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The merger of Wasoko and MaxAB demonstrates lessons all businesses can learn from as they seek to grow their scale and influence in a global marketplace. African consumers continue to [...]

Objective. Total knee replacement (TKR) is a common solution for patients with advanced knee osteoarthritis (OA). Still, fall rates remain relatively high after surgery. TKR may alter pain and knee function, balance control, and proprioception. However, given the role of complex (dual-task) walking in fall prediction for older adults, it is unknown how TKR alters the attentional demand of walking in older adults. The goal of this study was to examine the effect of TKR on dual-task walking among older adults. Methods. Participants were evaluated 1 month before surgery and 4.5 months after surgery. Participants walked along an instrumented 7-meter path for 1 minute with and without a cognitive task (serial-3 subtraction). Pain and knee function, knee proprioception, dynamic balance, and balance confidence, as well as dual-task costs (DTC) were compared before and after the surgery and factors associated with change in gait DTCs were assessed. Results. Thirty-eight participants completed the study (age 72.6 years, SD = 4.9; 11 men). A significant decrease in pain was found following TKR, with no change in balance, balance confidence, or proprioception. There were no differences in gait DTCs before and after the surgery. However, change in dynamic balance, specifically reactive postural control and dynamic gait, predicted changes in gait speed and stride time DTCs. Conclusion. The absence of an effect of TKR on gait DTCs can potentially underlie increased fall risk after TKR. Results from this study emphasize the significance of balance as a measure and focal point for rehabilitation after TKR. Impact. This study contributes to our understanding of the attentional cost of walking in people before and after TKR, as well as to factors associated with it. Results from this work can assist formulation of rehabilitation programs for people with knee OA. Keywords: Balance, Dual-Task Cost, Gait Speed, Pain, Proprioception, Introduction Knee osteoarthritis (OA) is one of the most common causes of disability among the elderly, with 13% of women and 10% of men over the age of 60 experiencing [...]

Purpose: This study examines the influence of social norms on tax morale among individual taxpayers in Malaysia by applying the multidimensional model of the theory of Social Norms. Design/methodology/approach: The study develops the research instrument by including hypothetical tax scenarios with specific items. Using the purposive sampling method, the online and paper surveys were distributed across all states in Malaysia, resulting in 319 usable responses from salaried individual taxpayers. The partial least square-structural equation modelling (PLS-SEM) tool was used to analyse the data collected. Findings: The results show that social norms positively influence tax morale. The findings provide evidence to support the hypothesis related to personal, descriptive, injunctive, and subjective norms. Social norms are powerful determinants of tax morale that increase social awareness and influence social interactions and dynamics for taxpayers in making compliance decisions. Research limitations/implications: The scope of the study is exclusively focused on non-economic intervening variables; thus, only a social perspective is adapted to explain the reasons why people pay taxes. Practical implications: The study expects to benefit many stakeholders, including researchers, policymakers, practitioners, and the taxpayers' community, by enhancing tax morale through a multifaceted approach. Governments can create a more efficient, fair, and resilient tax system by understanding and fostering tax morale. Originality/value: The study extends the literature on social norms in the context of tax morale, while prior literature only examined the relationships between social norms and tax compliance. Furthermore, this study empirically tested the valid and reliable social norms dimensions, thus modelling the direct role that examined their impact on tax morale. This study evaluates social norms as a higher-order construct reflected by its multidimensionality. Hence, this study enriches the limited literature on social norms and tax morale and demonstrates that each dimension of social norms is interrelated. Keywords: Social Norms, Personal Norms, Descriptive Norms, Tax Morale, Social Psychology, Introduction Tax morale is a dynamic and multifaceted concept which has garnered worldwide attention over the past decade. It has been widely studied and differently defined by many scholars as [...]

Background: Parental involvement can assist health professionals in providin successful pain care for children. Effective interaction between parents and healt professionals reduces the severity and impact of the child's pain. Aim: To inductively generate a model of mother capacity for pain care (MCfPC) i a Saudi Arabian health care setting, where capacity is defined as mother influ ences and abilities in participatory childcare. Methods: The researcher used a qualitative case study design, with semi-struc tured interview and observation methods, and analysis of hospital documentatio of policy and procedure. Data were collected over three months, betwee September 10 and December 10, 2016, from mother (n = 20) and nurse (n = 2' participants. The study took place in a pediatric surgical ward at King Abdulazi University Hospital, a Saudi Arabian surgical health care center. A thematic analy sis was incorporated to analyze the data. Findings: A model was generated showing three central themes and three sub themes impacting the MCfPC. The core themes included the hospital environ ment, the institutional organization, and socio-cultural conditions, with sub themes of comfort, communication, and support, respectively. Conclusion: The hierarchical model determining MCfPC shows optimal healt care practices to improve pain care. Keywords: Pediatric, child health care, mother participation, family-centere care, capacity for care., Parental involvement in the care of hospitalized children is necessary for optimizing pain care (Melo et al., 2014; Twycross & Finley, 2013). Many studies have identified the significance of parental [...]

Over the past decade, enormous collaborative efforts have completed prospective, randomized, multimodality, locally advanced rectal cancer (LARC) trials with long-term oncologic follow-up. (1-3) Long-term overall survival and disease-free survival across [...]

