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A 53-year-old woman presented with 10-year history of pain and limited range of motion in both shoulders. Radiographs of both shoulders showed severe shoulder osteoarthritis with glenoid bone defect. Very thin rotator cuff and superior migration of the humerus were also observed on computed tomography images. We performed bony increased-offset reverse total shoulder arthroplasty on her both shoulders. The patient had a good clinical outcome without any particular complication.

Gastrodia elata(GE) is traditionally used for treatment of various disorders including neurodegenerative diseases such as Alzheimer’s disease. To investigate the neuroprotective effect of GE, amyloid-β peptide (Aβ)-treated PC12 cells were cultured with GE aqueous extract. In vitroassay demonstrated that 50 µM of pre-aggregated Aβ was lethal to about a half portion of PC12 cells and that Aβ aggregate-induced cell death was significantly decreased with GE treatment at ≤10 mg/mL in a dose-dependent manner. To further examine in vivocognitive-improving effects, an artificial amnesic animal model, scopolamineinjected Sprague-Dawley rats, were orally administered the extract for 6 weeks followed by behavioral tests (the passive avoidance test and Morris water maze test). The results showed that an acute treatment with scopolamine (1 mg/kg of body weight) effectively induced memory impairment in normal rats and that the learning and memory capability of scopolamine-treated rats improved after prolonged administration of GE extract (50, 250 and 500 mg/kg of body weight for 6 weeks). These findings suggest that a GE regimen may potentially ameliorate learning and memory deficits and/or cognitive impairments caused by neuronal cell death.

2020 DEC 5 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Oncology - Liver Cancer. According to news [...]

2020 JUL 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Oncology - Colon Cancer are discussed in a new [...]