Author: "Loo, Joseph A" / Publication Type: Magazines - Searchworks@Jio Institute Digital Library Search Results

1. Ultrafast Au(III)-Mediated Arylation of Cysteine

Author: Doud, Evan A., Tilden, James A. R., Treacy, Joseph W., Chao, Elaine Y., Montgomery, Hayden R., Kunkel, Grace E., Olivares, Eileen J., Adhami, Nima, Kerr, Tyler A., Chen, Yu, Rheingold, Arnold L., Loo, Joseph A., Frost, Christopher G., Houk, K. N., Maynard, Heather D., and Spokoyny, Alexander M.
Abstract: Through mechanistic work and rational design, we have developed the fastest organometallic abiotic Cys bioconjugation. As a result, the developed organometallic Au(III) bioconjugation reagents enable selective labeling of Cys moieties down to picomolar concentrations and allow for the rapid construction of complex heterostructures from peptides, proteins, and oligonucleotides. This work showcases how organometallic chemistry can be interfaced with biomolecules and lead to a range of reactivities that are largely unmatched by classical organic chemistry tools.
Published: 2024
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2. Top-down mass spectrometry of native proteoforms and their complexes: a community study

Author: Habeck, Tanja, Brown, Kyle A., Des Soye, Benjamin, Lantz, Carter, Zhou, Mowei, Alam, Novera, Hossain, Md Amin, Jung, Wonhyeuk, Keener, James E., Volny, Michael, Wilson, Jesse W., Ying, Yujia, Agar, Jeffrey N., Danis, Paul O., Ge, Ying, Kelleher, Neil L., Li, Huilin, Loo, Joseph A., Marty, Michael T., Paša-Tolić, Ljiljana, Sandoval, Wendy, and Lermyte, Frederik
Abstract: The combination of native electrospray ionization with top-down fragmentation in mass spectrometry (MS) allows simultaneous determination of the stoichiometry of noncovalent complexes and identification of their component proteoforms and cofactors. Although this approach is powerful, both native MS and top-down MS are not yet well standardized, and only a limited number of laboratories regularly carry out this type of research. To address this challenge, the Consortium for Top-Down Proteomics initiated a study to develop and test protocols for native MS combined with top-down fragmentation of proteins and protein complexes across 11 instruments in nine laboratories. Here we report the summary of the outcomes to provide robust benchmarks and a valuable entry point for the scientific community.
Published: 2024
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3. Impact of Internal Fragments on Top-Down Analysis of Intact Proteins by 193 nm UVPD

Author: Dunham, Sean D., Wei, Benqian, Lantz, Carter, Loo, Joseph A., and Brodbelt, Jennifer S.
Abstract: 193 nm ultraviolet photodissociation (UVPD) allows high sequence coverage to be obtained for intact proteins using terminal fragments alone. However, internal fragments, those that contain neither N- nor C- terminus, are typically ignored, neglecting their potential to bolster characterization of intact proteins. Here, we explore internal fragments generated by 193 nm UVPD for proteins ranging in size from 17–47 kDa and using the ClipsMS algorithm to facilitate searches for internal fragments. Internal fragments were only retained if identified in multiple replicates in order to reduce spurious assignments and to explore the reproducibility of internal fragments generated by UVPD. Inclusion of internal fragment improved sequence coverage by an average of 18% and 32% for UVPD and HCD, respectively, across all proteins and charge states studied. However, only an average of 18% of UVPD internal fragments were identified in two out of three replicates relative to the average number identified across all replicates for all proteins studied. Conversely, for HCD, an average of 63% of internal fragments were retained across replicates. These trends reflect an increased risk of false-positive identifications and a need for caution when considering internal fragments for UVPD. Additionally, proton-transfer charge reduction (PTCR) reactions were performed following UVPD or HCD to assess the impact on internal fragment identifications, allowing up to 20% more fragment ions to be retained across multiple replicates. At this time, it is difficult to recommend the inclusion of the internal fragment when searching UVPD spectra without further work to develop strategies for reducing the possibilities of false-positive identifications. All mass spectra are available in the public repository jPOST with the accession number JPST001885.
Published: 2023
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4. Native Top-Down Mass Spectrometry with Collisionally Activated Dissociation Yields Higher-Order Structure Information for Protein Complexes

