guwahati have developed a paper-based microfluidic device for detecting methanol in alcoholic beverages. The device uses chemical reagents to produce a color change when methanol is present, allowing for easy visual assessment or quantification. This innovative technology offers a cost-effective and portable solution for detecting methanol contamination in alcoholic beverages, with a detection range of 5% to 30% methanol concentration. The study highlights the benefits of this paper-based technology over conventional methods, such as lower costs, simplicity of operation, and potential for large-scale manufacturing and distribution in resource-limited areas. [Extracted from the article]

Researchers have submitted a patent application for "Integrated Human Organ-On-Chip Microphysiological Systems" that aims to provide alternatives to animal studies for drug development and national defense. The system consists of microfluidic devices called Organ Chips that mimic the functions of various human organs, such as the lung, heart, liver, kidney, gut, and brain. These Organ Chips can be integrated into an Organ Cartridge and further connected to an Organ Farm or Organ Interrogator for long-term culture and analysis, potentially revolutionizing drug development processes. [Extracted from the article]

Researchers at the University of Technology Sydney have published a study on recent advances in microfluidics for nucleic acid analysis of small extracellular vesicles (sEVs) in cancer. sEVs are membranous vesicles released from cells containing various cellular components, and their discovery has revolutionized cancer diagnosis, prognosis, and treatment. The development of microfluidic devices offers improved precision in isolating and analyzing sEVs, holding promise for next-generation diagnostic and prognostic tools. This research has been peer-reviewed and explores the potential for practical clinical applications of microfluidics in cancer research. [Extracted from the article]

A patent has been issued for organomimetic devices and methods of use and manufacturing by the President and Fellows of Harvard College. These devices, also known as organ-on-a-chip, aim to replicate tissue and organ-level functions in vitro, potentially replacing animal studies for drug development and toxicology evaluation. The devices can mimic dynamic mechanical forces and be interconnected to form multi-organ systems, offering a more holistic approach to studying human organ functions. The patent details the design and materials used in these microfluidic devices, emphasizing their potential for drug screening, disease models, and toxicology studies. [Extracted from the article]

A recent study conducted at the National NanoFab Center in Daejeon, South Korea, focused on the development of an advanced microfluidic device for the synthesis of lipid nanoparticles (LNPs) for gene delivery. The research highlighted the device's ability to produce LNPs with a diameter ranging from 70 to 190 nm in less than 2 minutes, showcasing its potential for gene therapy and vaccine applications. Funded by various organizations, the study emphasized the simplicity, speed, reliability, and cost-effectiveness of the microfluidic system in facilitating the production of LNPs for medical purposes. [Extracted from the article]

A patent was issued to Bio-Rad Laboratories Inc. for a method of analysis developed by inventors from California. The method involves using a microfluidic device to isolate and image volumes of a sample-containing fluid in a two-dimensional monolayer. This innovation aims to improve assay systems, particularly in the field of nucleic acid analysis, by providing a faster and more accurate method for detecting specific components in complex samples. [Extracted from the article]

Researchers at the Georgia Institute of Technology have developed a microfluidic device that can detect apoptotic cells by identifying externalized phosphatidylserine on cell membranes. This technology offers a more accessible and cost-effective alternative to traditional methods of apoptosis detection, such as flow cytometers and fluorescence microscopes. The study, funded by the Arnold and Mabel Beckman Foundation and the National Science Foundation, has the potential to revolutionize cell-based diagnostics and therapeutics, contributing to improved healthcare outcomes on a larger scale. [Extracted from the article]

Researchers at Southwest University have published a report on personalized medicine, focusing on bio-energy-powered microfluidic devices. The study highlights the challenges faced by these technologies, particularly the need for external power sources, and discusses innovative methods utilizing body fluids, motion, and heat to address this issue. The integration of bio-microfluidic platforms shows promise for personalized healthcare applications, potentially revolutionizing healthcare delivery. The research was supported by various funding sources and can be accessed through Biomicrofluidics. [Extracted from the article]

A recent study conducted by researchers at IRCCS Istituto Ortopedico Rizzoli in Bologna, Italy, focused on personalized medicine in oncology, specifically for rare and aggressive cancers like osteosarcoma and chondrosarcoma. The study introduced a novel microfluidic device for personalized drug screening, which showed a significant decrease in spheroid viability when treated with the anticancer agent doxorubicin. Osteosarcoma spheroids were found to be more sensitive to the drug compared to chondrosarcoma spheroids, highlighting the potential for personalized cancer treatments tailored to individual patients. The research, funded by the European Union, provides a promising in vitro model for aggressive sarcomas, despite some implementation challenges. [Extracted from the article]

