38 results on '"Li, Shisheng"'
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2. Postoperative tumor treatment strategies: From basic research to clinical therapy
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Xiao, Minna, Wang, Lin, Tang, Qinglai, Yang, Qian, Yang, Xinming, Zhu, Gangcai, Lei, Lanjie, and Li, Shisheng
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Despite progression in advanced treatments for malignant tumors, surgery remains the primary treatment intervention, which removes a large portion of firm tumor tissues; however, the postoperative phase poses a possible risk for provincial tumor recurrence and metastasis. Consequently, the prevention of tumor recurrence and metastasis has attracted research attention. In this review, we summarized the postoperative treatment strategies for various tumors from both basic research and clinical perspectives. We delineated the underlying factors contributing to the recurrence of malignant tumors with a substantial prevalence rate, related molecular mechanisms of tumor recurrence post‐surgery, and related means of monitoring recurrence and metastasis after surgery. Furthermore, we described relevant therapeutic approaches for postoperative tumor recurrence, including chemotherapy, radiation therapy, immunotherapy, targeted therapy, and photodynamic therapy. This review focused on the emerging technologies used for postoperative tumor treatment in recent years in terms of functional classification, including the prevention of postoperative tumor recurrence, functional reconstruction, and monitoring of recurrence. Finally, we discussed the future development and deficiencies of postoperative tumor therapy. To understand postoperative treatment strategies for tumors from clinical treatment and basic research and further guide the research directions for postoperative tumors. The latest research on the molecular mechanism of tumor and clinical treatment for postoperative recurrence of tumors has been introduced. This review focuses on the emerging technologies used for postoperative tumor treatment in recent years in terms of functional classification.
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- 2024
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3. Two-dimensional alloyed transition metal dichalcogenide nanosheets: Synthesis and applications
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Huang, Haoxin, Zha, Jiajia, Li, Shisheng, and Tan, Chaoliang
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Two-dimensional (2D) transition metal dichalcogenide (TMD) nanosheets have attracted considerable attention owing to their diverse properties and great potential in a wide range of applications. In order to further tune their properties and then broaden their application domain, large efforts have been devoted into engineering the structures of 2D TMD nanosheets at atomic scale, especially the alloying technology. Alloying different 2D TMD nanosheets into 2D alloys not only offers the opportunities to fine-tune their physical/chemical properties, but also opens up some unique properties, which are highly desirable for wide applications including electronics, optoelectronics and catalysis. This review summarizes the recent progress in the preparation, characterization and applications of 2D alloyed TMD nanosheets.
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- 2022
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4. Mixed-Salt Enhanced Chemical Vapor Deposition of Two-Dimensional Transition Metal Dichalcogenides
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Li, Shisheng, Lin, Yung-Chang, Hong, Jinhua, Gao, Bo, Lim, Hong En, Yang, Xu, Liu, Song, Tateyama, Yoshitaka, Tsukagoshi, Kazuhito, Sakuma, Yoshiki, Suenaga, Kazu, and Taniguchi, Takaaki
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The usage of molten salts, for example, Na2MoO4and Na2WO4, has shown great success in the growth of two-dimensional (2D) transition metal dichalcogenides (TMDCs) by chemical vapor deposition (CVD). In comparison with the halide salt (i.e., NaCl, NaBr, and KI)-assisted growth (Salt 1.0), the molten salt-assisted vapor–liquid–solid growth technique (Salt 2.0) has improved the reproducibility, efficiency, and scalability of synthesizing 2D TMDCs. However, the growth of large-area MoSe2and WTe2is still quite challenging with the use of the Salt 2.0 technique. In this study, a renewed Salt 2.0 technique using mixed salts (e.g., Na2MoO4–Na2SeO3and Na2WO4–Na2TeO3) is developed for the enhanced CVD growth of 2D MoSe2and WTe2crystals with a large grain size and yield. A continuous monolayer MoSe2film with a grain size of 100–250 μm or isolated flakes up to ∼450 μm is grown on a halved 2 inch SiO2/Si wafer. Our study further confirms the synergistic effect of Na+and SeO32–in the enhanced CVD growth of the wafer-scale monolayer MoSe2film. Thus, the addition of Na2SeO3and Na2TeO3into the transition metal salts could be a general strategy for the enhanced CVD growth of many other 2D metal selenides and tellurides.
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- 2021
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5. Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability
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Geijer, Marit E., Zhou, Di, Selvam, Kathiresan, Steurer, Barbara, Mukherjee, Chirantani, Evers, Bastiaan, Cugusi, Simona, van Toorn, Marvin, van der Woude, Melanie, Janssens, Roel C., Kok, Yannick P., Gong, Wenzhi, Raams, Anja, Lo, Calvin S. Y., Lebbink, Joyce H. G., Geverts, Bart, Plummer, Dalton A., Bezstarosti, Karel, Theil, Arjan F., Mitter, Richard, Houtsmuller, Adriaan B., Vermeulen, Wim, Demmers, Jeroen A. A., Li, Shisheng, van Vugt, Marcel A. T. M., Lans, Hannes, Bernards, René, Svejstrup, Jesper Q., Ray Chaudhuri, Arnab, Wyrick, John J., and Marteijn, Jurgen A.
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Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA polymerase II, causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counteract the severe consequence of these transcription-blocking lesions. However, the exact mechanism and factors involved remain largely unknown. Here, using a genome-wide CRISPR–Cas9 screen, we identified the elongation factor ELOF1 as an important factor in the transcription stress response following DNA damage. We show that ELOF1 has an evolutionarily conserved role in transcription-coupled nucleotide excision repair (TC-NER), where it promotes recruitment of the TC-NER factors UVSSA and TFIIH to efficiently repair transcription-blocking lesions and resume transcription. Additionally, ELOF1 modulates transcription to protect cells against transcription-mediated replication stress, thereby preserving genome stability. Thus, ELOF1 protects the transcription machinery from DNA damage via two distinct mechanisms.