Purpose: This study seeks to empirically explore the donors' intention to donate (infaq and sadaqah), focusing on how the internal and external factors can support ideas about donors' propensity to make financial contributions. This study examined whether internal factors, which are attitude and belief and also external factors, trust in charities and charity project, influence people's general attitude towards donation and their intention to donate. Design/methodology/approach: A non-experimental study survey technique was implemented. Descriptive and inferential analyses were carried out using a multiple linear regression model (MLR). Findings: The results show that attitudes, trust, belief and charity project predict the intention to donate. Research limitations/implications: This study is subject to size limitation.The finding may not encompass the most recent development in the field of charity project in Malaysia. Further research is needed to explore the variety background of donors and to identify additional factors influencing the intention to donate to make financial contribution Practical implications: Gaining a better understanding of donors and their motivations can help organizations to make informed decisions. Originality/value: This study contribute to the existing literature by highlighting the significance of charity project in Malaysia and addressing the internal and external factors influencing donors to make financial contribution. Keywords: sadaqah, infaq, intention to donate, philanthropy, corporate social responsibility (csr), Introduction Islam provides us with more than just a way to cleanse ourselves of our flaws. Giving assistance to those in need, either material or moral support is an example [...]

Au Canada, 10,3 % de la population s'adonne au tabagisme (1). Chaque annee, 8 millions de deces dans le monde sont attribues au tabac (2). A l'heure actuelle, 3 pharmacotherapies [...]

Purpose: This study aims to investigate members' perceptions and expectations of the Mutual Benevolent Death Fund (MBDF) managed by Malaysian Mosque Committees. Design/methodology/approach: Employing a qualitative research method, the study employs various techniques including interviews, content analysis, and small-group discussions to explore beliefs, attitudes, and concepts of normative behavior related to the fund. Purposive sampling is utilized to collect data from participants with specific characteristics, and semi-structured interviews are conducted to examine the aspects of their perceptions and expectations. The study follows a four-phase interview protocol framework, ensuring alignment with research questions, constructing an inquiry-based conversation, receiving feedback, and piloting the refined protocol. Data analysis is conducted using Atlas ti software, employing techniques such as coding, smart codes, smart groups, and word cruncher to organize and interpret textual and verbal data. Thematic analysis is applied to explore participants' experiences, meanings, and realities, shedding light on current management practices of the Mutual Benevolent Death Fund and contributors' expectations from mosque committees. Findings: The results indicate that the majority of members prefer a young and educated leader to manage the fund, primarily due to innovative and creative ideas. The fund committee also needs to clearly understand its role, whether it is solely for providing financial support in case of death or for managing funds in various areas, considering that different preferences exist in different regions. Research limitations/implications: Limited sample size. Future research might expand to other places including Sabah, Sarawak and Asean countries. Practical implications: The research can be made as a guidance for Mutual Benevolent Death Fund committee to replicate the best conduct for the future. Keywords: Mutual Benevolent Death Fund, Malaysian Mosque Committees, Qualitative research, Member preferences, Introduction In the diverse landscape of financial instruments designed to support and empower communities, Mutual Benevolent Death Funds (MBDFs) have emerged as a distinctive approach to provide financial security and [...]

Purpose: This study intends to gauge the different practices and management governing the mutual benevolent Khairat death fund in Malaysia. Design/methodology/approach: A series of interviews were conducted with the representatives from the State Islamic Religious Council (SIRC) and the Mutual Benevolent Death Fund committees in the rural areas of three different states. This qualitative study employed thematic analysis to analyze the different practices and management of this death fund. Findings: Results show there are three different forms of governance practices of this Khairat death fund namely: (i) management and governance under a committee registered under the Register of Society (ROS); (ii) management and governance under a mosque committee registered under ROS; and (iii) administration exclusively under a mosque committee Research limitations/implications: Findings from this research are applicable to the sampled rural areas only. Practical implications: This study suggests that all relevant players, such as the ROS, Khairat Society, mosque management, and SIRC should actively contribute to addressing the issue to safeguard the rights and interests of Khairat members and ensure the long-term viability and sustainability of the fund. Originality/value: Provide empirical evidence the presence of separate governance frameworks for the management and supervision of the Khairat death fund. Keywords: mutual benevolence, Khairat death fund, governance., Introduction Khairat Death Fund and Welfare Institution is an organization that is synonymous with the Islamic community in Malaysia, especially among the Malays who live in villages and rural areas. [...]

Purpose: To explore regulations and governance matters related to Malaysian mosques in managing the social death fund (khairat). Design/methodology/approach: This study employed a qualitative research method. Data was collected via semi-structured interviews with respondents from selected State Islamic Religious Councils (SIRC) and State Mosque Management Departments (SMMD). Respondents were chosen based on a purposive sampling. The transcribed interviews were organized, coded, and analyzed by ATLAS.ti 23. Findings: SIRC representatives stated the mosque committees were accountable to at least three parties: SIRCs, SMMDs, and the audit unit. Under the State Islamic Religion Administration Enactment, the council is the sole trustee of all registered mosques and musollas (surau) in Malaysia. Depending on the state, examples of the relevant source of regulations are the Mosque and Surau Regulations 2017, Section 104, Section 96, and Article 43 (1). However, these rules only pertain to the functions, rights, and responsibilities of the mosque committees, collection of general khairat, and management of the cemeteries. The mosque committees that manage the khairat are not subjected to any direct regulations by the Islamic authorities. Instead, the regulations and governance matters are being imposed indirectly via the enactment, rules, and policy issues for the mosques. The most important element in existing practice to govern the management of khairat is trust and obligation to serve the community for the sake of Allah. The officials from the SIRCs prefer the social death fund (khairat) to be managed by the mosque committees rather than by separate entities. Research limitations/implications: The source of regulations discussed in this paper only applies to the selected states only. Practical implications: The research findings provide empirical evidence for the SIRC to craft new policies that cover social death fund (khairat) in the future. Originality/value: The study findings were based on primary data from state Islamic authorities and the mosque committees entrusted to administer social death fund (khairat) in rural areas. Keywords: accountability, governance, mosque committee, social death fund (khairat), regulation, Introduction Since the establishment of the first Muslim association, al-ikhwan al-masakin in 1926, to specifically manage social death fund (khairat) for the Muslim community in Malay land, many Malaysian mosques [...]

