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The 5280 magazine article features a list of over 900 top doctors in the Denver metro area, compiled in partnership with Castle Connolly, a reputable health care research company. The list covers a wide range of medical specialties, including addiction medicine, cardiovascular disease, and family medicine, among others. The Castle Connolly Doctor Directory provides contact information for these physicians, who are affiliated with healthcare facilities like Kaiser Permanente, UCHealth, and Rocky Mountain Cancer Centers, offering a comprehensive resource for individuals seeking specific healthcare services in the Denver area. [Extracted from the article]

A recent study conducted at the University of Colorado focused on identifying microRNAs that could serve as biomarkers for congenital diaphragmatic hernia (CDH) and provide insights into altered molecular pathways associated with the condition. The research aimed to distinguish CDH pregnancies from healthy controls and assess the severity of the disease. Findings indicated significant differences in microRNA expression between CDH cases and control samples, with potential implications for predicting outcomes and identifying therapeutic targets in pathways related to pulmonary hypertension and lung hypoplasia. Further studies with larger cohorts are needed to validate these findings and explore the clinical application of microRNA biomarkers in CDH management. [Extracted from the article]

Byline: Henry L. Galan, Maciej Jozwik, Serena Rigano, Timothy R.H. Regnault, John C. Hobbins, Frederick C. Battaglia, Enrico Ferrazzi Keywords: Fetus; ovine; placenta; ultrasonography; umbilical blood flow; umbilical vein Abstract: Objective: This study was undertaken to assess the accuracy of triplex ultrasonographic measurement of venous umbilical blood flow in comparison with the steady-state diffusion technique and to determine the impact of cotyledon weight and number on umbilical blood flow. Study Design: Six late-gestation ewes with long-term catheter placement were studied for venous umbilical blood flow with the ethanol steady-state diffusion technique and with triplex-mode ultrasonography (color Doppler, pulsed-wave Doppler, and real-time ultrasonography). At necropsy the number and weight of the cotyledons serving each umbilical vein were recorded. Results: Umbilical blood flow determined by triplex-mode ultrasonography (207.5 [+ or -] 8.6 mL * kg.sup.-1 fetus * min.sup.-1) was virtually identical to that determined with the steady-state diffusion technique (208.1 [+ or -] 7.3 mL * kg.sup.-1 fetus * min.sup.-1; P = .9). When values were normalized for the weight or number of cotyledons serving each vein, there was no difference in umbilical blood flow between small and large umbilical veins in all the sheep. Conclusions: Our study validates the accuracy of the triplex ultrasonographic method and provides justification for its use in future human investigations. In absolute terms umbilical blood flow frequently differs between the 2 veins. When expressed per number or mass of cotyledons, however, the umbilical blood flows are similar. (Am J Obstet Gynecol 1999;181:1149-53.) Author Affiliation: Denver, Colorado, Bialystok, Poland, and Milan, Italy From the Division of Perinatal Medicine, Departments of Obstetrics and Gynecology.sup.a and Pediatrics,.sup.b University of Colorado, the Department of Gynecology, Bialystok Medical University,.sup.c and the Department of Obstetrics and Gynecology, University of Milan..sup.d Article Note: (footnote) [star] Supported by National Institutes of Health Program Project Grants PO1 HD20761 and 1RO1 HD34837, March of Dimes Grant 6-F497-0174, and the American Association of Obstetricians and Gynecologists Foundation., [star][star] Reprint requests: Henry L. Galan, MD, Assistant Professor, Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, 4200 E 9th Ave, Campus Box B-198, Denver, CO 80262., a 0002-9378/99 $8.00 + 0 6/6/102316

