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Byline: Just Earth News A 24-year-old Chinese mukbang streamer died during a live broadcast due to overeating, media reports said. The deceased was identified as Pan Xiaoting. During the fatal [...]

Rhythm Pharmaceuticals announced the presentation of the first patient and caregiver reported experiences from qualitative interviews following the completion of a Phase 2 trial that evaluated treatment with setmelanotide in [...]

Results of a new study based on in‐depth interviews with 23 Narcotics Anonymous (NA) attendees in South Africa suggest that treatment and recovery programs should pay closer attention to potentially problematic substitute behaviors in recovery. Nineteen of the 23 participants reported engaging in a substitute behavior, with nicotine the most common replacement substance and binge eating/overeating the most common non‐substance behavior. [ABSTRACT FROM AUTHOR]

2023 NOV 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on proinsulin have been presented. According to news reporting from [...]

A study conducted at Vanderbilt University in Nashville, Tennessee, examined the time-dependent changes in feeding behavior and energy balance associated with weight gain in mice fed high-fat diets. The researchers found that switching mice to obesogenic diets led to transient bouts of hyperphagia (excessive eating) during the first two weeks, followed by persistent caloric hyperphagia. Although energy expenditure increased, it was not enough to offset the increased caloric intake, resulting in a sustained net positive energy balance. The study also found that exercise, specifically running wheel exercise, delayed weight gain in male mice by enhancing satiation and increasing energy expenditure. However, the effects of exercise on satiation were no longer apparent after two weeks, coinciding with weight gain. The researchers concluded that insights into the etiology of obesity can be obtained by investigating changes to satiation and satiety mechanisms during the initial two weeks of high-fat diet exposure. [Extracted from the article]

A study published in Obesity, Fitness & Wellness Week explores the phenomenon of persistent hyperphagia, or increased appetite, following weight loss in mice. The researchers created a model of reduced dietary obesity (ReDO) in male mice with diet-induced obesity (DIO) and restricted their calorie intake until their weight matched that of control mice. They found that the ReDO mice exhibited hyperphagia following calorie restriction, and a persistent form of hyperphagia was observed in mice that were pair-fed for 8 or 28 days. The study suggests that initial weight gain on a high-fat diet may predict the degree of weight regain in mice. Further research is needed to understand the neurobiological basis of persistent hunger following weight loss. Please note that this study has not yet undergone peer review. [Extracted from the article]

Tonix Pharmaceuticals Holding announced that Herbert Harris, M.D., Ph.D., Executive Vice President, Translational Medicine of Tonix Pharmaceuticals, delivered an oral presentation on March 23 at the Rare Disease Innovation and [...]

A recent report from University Hospital Toulouse in France discusses the findings of a study on Prader-Willi Syndrome (PWS). The researchers focused on the role of acylated and unacylated ghrelin levels in the switch from failure to thrive to excessive weight gain and hyperphagia in children with PWS. The study found that the ratio between acylated and unacylated ghrelin (AG/UAG ratio) was lower in the early years of life in children with PWS compared to healthy controls, but started to increase from the age of 3 years. This increase in the AG/UAG ratio coincided with the onset of hyperphagia. The study suggests that longitudinal changes in ghrelin levels may be involved in the underlying mechanisms of the switch in nutritional phases in PWS. [Extracted from the article]

A recent study conducted at Citta della Salute e della Scienza Hospital in Torino, Italy, aimed to evaluate the microbiome characteristics of adult patients with type 1 Short Bowel Syndrome (SBS) and Chronic Intestinal Failure (CIF). The study found that patients with increased stomal output had a greater frequency of Lactobacilli, while hyperphagia was associated with higher concentrations of short-chain fatty acid (SCFA) esters. Additionally, dietary fiber intake was directly correlated with most volatile organic compounds (VOCs). These findings may have implications for clinical practice. [Extracted from the article]

A recent study conducted by researchers at the National University of La Plata in Buenos Aires, Argentina, explored the role of the growth hormone secretagogue receptor (GHSR) in controlling food intake. The study found that GHSR is primarily expressed in a subset of gamma-aminobutyric acid (GABA) neurons in the brain, and that these neurons play a significant role in regulating feeding behavior. The researchers used genetically modified mice to demonstrate that GHSR-expressing GABA neurons are responsible for the compensatory hyperphagia observed during food deprivation. This research provides valuable insights into the mechanisms underlying hyperphagia and may have implications for understanding and treating eating disorders. [Extracted from the article]

A study conducted by researchers at the Department of Musculoskeletal Functional Research and Regeneration examined the effects of exercise and detraining on fat accumulation in various organs. The study used male Otsuka Long-Evans Tokushima Fatty (OLETF) rats and found that exercise between 4 and 12 weeks of age resulted in lower body weight and suppressed fat accumulation in adipose tissue, liver, and brown adipose tissue. However, when exercise was ceased at a young age, the rats experienced extreme obesity with fatty liver and brown adipose tissue whitening due to hyperphagia. The researchers concluded that overeating should be avoided during detraining periods after exercise cessation at a young age. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the neural mechanisms behind the hyperphagia and weight gain induced by antipsychotic drugs, specifically clozapine. The study introduces a new mouse model that replicates overeating caused by clozapine and identifies the molecular pathway involved. The researchers found that clozapine inhibits melanocortin 4 receptor (MC4R) expressing neurons in the hypothalamus, leading to increased food intake. This effect is achieved by enhancing the coupling between MC4R and Kir7.1, an inwardly rectifying potassium channel. The study suggests that targeting this pathway could be a potential therapeutic approach. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

A recent study conducted by Penn State College of Medicine explores the relationship between catatonia and hyperphagia, or excessive eating. The study highlights the importance of identifying and understanding repetitive behaviors, such as eating, in patients with catatonia. The researchers present the case of a 30-year-old male with a history of treatment-resistant depression who exhibited signs of catatonia, including purposeless eating. The patient responded positively to lorazepam treatment. This study sheds light on the potential connection between hyperphagia and catatonia, emphasizing the need for further research in this area. [Extracted from the article]

Sometimes it may seem your child or teen eats all the time. It may seem they are eating lots of snacks between meals or overeating at meals. How do you [...]