Researchers at the University of Latvia have developed a microfluidic device that can efficiently isolate cancer-derived extracellular vesicles (EVs) for diagnostic purposes. The device, made using off-stoichiometry thiol-ene and cyclic olefin copolymer, streamlines the process and offers a faster alternative to traditional methods. By measuring the binding kinetics between EVs and anti-CD9 nanobodies, the study demonstrates the device's potential to enhance clinical diagnostics by reducing manual labor without compromising accuracy. The research was supported by the European Regional Development Fund, Latvian Council of Science, and the European Union's Horizon 2020 Framework Programme. [Extracted from the article]

A study conducted at Bauman Moscow State Technical University explores the development of a four-channel microfluidic model of the blood-brain and blood-cerebrospinal fluid barriers, known as brain-on-a-chip technology. This model aims to mimic the dual system of barriers in the brain to enhance understanding of brain physiology and pathology. The research findings suggest that this technology could lead to advancements in tissue engineering and the study of brain function and diseases. For more information, readers can access the full article in Micro and Nano Systems Letters. [Extracted from the article]

A patent application titled "Flow Cytometer, Imaging Device, Position Detection Method, And Program" was published online by inventors Imai, Toru and Nakagawa, with ThinkCyte K.K as the assignee. The application addresses the challenges of detecting observation objects using a random structured illumination pattern in flow cytometers, focusing on monitoring and correcting position deviations of the flow line in real time. The invention aims to provide a flow cytometer capable of detecting position deviations of a flow line, offering solutions to ensure reproducibility of data and precise control of the flow path. [Extracted from the article]

Researchers at Griffith University in Brisbane, Australia, conducted a study on how laser machining affects wicking dynamics in microstructures. The research found that laser micromachining can alter a surface's physical and chemical properties to induce unidirectional wicking, which is crucial in fields like biomedicine and environmental monitoring. The study provides insights into optimizing microfluidic devices by understanding the impact of surface roughness on wicking performance in different channel orientations. This research was published in the Journal of Science: Advanced Materials and Devices, and the findings offer strategies for enhancing wicking efficiency in various applications. [Extracted from the article]

A report from Guangdong University of Technology discusses research findings on the ultrasensitive and visual detection of osteoprotegerin using a rotation microfluidic device for ELISA on paper. The study highlights the importance of efficient osteoprotegerin detection in clinical settings, overcoming current diagnostic limitations. The innovative method utilizes a rotating paper-based microfluidic chip with a modified ELISA colorimetric technique, offering a portable point-of-care solution with low cost, operational simplicity, stability, and high sensitivity. This research has been peer-reviewed and provides a promising avenue for improved OPG analysis. [Extracted from the article]

Researchers from Shanghai University have published new data on gene therapy, specifically focusing on mechanically mediated cargo delivery to cells using microfluidic devices. The study highlights the importance of drug delivery technologies in enhancing therapeutic efficacy and minimizing off-target effects. The research explores the potential application of artificial intelligence in optimizing cargo delivery technologies and provides theoretical support for the future development of novel cellular drug delivery technologies. The study was supported by various funding sources and is available for further reading in the journal Biomicrofluidics. [Extracted from the article]

A patent application by inventors from Georgia has been made available online, focusing on methods, devices, and systems for generating a chemical gradient for personalized therapy and drug discovery. The inventors highlight the need for more efficient systems to identify and validate effective new combination therapies for clinical investigation, particularly in cancer treatment. The patent application describes a microfluidic device with multiple layers and chambers that can provide different concentrations of agents for testing various combinations and concentrations. This innovation aims to address the limitations of current methods in drug discovery and personalized medicine. [Extracted from the article]

Researchers from Cornell University have published new studies on organ-on-a-chip models in ophthalmology, highlighting their potential in studying ocular diseases and testing therapeutic interventions. These microfluidic devices replicate human eye tissue architecture, offering insights into diseases like dry eye disease, age-related macular degeneration, and glaucoma. While advancements in microengineering and cellular integration have improved these models, challenges such as scalability and regulatory validation remain. Organ-on-a-chip models are expected to enhance preclinical research and clinical applications in ophthalmology, with the need to address scalability and regulatory hurdles to unlock their full potential in drug discovery and disease modeling. [Extracted from the article]