Byline: Henry L. Galan, Michael J. Hussey, Antonio Barbera, Enrico Ferrazzi, Misoo Chung, John C. Hobbins, Frederick C. Battaglia Keywords: Fetus; intrauterine growth restriction; ultrasonography; heat stress; placenta Abstract: Objective: Intrauterine growth restriction in an ovine model occurs after exposure to environmental heat stress for 80 days beginning at 35 days' gestation. Our objective was to determine whether intrauterine growth restriction is reversible on removal of the heat stress after only 55 days of exposure; that is, does a brief exposure at a critical point of development suffice? Study Design: Five pregnant ewes were exposed to heat stress beginning at 35 days' gestation and were removed after 55 days of exposure. Five ewes in a control group were studied as contemporaneous controls and added to data from 37 ewes in a control group previously studied. Serial fetal biometric ultrasonographic measurements (biparietal diameter, abdominal circumference, femur length, and tibia length) were obtained beginning at 50 days' gestation. Growth curves were calculated for each parameter, and comparisons were made between fetuses in the group exposed to heat stress for 55 days and 42 fetuses in the control group and 4 fetuses from a previous study that were exposed to heat for 80 days. Regression lines, 95% confidence intervals, and slopes were determined for each study group. Results: Both the 55-day and the 80-day heat exposure groups showed a significant reduction in fetal and placental weights compared with the control group. Animals in the 80-day group had significantly lower fetal and placental weights than the animals in the 55-day group (P < .05). Indexes of somatic growth (abdominal circumference, femur length, and tibia length) for the control group were significantly greater than those of either the 55-day group or the 80-day group (P < .001). Asymmetric growth restriction was evident in both heat groups by a biparietal diameter/abdominal circumference ratio that was significantly higher than in the control group (P < .004 for the 55-day group and P < .001 for the 80-day group). The slopes for somatic parameters (abdominal circumference, femur length, and tibia length) versus time became significantly different between the control and 55-day groups at 77, 101, and 80 days' gestation, respectively. The 55-day group had abdominal circumference and femur length measurements that were significantly greater than those in the 80-day group. Conclusion: The fetuses in the 55-day and 80-day groups reflect a pattern of asymmetric intrauterine growth restriction. Our findings suggest that the initial insult affecting fetal and placental growth occurs early in gestation, but removal of fetuses after only 55 days of exposure significantly reduces the degree of fetal growth restriction compared with that found in those fetuses exposed for 80 days. (Am J Obstet Gynecol 1999;180:1278-82.) Author Affiliation: Denver, Colorado, and Milan, Italy From the Division of Perinatal Medicine in the Departments of Obstetrics and Gynecology.sup.a and Pediatrics,.sup.b and the Department of Biometrics,.sup.c University of Colorado Health Sciences Center, and the Department of Obstetrics and Gynecology, University of Milan, San Paolo Hospital..sup.d Article History: Received 27 August 1998; Revised 28 December 1998; Accepted 14 January 1999 Article Note: (footnote) [star] Supported by National Institutes of Health Program Project grant PO 1 HD20761, by March of Dimes grant 6-F497-0174, and by the American Association of Obstetricians and Gynecologists Foundation., [star][star] Reprint requests: Henry L. Galan, MD, Assistant Professor, Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, 4200 E. 9th Ave, Campus Box B-198, Denver, CO 80262., a 0002-9378/99 $8.00 + 0 6/1/97173

Byline: Henry L. Galan, Michael J. Hussey, Misoo Chung, Jacquelyn K. Chyu, John C. Hobbins, Frederick C. Battaglia Keywords: Intrauterine growth restriction; Doppler ultrasonography; flow velocity waveforms; umbilical blood flow; pulsatility index; umbilical artery Abstract: Objective: With an ovine model in which growth restriction was induced by exposure to heat stress, our aims were as follows: (1) to describe the normal gestational age-related changes in Doppler velocimetry in the ovine fetal aorta and umbilical artery and (2) to compare Doppler velocimetry between heat-stressed and non-heat-stressed fetuses. Study Design: Five ewes were exposed to heat stress for 55 days beginning at 35 days' gestation. Five ewes were not exposed and served as controls. Aortic and umbilical artery pulsed Doppler velocimetry was obtained, including the systolic/diastolic ratio, pulsatility index, and resistance index. Data were obtained between 50 and 120 days' gestation. Linear regression analysis was used to analyze gestational age-related changes in velocimetry. Comparison of mean index values between heat-stressed and non-heat-stressed fetuses were made with analysis of variance. Results: Heat-stressed fetuses demonstrated significantly higher systolic/diastolic ratios and pulsatility index values for both umbilical artery (p < 0.025; p < 0.033) and aorta (p < 0.017; p < 0.022) compared with controls. The umbilical artery and aortic resistance index values were not different between groups (p < 0.079; p < 0.28). The slopes for each of the Doppler index values were negative in both normal and heat-stressed fetuses. Umbilical artery and aortic end-diastolic flows remained absent through the first 70 days of gestation in both groups. Conclusion: Doppler velocimetry index values decrease with increasing gestational age, reflecting decreased placental bed vascular resistance. The higher Doppler index values seen in the heat-stressed group are consistent with increased placental vascular resistance. The normal absence of diastolic flow until 70 days' gestation is similar to the pattern described in humans. (Am J Obstet Gynecol 1998;178:451-6.) Author Affiliation: Denver, Colorado Article History: Received 6 June 1997; Revised 29 September 1997; Accepted 30 September 1997 Article Note: (footnote) [star] From the Division of Perinatal Medicine in the Departments of Obstetrics and Gynecologya and Pediatricsb and the Department of Biometrics,c University of Colorado Health Sciences Center at Denver., [star][star] Supported by National Institutes of Health Program Project grant No. PO1HD20761 and by March of Dimes grant No. 6-F497-0174. Also supported in part by the University of Colorado Perinatal Institute and the American Association of Obstetricians and Gynecologists Foundation., a Reprint requests: Henry L. Galan, MD, Assistant Professor, Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, 4200 E. 9th Ave., Campus Box B-198, Denver, CO 80262., aa 6/1/86553