Author: Lantz, Carter, Wei, Benqian, Zhao, Boyu, Jung, Wonhyeuk, Goring, Andrew K., Le, Jessie, Miller, Justin, Loo, Rachel R. Ogorzalek, and Loo, Joseph A.
Abstract: Native mass spectrometry (MS) of proteins and protein assemblies reveals size and binding stoichiometry, but elucidating structures to understand their function is more challenging. Native top-down MS (nTDMS), i.e., fragmentation of the gas-phase protein, is conventionally used to derive sequence information, locate post-translational modifications (PTMs), and pinpoint ligand binding sites. nTDMS also endeavors to dissociate covalent bonds in a conformation-sensitive manner, such that information about higher-order structure can be inferred from the fragmentation pattern. However, the activation/dissociation method used can greatly affect the resulting information on protein higher-order structure. Methods such as electron capture/transfer dissociation (ECD and ETD, or ExD) and ultraviolet photodissociation (UVPD) can produce product ions that are sensitive to structural features of protein complexes. For multi-subunit complexes, a long-held belief is that collisionally activated dissociation (CAD) induces unfolding and release of a subunit, and thus is not useful for higher-order structure characterization. Here we show not only that sequence information can be obtained directly from CAD of native protein complexes but that the fragmentation pattern can deliver higher-order structural information about their gas- and solution-phase structures. Moreover, CAD-generated internal fragments (i.e., fragments containing neither N-/C-termini) reveal structural aspects of protein complexes.
Published: 2022
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5. Are Internal Fragments Observable in Electron Based Top-Down Mass Spectrometry?

Author: Mikawy, Neven N., Rojas Ramírez, Carolina, DeFiglia, Steven A., Szot, Carson W., Le, Jessie, Lantz, Carter, Wei, Benqian, Zenaidee, Muhammad A., Blakney, Greg T., Nesvizhskii, Alexey I., Loo, Joseph A., Ruotolo, Brandon T., Shabanowitz, Jeffrey, Anderson, Lissa C., and Håkansson, Kristina
Abstract: Protein tandem mass spectrometry (MS/MS) often generates sequence-informative fragments from backbone bond cleavages near the termini. This lack of fragmentation in the protein interior is particularly apparent in native top-down mass spectrometry (MS). Improved sequence coverage, critical for reliable annotation of posttranslational modifications and sequence variants, may be obtained from internal fragments generated by multiple backbone cleavage events. However, internal fragment assignments can be error prone due to isomeric/isobaric fragments from different parts of a protein sequence. Also, internal fragment generation propensity depends on the chosen MS/MS activation strategy. Here, we examine internal fragment formation in electron capture dissociation (ECD) and electron transfer dissociation (ETD) following native and denaturing MS, as well as LC/MS of several proteins. Experiments were undertaken on multiple instruments, including quadrupole time-of-flight, Orbitrap, and high-field Fourier-transform ion cyclotron resonance (FT-ICR) across four laboratories. ECD was performed at both ultrahigh vacuum and at similar pressure to ETD conditions. Two complementary software packages were used for data analysis. When feasible, ETD-higher energy collision dissociation MS3was performed to validate/refute potential internal fragment assignments, including differentiating MS3fragmentation behavior of radical versuseven-electron primary fragments. We show that, under typical operating conditions, internal fragments cannot be confidently assigned in ECD or ETD. On the other hand, such fragments, along with some b-type terminal fragments (not typically observed in ECD/ETD spectra) appear at atypical ECD operating conditions, suggesting they originate from a separate ion-electron activation process. Furthermore, atypical fragment ion types, e.g., xions, are observed at such conditions as well as upon EThcD, presumably due to vibrational activation of radical z-type ions.
Published: 2024
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6. Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43

