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Prolonged oral administration of Gastrodia elataextract improves spatial learning and memory of scopolamine-treated rats
- Source :
- Laboratory Animal Research; April 2015, Vol. 31 Issue: 2 p69-77, 9p
- Publication Year :
- 2015
-
Abstract
- Gastrodia elata(GE) is traditionally used for treatment of various disorders including neurodegenerative diseases such as Alzheimer’s disease. To investigate the neuroprotective effect of GE, amyloid-β peptide (Aβ)-treated PC12 cells were cultured with GE aqueous extract. In vitroassay demonstrated that 50 µM of pre-aggregated Aβ was lethal to about a half portion of PC12 cells and that Aβ aggregate-induced cell death was significantly decreased with GE treatment at ≤10 mg/mL in a dose-dependent manner. To further examine in vivocognitive-improving effects, an artificial amnesic animal model, scopolamineinjected Sprague-Dawley rats, were orally administered the extract for 6 weeks followed by behavioral tests (the passive avoidance test and Morris water maze test). The results showed that an acute treatment with scopolamine (1 mg/kg of body weight) effectively induced memory impairment in normal rats and that the learning and memory capability of scopolamine-treated rats improved after prolonged administration of GE extract (50, 250 and 500 mg/kg of body weight for 6 weeks). These findings suggest that a GE regimen may potentially ameliorate learning and memory deficits and/or cognitive impairments caused by neuronal cell death.
Details
- Language :
- English
- ISSN :
- 17386055 and 22337660
- Volume :
- 31
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Laboratory Animal Research
- Publication Type :
- Periodical
- Accession number :
- ejs51368929
- Full Text :
- https://doi.org/10.5625/lar.2015.31.2.69