Purpose: To explore the pros and cons of managing social or khairat death funds by the mosque committees versus by the registered societies. Design/methodology/approach: This study is qualitative, and data was obtained through discussions and interviews with representatives from the relevant authorities and the mosque committees. A thematic analysis was used to analyze the data whereas ATLAS ti 23 was utilized to code and analyze the data. Findings: The State Islamic Religious Councils (SIRC) prefer the mosque committees to manage the social death funds. Their arguments revolve around easy-to-monitor, stronger accountability, proper and sufficient resources, and ongoing concern matters. Nevertheless, independent societies are perceived to have better procedures and bigger pools of human resources to manage social death funds. Research limitations/implications: Findings from this research are applicable to the sampled rural areas only. Practical implications: This study suggests that the SIRC plays a central role in overseeing the social death funds in rural areas, particularly, those managed by the mosque committees. Nevertheless, community societies are also important as they offer alternative social death funds to rural communities in Malaysia. These societies commonly co-operate with the mosque committees due to all funeral sites are administered by the mosque committees and mosques are equipped with proper equipment and resources for a funeral. Originality/value: Provide empirical evidence for the merits of having social khairat death funds or managed by the mosque committees over local societies. Keywords: death funds, funeral costs, societies, management, mosque committees, Introduction A social death fund is essential in today's world. Inflation causes the cost of products and services to increase over time, including costs related to funerals (Muhamed et al., [...]

Purpose: The purpose of this paper is to study and review the current practice of waqf governance and accountability in Malaysia's State Islamic Religious Council (SIRC) in general. Waqf is becoming an increasingly important transaction practiced in most Muslim countries, and it provides benefits to the Muslim community in a variety of domains such as religion, education, medicine, and socioeconomic activities. The benefit of waqf is its long-term viability. Waqf is explored worldwide and it has become a SIRC stream discipline embedded in most organizations. The rapid development of waqf demands a good governance system to ensure the sustainability of waqf assets and benefits. However, it was found that waqf did not successfully meet the needs of the community as it should have because of issues such as mismanagement, non-uniformity in its practices, and lack of awareness by the Muslim community. The status of waqf has deteriorated to the extent that in some countries waqf assets have been neglected. In Malaysia, waqf management is under the jurisdiction of the state government and is entrusted to the SIRC. This has effects on the non-uniformity of laws and governance systems. Design/Methodology/Approach: Based on waqf practices, this study combines a qualitative research technique with an exploratory research design with content analysis and library research. It is appropriate because it entails the examination of documents, including the relevant books and empirical articles Findings: The findings from this study summarize the governance principles of both the public sector and the COSO 2013 standards are in line with Shariah governance, but the advantage of Shariah governance is dual accountability, which involves accountability to God and fellow human beings. This means that these governance systems and principles are complementary. Originality/value: In this contribution, we propose the improvement of the governance and accountability system. These improvements are important in assisting SIRC, as the sole trustee, in properly managing waqf. Indeed, the establishment of good and systematic governance is a paradigm shift that can assist in ensuring waqf assets and funds are managed and grown in a systematic manner, thus further ensuring their sustainability. Keywords: Waqf, Governance, Accountability, State Islamic Religious Council., Introduction Waqf has recently grown fast, and several types of waqf have emerged. Waqf was once limited to cemeteries, places of worship, educational institutions, and immovable property and buildings. However, [...]

Purpose: Understanding the factors that contribute to students' failure is crucial to sustaining the mental health of educators. When educators can identify these factors, they can create a more supportive learning environment and reduce stress and frustration for them and their students. This study investigates the failure factors among students in Introduction to Statistics subject. Design/methodology/approach: 200 students were involved in this study and the collected data was analyzed using SPSS. Multiple linear regression is used to analyze the failure factors such as test score, absentee, gender, and repetition. Findings: Based on the findings, early warning signs can be determined by educators for struggling students, based on their attendance and test score. Gender and repetition are not important in predicting academic performance. Screening test on mathematics literacy and topic by topic understanding should be done prior to official test, so that weak students can be determined and supported. Research limitations/implications: Better relationships can be developed by having effective communication on students' needs and expectations. By understanding the factors contributing to students' failure and proactively addressing them, educators can create a more inclusive and supportive learning environment. Practical implications: This, in turn, can contribute to better mental health outcomes for both educators and students. Originality/value: To be completed Keywords: Academic performance, performance predictor, educator, failure, mathematics literacy, Introduction The mental health of educators is important as they shape the minds of the students and contribute significantly to their development and learning. However, the pressures of dealing with [...]