Author: Jiang, Yi Xiao, Cao, Qin, Sawaya, Michael R., Abskharon, Romany, Ge, Peng, DeTure, Michael, Dickson, Dennis W., Fu, Janine Y., Ogorzalek Loo, Rachel R., Loo, Joseph A., and Eisenberg, David S.
Abstract: Frontotemporal lobar degeneration (FTLD) is the third most common neurodegenerative condition after Alzheimer’s and Parkinson’s diseases1. FTLD typically presents in 45 to 64 year olds with behavioural changes or progressive decline of language skills2. The subtype FTLD-TDP is characterized by certain clinical symptoms and pathological neuronal inclusions with TAR DNA-binding protein (TDP-43) immunoreactivity3. Here we extracted amyloid fibrils from brains of four patients representing four of the five FTLD-TDP subclasses, and determined their structures by cryo-electron microscopy. Unexpectedly, all amyloid fibrils examined were composed of a 135-residue carboxy-terminal fragment of transmembrane protein 106B (TMEM106B), a lysosomal membrane protein previously implicated as a genetic risk factor for FTLD-TDP4. In addition to TMEM106B fibrils, we detected abundant non-fibrillar aggregated TDP-43 by immunogold labelling. Our observations confirm that FTLD-TDP is associated with amyloid fibrils, and that the fibrils are formed by TMEM106B rather than TDP-43.
Published: 2022
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7. PEPPI-MS: Polyacrylamide-Gel-Based Prefractionation for Analysis of Intact Proteoforms and Protein Complexes by Mass Spectrometry

Author: Takemori, Ayako, Butcher, David S., Harman, Victoria M., Brownridge, Philip, Shima, Keisuke, Higo, Daisuke, Ishizaki, Jun, Hasegawa, Hitoshi, Suzuki, Junpei, Yamashita, Masakatsu, Loo, Joseph A., Loo, Rachel R. Ogorzalek, Beynon, Robert J., Anderson, Lissa C., and Takemori, Nobuaki
Abstract: Prefractionation of complex mixtures of proteins derived from biological samples is indispensable for proteome analysis via top-down mass spectrometry (MS). Polyacrylamide gel electrophoresis (PAGE), which enables high-resolution protein separation based on molecular size, is a widely used technique in biochemical experiments and has the potential to be useful in sample fractionation for top-down MS analysis. However, the lack of a means to efficiently recover the separated proteins in-gel has always been a barrier to its use in sample prefractionation. In this study, we present a novel experimental workflow, called Passively Eluting Proteins from Polyacrylamide gels as Intact species for MS (“PEPPI-MS”), which allows top-down MS of PAGE-separated proteins. The optimization of Coomassie brilliant blue staining followed by the passive extraction step in the PEPPI-MS workflow enabled the efficient recovery of proteins, separated on commercial precast gels, from a wide range of molecular weight regions in under 10 min. Two-dimensional separation combining offline PEPPI-MS with online reversed-phase liquid chromatographic separation resulted in identification of over 1000 proteoforms recovered from the target region of the gel (≤50 kDa). Given the widespread availability and relatively low cost of traditional sodium dodecyl sulfate (SDS)-PAGE equipment, the PEPPI-MS workflow will be a powerful prefractionation strategy for top-down proteomics.
Published: 2020
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8. Kinetics and Optimization of the Lysine–Isopeptide Bond Forming Sortase Enzyme from Corynebacterium diphtheriae