The article discusses a patent issued to Ecole Polytechnique Federale de Lausanne (EPFL) for a micro-fluidic particle concentrator and filtering device created by Ludovic Serex. The device aims to address challenges in cell seeding density for 3D bio-printing by concentrating cells on chip before printing, allowing for the printing of tissues with high cell density. The device features a flow channel with pillars and crossflow channels to optimize particle concentration and flow balance, enhancing the efficiency of producing cell-loaded biomaterial for tissue engineering. [Extracted from the article]

Research conducted at the Hospital Clinic of Barcelona focused on platelet adhesiveness in patients with venous thromboembolic disease (VTE). The study found that platelets from VTE patients exhibit a proadhesive phenotype under flow conditions, potentially linked to shortened occlusion times. This increased adhesiveness may be attributed to higher intraplatelet ZAP70/SYK72 phosphorylation and elevated plasma von Willebrand factor (VWF) levels in patients, highlighting the role of primary hemostasis in VTE pathophysiology. [Extracted from the article]

A patent application titled "Microfluidic Device" was published online by inventors from Switzerland, addressing the need for faster, cheaper, and simpler diagnostic assays. The device aims to overcome challenges such as manufacturing restrictions, cross-contamination, gas bubble entrapment, and liquid evaporation in microfluidic structures. By utilizing a honeycomb structured array of hexagonal wells with varying hydrophilicities, the device allows for improved thermocycling of a reaction mixture for digital polymerase chain reaction (dPCR) assays. This innovation seeks to enhance the precision and efficiency of diagnostic assays on a miniaturized scale. [Extracted from the article]

The University of Jinan has conducted research on biosensor-based microfluidic platforms for the rapid clinical detection of pathogenic bacteria. The study emphasizes the importance of early and sensitive strategies for monitoring bacterial proliferation to ensure public health, medical diagnosis, and food safety. The research highlights the advancements in microfluidic devices for point-of-care testing and discusses various strategies, platforms, and case studies related to detecting diseases caused by bacterial imbalances. The study concludes by proposing research perspectives for further development in effective biosensor-based microfluidics for clinical detection of pathogenic bacteria. [Extracted from the article]

Researchers from the University of the Chinese Academy of Sciences have developed a multi-volume digital loop-mediated isothermal amplification (dLAMP) chip for nucleic acid quantification in biomedical applications. The chip features 1024 large chambers and 6400 small chambers, offering a wide dynamic range exceeding 105 for quantification. This innovative chip provides enhanced automation, accuracy, and dynamic range, paving the way for broader applications in biomedical research fields. The study was funded by various organizations and has been peer-reviewed for publication in Advanced Materials Technologies. [Extracted from the article]

A patent application by inventors from various locations in California focuses on methods and systems for sorting biological particles, particularly senescent cells, using microfluidic-based platforms. The application highlights the importance of isolating specific biological molecules or particles for various biomedical applications, such as diagnostics, therapeutics, and fundamental cell biology. The patent application emphasizes the need for a platform that can achieve specificity, sensitivity, and high throughput for the isolation and removal of diverse cells from biofluids, particularly senescent cells, which play a crucial role in aging and age-related diseases. [Extracted from the article]

A study conducted at NOVA University Lisbon in Caparica, Portugal, focuses on the development of a Tumor-on-chip (ToC) device for gene silencing assays in cancer research. The research highlights the use of polystyrene (PS) as a material for microfluidics due to its biocompatibility, affordability, and optical transparency. The study aims to address barriers in cancer research by creating accessible and customizable chip-based cancer models to improve efficiency in cell culture approaches. This research has been peer-reviewed and offers a promising approach to advancing cancer research methodologies. [Extracted from the article]

The patent issued by Novel Microdevices Inc. focuses on automated point-of-care devices for complex sample processing, particularly in the context of HIV/AIDS testing. The invention aims to streamline sample preparation and fluid handling steps in microfluidic devices to minimize human interaction and contamination risks. By integrating reagent-dispensing units and actuator elements, the patent seeks to enable simple, low-power automation of sample processing for complex diagnostic assays, ultimately facilitating point-of-care implementation in non-laboratory settings. The patent emphasizes the need for cost-effective, standalone, and disposable instrumentation to run multi-step nucleic acid, protein, and immunoassays from sample to answer, addressing challenges faced by traditional kit-based tests that rely on manual user intervention and risk contamination. [Extracted from the article]