Byline: Henry L. Galan, Lucile B. Tennant, Daniel R. Marsh, Robert K. Creasy Abstract: OBJECTIVE: Whether fetal breathing movements or gasping result in the movement of amniotic fluid substances into the distal airways remains controversial. We evaluated the effect of paralysis of the preterm rabbit fetus on the pulmonary distribution of iron dextran. STUDY DESIGN: Laparotomy was performed on 10 New Zealand White rabbits of 25 days' gestation (term 31 days) under general anesthesia. Fetuses in one uterine horn were given an intramuscular injection of pancuronium (1.5 mg/kg) and fetuses in the other horn were given an equal volume of normal saline solution as controls. A 1 ml volume of iron dextran (100 mg/ml) was injected into the amniotic sac of all fetuses. The laparotomy was closed, and 20 to 24 hours later the fetuses were removed by hysterotomy and assessed for paralysis. Necropsy was performed. Lungs were stained with prussian blue and evaluated histologically for the presence of iron. RESULTS: A total of 92 pups were delivered (49 given pancuronium, 43 given normal saline solution), of which 64 were born alive. There were no differences between groups for live births (31 pancuronium, 33 normal saline solution), pup body weight, or lung weight. Pups given normal saline solution demonstrated more breathing motions, spontaneous movement, and brown (color of iron dextran) stomach contents than did the pups given pancuronium (p < 0.001). At necropsy a greater number of control pups (31/33) had brown lungs grossly compared with pups given pancuronium (2/31, p < 0.001). Lung histologic examination showed that more control pups (29/29) had iron in the trachea and main bronchi compared with pancuronium pups (0/27, p < 0.001), and more control pups (29/29) had iron in the distal lung airways compared with pancuronium pups (0/27, p < 0.001). With use of the Optimas Image Analysis System, iron in the lungs of control pups was found to be equally distributed between right versus left lungs, upper half versus lower half lungs, and anterior versus posterior lung sections. More iron was identified in the central airways than in the periphery (p < 0.001). CONCLUSION: We conclude that paralysis prevents the uptake of iron dextran into the main and distal airways of the rabbit fetus. Although lung fluid production results in a net efflux of fluid, we speculate that fetal breathing movements can result in the movement of fluid into distal airways and potentially provide fetal therapy.(Am J Obstet Gynecol 1997;177:42-9.) Key words: Rabbit, fetus, lung, breathing, amniotic fluid Author Affiliation: Houston, Texas Article History: Received 26 February 1997; Accepted 10 March 1997 Article Note: (footnote) [star] From the Departments of Obstetrics, Gynecology, and Reproductive Sciences,a Pathology,b and Physiology,c University of Texas Health Science Center at Houston., [star][star] Reprint requests: Henry L. Galan, MD, Department of Obstetrics and Gynecology, University of Colorado Health Science Center, Campus Box B-198, 4200 E. 9th Ave., Denver, CO 80262., a 6/1/81731

Researchers at the University of Pittsburgh conducted a multicenter, prospective, observational study through the North American Fetal Therapy Network (NAFTNet) to determine the accuracy of prenatal diagnosis of fetal aqueductal stenosis (fetal AS) and its potential for in-utero intervention. The study included 64 subjects with severe fetal central nervous system ventriculomegaly. Ultrasound and magnetic resonance imaging (MRI) were used for diagnosis, with ultrasound showing a sensitivity of 0.82 and specificity of 0.76, and MRI showing a sensitivity of 0.95 and specificity of 0.69. The researchers concluded that diagnostic accuracy of fetal AS is likely to improve with increased experience. [Extracted from the article]