Author: Sue, Christopher K., McConnell, Scott A., Ellis-Guardiola, Ken, Muroski, John M., McAllister, Rachel A., Yu, Justin, Alvarez, Ana I., Chang, Chungyu, Ogorzalek Loo, Rachel R., Loo, Joseph A., Ton-That, Hung, and Clubb, Robert T.
Abstract: Site-specifically modified protein bioconjugates have important applications in biology, chemistry, and medicine. Functionalizing specific protein side chains with enzymes using mild reaction conditions is of significant interest, but remains challenging. Recently, the lysine–isopeptide bond forming activity of the sortase enzyme that builds surface pili in Corynebacterium diphtheriae(CdSrtA) has been reconstituted in vitro. A mutationally activated form of CdSrtA was shown to be a promising bioconjugating enzyme that can attach Leu-Pro-Leu-Thr-Gly peptide fluorophores to a specific lysine residue within the N-terminal domain of the SpaA protein (NSpaA), enabling the labeling of target proteins that are fused to NSpaA. Here we present a detailed analysis of the CdSrtA catalyzed protein labeling reaction. We show that the first step in catalysis is rate limiting, which is the formation of the CdSrtA-peptide thioacyl intermediate that subsequently reacts with a lysine ε-amine in NSpaA. This intermediate is surprisingly stable, limiting spurious proteolysis of the peptide substrate. We report the discovery of a new enzyme variant (CdSrtAΔ) that has significantly improved transpeptidation activity, because it completely lacks an inhibitory polypeptide appendage (“lid”) that normally masks the active site. We show that the presence of the lid primarily impairs formation of the thioacyl intermediate and not the recognition of the NSpaA substrate. Quantitative measurements reveal that CdSrtAΔgenerates its cross-linked product with a catalytic turnover number of 1.4 ± 0.004 h–1and that it has apparent KMvalues of 0.16 ± 0.04 and 1.6 ± 0.3 mM for its NSpaA and peptide substrates, respectively. CdSrtAΔis 7-fold more active than previously studied variants, labeling >90% of NSpaA with peptide within 6 h. The results of this study further improve the utility of CdSrtA as a protein labeling tool and provide insight into the enzyme catalyzed reaction that underpins protein labeling and pilus biogenesis.
Published: 2020
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9. ProForma: A Standard Proteoform Notation

Author: LeDuc, Richard D., Schwämmle, Veit, Shortreed, Michael R., Cesnik, Anthony J., Solntsev, Stefan K., Shaw, Jared B., Martin, Maria J., Vizcaino, Juan A., Alpi, Emanuele, Danis, Paul, Kelleher, Neil L., Smith, Lloyd M., Ge, Ying, Agar, Jeffrey N., Chamot-Rooke, Julia, Loo, Joseph A., Pasa-Tolic, Ljiljana, and Tsybin, Yury O.
Abstract: The Consortium for Top-Down Proteomics (CTDP) proposes a standardized notation, ProForma, for writing the sequence of fully characterized proteoforms. ProForma provides a means to communicate any proteoform by writing the amino acid sequence using standard one-letter notation and specifying modifications or unidentified mass shifts within brackets following certain amino acids. The notation is unambiguous, human-readable, and can easily be parsed and written by bioinformatic tools. This system uses seven rules and supports a wide range of possible use cases, ensuring compatibility and reproducibility of proteoform annotations. Standardizing proteoform sequences will simplify storage, comparison, and reanalysis of proteomic studies, and the Consortium welcomes input and contributions from the research community on the continued design and maintenance of this standard.
Published: 2024
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10. Added Value of Internal Fragments for Top-Down Mass Spectrometry of Intact Monoclonal Antibodies and Antibody–Drug Conjugates

Author: Wei, Benqian, Lantz, Carter, Liu, Weijing, Viner, Rosa, Ogorzalek Loo, Rachel R., Campuzano, Iain D. G., and Loo, Joseph A.
Abstract: Monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) are two of the most important therapeutic drug classes that require extensive characterization, whereas their large size and structural complexity make them challenging to characterize and demand the use of advanced analytical methods. Top-down mass spectrometry (TD-MS) is an emerging technique that minimizes sample preparation and preserves endogenous post-translational modifications (PTMs); however, TD-MS of large proteins suffers from low fragmentation efficiency, limiting the sequence and structure information that can be obtained. Here, we show that including the assignment of internal fragments in native TD-MS of an intact mAb and an ADC can improve their molecular characterization. For the NIST mAb, internal fragments can access the sequence region constrained by disulfide bonds to increase the TD-MS sequence coverage to over 75%. Important PTM information, including intrachain disulfide connectivity and N-glycosylation sites, can be revealed after including internal fragments. For a heterogeneous lysine-linked ADC, we show that assigning internal fragments improves the identification of drug conjugation sites to achieve a coverage of 58% of all putative conjugation sites. This proof-of-principle study demonstrates the potential value of including internal fragments in native TD-MS of intact mAbs and ADCs, and this analytical strategy can be extended to bottom-up and middle-down MS approaches to achieve even more comprehensive characterization of important therapeutic molecules.
Published: 2024
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11. Fixed-Charge Trimethyl Pyrilium Modification for Enabling Enhanced Top-Down Mass Spectrometry Sequencing of Intact Protein Complexes