Purpose: This study examine, from an Islamic standpoint, the problems and difficulties that single mother encounter with regard to their mental health. First among the study's goals is figuring out what influences single mothers mental health. Second, consider the detrimental effects that mental health issues have on children and single mothers. The third goal is to provide Islamically based solutions for the mental health issues faced by single mothers. Design/methodology/approach: Semi-structured interviews have been used to gather information from single mothers and professional opinions in a particular field. Survey respondents distributed multiple semi-structured questionnaires and conducted interviews with community members using a straightforward sampling technique. Ten Melaka single mothers were interviewed. The director of the Social Welfare Department, the Director of the Office of Women's Development, and a syarie lawyer also being interviewed. In addition primary and secondary data in the form of documents, correspondence, official archives, and surveys where gathered from related departments. Findings: The study's findings revealed that the single mother had to deal with a number of difficulties, such as financial stress, lack of social support, career-family conflict, low quality of life and daily routine disruptions brought on by the COVID-19 pandemic. There are five mental health consequences for single moms: depression, anxiety, stress, low self-esteem and social isolation. From an Islamic perspective, this study revealed multiple solutions to address the mental health issues faced by single mother and improve their mental well-being. Research limitations/implications: This study comprises limited number of respondent in the analysis. Practical implications: The Islamic strategies that being suggested would enable single mother to achieve healthy mental wellbeing. Originality/value: This study covering strategies to enhance mental well being of single mother from Islamic perspective. Keywords: mental well-being, single mother, preliminary review, issues and challenges, Islam, Introduction Single mothers are a group of women who face various challenges and pressures in their lives, especially in economic, social, and emotional terms. They have to take on the [...]

The line of demarcation drawn between active and passive verbs resides in the direction of the action. The passive voice in standard Arabic can be used when the agent of the sentence is not expressed. The active Arabic sentences are passivized by skipping the agent of the sentence, but without changing the word order. The paper investigates the misuse and abuse of passive voice in Jordanian newspapers. Four cases of Arabic Passive violation spotted in Jordanian written media are analyzed. Three major official newspapers issued in Jordan are chosen for this purpose: Alqhad, Addustoor, and Alrai. It also focuses on violating the Arabic passive rules. Index Terms--Arabic passive form, Arabic passive violation, written media, I. INTRODUCTION Arabic passive voice is used in written and spoken forms when the subject of the sentence is unknown or unnecessary to be used or when it is very [...]

The current study investigated the integration of the Form-Focused Instruction and Discovery Approach termed Form Focused Discovery Approach (FFDA) for developing English Foreign language university students' writing skills through teaching novel. The study aims to shift from the teacher-centered approach to the student-centered one by discovering the literary text's form and meaning. Therefore, sixty female fourth-year students at King Khalid University in Saudi Arabia were randomly chosen and divided into two groups: an experimental and a control one taught for two months. The experimental group received instructions through the Form-Focused Discovery Approach (FFDA), examining various tasks ranging from exploring, anticipating, questioning, discussing, analyzing, reconstructing, and practicing writing and reflection. In contrast, the control group received instruction through the traditional mode. A pre-post writing test for measuring skills of grammar, word choice, mechanics, organization, coherence, and style was administered. Results showed that the experimental group outperformed the control group in overall writing skills. However, for each skill, it is revealed that four primary skills have been significantly enhanced (i.e., grammar, organization, word choice, and mechanics). The other two skills (style and coherence) have been slightly improved but with no significant differences in the post-administration of the experimental group scores. More practice should be given to recognizing the text's unity and style when implementing FFDA to enhance EFL writing skills. Index Terms--Form-Focused Instruction, Discovery Approach, writing skills, literary texts, Saudi EFL learners, I. INTRODUCTION Writing is an essential skill for all learners, as it allows them to express their understanding, ideas, and perspectives to communicate effectively. It encourages individuals to gather, organize, [...]

In Canada, 10.3% of the population smokes tobacco. (1) Each year, 8 million deaths worldwide are attributed to smoking. (2) Currently, 3 pharmacotherapies are approved for smoking cessation in Canada: [...]

THE NASHUA RIVER MARKS the western border of the 480-acre campus of Groton School, established in 1884 on a site planned by Frederick Law Olmsted. Mount Watatic anchors the northwestern [...]

Purpose: This study investigates how the use of social media in workplace can affect towards employee job performance among employees at workplace. Design/methodology/approach: The authors decided to use the correlational method as a research design for this study and collected 148 social media users in three workplaces. Findings: This study finds out that the Internet adoption was the highest level of social media usage that influence the employees' job performance. Meanwhile, the lowest was Internet accessibility factor. Research limitations/implications: The limitations of the study are those characteristics of design or methodology that impacted or influenced the interpretation of the findings. such as population, geographical or any other concepts pertinent. These limitations of the study will evaluate on gender and level of education from Baby Boomers generation employees was born on 1946 until 1964 (55 until 73 years old). Finally, the limitations of the study to the old generations which is baby boomers that are not very familiar in this questions that related to social media. Practical implications: The organization need to provide the accessibility for the employees to do their job. Therefore, they can improve their job performance by using the social media usage. Originality/value: First, this study contributes to the literature on the business value of IT by providing theoretical arguments on how companies can capitalize efforts to consider Internet adoption use in combination with social-related use to create business value. Second, this research considers the interdependent effects of Internet accessibility and social-related use on employee performance. Third, the authors find that the links from knowledge-sharing and social-related use of social media to job performance vary in different contexts. Keywords: Social media, social media usage, Internet adoption, Internet accessibility, knowledge sharing, job performance., Introduction According to Pivec and Macek (2018), social media is playing an important role in project work. Social media is generally defined as being 'a group of internet-based applications that [...]