Researchers from the Beijing Institute of Technology have published a review article in Engineering on the use of droplet-based microfluidics with mass spectrometry to enhance single-cell proteomics studies. This technology allows for precise manipulation of microdroplets on a chip, improving analytical efficiency and sensitivity in proteomic analysis. The integration of droplet microfluidics with mass spectrometry offers researchers rapid and sensitive tools for in-depth proteomic analysis, with potential applications in biological research and precision medicine. Despite challenges, further advancements in microfluidics and mass spectrometry are expected to push single-cell proteomics to new frontiers, revolutionizing our understanding of cellular systems and leading to groundbreaking advancements in research and clinical applications. [Extracted from the article]

Researchers at Saveetha University in Chennai, India, have conducted a study on personalized medicine in oral squamous cell carcinoma (OSCC). The research highlights the importance of the tumor microenvironment in OSCC progression and the use of 3D in vitro models for studying the disease and evaluating targeted therapies. The study emphasizes the potential of personalized medicine in treating OSCC by recreating the tumor microenvironment in advanced in vitro models. This research provides valuable insights into the development of personalized therapies for this aggressive form of cancer. [Extracted from the article]

Researchers at the University of Birmingham have developed a versatile and cost-effective microfluidic system for biofabrication in regenerative medicine. This system allows for the fabrication of multi-material fibers with complex geometries, enabling rapid mixing of fluids and high cell compatibility. The research, funded by the Engineering & Physical Sciences Research Council, shows great potential for advancing microfluidic platforms in regenerative medicine. The study has been peer-reviewed and offers valuable insights into the field of biomedical engineering and biotechnology. [Extracted from the article]

The article discusses the development of the Under-Flow Migration Tracker (UFMTrack) framework, which enables the analysis of immune cell interactions with brain microvascular endothelial cells across the blood-brain barrier in vitro. This tool allows for the study of the multi-step extravasation cascade of immune cells under physiological flow, providing insights into the mechanisms involved in neuroinflammatory diseases like multiple sclerosis. The UFMTrack framework is designed to analyze and quantify the interactions of different immune cell subsets with the blood-brain barrier, offering a valuable resource for researchers in immunology and brain research. [Extracted from the article]

A patent was issued for microfluidic systems and methods of use by inventors from Pleasanton, California, and Alameda, California, with patent number 12138628 assigned to 10X Genomics Inc. The patent discusses advancements in microfluidics, emphasizing the need for increased complexity and functionality to meet research and diagnostic demands. The patent details novel microfluidic structures, systems, and methods for fluid manipulations in microscale channel networks, offering a variety of applications and uses. [Extracted from the article]

A recent study from Harvard University discusses the development of Organ Chips with integrated multifunctional sensors that enable continuous metabolic monitoring at controlled oxygen levels. The research aims to recreate tissue-relevant physiological conditions and analyze tissue functions using multiple sensors simultaneously. This innovative system allows for the non-invasive monitoring of various physiological functions in Organ Chip models, enhancing their evaluation in basic research, preclinical modeling, and drug development. The study was supported by various organizations and has been peer-reviewed, providing valuable insights into biotechnology and biosensors. [Extracted from the article]

Researchers at St. Petersburg Electrotechnical University "LETI" have conducted a study on tumor-on-a-chip technology, focusing on mimicking malignant brain tumors for targeted drug delivery and personalized therapy. The study emphasizes the importance of developing precise diagnostics and efficient therapies to reduce disability and mortality rates associated with brain tumors, particularly glioblastoma. The research explores the use of microfluidic chips for growing cell cultures and evaluating treatment options, with a specific focus on modeling angiogenesis and the blood-brain barrier. This study provides valuable insights into the advancements in tumor-on-a-chip technology for in vitro drug delivery and personalized therapy approaches. [Extracted from the article]

