UFMTrack: Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices (Updated November 15, 2024).

The article discusses the development of the Under-Flow Migration Tracker (UFMTrack) framework, which enables the analysis of immune cell interactions with brain microvascular endothelial cells across the blood-brain barrier in vitro. This tool allows for the study of the multi-step extravasation cascade of immune cells under physiological flow, providing insights into the mechanisms involved in neuroinflammatory diseases like multiple sclerosis. The UFMTrack framework is designed to analyze and quantify the interactions of different immune cell subsets with the blood-brain barrier, offering a valuable resource for researchers in immunology and brain research. [Extracted from the article]