Objective. There is no consensus about the optimal frequency of patient visits during the rehabilitation program after arthroscopic rotator cuff repair (ARCR). This study aimed to investigate the short- and long-term effects of high-frequency (HF) and low-frequency (LF) visits of the patients in the first 12 weeks of rehabilitation after ARCR. Methods. This was a quasi-randomized study with 2 parallel groups. Forty-seven patients with ARCR were included in 2 different patient visit frequency protocols (HF =23, LF =24) in 12 weeks of postoperative rehabilitation. Patients in the HF group visited the clinic twice a week, whereas patients in the LF group visited once every 2 weeks for the first 6 weeks and once a week for the following 6 weeks. Both groups performed the same exercise protocol. Outcome measurements were pain and range of motion measured at baseline; at the 3rd, 5th, 8th, 12th, and 24th weeks; and at 1-year follow-up. Shoulder function was assessed at the 12th and 24th weeks and at 1-year follow-up with an American Shoulder and Elbow Surgeons score. Results. There was a significant group * time interaction in pain intensity during the activity between the groups. The activity pain intensity was higher in the LF group (4.2 points) at 8 weeks post surgery than in the HF group (2.7 points) (mean difference: 1.5 points, P Conclusion. Both rehabilitation programs at different visit frequencies after ARCR showed similar clinical results in the long term. A supervised, controlled rehabilitation program with LF visits in the first 12 weeks after surgery can be sufficient to achieve optimal clinical results and reduce rehabilitation-related costs after ARCR. Impact. This study highlights that LF treatment protocols under the supervision of the therapist can be adopted after the arthroscopic rotator cuff repair to achieve successful results while decreasing the treatment costs. Physical therapists should plan the treatment sessions efficiently for the compliance of the patients to the exercise treatment. Lay Summary. If you are a patient with arthroscopic rotator cuff repair, a supervised, controlled rehabilitation program with low-frequency visits in the first 12 weeks after surgery could help you achieve the best outcome and help lower the costs of rehabilitation. A total of 3 visits in the first 6 weeks might be sufficient (once every 2 weeks). More frequent visits (1-2 visits a week) should happen 6 to 12 weeks after the surgery. Keywords: Cost-Effectiveness, Patient-Reported Outcomes, Postoperative Pain, Postoperative Rehabilitation, Rotator Cuff Repair, Supervised Therapy, Introduction Rotator cuff tears (RCTs) are one of the most common causes of shoulder pain. The prevalence of degenerative RCTs increases with age and is especially higher in individuals aged [...]

Abstract Based on the career construction model of adaptation, this study examined the relationships of career adaptability with measures of adaptivity, and adaptation results. Specifically, we investigated the link among [...]

The combination of LED sources, circadian tuning and smart lighting systems have opened new avenues for lighting professionals. But without the data at your fingertips, the choices can be overwhelming [...]

In recent weeks, Israel has been on an assassination spree, killing several high-profile Hamas and Hezbollah leaders in quick succession. Yet there is reason to believe these killings, widely celebrated [...]

In many countries, Childhood is a magical realm where the days are filled with boundless play and endless discovery, far removed from the burdens and responsibilities of adulthood. In this [...]

Mark 12:28-34 THIS SUNDAY'S GOSPEL READING captures a pivotal moment in the ministry of Jesus, in which he articulates the core of his ethical teaching in response to a question [...]

Isaiah 25:6-9; Revelation 21:1-6a THE ASSIGNED READING from Isaiah embodies key themes for All Saints' Day: hope, resurrection, and divine triumph over death. It vividly portrays God swallowing up death [...]

Purpose: Traceability in aerospace industries starts from procuring raw materials until the final assembly part of the aircraft. These processes involve different parts of the supply chain network, including raw material suppliers, manufacturers, and original equipment manufacturers. Due to the complexity of the supply chain process in aerospace industries, robust technologies such as blockchain technology are required to assist the supply chain process, which can lead to a company's operational excellence. The purpose of this research is to look at the existing practice of aerospace supply chain management and to identify the concerns and challenges that impede the use of blockchain technology in the management of aerospace supply chains. Design/methodology/approach: The qualitative research method was chosen, and an online interview was conducted to collect the information from informants. Findings: The findings reveal that the main challenges to blockchain adoption in the aerospace supply chain are cost and lack of knowledge. The outcome of this study presents significant theoretical and managerial implications and a deep understanding for practitioners who plan to develop blockchain technology in the aerospace supply chain. Research limitations/implications: The scope of this research is limited to the usage of blockchain in the aerospace industry's supply chain. It would be beneficial to broaden the scope of this research to include a comparison of the applications of blockchain technology in different industries. Practical implications: The successful implementation of blockchain technology in managing the aerospace supply chain can strengthen the manufacturing sector. It helps achieve sustainability by bringing transparency to the system and enhancing the market position. The emphasis on blockchain technology also helps take organizational practices toward achieving a competitive advantage by generating new operational excellence in the current complexity of the supply chain landscape. Originality/value: The results can be used as the framework to foresee the successful implementation of blockchain technology in managing an aerospace supply chain. Keywords: Blockchain Technology, Qualitative Research, Aerospace Supply Chain, Supply Chain Management, Operational Excellence, Introduction Supply chain management (SCM) practitioners are being compelled to create distinctive business strategies that include the nascent industry 4.0 technology. Blockchain technology (BCT) is one of the most promising [...]