A recent study conducted at Southern Federal University in Rostov Na Donu, Russia, has highlighted the innovative applications of nanochannels in microfluidics. These microfluidic devices have revolutionized biological research by enabling high sensitivity analysis of complex biological materials. The research emphasizes the advantages of microfluidic devices, such as improved automation, cost-effectiveness, and high-throughput processing capabilities, making them a valuable tool in biotechnology research. Additionally, the study discusses the integration of microfluidics with advanced techniques like Raman spectroscopy and mass spectrometry to enhance biomedical applications and sensing capabilities. [Extracted from the article]

A study conducted by Ludong University in Shandong, People's Republic of China, introduced a novel micromixer based on coastal fractals for manufacturing controllable size liposomes. The research aimed to address the complexity and cost associated with traditional lipid preparation methods by optimizing a micro-mixer design. The results showed that the optimized micro-mixer enhanced mixing efficiency, leading to the production of microfluidic blank liposomes with specific particle sizes. The study concluded that the wall-type fractal micro-mixer has promising applications due to its high mixing efficiency. [Extracted from the article]

A patent application titled "Integrated Microfluidic System For Monitoring A Sample Over A Digestion Process" was published online by inventors from various locations in California. The application focuses on the need for improved tissue dissociation methods to enhance single-cell analysis for tissue diagnostics and disease understanding, particularly in cancer research. The system described in the patent application involves a microfluidic device for processing tissue samples, incorporating a camera for monitoring the tissue sample during the digestion and disaggregation process. This innovative technology aims to address the challenges of tissue processing and monitoring, potentially advancing personalized medicine and therapy development. [Extracted from the article]

A recent study conducted at the University of Wisconsin focused on head and neck cancer, highlighting the challenges in predicting treatment efficacy due to the disease's heterogeneity. The research introduced patient-specific microphysiological systems (MPS) as a promising approach to understanding the tumor microenvironment and improving patient outcomes. By creating patient-specific models that mimic the tumor microenvironment, researchers were able to study treatment responses and resistance, paving the way for personalized treatment strategies. The study was presented at the AACR Special Conference in Cancer Research, emphasizing the importance of engineering the tumor microenvironment for better treatment outcomes in head and neck cancer. [Extracted from the article]

Seabirds feed at plastic hotspots Threatened seabirds are foraging around floating garbage patches in the ocean, according to data from tracking devices. Corn vulnerable to extreme heat The huge amounts of maize grown in the US Midwest could be under threat from climate change. When water is added to a gel of nanoparticles of silicon dioxide, it forms a pancake-shaped blob. [Extracted from the article]

Abs Global Inc. has been issued a patent for modular flow cytometry systems and methods of processing samples. The patent aims to improve flow cytometry systems by introducing a modular design that allows for the removal and cleaning of sample pathway modules, reducing downtime and manual intervention. The system includes components such as electronics modules, fluidics modules, interrogation modules, and sample mixing and collection modules, all designed for near-continuous operation. The patent addresses the need for improved detection and destruction of particles in flow cytometry systems, particularly focusing on preserving the viability of sperm cells during sorting processes. [Extracted from the article]

A study conducted at Addis Ababa University focused on developing a paper-based microfluidic analytical device (mPAD) for the determination of paracetamol in water samples. The research aimed to address the challenges of detecting and quantifying pharmaceutical compounds in environmental matrices by optimizing key parameters such as reaction time, concentration, reagent volume, and channel length. The mPAD demonstrated detection limits at 0.03 mg/ml, showing promise for trace-level paracetamol quantification in water samples without conventional analytical instruments. The study concluded that mPADs provide excellent sensitivity, precision, and accuracy for analyzing paracetamol. [Extracted from the article]

The article discusses biases observed in the Parsortix system when detecting pancreatic cancer cell lines. The study found that the system may underestimate the presence of mesenchymal circulating tumor cells (CTCs) compared to epithelial and hybrid phenotypes. This research highlights the challenges in detecting CTCs and the importance of reliable biomarkers for early detection and disease monitoring in pancreatic cancer. [Extracted from the article]

A recent study from Chulalongkorn University in Bangkok, Thailand, focused on developing a capillary-driven microfluidic device for accurately measuring the concentrations of z9-tetrahydrocannabinol (z9-THC) and cannabidiol (CBD) in medical-grade cannabis flowers. The device integrated electrochemical and colorimetric detections, offering a practical alternative for quality control in assessing THC and CBD levels. The research was supported by various funding sources and has been peer-reviewed, providing valuable insights into the analysis of cannabinoids in cannabis flowers. [Extracted from the article]