Author: Polasky, Daniel A., Lermyte, Frederik, Nshanian, Michael, Sobott, Frank, Andrews, Phillip C., Loo, Joseph A., and Ruotolo, Brandon T.
Abstract: Mass spectrometry of intact proteins and protein complexes has the potential to provide a transformative level of information on biological systems, ranging from sequence and post-translational modification analysis to the structures of whole protein assemblies. This ambitious goal requires the efficient fragmentation of both intact proteins and the macromolecular, multicomponent machines they collaborate to create through noncovalent interactions. Improving technologies in an effort to achieve such fragmentation remains perhaps the greatest challenge facing current efforts to comprehensively analyze cellular protein composition and is essential to realizing the full potential of proteomics. In this work, we describe the use of a trimethyl pyrylium (TMP) fixed-charge covalent labeling strategy aimed at enhancing fragmentation for challenging intact proteins and intact protein complexes. Combining analysis of TMP-modified and unmodified protein complexes results in a greater diversity of regions within the protein that give rise to fragments, and results in an up to 2.5-fold increase in sequence coverage when compared to unmodified protein alone, for protein complexes up to 148 kDa. TMP modification offers a simple and powerful platform to expand the capabilities of existing mass spectrometric instrumentation for the complete characterization of intact protein assemblies.
Published: 2024
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12. Native-MS Analysis of Monoclonal Antibody Conjugates by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Author: Campuzano, Iain D. G., Netirojjanakul, Chawita, Nshanian, Michael, Lippens, Jennifer L., Kilgour, David P. A., Van Orden, Steve, and Loo, Joseph A.
Abstract: Antibody-drug conjugates (ADCs) are an important class of therapeutic molecule currently being used to treat HER2-positive metastatic breast cancer, relapsed or refractory Hodgkin lymphoma, systemic anaplastic large cell lymphoma, relapsed or refractory B-cell precursor acute lymphoblastic leukemia, and acute myeloid leukemia. An ADC typically consists of a small molecule or peptide-based cytotoxic moiety covalently linked, via lysine or cysteine residues, to a monoclonal antibody (mAb) scaffold. Mass spectrometric (MS) characterization of these molecules affords highly accurate molecular weight (MW) and drug-to-antibody ratio (DAR) determination and is typically performed using orthogonal acceleration time-of-flight (oa-ToF) analyzers and more recently, Orbitrap instruments. Herein we describe for the first time the use of a 15 T solariX Fourier transform ion cyclotron mass spectrometer to characterize an IgG1 mAb molecule conjugated with biotin via native lysine and cysteine residues, under native-MS and solution conditions. The cysteine–biotin conjugates remained fully intact, demonstrating the ability of the FT-ICR to maintain the noncovalent interactions and efficiently transmit labile protein complexes. Native-MS was acquired and is displayed in magnitude mode using a symmetric Hann apodization function. Baseline separation is achieved on all covalent biotin additions, for each charge state, for both the lysine– and cysteine–biotin conjugates. Average DAR values obtained by native-MS for the lysine conjugate are compared to those derived by denaturing reversed phase liquid chromatography using an oa-ToF MS system (1.56 ± 0.02 versus 2.24 ± 0.02 for the 5 equivalent and 3.99 ± 0.09 versus 4.43 ± 0.01 for the 10 equivalent, respectively). Increased DAR value accuracy can be obtained for the higher biotin-load when using standard ESI conditions as opposed to nanoESI native-MS conditions.
Published: 2024
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13. Internal Fragments Enhance Middle-Down Mass Spectrometry Structural Characterization of Monoclonal Antibodies and Antibody-Drug Conjugates