Background: Studies on renal vein thrombosis have been conducted as case reports or case series. The renal outcomes and mortality risk of renal vein thrombosis have not been fully established. We aimed to investigate the clinical characteristics, treatment modalities, and predictors of renal outcomes and mortality in patients with renal vein thrombosis in a large multicenter cohort. Methods: We retrospectively assessed 182 patients with renal vein thrombosis diagnosed between January 2011 and May 2023 using either Doppler ultrasonography or computed tomography venography. The main outcomes analyzed were all-cause mortality, and worsening kidney function. Results: We evaluated 182 patients comprising 76 males (41.8%) and 106 females (58.2%). Nephrotic syndrome was the most common cause (51.6%) followed by malignancy (33%) and post-trauma or surgery (11%). Kidney function worsened in 126 patients (69.2%). Acute kidney injury (AKI) was identified in 72 patients (39.6%), whereas 54 patients (29.7%) developed chronic kidney disease (CKD). Multivariate logistic regression showed that declining kidney function was reliably predicted by nephrotic syndrome (Odds ratio (OR): 6.41, P= 0.004), serum albumin (OR: 0.31, P= 0.003), and diabetes mellitus (OR: 14.04, P< 0.001). Eighty-two patients (45.1%) died while being monitored. Sepsis accounted for the majority of deaths (25.3%). Bilateral renal vein thrombosis (Hazard Ratio (HR): 5.61, P< 0.001), malignancy (HR: 6.15, P= 0.004), serum albumin (HR: 0.12, P< 0.001), hemoglobin (Hb) level (HR: 0.102, P< 0.001) and diabetes mellitus (HR: 2.42, P= 0.007) were all reliable predictors of all-cause mortality using multivariate Cox regression. Conclusion: Renal vein thrombosis is associated with a higher risk of mortality and worsening kidney function. It is essential to promptly identify high risk patients and start early treatment to prevent unfavorable outcomes. Graphical abstract:

La greffe haplo-identique est devenue aujourd’hui une pratique courante dans la plupart des centres de greffe de cellules souches hématopoïétiques. Néanmoins, son application dans les pays à ressources limitées reste peu développée. Cet atelier, conduit dans le cadre des treizièmes ateliers d’harmonisation des pratiques de greffe de la société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC), avait pour but d’établir des recommandations générales pour permettre de développer au mieux cette procédure dans ces pays. Notre groupe de travail s’est basé sur les données de la littérature et l’expérience des différents participants ainsi que sur le précédent atelier consacré à la greffe haplo-identique, publié en 2016. La greffe haplo-identique apparaît comme la première alternative à la greffe géno-identique du fait de l’absence de fichiers de donneurs disponibles, avec pour principaux avantages l’accès rapide à plusieurs donneurs potentiels et un faible coût de la procédure. Elle doit s’envisager si le centre a déjà une bonne expérience de la greffe géno-identique (plus de dix par an). Elle peut être proposée à tout patient avec une indication de greffe et sans donneur géno-identique, en utilisant des conditionnements d’intensité variable selon les indications avec une prophylaxie de la GVHD par le cyclophosphamide en post-greffe. Une évaluation régulière est nécessaire pour permettre l’amélioration des pratiques.

Graphical abstract:

AbstractEpidermal growth factor receptor (EGFR) controls cell growth, death, and proliferation through a variety of signaling mechanisms. The expression of vascular endothelial growth factor receptor-2 (VEGFR-2) by endothelial cells from malignant tissues triggers a series of signaling pathways that lead to tumor angiogenesis and increase cancer cell survival, proliferation, migration, and vascular permeability. The aim is to find novel inhibitors for EGFR and VEGFR-2 kinases by molecular docking drug-likeness models, pharmacokinetic, interaction analysis, and molecular dynamic simulation. Over 482 ligands were tested against the kinases, there are about 20 compounds that had the best docking scores for the 2 kinases but only compound 2C inhibited them with the highest score values by binding to active sites pocket established through molecular docking study. Secondly, the drug-likeness score of 2C was very good compared to the other compounds. The pharmacokinetics, physicochemical properties, and toxicity of 2C were much better than sorafenib and erlotinib as references. Analysis of interaction showed a strong interaction between 2C and active sites of EGFR and VEGFR-2 kinases illustrated by calculation of halogen bonds, π-Cation Interactions, Hydrogen Bonds, and Hydrophobic Interactions. Finally, the molecular dynamic simulation was also used to assess the stability of the EGFR and VEGFR-2 kinases-2C complexes. The complexes’ stability was validated by RMSD, Rg, RMSF, SASA, and several hydrogen bonds analysis. 2C was shown to interact stably with pocket residues after MD simulation. Compound 2C may be a promising way to slow the signaling cascade of proteins that are significant contributors to the spread of cancer.Communicated by Ramaswamy H. Sarma

•InO-exposed patients with R/R B-ALL have inferior outcomes after brexu-cel, particularly those who were nonresponders to InO.•The negative association is unrelated directly to InO per se; rather, it reflects selection of patients with intrinsically adverse-risk ALL.