A recent report from the University of Colorado discusses a new form of transient antenatal Bartter syndrome (aBS) associated with the X-linked MAGED2 variant. This variant can lead to severe polyhydramnios, which may result in preterm birth or pregnancy loss. The report highlights a case study of a woman with two affected pregnancies and suggests that amnioreductions may improve fetal outcomes in this rare condition. The study also provides a review of published cases of MAGED2-related transient aBS, emphasizing the importance of antenatal treatment and serial amnioreduction for managing the condition. [Extracted from the article]

Cardiology, Edema, Health and Medicine, Oncology, Pericardial, Teratoma, Urology Keywords: Cardiology; Edema; Health and Medicine; Oncology; Pericardial; Teratoma; Urology EN Cardiology Edema Health and Medicine Oncology Pericardial Teratoma Urology 660 660 1 09/11/23 20230911 NES 230911 2023 SEP 11 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Current study results on teratoma have been published. [Extracted from the article]

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2006.06.018 Byline: Juan A. Arroyo (a), Russell V. Anthony (b), Thomas A. Parker (b), Henry L. Galan (a) Abstract: The objective of the study was to evaluate endothelial nitric oxide synthase concentration in the placenta, uterine, and umbilical vessels near term in an ovine model of intrauterine growth restriction induced by hyperthermia beginning in early gestation. Author Affiliation: (a) Division of Perinatal Medicine, Departments of Obstetrics and Gynecology (b) Pediatrics, University of Colorado Health Sciences Center, Denver, CO Article History: Received 14 March 2006; Revised 2 May 2006; Accepted 2 June 2006 Article Note: (footnote) Supported by National Institutes of Health Grant HL071990.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2004.06.045 Byline: Alessandra Padoan (a), Serena Rigano (a), Enrico Ferrazzi (a), Brenda L. Beaty (b), Frederick C. Battaglia (c), Henry L. Galan (d) Abstract: The purpose of this study was to assess fetal subcutaneous fat and lean mass areas as predictors of fetal growth restriction. Author Affiliation: (a) Department of Obstetrics and Gynecology DMC L. Sacco, University of Milan, Italy (b) the University of Colorado Health Science Center, Colorado Health Outcomes Program, Aurora, Colo (c) the Department of Pediatrics (d) and the Division of Obstetrics in the Department of Obstetrics & Gynecology, the University of Colorado Health Sciences Center, Denver, Colo Article Note: (footnote) Supported by the Colorado Women's Reproductive Health Research Career Development Center, by the National Institutes of Health grant 1 R01 HL071990-01A1, and by the General Clinical Research Centers Program National Centers for Research Resources-National Institutes of Health grant M01 RR00069. Presented at the Twenty-Fourth Annual Meeting of the Society for Maternal-Fetal Medicine, February 2-7, 2004, New Orleans, La.