Author: Wei, Benqian, Lantz, Carter, Ogorzalek Loo, Rachel R., Campuzano, Iain D. G., and Loo, Joseph A.
Abstract: Monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) are important large biotherapeutics (∼150 kDa) and high structural complexity that require extensive sequence and structure characterization. Middle-down mass spectrometry (MD-MS) is an emerging technique that sequences and maps subunits larger than those released by trypsinolysis. It avoids potentially introducing artifactual modifications that may occur in bottom-up MS while achieving higher sequence coverage compared to top-down MS. However, returning complete sequence information by MD-MS is still challenging. Here, we show that assigning internal fragments in direct infusion MD-MS of a mAb and an ADC substantially improves their structural characterization. For MD-MS of the reduced NIST mAb, including internal fragments recovers nearly 100% of the sequence by accessing the middle sequence region that is inaccessible by terminal fragments. The identification of important glycosylations can also be improved after the inclusion of internal fragments. For the reduced lysine-linked IgG1-DM1 ADC, we show that considering internal fragments increases the DM1 conjugation sites coverage to 80%, comparable to the reported 83% coverage achieved by peptide mapping on the same ADC (Luo et al. Anal. Chem.2016, 88, 695–702). This study expands our work on the application of internal fragment assignments in top-down MS of mAbs and ADCs and can be extended to other heterogeneous therapeutic molecules such as multispecifics and fusion proteins for more widespread applications.
Published: 2024
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14. Native and Denaturing MS Protein Deconvolution for Biopharma: Monoclonal Antibodies and Antibody–Drug Conjugates to Polydisperse Membrane Proteins and Beyond

Author: Campuzano, Iain D. G., Robinson, John H., Hui, John O., Shi, Stone D.-H., Netirojjanakul, Chawita, Nshanian, Michael, Egea, Pascal F., Lippens, Jennifer L., Bagal, Dhanashri, Loo, Joseph A., and Bern, Marshall
Abstract: Electrospray ionization mass spectrometry (ESI-MS) is a ubiquitously used analytical method applied across multiple departments in biopharma, ranging from early research discovery to process development. Accurate, efficient, and consistent protein MS spectral deconvolution across multiple instrument and detector platforms (time-of-flight, Orbitrap, Fourier-transform ion cyclotron resonance) is essential. When proteins are ionized during the ESI process, a distribution of consecutive multiply charged ions are observed on the m/zscale, either positive [M + nH]n+or negative [M – nH]n−depending on the ionization polarity. The manual calculation of the neutral molecular weight (MW) of single proteins measured by ESI-MS is simple; however, algorithmic deconvolution is required for more complex protein mixtures to derive accurate MWs. Multiple deconvolution algorithms have evolved over the past two decades, all of which have their advantages and disadvantages, in terms of speed, user-input parameters (or ideally lack thereof), and whether they perform optimally on proteins analyzed under denatured or native-MS and solution conditions. Herein, we describe the utility of a parsimonious deconvolution algorithm (explaining the observed spectra with a minimum number of masses) to process a wide range of highly diverse biopharma relevant and research grade proteins and complexes (PEG-GCSF; an IgG1k; IgG1- and IgG2-biotin covalent conjugates; the membrane protein complex AqpZ; a highly polydisperse empty MSP1D1 nanodisc and the tetradecameric chaperone protein complex GroEL) analyzed under native-MS, denaturing LC-MS, and positive and negative modes of ionization, using multiple instruments and therefore multiple data formats. The implementation of a comb filter and peak sharpening option is also demonstrated to be highly effective for deconvolution of highly polydisperse and enhanced separation of a low level lysine glycation post-translational modification (+162.1 Da), partially processed heavy chain lysine residues (+128.1 Da), and loss of N-acetylglucosamine (GlcNAc; −203.1 Da).
Published: 2019
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15. Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

