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Part II: How to Overcome Pitfalls in This Legal Landscape to Make the Most Beneficial Impact for Our Most Threatened Species Part I of this article discussed federal conservation easement [...]

Ecologists around the world acknowledge that a single organism's extinction affects other organisms in the ecosystem and that the loss of even one species can start a harmful chain reaction [...]

The Florida panther (puma concolor coryi), the official state animal of Florida, is the last remaining subspecies of 'Puma' (also known as mountain lion or cougar) still surviving in the [...]

Despite overwhelming international evidence of elevated rates of poor mental health in LGBTQ+ youth compared to their cis-heterosexual peers, we know relatively little about effective mental health services for this population group. This study aims to produce the first early intervention model of “what works” to support LGBTQ+ youth with emerging mental health problems. Utilizing a mixed method case study, we collected data across 12 UK mental health service case study sites that involved: (a) interviews with young people, parents, and mental health practitioners (n = 93); (b) documentary analysis; (c) nonparticipant observation. The data analysis strategy was theoretical using the “explanation-building” analytical technique. Our analysis suggests an intersectional youth rights approach with 13 principles that must be enacted to provide good mental health services as advocated by the United Nations Convention on the Rights of the Child and World Health Organization. This approach should address the multiple forms of marginalization and stigmatization that LGBTQ+ youth may experience, enable informed independent decision-making, and uphold the right to freedom of safe self-expression. A rights-based approach to mental health services for LGBTQ+ young people is not prominent. This needs to change if we are to tackle this mental health inequality and improve the mental well-being of LGBTQ+ youth worldwide.

Introduction:C3 is central for all complement activation pathways, thus making it an attractive therapeutic target. Many C3-targeted agents are under extensive development with one already approved for clinical use. However, most, if not all, C3 inhibitors are human or nonhuman primate C3-specific, making evaluating their efficacies in vivo before a clinical trial extremely difficult and costly. Methods:We first studied the compatibility of human C3 in the rat complement system, then developed a C3 humanized rat using the CRISPR/Cas9 technology. We thoroughly characterized the resultant human C3 humanized rats and tested the treatment efficacy of an established primate-specific C3 inhibitor in a model of complement-mediated hemolysis in the C3 humanized rats. Results:We found that supplementing human C3 protein into the C3-deficient rat blood restored its complement activity, which was inhibited by rat factor H or compstatin, suggesting that human C3 is compatible to the rat complement system. The newly developed C3 humanized rats appeared healthy and expressed human but not rat C3 without detectable spontaneous C3 activation. More importantly, complement-mediated hemolysis in the C3 humanized rats was also inhibited by compstatin both in vitro and in vivo. Conclusion:The successfully developed C3 humanized rats provided a much-desired rodent model to evaluate novel C3 inhibitors in vivo as potential drugs.

Mathematical knowledge and skills are critical in the development of students. In this article, we begin to unpack the concept of mathematics disabilities and how they are presented across classrooms. We explain commonly used terms such as, specific learning disability and dyscalculia, and emphasize how students qualify for math support. We provide overview regarding difficulties students encounter with math and how to support student learning.

Approximately 30–50% of people with serious mental illness have co-existing drug or alcohol problems (COSMHAD), associated with adverse health and social care outcomes. UK guidelines advocate both co-occurring needs being met within mental health services, but uncertainty remains about how to operationalise this to improve outcomes. Various unevaluated service configurations exist in the UK. A realist synthesis was done to identify, test, and refine programme theories of how context shapes the mechanisms through which UK service models for COSMHAD work, for whom, and in what circumstances. Structured and iterative realist searches of seven databases identified 5099 records. A two-stage screening process identified 132 papers. Three broad contextual factors shaped COSMHAD services across 11 programme theories: committed leadership, clear expectations regarding COSMHAD from mental health and substance use workforces, and clear care-coordination processes. These contextual factors led to increased staff empathy, confidence, legitimisation, and multidisciplinary ethos, which improved care coordination and increased the motivation of people with COSMHAD to work towards their goals. Our synthesis highlights that integrating COSMHAD care is complex, and both individual and cultural behavioural shifts in leadership, workforce, and service delivery are essential to ensure people with COSMHAD receive compassionate, trauma-informed care that meets their needs.

The recent decision by the Fourth District Court of Appeal in Parker v. Parker, 185 So. 3d 616 (Fla. 4th DCA 2016), highlights the uncertainty in Florida law over the [...]