AbstractGlobally, dengue (DENV) fever has appeared as the most widespread vector-borne disease, affecting more than 100 million individuals annually. No approved anti-DENV therapy or preventive vaccine is available yet. DENV NS3 protein is associated with protease activity and is essential for viral replication process within the host cell. NS2B is linked with NS3 protein as a cofactor. Hence, NS3/NS2B is a potential druggable target for developing inhibitors against dengue virus. In the present study, a dataset of Beta vulgarisL.-based natural compounds was developed. Virtual ligand screening of 30 phytochemicals was carried out to find novel inhibitors against the NS2B/NS3 protein. Spatial affinity, drug-likeness, and binding behaviors of selected phytochemicals were analyzed. Post-simulation analysis, including Principal Component Analysis (PCA), MMGBSA, and Co-relation analysis, was also performed to provide deep insight for elucidating protein-ligand complexes. This computer-aided screening scrutinized four potent phytochemicals, including betavulgaroside II, vitexin xyloside, epicatechin, and isovitexin2-O-xyloside inhibitors exhibiting optimal binding with viral NS3/NS2B protein. Our study brings novel scaffolds against DENV NS2B/NS3 of serotype-2 to act as lead molecules for further biological optimization. In future, this study will prompt the exploration and development of adjuvant anti-DENV therapy based on natural compounds.Communicated by Ramaswamy H. Sarma

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This study conducts a thorough economic and technical analysis to assess the viability of green hydrogen and green ammonia production using renewable energy sources in the Republic of Djibouti. We explore the economic competitiveness of utilizing wind and solar power for sustainable energy production through various measures including levelized cost of energy (LCOE), hydrogen (LCOH), and ammonia (LCOA). Our analysis incorporates sensitivity assessments and Monte Carlo simulations to predict financial feasibility and environmental impact, focusing on CO2emission reductions. A cost mapping of electricity, green hydrogen, and green ammonia from solar and wind resources was created to find Djibouti's most cost-effective production sites. The feasibility of exporting green ammonia to neighboring countries with high fertilizer demand was also evaluated using rail and truck transport scenarios. Key findings demonstrate that Moulouhlé, endowed with robust wind and solar resources, presents a strategic site for deploying renewable energy technologies. Wind energy, with a lower LCOE of 0.066 $/kWh compared to solar's 0.093 $/kWh, emerges as a more cost-effective solution for both hydrogen and ammonia production. Notably, wind-powered hydrogen production costs are 2.25 $/kgH2, significantly lower than solar-powered costs at 4.17 $/kgH2. In terms of green ammonia, wind power achieves production costs of 399.76 $/tonNH3, outperforming solar power which stands at 537.11 $/tonNH3. Additionally, our study evaluates the logistics of exporting green ammonia, determining rail transport as a more economically viable option than trucking. This research not only underscores Djibouti's potential as a leader in green energy exportation but also aligns with global decarbonization efforts, showcasing significant CO2savings—154.94 Mt annually from wind. This work emphasizes the importance of strategic resource utilization in Djibouti, offering insights critical for stakeholders in making informed decisions about investing in renewable energy infrastructures. The outcomes suggest a promising future for regional energy sustainability and economic resilience, fostering a transition towards low-carbon energy systems.

Gastric ulcers are the most common chronic gastrointestinal tract disorders, marked by an inflamed break of the mucus membrane covering the alimentary tract. According to recent research, stress-induced ulcers are widespread in our society. A stress ulcer is a mucosal defect that may become complicated due to upper gastrointestinal tract bleeding. The underlying cause of this condition is pH. Physiological stress leads to severe sickness by triggering the excessive secretion of peptic juices or gastric acid. There is a never-ending quest for safe and affordable medication for this disorder. Nature offers many medicinal plants that can be used to treat a wide range of human ailments. Due to their relatively harmless and comparatively free of harmful effects, health-promoting features, pharmacological practices, and affordability to common people to regulate various diseases, medicinal plants, and herbal preparations are gaining a lot of interest in scientific communities these days. Many studies have recently been performed to classify extracts and their constituents that may have a therapeutic effect on peptic ulcers. Therefore, this review aims to address the molecular mechanisms and pharmacological effects of various phytochemicals related to stress-induced gastric ulcers. Combining phytochemical constituents with modern drugs and treatment methods can lead to the development of therapeutic drugs for gastric ulcers. Gastric ulcers and other related diseases may be treated permanently with this approach.

Background: Despite atrial fibrillation guideline recommendations, many patients with heart failure with reduced ejection fraction (EF) continue to receive IV diltiazem for acute rate control.Objective: Our institution recently implemented a clinical decision support system (CDSS)-based tool that recommends against the use of diltiazem in patients with an EF ≤ 40%. The objective of this study was to evaluate outcomes of adherence to the aforementioned CDSS-based tool.Methods: This multi-hospital, retrospective study assessed patients who triggered the CDSS alert and compared those who did and did not discontinue diltiazem. The primary outcome was the occurrence of clinical deterioration. The primary endpoint was compared utilizing a Fisher’s Exact Test, and a multivariate logistic regression model was developed to confirm the results of the primary analysis.Results: A total of 246 patients were included in this study with 146 patients in the nonadherent group (received diltiazem) and 100 patients in the adherent group (did not receive diltiazem). There was a higher proportion of patients experiencing clinical deterioration in the alert nonadherence group (33% vs 21%, P= 0.044), including increased utilization of inotropes and vasopressors, and higher rate of transfer to ICU.Conclusion and Relevance: In patients with heart failure with reduced EF, diltiazem use after nonadherence to a CDSS alert resulted in an increased risk of clinical deterioration. This study highlights the need for improved provider adherence to diltiazem clinical decision support systems.