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- 2021
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6. Twist Angle-Dependent Optical Responses in Controllably Grown WS2Vertical Homojunctions
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Shao, Gonglei, Xue, Xiong-Xiong, Liu, Xiao, Zhang, Danliang, Jin, Yuanyuan, Wu, Yangwu, You, Bingying, Lin, Yung-Chang, Li, Shisheng, Suenaga, Kazu, Wang, Xiao, Pan, Anlian, Li, Huimin, Hong, Jinhua, Feng, Yexin, and Liu, Song
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Interlayer coupling in two-dimensional (2D) materials with specific stacking modes results in angle-dependent electrical and optical behaviors. Compared to multilayered WS2with a 0° twist angle grown under normal conditions, WS2sheets with a 60° twist angle are prepared by chemical vapor deposition (CVD) with the assistance of tin (Sn) for reducing stacking energy. The layer number can be effectively regulated by the growth temperature and hydrogen flow. The 2H-like phase of the 60° bilayer structure is revealed by scanning transmission electron microscopy (STEM), displaying intense photoluminescence (PL) variation and diverse second harmonic generation due to interlayer coupling. The bilayer WS2with various twist angles can be obtained for angle-dependent Raman/PL response. Density functional theory (DFT) calculations demonstrate that heteroatom Sn can tip the balance between 0° and 60° bilayers, facilitating the formation of the bilayer with a 60° stacking angle. The heteroatom-assisted approach provides a general strategy for the self-assembly of 2D materials. The heterostructures with tunable twist angles can be prepared, which broadens their applications in moiré excitons, spintronics, and valley electronics of transition metal dichalcogenides.
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- 2020
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7. Na2SO4-Regulated High-Quality Growth of Transition Metal Dichalcogenides by Controlling Diffusion
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Jin, Yuanyuan, Cheng, Miao, Liu, Hang, Ouzounian, Miray, Hu, Travis Shihao, You, Bingying, Shao, Gonglei, Liu, Xiao, Liu, Yeru, Li, Huimin, Li, Shisheng, Guan, Jie, and Liu, Song
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The high diffusion rate of sulfur with respect to metal oxide creates precursors that deviate from the stoichiometric ratio, leading to poor growth controllability and defects in the as-grown transition metal dichalcogenides (TMDCs). The introduction of a sulfur precursor with a high melting point is a hopeful strategy to solve these problems. Here, we first introduce sodium sulfate (Na2SO4) as a sulfur precursor, which plays roles in tuning diffusion of source precursors and balancing their mass flux based on the temperature-confined decomposition of Na2SO4. We deduced the specific growth process by characterizing the composition of intermediates; the results show that emissions of sulfur and metal sources were synchronously released and spanning the entire growth stage. This temperature-controlled source-feeding system reduced the diffusion gap between sulfur and metal, which promoted a faster kinetics for reactions. Moreover, this method has the wide applicability for producing other TMDCs.
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- 2020
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8. On/Off Boundary of Photocatalytic Activity between Single- and Bilayer MoS2
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Taniguchi, Takaaki, Nurdiwijayanto, Leanddas, Li, Shisheng, Lim, Hong En, Miyata, Yasumitsu, Lu, Xueyi, Ma, Renzhi, Tang, Dang-Ming, Ueda, Shigenori, Tsukagoshi, Kazuhito, Sasaki, Takayoshi, and Osada, Minoru
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Molecularly thin two-dimensional (2D) semiconductors are emerging as photocatalysts owing to their layer-number-dependent quantum effects and high charge separation efficiency. However, the correlation among the dimensionality, crystallinity, and photocatalytic activity of such 2D nanomaterials remains unclear. Herein, a Ag photoreduction technique coupled with microscopic analyses is employed to spatially resolve the photocatalytic activity of MoS2as a model catalyst. Interestingly, we find that only monolayer (1L)-MoS2is active for a Ag photoreduction reaction. The photocatalytic activity of 1L-MoS2is enhanced by a built-in electrical field originated from the MoS2/SiO2interface, instead of by the specific surface structure and quantum electronic state of 1L-MoS2. Furthermore, we observe photocatalytic active sites to be geometrically distributed on triangular 1L-MoS2crystals, wherein the Ag particles are preferentially deposited on the outermost zigzag edges and defective inner parts of the triangular grains. The degradation of photocatalytic activity and electron mobility with the formation of Mo(VI) species indicates that the species inhibit the in-plane diffusion of the photogenerated electrons to the reductive sites. The monolayer-selectivity, activation, and inactivation mechanisms, unveiled in this work, will offer future directions in designing 2D nanophotocatalysts.
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- 2020
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9. Growth of Large-Area Homogeneous Monolayer Transition-Metal Disulfides via a Molten Liquid Intermediate Process
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Liu, Hang, Qi, Guopeng, Tang, Caisheng, Chen, Maolin, Chen, Yang, Shu, Zhiwen, Xiang, Haiyan, Jin, Yuanyuan, Wang, Shanshan, Li, Huimin, Ouzounian, Miray, Hu, Travis Shihao, Duan, Huigao, Li, Shisheng, Han, Zheng, and Liu, Song
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Growth of large-area, uniform, and high-quality monolayer transition-metal dichalcogenides (TMDs) for practical and industrial applications remains a long-standing challenge. The present study demonstrates a modified predeposited chemical vapor deposition (CVD) process by employing an annealing procedure before sulfurization, which helps in achieving large-area, highly uniform, and high-quality TMDs on various substrates. The annealing procedure resulted in a molten liquid state of the precursors in the CVD process, which not only facilitated a uniform redistribution of the precursor on the substrate (avoid the aggregation) because of the uniform redistribution of the liquid precursor on the substrate but more importantly avoided the undesired multilayer growth via the self-limited lateral supply precursors mechanism. A 2 in. uniform and continuous monolayer WS2film has been synthesized on the SiO2/Si substrate. Moreover, uniform monolayer WS2single crystals can be prepared on more general and various substrates including sapphire, mica, quartz, and Si3N4using the same growth procedure. Besides, this growth mechanism can be generalized to synthesize other monolayer TMDs such as MoS2and MoS2/WS2heterostructures. Hence, the present method provides a generalized attractive strategy to grow large-area, uniform, single-layer two-dimensional (2D) materials. This study has significant implications in the advancement of batch production of various 2D-material-based devices for industrial and commercial applications.