Author: Donnelly, Daniel P., Rawlins, Catherine M., DeHart, Caroline J., Fornelli, Luca, Schachner, Luis F., Lin, Ziqing, Lippens, Jennifer L., Aluri, Krishna C., Sarin, Richa, Chen, Bifan, Lantz, Carter, Jung, Wonhyeuk, Johnson, Kendall R., Koller, Antonius, Wolff, Jeremy J., Campuzano, Iain D. G., Auclair, Jared R., Ivanov, Alexander R., Whitelegge, Julian P., Paša-Tolić, Ljiljana, Chamot-Rooke, Julia, Danis, Paul O., Smith, Lloyd M., Tsybin, Yury O., Loo, Joseph A., Ge, Ying, Kelleher, Neil L., and Agar, Jeffrey N.
Abstract: One gene can give rise to many functionally distinct proteoforms, each of which has a characteristic molecular mass. Top-down mass spectrometry enables the analysis of intact proteins and proteoforms. Here members of the Consortium for Top-Down Proteomics provide a decision tree that guides researchers to robust protocols for mass analysis of intact proteins (antibodies, membrane proteins and others) from mixtures of varying complexity. We also present cross-platform analytical benchmarks using a protein standard sample, to allow users to gauge their proficiency.
Published: 2019
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16. Rapid LC–MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins

Author: Lippens, Jennifer L., Egea, Pascal F., Spahr, Chris, Vaish, Amit, Keener, James E., Marty, Michael T., Loo, Joseph A., and Campuzano, Iain D. G.
Abstract: Therapeutic target characterization involves many components, including accurate molecular weight (MW) determination. Knowledge of the accurate MW allows one to detect the presence of post-translational modifications, proteolytic cleavages, and importantly, if the correct construct has been generated and purified. Denaturing liquid chromatography–mass spectrometry (LC–MS) can be an attractive method for obtaining this information. However, membrane protein LC–MS methodology has remained relatively under-explored and under-incorporated in comparison to methods for soluble proteins. Here, systematic investigation of multiple gradients and column chemistries has led to the development of a 5 min denaturing LC–MS method for acquiring membrane protein accurate MW measurements. Conditions were interrogated with membrane proteins, such as GPCRs and ion channels, as well as bispecific antibody constructs of variable sizes with the aim to provide the community with rapid LC–MS methods necessary to obtain chromatographic and accurate MW measurements in a medium- to high-throughput manner. The 5 min method detailed has successfully produced MW measurements for hydrophobic proteins with a wide MW range (17.5 to 105.3 kDa) and provided evidence that some constructs indeed contain unexpected modifications or sequence clipping. This rapid LC–MS method is also capable of baseline separating formylated and nonformylated aquaporinZ membrane protein.
Published: 2018
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17. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
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18. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
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19. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
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20. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

21. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxiang, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

22. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

23. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

24. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

25. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

26. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxiang, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

27. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

28. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

29. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

30. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

31. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

32. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

33. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

34. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxiang, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

35. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

36. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

37. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

38. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

39. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

40. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

41. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

42. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

43. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

44. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

45. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

46. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

47. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

48. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

49. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

50. Confronting Racism in Chemistry Journals

Author: Burrows, Cynthia J., Huang, Jiaxing, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J., Schanze, Kirk, Lee, T. Randall, Lutkenhaus, Jodie L., Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W., Finn, M. G., Blum, Joel D., Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C., Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S., Zhang, Deqing, Ganesh, Krishna N., Atwater, Harry A., Gooding, J. Justin, Allen, David T., Voigt, Christopher A., Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J., Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W., Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F., Brennecke, Joan F., Holme, Thomas A., Merz, Kenneth M., Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I., Wang, Shaomeng, Proteau, Philip, Yates, John R., Stang, Peter, Walker, Gilbert C., Hillmyer, Marc, Taylor, Lynne S., Odom, Teri W., Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J., Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A., Milne, James, Tegen, Sarah B., Kulp, Daniel T., and Laskin, Julia
Published: 2020
Full Text: View/download PDF

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