Byline: Antonio Barbera, Henry L. Galan, Enrico Ferrazzi, Serena Rigano, Maciej Jozwik, Frederick C. Battaglia, Giorgio Pardi Keywords: Abdominal circumference; Doppler; head circumference; human fetus; sheep; ultrasonography; umbilical vein blood flow Abstract: Objective: Our purposes were to determine the relationship of the growth of umbilical blood flow to growth in body measurements of human fetuses in uncomplicated pregnancies. The study also aimed to assess the relative contributions of growth in umbilical vein diameter and of increased velocity to the increase in umbilical blood flow. Study Design: An animal study was conducted to assess the accuracy of umbilical vein blood flow measurements obtained by triplex mode ultrasonography. Seven pregnant ewes underwent triplex mode umbilical vein flow determination. These results were compared with historical flow data obtained by a steady-state diffusion technique in 34 ewes matched for gestational age and weight. In a separate study performed on human beings, reproducibility and precision of triplex mode flow determination were assessed, as were the relationships between umbilical vein flow and gestational age and head and abdominal circumferences. This cross-sectional study was performed with 70 healthy fetuses ranging from 20 weeks' gestation to term. Best-fit interpolating equations and confidence limits were calculated for blood flow measurements versus gestational age and head and abdominal circumferences. Results: In the validation study performed on sheep there were no significant differences between triplex mode and steady-state measurement groups with respect to gestational age or weight. The umbilical vein flows were similar between triplex mode and steady-state measurement groups (P = .881). In the human study the intraobserver and interobserver coefficients of variation for the vein diameter, mean velocity, and absolute umbilical vein blood flow varied from 2.9% to 12.7%. The mean duration of examination was 3 [+ or -] 1 minutes. The umbilical vein diameter and mean velocity increased throughout pregnancy. The absolute umbilical vein flow increased exponentially from 97.3 mL/min at midgestation to 529.1 mL/min at 38 weeks' gestation, whereas umbilical vein flow per kilogram of fetal weight did not change significantly with gestational age. There was a strong correlation between absolute umbilical vein flow and the fetal head and abdominal circumferences. Conclusions: The triplex mode ultrasonographic technique can play an innovative role in obtaining quick and reproducible measurements of umbilical vein blood flow. The approach was validated with a sheep model. Umbilical vein blood normalized for fetal weight (milliliters per minute per kilogram of fetal weight) and absolute flow (in milliliters per minute) are consistent with previous human studies. We have established new reference values of umbilical vein blood flow relative to head and abdominal circumferences. The growth of umbilical venous diameter accounted for most of the growth in umbilical vein flow. (Am J Obstet Gynecol 1999;181:174-9.) Author Affiliation: Milan, Italy, Denver, Colorado, and Bialystok, Poland From the Department of Obstetrics and Gynecology, Biomedical Sciences Institute, University of Milan,.sup.a the Departments of Obstetrics and Gynecology.sup.b and Pediatrics,.sup.c University of Colorado, and the Institute of Obstetrics and Gynecology, Bia>ystok Medical University..sup.d Article History: Received 12 January 1999; Accepted 9 February 1999 Article Note: (footnote) [star] Supported in part by March of Dimes Birth Defects Foundation grant 6-FY97-0174, by National Institutes of Health grants PO1 HD20761 and RO1 HD 34837, and by the American Association of Obstetricians and Gynecologists Foundation., [star][star] Reprint requests: Enrico Ferrazzi, MD, Department of Obstetrics and Gynecology, Biomedical Sciences Institute, University of Milan, via A. Di Rudini', 8, 20148 Milan, Italy., a 0002-9378/99 $8.00 + 0 6/1/97800