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- 2020
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10. Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAFV600Eexpression
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Ko, Tengyu, Sharma, Rahul, and Li, Shisheng
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The V600E mutation of BRAF (BRAFV600E), which constitutively activates the ERK/MAPK signaling pathway, is frequently found in melanoma and other cancers. Like most other oncogenes, BRAFV600Ecauses oncogenic stress to normal cells, leading to growth arrest (senescence) or apoptosis. Through genome-wide screening, we identified genes implicated in sensitivity of human skin melanocytes and fibroblasts to BRAFV600Eoverexpression. Among the identified genes shared by the two cell types are proto-oncogenes ERK2, a component of the ERK/MAPK pathway, and VAV1, a guanine nucleotide exchange factor for Rho family GTPases that also activates the ERK/MAPK pathway. CDKN1A, which has been known to promote senescence of fibroblasts but not melanocytes, is implicated in sensitivity of the fibroblasts but not the melanocytes to BRAFV600Eoverexpression. Disruptions of GPR4, a pH-sensing G-protein coupled receptor, and DBT, a subunit of the branched chain α-keto acid dehydrogenase that is required for the second and rate-limiting step of branched amino acid catabolism and implicated in maple syrup urine disease, are the most highly selected in the melanocytes upon BRAFV600Eoverexpression. Disruption of DBT severely attenuates ERK/MAPK signaling, p53 activation, and apoptosis in melanocytes, at least in part due to accumulation of branched chain α-keto acids. The expression level of BRAF positively correlates with that of DBT in all cancer types and with that of GPR4 in most cancer types. Overexpression of DBT kills all four melanoma cell lines tested regardless of the presence of BRAFV600Emutation. Our findings shed new lights on regulations of oncogenic stress signaling and may be informative for development of novel cancer treatment strategies.
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- 2020
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11. Obstructive sleep apnea in patients with laryngeal cancer after supracricoid or vertical partial laryngectomy
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Ouyang, Lei, Yi, Liang, Wang, Lin, Tang, Qinglai, Yang, Xinming, and Li, Shisheng
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To investigate whether partial laryngectomy is a risk factor for obstructive sleep apnea (OSA) and the effect of different partial laryngectomy methods on OSA. A prospective study was carried out involving 40 patients who underwent supracricoid partial laryngectomy (SCPL) (24) or vertical partial laryngectomy (VPL) (16) for carcinoma of the larynx. Apnea-hypopnea index (AHI) and oxygen saturation determined by polysomnography (PSG), Epworth sleepiness scale (ESS) score, and body mass index (BMI) were evaluated in patients before surgery, on the day of tracheal tube removal and three months later. In patients who developed apnea, laryngoscopy, Muller’s test, computer tomography (CT) and dynamic sleep magnetic resonance imaging (MRI) were performed to assess the location of airway stenosis and collapse. The AHI (P<0.001) increased and the lowest oxygen saturation (P<0.001), ESS score (P<0.001) and BMI (P=0.017) decreased after extubation compared with before surgery. Three months after extubation, the same changes were found in AHI (P<0.001) and the lowest oxygen saturation (P<0.001), but the ESS score (P<0.001) increased compared with that preoperatively. The AHI in the SCPL group was significantly higher than that in the VPL group post-operatively (P=0.010), while the miniSpO2 in the SCPL group was lower than that of the VPL group (P=0.022). Laryngoscopy showed that the patients with partial excision of the larynx had a narrowed retropalatal and retrolingual space post-operatively. Muller's test showed the collapse of the retropalatal and retrolingual space, and the CT scan showed that the tongue root was positioned lower in the SCPL group. Compared with the retropalatal and retrolingual space in the expiratory phase according to dynamic sleep MRI, the space in the inspiratory phase was clearly decreased. Laryngeal function preservation surgery for laryngeal cancer results in the occurrence of OSA by altering the anatomical structure of the larynx and pharynx. OSA was more severe in patients undergoing SCPL than in patients undergoing VPL. The effect of partial laryngectomy on OSA may be related to the surgical method used.
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- 2019
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12. Quantitative determination of vanilloid activation in TRPV1
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Li, Shisheng, Nguyen, Phuong T., Vu, Simon, Yarov-Yarovoy, Vladimir, and Zheng, Jie
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- 2024
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13. How Much Does TRPV1 Deviate from An Ideal MWC-Type Protein
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Li, Shisheng and Zheng, Jie
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Many ion channels are known to behave as an allosteric protein, coupling environmental stimuli captured by specialized sensing domains to the opening of a central pore. The classic Monod-Wyman-Changeux (MWC) model, originally proposed to describe binding of gas molecules to hemoglobin, has been widely used as a framework for analyzing ion channel gating. Here we address the issue of how accurate the MWC model predicts activation of the capsaicin receptor TRPV1 by vanilloids. Taking advantage of a concatemeric design that makes it possible to lock TRPV1 in states with zero-to-four bound vanilloid molecules, we showed quantitatively that the overall gating behavior is satisfactorily predicted by the MWC model. There is however a small yet detectable subunit position effect: ligand binding to two kitty-corner subunits is 0.3-to-0.4 kcal/mol more effective in inducing opening than binding to two neighbor subunits. This difference—less than 10% of the overall energetic contribution from ligand binding—might be due to the restriction on subunit arrangement imposed by the planar membrane; if this is the case, the position effect is not expected in hemoglobin, in which each subunit is related equivalently to all the other subunits.