Background: The incidence of discharge against medical advice (DAMA) in emergency departments (EDs) among Indigenous people is a growing concern in Australia. This study aimed to determine the incidence of ED DAMA in public hospitals in Queensland (QLD) from 2016 to 2021 and investigate the disparities in ED DAMA between Indigenous and non-Indigenous patients. The study also assessed the impact of the COVID-19 pandemic on the incidence of ED DAMA. Methods: A descriptive epidemiological study was conducted using aggregated data from QLD public hospital EDs. The data was retrieved from Clinical Excellence QLD, Healthcare Improvement Unit, in the QLD Health Open Data Portal for the period 1 January 2016 to 31 December 2021. Incidence rates and unadjusted odds ratios were calculated and compared using the chi-square test to identify differences between Indigenous and non-Indigenous patients. Results: The annual incidence of DAMA in EDs was 7.7% among Indigenous patients, compared to 4.8% among non-Indigenous patients, with the highest rate (8.9%) reported in 2021 among Indigenous patients. The incidence of ED DAMA was higher for Indigenous patients in major cities (20.0%) than in very remote areas (7.4%). Patients in triage categories 4 (10.0%) and 3 (7.3%) accounted for the vast majority of ED DAMA events among Indigenous patients. The acute group A hospitals had the highest incidence of ED DAMA (10.9% for Indigenous patients and 6.5% for non-Indigenous patients). The COVID-19 pandemic had no impact on the incidence of ED DAMA. Conclusion: Indigenous patients experience a disparity in ED DAMA incidence. Addressing this issue requires collaborative efforts from healthcare providers, policymakers, and community organizations.

Background Nasal irrigation is among the most widely used treatment modalities for sinonasal diseases. The extent of irrigation is well studied in operated sinuses but not for non-operated sinuses. Moreover, the preferred head positioning during irrigation is not known. Herein, we studied the extent of nasal irrigation in cadaveric heads with non-operated sinuses.Methods Nine cadaveric heads were used. Normal saline solution mixed with radiological contrast material was used to irrigate the nasal cavities with the heads in 2 different positions: standing-leaning-forward (SLF) and Head-down forward (HDF). After each irrigation, computed tomography images of the head were acquired. The extent of irrigation was assessed for each subunit of the sinonasal cavity.Results Irrigation was performed twice on a total of 18 sides, each time in 1 position. Nine subunits were evaluated: inferior, middle, and superior meati; the olfactory cleft; and the frontal, maxillary, anterior, and posterior ethmoid and sphenoid sinuses. The extent of irrigation was significantly better in the HDF position for the olfactory cleft (100% vs 33%), P-value=.001, frontal sinus (33% vs 11%), P-value=.002, maxillary sinus (78% vs 17%), P-value=.001, and anterior ethmoid sinus (89% vs 17%), P-value=.001. There was no significant difference in the extent of irrigation between the 2 positions for the other evaluated subunits. The overall extent of irrigation was 70.37% of the subunits in HDF position and 45.06% of the subunits for SLF position, P-value= .001Conclusions Nasal irrigation reached the cavities of non-operated paranasal sinuses. However, while the extent of irrigation was limited in the SLF, it was well achieved in the HDF position. Studies on the clinical efficacy of irrigation in this position are recommended.

Statins are the cornerstone treatment for patients with heterozygous familial hypercholesterolaemia but research suggests it could increase the risk of type 2 diabetes in the general population. A low prevalence of type 2 diabetes was reported in some familial hypercholesterolaemia cohorts, raising the question of whether these patients are protected against type 2 diabetes. Obesity is a well known risk factor for the development of type 2 diabetes. We aimed to investigate the associations of known key determinants of type 2 diabetes with its prevalence in people with heterozygous familial hypercholesterolaemia.

Despite growing agreement on the importance of sexual and reproductive health and rights at all stages of human development, the link between ageing and the sexual and reproductive rights of older African women has been an overlooked topic of research and policy formulation. This commentary takes a multidisciplinary approach to highlighting older African women's sexual and reproductive health and rights, identifying extant legislative frameworks, shortcomings, and strategies to improve their implementation. An examination of the legislative frameworks in place demonstrates that they are insufficient for the full implementation of these rights. As a result, a deliberate effort is required to correct historical wrongs and preserve older women's sexual and reproductive health and rights. (Afr J Reprod Health 2022; 26 [12s]: 21-26). Keywords: Older women, African women, SRHR, legislative frameworks Malgré un accord croissant sur l'importance de la santé et des droits sexuels et reproductifs àtous les stades du développement humain, le lien entre le vieillissement et les droits sexuels et reproductifs des femmes africaines âgées a été un sujet négligé de la recherche et de la formulation des politiques. Ce commentaire adopte une approche multidisciplinaire pour mettre en évidence la santé et les droits sexuels et reproductifs des femmes africaines âgées, en identifiant les cadres législatifs existants, les lacunes et les stratégies pour améliorer leur mise en oeuvre. L'examen des cadres législatifs en place montre qu'ils sont insuffisants pour la pleine mise en oeuvre de ces droits. En conséquence, un effort délibéré est nécessaire pour corriger les torts historiques et préserver la santé et les droits sexuels et reproductifs des femmes âgées. (Afr J Reprod Health 2022; 26[12s]: 21-26). Mots-clés: Femmes âgées, femmes africaines, SDSR, cadres législatifs, Introduction Available evidence indicates that the African population, as elsewhere around the world, is ageing (1). Ageing comes with a significant decline in physical and mental health that requires deliberate [...]