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2010.05.021 Byline: Juan A. Arroyo (a), Cun Li (b), Natalia Schlabritz-Loutsevitch (b), Tom McDonald (b), Peter Nathanielsz (b), Henry L. Galan (a) Keywords: apoptosis; caspase 3; MNR; placenta; XIAP Abstract: Our objective was to determine signaling molecules and apoptosis rate in the term placenta of a baboon model of maternal nutrient reduction (MNR). Author Affiliation: (a) Departments of Obstetrics and Gynecology at the University of Colorado Denver and Health Sciences Center, Denver, CO (b) University of Texas Health Science Center at San Antonio and the Southwest Foundation for Biomedical Research at San Antonio, TX Article History: Received 13 July 2009; Revised 26 February 2010; Accepted 11 May 2010 Article Note: (footnote) Supported by the National Institutes of Health Grants HD21350-17, HDO34837-08, and HL071990., Cite this article as: Arroyo JA, Li C, Schlabritz-Loutsevitch N, et al. Increased placental XIAP and caspase 3 is associated with increased placental apoptosis in a baboon model of maternal nutrient reduction. Am J Obstet Gynecol 2010;203:364.e13-18.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2009.07.031 Byline: Juan A. Arroyo (a), Laura D. Brown (b), Henry L. Galan (a) Keywords: hyperthermia; intrauterine growth restriction; protein S6 kinase 1; mammalian target of rapamycin Abstract: Both phosphorylated (p) mammalian target of rapamycin (mTOR) and protein S6 kinase 1 (p70.sup.S6K) are known to regulate protein synthesis and are affected during intrauterine growth restriction (IUGR). We studied the mTOR pathway during hyperthermia (HT)-induced IUGR in sheep. Author Affiliation: (a) Division of Perinatal Medicine, Department of Obstetrics and Gynecology, University of Colorado Denver and Health Sciences Center, Aurora, CO (b) Division of Perinatal Medicine, Department of Pediatrics, University of Colorado Denver and Health Sciences Center, Aurora, CO Article History: Received 3 March 2009; Revised 13 June 2009; Accepted 14 July 2009 Article Note: (footnote) This study was supported in part by National Institutes of Health Grant HL071990., Cite this article as: Arroyo JA, Brown LD, Galan HL. Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction. Am J Obstet Gynecol 2009;201:616.e1-7.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2008.06.054 Byline: Henry L. Galan (a), Anna Maria Marconi (c), Cinzia L. Paolini (c), Alex Cheung (b), Frederick C. Battaglia (b) Keywords: amino acids; fetus; maternal; nutrition; placenta Abstract: The purpose of this study was to assess the placental transport of the essential amino acids (EAAs) in normal pregnancies. Author Affiliation: (a) Section of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO (b) Division of Perinatal Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO (c) Department of Obstetrics and Gynecology, DMSD San Paolo, University of Milan, Milan, Italy Article History: Received 20 September 2007; Accepted 18 June 2008 Article Note: (footnote) Cite this article as: Galan HL, Marconi AM, Paolini CL, et al. The transplacental transport of essential amino acids in uncomplicated human pregnancies. Am J Obstet Gynecol 2009;200:91.e1-91.e7. , This work was supported by National Institutes of Health Grants 5 R01 HD34837-06 and M01 RR00069, a Grant from l'Oreal Italia Per le Donne e la Scienza, and a Grant from the Association for the Study of Malformations, Milan, Italy.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2007.11.048 Byline: Anita C. Manogura (a), Ozhan Turan (a), Michelle L. Kush (a), Christoph Berg (b), Amarnath Bhide (c), Sifa Turan (a)(d), Dolores Moyano (d), Sarah Bower (d), Kypros H. Nicolaides (d), Henry L. Galan (e), Thomas Muller (f), Baskaran Thilaganathan (c), Ulrich Gembruch (b), Christopher R. Harman (a), Ahmet A. Baschat (a) Keywords: Doppler ultrasound imaging; intrauterine growth restriction; necrotizing enterocolitis Abstract: The purpose of this study was to test the hypothesis that multivessel fetal Doppler imaging provides enhanced prediction of necrotizing enterocolitis (NEC) in preterm placental insufficiency. Author Affiliation: (a) Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD (b) Department of Obstetrics and Prenatal Medicine, Friedrich-Wilhelm University, Bonn, Germany (c) Fetal Medicine Unit, St George's Hospital Medical School, London, UK (d) Harris Birthright Research Centre for Fetal Medicine, Kings College Hospital, London, UK (e) Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, CO (f) Department of Obstetrics and Gynecology, Hanau City Hospital, Hanau, Germany. Article History: Received 18 June 2007; Accepted 26 November 2007 Article Note: (footnote) Cite this article as: Manogura AC, Turan O, Kush ML, et al. Predictors of necrotizing enterocolitis in preterm growth-restricted neonates. Am J Obstet Gynecol 2008;198:638.e1-638.e5.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2007.07.016 Byline: Bradley T. Ziebell (a), Henry L. Galan (a), Russell V. Anthony (b), Timothy R.H. Regnault (b), Thomas A. Parker (b), Juan A. Arroyo (a) Keywords: endothelial nitric oxide synthase; IUGR; ontogeny Abstract: To determine: 1) placental eNOS mRNA concentration across gestation in normal ovine pregnancy and in an ovine model of intrauterine growth restriction (IUGR), and 2) placental eNOS protein concentration in early ovine pregnancy. Author Affiliation: (a) Division of Perinatal Medicine, Department of Obstetrics & Gynecology, University of Colorado at Denver and Health Sciences Center, Denver, CO (b) Division of Perinatal Medicine, Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Denver, CO. Article History: Received 13 March 2007; Revised 20 June 2007; Accepted 16 July 2007 Article Note: (footnote) Supported by grant R01 HL071990-01A1 from the National Institutes of Health., Cite this article as: Ziebell BT, Galan HL, Anthony RV, et al. Ontogeny of endothelial nitric oxide synthase mRNA in an ovine model of fetal and placental growth restriction. Am J Obstet Gynecol 2007;197:420.e1-420.e5.

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VAIL, COLO. -- Cesarean section rates are headed up, up, and away. 'I suspect that the cesarean section rate is probably going to double by the next generation,' Dr. Ronald [...]