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- 2024
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14. Iodine-assisted ultrafast growth of high-quality monolayer MoS2with sulfur-terminated edges
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Wu, Qinke, Zhang, Jialiang, Tang, Lei, Khan, Usman, Nong, Huiyu, Zhao, Shilong, Sun, Yujie, Zheng, Rongxu, Zhang, Rongjie, Wang, Jingwei, Tan, Junyang, Yu, Qiangmin, He, Liqiong, Li, Shisheng, Zou, Xiaolong, Cheng, Hui-Ming, Liu, Bilu, Wu, Qinke, Zhang, Jialiang, Tang, Lei, Khan, Usman, Nong, Huiyu, Zhao, Shilong, Sun, Yujie, Zheng, Rongxu, Zhang, Rongjie, Wang, Jingwei, Tan, Junyang, Yu, Qiangmin, He, Liqiong, Li, Shisheng, Zou, Xiaolong, Cheng, Hui-Ming, and Liu, Bilu
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Two-dimensional (2D) semiconductors have attracted great attention to extend Moore’s law, which motivates the quest for fast growth of high-quality materials. However, taking MoS2as an example, current methods yield 2D MoS2with a low growth rate and poor quality with vacancy concentrations three to five orders of magnitude higher than silicon and other commercial semiconductors. Here, we develop a strategy of using an intermediate product of iodine as a transport agent to carry metal precursors efficiently for ultrafast growth of high-quality MoS2. The grown MoS2has the lowest density of sulfur vacancies (~1.41×1012cm−2) reported so far and excellent electrical properties with high on/off current ratios of 108and carrier mobility of 175 cm2V−1s−1. Theoretical calculations show that by incorporating iodine, the nucleation barrier of MoS2growth with sulfur-terminated edges reduces dramatically. The sufficient supply of precursor and low nucleation energy together boost the ultrafast growth of sub-millimeter MoS2domains within seconds. This work provides an effective method for the ultrafast growth of 2D semiconductors with high quality, which will promote their applications.
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- 2023
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15. Tunable Chemical Coupling in Two-Dimensional van der Waals Electrostatic Heterostructures
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Taniguchi, Takaaki, Li, Shisheng, Nurdiwijayanto, Leanddas, Kobayashi, Yu, Saito, Tetsuki, Miyata, Yasumitsu, Obata, Seiji, Saiki, Koichiro, Yokoi, Hiroyuki, Watanabe, Kenji, Taniguchi, Takashi, Tsukagoshi, Kazuhito, Ebina, Yasuo, Sasaki, Takayoshi, and Osada, Minoru
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Heterostructures of two-dimensional (2D) atomic crystals provide fascinating molecular-scale design elements for emergent physical phenomena and functional materials, as integrating distinct monolayers into vertical heterostructures can afford coupling between disparate properties. However, the available examples have been limited to either van der Waals (vdW) or electrostatic (ES) heterostructures that are solely composed of noncharged and charged monolayers, respectively. Here, we propose a “vdW–ES heterostructure” chemical design in which charge-neutral and charged monolayer-building blocks with highly disparate chemical and physical properties are conjugated vertically through asymmetrically charged interfaces. We demonstrate vdW–ES heteroassembly of semiconducting MoS2and dielectric Ca2Nb3O10–(CNO) monolayers using an amphipathic molecular starch, resulting in the emergence of trion luminescence observed at the lowest energy among MoS2-related materials, probably due to interfacial confinement effects given by vdW–ES dual interactions. In addition, interface engineering leads to tailored exciton of the vdW/ES heterostructures owing to the pronounced dielectric proximity effects, bringing an intriguing interlayer chemistry to modify 2D materials. Furthermore, the current approach was successfully extended to create a graphene/CNO heterostructure, which verifies the versatility of the preparative method.
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- 2019
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16. Defect Heterogeneity in Monolayer WS2Unveiled by Work Function Variance
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Wang, Xinyun, Dan, Jiadong, Hu, Zhenliang, Leong, Jin Feng, Zhang, Qi, Qin, Ziyu, Li, Shisheng, Lu, Junpeng, Pennycook, Stephen J., Sun, Wanxin, and Sow, Chorng Haur
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Defects are commonly found in two-dimensional (2D) transition-metal dichalcogenide (TMD) materials. Such defects usually dictate the optical and electrical properties of TMDs. It is thus important to develop techniques to characterize the defects directly with good spatial resolution, specificity, and throughput. Herein, we demonstrate that Kelvin probe force microscopy (KPFM) is a versatile technique for this task. It is able to unveil defect heterogeneity of 2D materials with a spatial resolution of 10 nm and energy sensitivity better than 10 meV. KPFM mappings of monolayer WS2exhibit interesting work function variances that are associated with defects distribution. This finding is verified by aberration-corrected scanning transmission electron microscopy and density functional theory calculations. In particular, a strong correlation among the work function, electrical and optical responses to the defects is revealed. Our findings demonstrate the potential of KPFM as an effective tool for exploring the intrinsic defects in TMDs.
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- 2019
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17. Pestle needling at Yāoyángguān-Bāzhènpoints for intractable lumbodynia after lumbar disc herniation surgery: A randomized controlled trial
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ZHANG, Junfeng, WU, Yaochi, LI, Shisheng, and SUN, Yijun
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To observe the differences of clinical efficacy of intractable lumbodynia after lumbar disc herniation surgery treated by pestle needling at Yāoyángguān Bāzhènpoints, electroacupuncture and western medication.
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- 2019
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18. Shape-Engineered Synthesis of Atomically Thin 1T-SnS2Catalyzed by Potassium Halides
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Shao, Gonglei, Xue, Xiong-Xiong, Zhou, Xionglin, Xu, Jie, Jin, Yuanyuan, Qi, Shuyan, Liu, Nan, Duan, Huigao, Wang, Shanshan, Li, Shisheng, Ouzounian, Miray, Hu, Travis Shihao, Luo, Jun, Liu, Song, and Feng, Yexin
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Shape engineering plays a crucial role in the application of two-dimensional (2D) layered metal dichalcogenide (LMD) crystalline materials in terms of physical and chemical property modulation. However, controllable growth of 1T phase tin disulfide (SnS2) with multifarious morphologies has rarely been reported and remains challenging. Herein, we report a direct synthesis of large-size, uniform, and atomically thin 1T-SnS2with multiple morphologies by adding potassium halides viaa facile chemical vapor deposition process. A variety of morphologies, i.e., from hexagon, triangle, windmill, and dendritic to coralloid, corresponding to fractal dimensions from 1.01 to 1.81 are accurately controlled by growth conditions. Moreover, the Sn concentration controls the morphology change of SnS2. The edge length of the SnS2dendritic flake can grow larger than 500 μm in 5 min. Potassium halides can significantly reduce the surface migration barrier of the SnS2cluster and enhance the SnS2adhesion force with substrate to facilitate efficient high in-plane growth of monolayer SnS2compared to sodium halides by density functional theory calculations. More branched SnS2with higher fractal dimension provides more active sites for enhancing hydrogen evolution reactions. Importantly, we prove that potassium halides are preferable for 1T-phase LMDs structures, while sodium halides are more suitable for 2H-phase materials. The growth mechanism proposed here provides a general approach for controllable-phase synthesis of 2D LMD crystals and related heterostructures. Shape engineering of 2D materials also provides a strategy to tune LMD properties for demanding applications.