Many students with autism spectrum disorder (ASD) experience academic challenges and difficulties. These struggles are especially pronounced in mathematics with students with ASD performing significantly below than their peers without disabilities on measures of mathematical performance. The current study used a single case experimental design with concurrent multiple probe across students to investigate the effects of a point-of-view video modeling (POVM) intervention on accuracy of addition with regrouping word problems. The participants were three secondary grade level students with ASD. Findings showed that each student demonstrated considerable improvement during intervention over baseline levels, and subsequently sustaining their performance through the maintenance phase. Limitations, implications for practitioners and future research directions are presented.

Assessments for eating disorders rely primarily on self-report; yet, the denial of symptoms or symptom severity among adolescents with anorexia nervosa can complicate assessment and delay treatment in this population. The Parent Eating Disorder Examination (PEDE) is the first semi-structured interview formally developed to improve childhood eating disorder assessment by including caregiver perspectives. In this study, a large sample of adolescents with anorexia nervosa completed a self-report interview (the Eating Disorder Examination or EDE) and their parents completed the PEDE. The PEDE appeared to measure parents’ report of their child’s eating disorder symptoms consistently. Results from both interviews were related to one another but did not completely agree. This suggests that in an eating disorder assessment, the PEDE can provide additional information from caregivers that might reduce diagnostic confusion and lead to earlier intervention for youth with anorexia nervosa.

Byline: Elizabeth Blish Hughes When immigrants from Southeast Asia come into the AARP Foundation Tax-Aide office in Sunnyvale looking for help preparing their returns, they often turn to Elaine Tran. [...]

The architectural designing of house, by designers, Kevin Roberts and Tim Haynes, and details of furnishing materials used for the design are also discussed.

An insight into the redesigning and renovation details of a ranch-style house in rural Connecticut, designed by Eric Cohler, is presented.

The award-winning modernization of a beach house in Florida is discussed. The restoration project lasted for seven months and bagged the prestigious Ballinger Award.

The house of Dixon Boardman and Arriana Hohenlohe located at the island, Long Island Sound, which is redesigned by New York designer Ralph Harvard with furnishings and furniture that enhances the comfort is described.

The twelve room penthouse duplex that is owned by Andrea and John Stark in New York, which is designed by an interior designer Jeffrey Bilhuber, is described.

The makeover of a 7600 square foot New York apartment into a magnificent building by a Dutch architect, Piet Boon is presented. The ideas of Piet, used to renovate the apartment and turn it into a well-equipped oasis, are described.

The story of renovation, of an old wreck of a stone house in California into a beautiful designer house, by an architectural designer John F. Saladino, is presented.

The decor of antique dealer Amy Perlin's cottage in Hampton is discussed. The cottage has been tastefully decorated by her with antiques an collectibles.

Charles Edwards and Julia Boston, both antique dealers have painstakingly combined two cottages to put together a beautiful house. The Tile Barn, an old house in Northamtonshire, has been uninhabited for over 50 years.

Jeffrey Bilhuber, an interior designer, designed a handsome house located in rural Connecticut, using colors and furnishings of the past in a contemporary way. The seating arrangement in the huge living room is so well organized that it facilitates an easy communication.

Designer Alberto Pinto has redone a Palm Beach villa, which now composes of trio of harmonious bedrooms that invite indulgence. The wooden clostra filter light beautifully in the Chinese-themed guest room, which also eliminates the need for curtains, a mix of understated fabrics and Louis XVI furniture provides a balance of luxury and simplicity to the other bedrooms.

A Spanish village atmosphere at the ranch in rural San Francisco and using the 82-acre land to re-create the magic of the place is presented. Using the steep hills, the creek flowing around the house the permanently squabbling siblings worked on the place instilling the values of the village are described.

Designer duo, Diamond and Barata, re-created a fifth avenue apartment, giving it an airy feel and loft like space. The duo did away with all the typical fifth avenue props in the apartment except for one column and painted the house in bright colors using opulent upholstery fabrics and plush sofas to enhance the look of the living room.

Interior designer Tim Haynes along with Kevin Roberts transformed a run-of-the-mill Manhattan apartment into a swank silver palace for a sports couple living with their daughters. The no clutter apartment is very child friendly right down to the minutest details and even as the children indulge in a scooter race in their house there is no fear of any damage to the surroundings.

The article discusses the importance of effective communication in local government and how it has become overly specialized and formalized. The author argues that all staff members should be empowered to be effective communicators, rather than relying solely on a few specialists. They suggest that communication skills should be a requirement for all staff, similar to the emphasis placed on health and safety. The article encourages local governments to adopt a model that provides basic communication knowledge and skills for all staff, in addition to specialized communication teams. [Extracted from the article]

An old East side twon house in New York has been redesigned. The aim of the restoration was to give it a French formality alongside New York traditional design.