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- 2019
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19. Synthesis and Transport Properties of Degenerate P-Type Nb-Doped WS2Monolayers
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Jin, Yuanyuan, Zeng, Zanyang, Xu, Zhengwei, Lin, Yung-Chang, Bi, Kaixi, Shao, Gonglei, Hu, Travis Shihao, Wang, Shanshan, Li, Shisheng, Suenaga, Kazu, Duan, Huigao, Feng, Yexin, and Liu, Song
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Substitutional doping has been proven to be an effective route to engineer band gap, transport characteristics, and magnetism in transition metal dichalcogenides. Herein, we demonstrate substitutional doping of monolayer tungsten disulfide (WS2) with Nb via the chemical vapor deposition technique. Scanning transmission electron microscopy confirms that Nb successfully substituted the W atom in the WS2lattice. Moreover, photoluminescence indicates a significant red shift when different concentrations of Nb are introduced, in agreement with density functional theory calculations. Electrical measurements reveal the degenerate p-type semiconductor behavior of Nb-doped WS2field-effect transistors. The successful synthesis of p-type WS2in this study provides a promising method to expand the electronic and photonic engineering of two-dimensional materials.
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- 2019
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20. Vapour–liquid–solid growth of monolayer MoS2nanoribbons
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Li, Shisheng, Lin, Yung-Chang, Zhao, Wen, Wu, Jing, Wang, Zhuo, Hu, Zehua, Shen, Youde, Tang, Dai-Ming, Wang, Junyong, Zhang, Qi, Zhu, Hai, Chu, Leiqiang, Zhao, Weijie, Liu, Chang, Sun, Zhipei, Taniguchi, Takaaki, Osada, Minoru, Chen, Wei, Xu, Qing-Hua, Wee, Andrew, Suenaga, Kazu, Ding, Feng, and Eda, Goki
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Chemical vapour deposition of two-dimensional materials typically involves the conversion of vapour precursors to solid products in a vapour–solid–solid mode. Here, we report the vapour–liquid–solid growth of monolayer MoS2, yielding highly crystalline ribbons with a width of few tens to thousands of nanometres. This vapour–liquid–solid growth is triggered by the reaction between MoO3and NaCl, which results in the formation of molten Na–Mo–O droplets. These droplets mediate the growth of MoS2ribbons in the ‘crawling mode’ when saturated with sulfur. The locally well-defined orientations of the ribbons reveal the regular horizontal motion of the droplets during growth. Using atomic-resolution scanning transmission electron microscopy and second harmonic generation microscopy, we show that the ribbons are grown homoepitaxially on monolayer MoS2with predominantly 2H- or 3R-type stacking. Our findings highlight the prospects for the controlled growth of atomically thin nanostructure arrays for nanoelectronic devices and the development of unique mixed-dimensional structures. Monolayer MoS2can be laterally grown in the vapour–liquid–solid mode, forming highly crystalline nano- and microribbon structures.
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- 2018
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21. Effects of carbon nanotube content on morphology of SiCp(CNT) hybrid reinforcement and tensile mechanical properties of SiCp(CNT)/Al composites
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Li, Shisheng, Su, Yishi, Jin, Huiling, Huang, Yu, Ouyang, Qiubao, and Zhang, Di
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Abstract
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- 2017
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22. Energetics and structural determinations of TRPV1 activation by vanilloids
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Li, Shisheng, Nguyen, Phuong T., Yarov-Yarovoy, Vladimir, and Zheng, Jie
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- 2023
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23. Proteomics Profiling Reveals the Molecular Signatures and Potential Therapeutic Targets of Human Nasopharyngeal Carcinoma
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Fu, Ying, Liang, Xujun, Yang, Xinming, Liu, Jianping, Huang, Huichao, Zhang, Pengfei, Li, Shisheng, Zhu, Dandan, Zhang, Ye, Peng, Fang, Chen, Yongheng, and Chen, Zhuchu
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Nasopharyngeal carcinoma (NPC), a malignant tumor distinctly characterized by ethnic and geographic distribution, is highly prevalent in Southern China and Southeast Asia. However, the molecular mechanisms of NPC have not been fully revealed at the proteomic level. In this study, 30 primary NPC samples and 22 normal nasopharyngeal epithelial tissues were collected for proteomics analysis, and a relatively complete proteomics landscape of NPC was depicted for the first time. By combining differential expression analysis, differential co-expression analysis, and network analysis, potential biomarkers and therapeutic targets were identified. Some identified targets were verified by biological experiments. We found that 17-AAG, a specific inhibitor of the identified target, heat shock protein 90, could be a potential therapeutic drug for NPC. Finally, consensus clustering identified two NPC subtypes with specific molecular features. The subtypes and the related molecules were verified by an independent data set and may have different progression-free survival. The results of this study provide a comprehensive understanding of the molecular signatures of NPC and provide new perspectives and inspiration for prognostic determination and treatment of NPC.
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- 2023
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24. Occurrence and distribution of antibiotics and antibiotic resistance genes in water of Liaohe River Basin, China
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Gao, Hui, Zhao, Fuqiang, Li, Ruijing, Jin, Shuaichen, Zhang, Haibo, Zhang, Keyu, Li, Shisheng, Shu, Qin, and Na, Guangshui
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Surface water environment is an important repository of antibiotics and antibiotic resistance genes (ARGs). It is of great significance to study the occurrence and distribution of antibiotics and ARGs in surface water environment. In this study, the Liaohe River Basin, China was taken as the study area, and the concentrations of antibiotics and ARGs in water were investigated by HPLC-MS/MS and HT-qPCR. The results showed that a total of 53 antibiotics of 6 types were detected in water, and the pollution level was at ND~331.64 ng/L, where PCG was the highest. Totally 164 ARGs and 10 mobile genetic elements (MGEs) were detected in the water, and the absolute abundances were at 2.18 × 104~3.95 × 107copies/L and 1.82 × 105–3.78 × 107copies/L, respectively. The multidrug and aminoglycoside were the dominant ARG types. Amoxicillin, erythromycin, anhydroerythromycin and ofloxacin posed certain ecological risks for sensitive aquatic organisms. In spatial distribution, the pollution of antibiotics and ARGs in the Daliao River system was higher than that in the Liaohe River system. There was a significant positive correlation between total concentrations of antibiotics and total relative abundance of ARGs (r = 0.66, p < 0.05). The co-occurrence of multiple antibiotics promoted the pollution and spread of ARGs. In addition, the total relative abundance of MGEs and ARGs showed a significant positive correlation (r = 0.946, p < 0.01), and MGEs played an important role in the occurrence and evolution of ARGs in water.
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- 2022
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25. Enrichment of Semiconducting Single-Walled Carbon Nanotubes by Carbothermic Reaction for Use in All-Nanotube Field Effect Transistors
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Li, Shisheng, Liu, Chang, Hou, Peng-Xiang, Sun, Dong-Ming, and Cheng, Hui-Ming
- Abstract
Selective removal of metallic single-walled carbon nanotubes (SWCNTs) and consequent enrichment of semiconducting SWCNTs were achieved through an efficient carbothermic reaction with a NiO thin film at a relatively low temperature of 350 °C. All-SWCNT field effect transistors (FETs) were fabricated with the aid of a patterned NiO mask, in which the as-grown SWCNTs behaving as source/drain electrodes and the remaining semiconducting SWCNTs that survive in the carbothermic reaction as a channel material. The all-SWCNT FETs demonstrate improved current ON/OFF ratios of ∼103.
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- 2012
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26. Growth Velocity and Direct Length-Sorted Growth of Short Single-Walled Carbon Nanotubes by a Metal-Catalyst-Free Chemical Vapor Deposition Process
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Liu, Bilu, Ren, Wencai, Liu, Chang, Sun, Cheng-Hua, Gao, Libo, Li, Shisheng, Jiang, Chuanbin, and Cheng, Hui-Ming
- Abstract
We report on the observation of a very low growth velocity of single-walled carbon nanotubes (SWNTs) and consequently the direct length-sorted growth and patterned growth of SWNTs by using a metal-catalyst-free chemical vapor deposition (CVD) process proposed recently by our group, in which SiO2serves as catalyst. We found that the growth velocity of the SWNTs from SiO2catalyst is only 8.3 nm/s, which is about 300 times slower than that of the commonly used iron group catalysts (Co as a counterpart catalyst in this study). Such a slow growth velocity renders direct length-sorted growth of SWNTs, especially for short SWNTs with hundreds of nanometers in length. By simply adjusting the growth duration, SWNTs with average lengths of 149, 342, and 483 nm were selectively obtained and SWNTs as short as ∼20 nm in length can be grown directly. Moreover, comparative studies indicate that the SiO2catalyst possesses a much longer catalytic active time, showing sharp contrast with the commonly used Co catalyst which quickly loses its catalytic activity. Taking advantage of the very slow growth velocity of the SiO2catalyst, patterned growth of SWNT networks confined in a narrow region of <5 μm was also achieved. The short SWNTs may show intriguing physics owing to their finite length effect and are attractive for various practical applications.
- Published
- 2009
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27. Surface and Interference Coenhanced Raman Scattering of Graphene
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Gao, Libo, Ren, Wencai, Liu, Bilu, Saito, Riichiro, Wu, Zhong-Shuai, Li, Shisheng, Jiang, Chuanbin, Li, Feng, and Cheng, Hui-Ming
- Abstract
We propose a novel surface and interference coenhanced Raman scattering technique to dramatically enhance the Raman signal intensity of graphene by using a specifically designed substrate of Si capped with surface-active metal and oxide double layers (SMO). The total enhancement ratio can reach the order of 103compared with the original Si substrate. Combining the visibility of graphene on the SMO substrate, we demonstrate that the tiny structure change and surface structure of graphene can be easily detected. This technique makes Raman spectroscopy a more powerful tool in the field of ultrasensitive characterization of graphene, isolated carbon nanotubes, and other film-like materials.
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- 2009
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28. Distinct open states of TRPV1 induced by capsaicin and RTX
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Li, Shisheng, Vu, Simon, and Zheng, Jie
- Published
- 2022
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29. Optical Control of High-Harmonic Generation at the Atomic Thickness
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Wang, Yadong, Iyikanat, Fadil, Bai, Xueyin, Hu, Xuerong, Das, Susobhan, Dai, Yunyun, Zhang, Yi, Du, Luojun, Li, Shisheng, Lipsanen, Harri, García de Abajo, F. Javier, and Sun, Zhipei
- Abstract
High-harmonic generation (HHG), an extreme nonlinear optical phenomenon beyond the perturbation regime, is of great significance for various potential applications, such as high-energy ultrashort pulse generation with outstanding spatiotemporal coherence. However, efficient active control of HHG is still challenging due to the weak light–matter interaction displayed by currently known materials. Here, we demonstrate optically controlled HHG in monolayer semiconductors via the engineering of interband polarization. We find that HHG can be efficiently controlled in the excitonic spectral region with modulation depths up to 95% and ultrafast response speeds of several picoseconds. Quantitative time-domain theory of the nonlinear optical susceptibilities in monolayer semiconductors further corroborates these experimental observations. Our demonstration not only offers an in-depth understanding of HHG but also provides an effective approach toward active optical devices for strong-field physics and extreme nonlinear optics.
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- 2022
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30. Nucleosome structure and repair of N-methylpurines in the GAL1-10 genes of Saccharomyces cerevisiae.
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Li, Shisheng and Smerdon, Michael J
- Abstract
Nucleosome structure and repair of N-methylpurines were analyzed at nucleotide resolution in the divergent GAL1-10 genes of intact yeast cells, encompassing their common upstream-activating sequence. In glucose cultures where genes are repressed, nucleosomes with fixed positions exist in regions adjacent to the upstream-activating sequence, and the variability of nucleosome positioning sharply increases with increasing distance from this sequence. Galactose induction causes nucleosome disruption throughout the region analyzed, with those nucleosomes close to the upstream-activating sequence being most striking. In glucose cultures, a strong correlation between N-methylpurine repair and nucleosome positioning was seen in nucleosomes with fixed positions, where slow and fast repair occurred in nucleosome core and linker DNA, respectively. Galactose induction enhanced N-methylpurine repair in both strands of nucleosome core DNA, being most dramatic in the clearly disrupted, fixed nucleosomes. Furthermore, N-methylpurines are repaired primarily by the Mag1-initiated base excision repair pathway, and nucleotide excision repair contributes little to repair of these lesions. Finally, N-methylpurine repair is significantly affected by nearest-neighbor nucleotides, where fast and slow repair occurred in sites between pyrimidines and purines, respectively. These results indicate that nucleosome positioning and DNA sequence significantly modulate Mag1-initiated base excision repair in intact yeast cells.
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- 2002
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31. Low- and High-Resolution Mapping of DNA Damage at Specific Sites
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Li, Shisheng, Waters, Raymond, and Smerdon, Michael J.
- Abstract
Measurement of DNA damage and repair at the nucleotide level in intact cells has provided compelling evidence for the molecular details of these events as they occur in intact organisms. Furthermore, these measurements give the most accurate picture of the rates of repair in different structural domains of DNA in chromatin. In this report, we describe two methods currently used in our laboratories to map DNA lesions at (or near) nucleotide resolution in yeast cells. The low-resolution method couples damage-specific strand breaks in DNA with indirect end-labeling to measure DNA lesions over a span of 1.5 to 2 kb of DNA sequence. The resolution of this method is limited by the resolution of DNA length measurements on alkaline agarose gels (about ±20 bp on average). The high-resolution method uses streptavidin magnetic beads and special biotinylated oligonucleotides to facilitate end-labeling of DNA fragments specifically cleaved at damage sites. The latter method maps DNA damage sites at nucleotide resolution over a shorter distance (<500 bp), and is constrained to the length of DNA resolvable on DNA sequencing gels. These methods are used in tandem for answering questions regarding DNA damage and repair in different chromatin domains and states of gene expression.
- Published
- 2000
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32. High-Efficiency Stable DNA Transfection Using Cationic Detergent and Glycerol
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Li, Shisheng and Thacker, John
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We show that a brief exposure to a simple cationic detergent, in combination with a glycerol ‘shock’, can result in high frequencies of stable DNA transfection into mammalian cells. Using both Chinese hamster and human cell lines, frequencies of 1 per 1000, or even 1 per 100, viable cells can be achieved readily after optimizing the transfection conditions in a simple buffer. The mechanism of DNA transfer is proposed to differ from that for polycationic liposomes: as well as supplying a hydrophobic counterion, CDAB may promote a conformational change in DNA, allowing the DNA to be readily taken up after the glycerol shock to the cell.
- Published
- 1997
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33. Excision Repair at the Level of the Nucleotide in theSaccharomyces cerevisiae MFA2Gene: Mapping of Where Enhanced Repair in the Transcribed Strand Begins or Ends and Identification of only a Partial Rad16 Requisite for Repairing Upstream Control Sequences
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Teng, Yumin, Li, Shisheng, Waters, Raymond, and Reed, Simon H.
- Abstract
We wished to determine where transcription enhanced nucleotide excision repair begins and ends for aSaccharomyces cerevisiaegene transcribed by RNA polymerase II, and to examine the role of theRAD16gene in repairing upstream, non-transcribed control sequences of such a gene. To do so, we developed a method to study the repair of UV induced cyclobutane pyrimidine dimers (CPDs) at the level of the nucleotide in the control and coding sequences of theMFA2gene. This gene is active in haploid a mating type cells but inactive in α cells: its regulation is mediated by changes in chromatin structure. DNA from UV irradiated cells was cut with a CPD-specific endonuclease, restricted and selected strands of theMFA2gene separated from genomic DNA prior to end-labelling and resolution on a sequencing gel. We confirmed repair trends seen using Southern blotting to examine kilobase size fragments, but were additionally able to elucidate subtle differences in repairing portions of the transcribed strand (TS) ofMFA2. Enhanced repair of the TS when the gene is active, began well before the start of transcription. Clearly, enhanced repair in this region cannot be due to mRNA synthesis. The repair of CPDs is even further enhanced in the transcribed portion of the TS, and returns to a basal level after the termination of transcription. The approach also revealed thatRAD16has a role in the repair of the TS whenMFA2is active. Removal of CPDs from the TS control region was impaired but not totally defective in arad16a mutant. Repair from the TS coding sequence also has a Rad16 component, but a lesser one than for the upstream control sequences, and this was more marked for the sequences towards the end of the transcribed region. The system developed permits further dissection of the relationships between DNA repair, chromatin structure and transcription at theMFA2locus.
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- 1997
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34. Excision repair at the level of the nucleotide in the Saccharomyces cerevisiae MFA2 gene: mapping of where enhanced repair in the transcribed strand begins or ends and identification of only a partial rad16 requisite for repairing upstream control sequences11Edited by J. Karn
- Author
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Teng, Yumin, Li, Shisheng, Waters, Raymond, and Reed, Simon H.
- Abstract
We wished to determine where transcription enhanced nucleotide excision repair begins and ends for a Saccharomyces cerevisiae gene transcribed by RNA polymerase II, and to examine the role of the RAD16 gene in repairing upstream, non-transcribed control sequences of such a gene. To do so, we developed a method to study the repair of UV induced cyclobutane pyrimidine dimers (CPDs) at the level of the nucleotide in the control and coding sequences of the MFA2 gene. This gene is active in haploid a mating type cells but inactive in α cells: its regulation is mediated by changes in chromatin structure. DNA from UV irradiated cells was cut with a CPD-specific endonuclease, restricted and selected strands of the MFA2 gene separated from genomic DNA prior to end-labelling and resolution on a sequencing gel. We confirmed repair trends seen using Southern blotting to examine kilobase size fragments, but were additionally able to elucidate subtle differences in repairing portions of the transcribed strand (TS) of MFA2. Enhanced repair of the TS when the gene is active, began well before the start of transcription. Clearly, enhanced repair in this region cannot be due to mRNA synthesis. The repair of CPDs is even further enhanced in the transcribed portion of the TS, and returns to a basal level after the termination of transcription. The approach also revealed that RAD16 has a role in the repair of the TS when MFA2 is active. Removal of CPDs from the TS control region was impaired but not totally defective in a rad16 a mutant. Repair from the TS coding sequence also has a Rad16 component, but a lesser one than for the upstream control sequences, and this was more marked for the sequences towards the end of the transcribed region. The system developed permits further dissection of the relationships between DNA repair, chromatin structure and transcription at the MFA2 locus.
- Published
- 1997
- Full Text
- View/download PDF
35. Induction and repair of cyclobutane pyrimidine dimers in the Escherichia coli tRNA gene tyrT:Fis protein affects dimer induction in the control region and suppresses preferential repair in the coding region of the transcribed strand, except in a short region near the transcription start site11Edited by J. Karn
- Author
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Li, Shisheng and Waters, Raymond
- Abstract
We analysed induction and repair of UV induced pyrimidine dimers in the Escherichia coli tRNA gene tyrT. In wild-type (WT) log or stationary phase different patterns of induction occurred in the three Fis binding sites and the core promoter −35 sequence of the control region: this was absent in fis− cells. In stationary WT cells, slow, similar rates of repair occurred throughout the non-transcribed strand (NTS). Faster repair occurred in the NTS control region in WT log phase. NTS repair in fis− cells was similar, except the control region differed less between phases. Heterogeneous repair occurred along the transcribed strand (TS). In the control region repair was faster than in the NTS. Repair in the TS coding region changed between growth phases or if repair took place in different media. When irradiated log phase WT cells were in rich medium, two TS domains were evident: a fast-repaired domain within 31 nucleotides from the transcription start site; and a more slowly repaired domain composed of the rest of the TS. A sharp gradient existed in the small domain with very fast repair at the beginning and diminished repair towards the end. Fast transcription coupled repair (TCR) in the small domain was absent in the TS large domain, where repair was similar to the NTS and to the entire TS in mfd− cells. In similarly treated stationary phase WT cells, TCR occurred in the large domain. Depletion of Fis reinstates TCR to a lesser extent, whilst a substitution of five nucleotides at the Fis binding sites in the upstream activating sequence reinstates TCR. Reinstatement of TCR was also achieved by incubating irradiated WT cells in minimal salt medium without the required amino acid. Our results suggest that Fis indirectly suppresses preferential repair in the TS large domain by stimulating transcription.
- Published
- 1997
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36. Broadband Plasmon-Enhanced Four-Wave Mixing in Monolayer MoS2
- Author
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Dai, Yunyun, Wang, Yadong, Das, Susobhan, Li, Shisheng, Xue, Hui, Mohsen, Ahmadi, and Sun, Zhipei
- Abstract
Two-dimensional transition-metal dichalcogenide monolayers have remarkably large optical nonlinearity. However, the nonlinear optical conversion efficiency in monolayer transition-metal dichalcogenides is typically low due to small light–matter interaction length at the atomic thickness, which significantly obstructs their applications. Here, for the first time, we report broadband (up to ∼150 nm) enhancement of optical nonlinearity in monolayer MoS2with plasmonic structures. Substantial enhancement of four-wave mixing is demonstrated with the enhancement factor up to three orders of magnitude for broadband frequency conversion, covering the major visible spectral region. The equivalent third-order nonlinearity of the hybrid MoS2-plasmonic structure is in the order of 10–17m2/V2, far superior (∼10–100-times larger) to the widely used conventional bulk materials (e.g., LiNbO3, BBO) and nanomaterials (e.g., gold nanofilms). Such a considerable and broadband enhancement arises from the strongly confined electric field in the plasmonic structure, promising for numerous nonlinear photonic applications of two-dimensional materials.
- Published
- 2021
- Full Text
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37. Publisher Correction: Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability
- Author
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Geijer, Marit E., Zhou, Di, Selvam, Kathiresan, Steurer, Barbara, Mukherjee, Chirantani, Evers, Bastiaan, Cugusi, Simona, van Toorn, Marvin, van der Woude, Melanie, Janssens, Roel C., Kok, Yannick P., Gong, Wenzhi, Raams, Anja, Lo, Calvin S. Y., Lebbink, Joyce H. G., Geverts, Bart, Plummer, Dalton A., Bezstarosti, Karel, Theil, Arjan F., Mitter, Richard, Houtsmuller, Adriaan B., Vermeulen, Wim, Demmers, Jeroen A. A., Li, Shisheng, van Vugt, Marcel A. T. M., Lans, Hannes, Bernards, René, Svejstrup, Jesper Q., Ray Chaudhuri, Arnab, Wyrick, John J., and Marteijn, Jurgen A.
- Published
- 2021
- Full Text
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38. O XIV A.1 DNA damage and repair at the level of the nucleotide: A novel approach and a model system
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Waters, Raymond, Li, Shisheng, Meniel, Valerie, Scott, Andrew, and Teng, Yumin
- Published
- 1997
- Full Text
- View/download PDF
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