The article offers tips to quit anything. Topics discussed include how to avoid excessive sugar by paying attention to when cravings hit; trying to keep plates as diverse as possible rich in protein, veggies, healthy fats and, yes, carbohydrates to feel fuller longer and to stabilize your blood sugar; and how to quit overthinking, and to avoid overeating.

The article focuses on how certain foods and eating habits can lead to symptoms similar to a hangover, even without alcohol consumption. Topics include sensitivities to specific ingredients triggering gastrointestinal symptoms, overeating leading to bloating and discomfort, and the negative impact of excessive salt, sugar, and ultraprocessed foods on overall health and well-being.

The article discusses the role of inflammasomes and inflammation in diseases such as gout, fatty liver disease, and Alzheimer's. The author comments on immune responses, the role of macrophage or white blood cells, and cytokines. Other topics include inflammation as a response to overeating and obesity.

A recent study conducted by the National Institutes of Health (NIH) in Bethesda, Maryland, explored the role of melanocortin 4 receptor (MC4R) mutations in obesity. The researchers found that a specific MC4R mutation, known as MC4RF51L, led to obesity, hyperphagia (excessive eating), and increased linear growth in mice. This mutation affected the MC4R/Gq/11 alpha signaling pathway, which is involved in regulating food intake and growth. The study suggests that targeting this pathway with a biased MC4R agonist could be a potential treatment for obesity with limited side effects. [Extracted from the article]

The document provides information about a clinical trial, NCT06295315, that is investigating the psychological profile of adult patients with Prader-Willi Syndrome (PWS) and the fatigue experienced by their family members. The study aims to examine the psychological well-being, life quality, and psychopathological functioning of individuals with PWS, as well as the psychological distress, well-being, quality of life, and coping strategies of their family members and caregivers. The trial will involve 36 subjects with PWS and their caregivers at the U.O. of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo. The study is currently recruiting participants and is expected to be completed by December 2024. Contact information for those interested in participating is provided. [Extracted from the article]

According to a preprint abstract from biorxiv.org, researchers have studied the time-dependent changes in feeding behavior and energy balance associated with weight gain in mice fed obesogenic diets. The study found that switching mice to obesogenic diets initially led to bouts of hyperphagia (excessive eating), followed by persistent caloric hyperphagia. Although energy expenditure increased, it was not enough to offset the increased caloric intake, resulting in a sustained net positive energy balance. The study also found that running wheel exercise delayed weight gain in male mice fed a high-fat diet by enhancing satiation and increasing energy expenditure, but these effects were no longer apparent after 2 weeks. The researchers suggest that investigating changes to satiation and satiety mechanisms during the initial 2 weeks of high-fat diet exposure can provide insights into the etiology of obesity. [Extracted from the article]

A recent study conducted by researchers at Public Assistance - Paris Hospitals (AP-HP) aimed to explore eating behavior in children with severe, early-onset obesity. The study included 75 children with severe obesity, categorized into three groups based on different etiologies. The researchers used self-administered questionnaires to evaluate eating behavior and found that hyperphagia (excessive eating) and impulsivity were prevalent in the children. The study concluded that the questionnaires can help diagnose hyperphagia in children with early-onset obesity, regardless of the disease's origin, and can aid in targeted management of food access control. [Extracted from the article]

A recent report from Vanderbilt University discusses the development and validation of a new measure called the Prader-Willi syndrome Profile. Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder characterized by various behavioral and emotional problems, including hyperphagia, anxiety, compulsivity, and aggression. The researchers developed a questionnaire consisting of 57 items that tap into these distinctive problems in PWS. The questionnaire was tested on 761 participants and showed good reliability and validity. The Prader-Willi syndrome Profile can be used in future clinical trials to evaluate the impact of treatments on the emotional and behavioral problems associated with PWS. [Extracted from the article]

Protein powders aren't just for boring shakes! These five recipes incorporate them in new and exciting ways When it comes to what we eat, it's best not to overlook protein. [...]

Eating hyper-palatable foods (foods with a certain hard-to-resist combination of fat, salt, sugar and/or carbohydrates) is one of three factors associated with overeating, according to researchers. In the study, 2,733 [...]

Poor nutrition can result from lack of food as well as overeating, since nutrition is about more than simple caloric intake. Proper child development relies on a solid nutritional foundation, [...]

The article discusses the physiological aspects of food addiction, with a focus on highly processed snack and junk foods which are high in carbohydrates. Topics include the theory that the brain responds to high-fat, high-calorie, low-nutrition foods in a way that is similar to the response for addictive substances or drugs; obesity research on the physiological aspects of overeating disorders; and the brain chemistry of food addiction.

New findings from the Eunice Kennedy Shriver National Institute of Child Health and Human Development discuss the associations between subjective and objective socioeconomic status (SSES and OSES) with body composition and eating behavior in children. Low OSES may limit access to healthier foods, while low SSES has been linked to a preference for higher energy foods. The study found that low SSES was associated with greater severity of hyperphagia (excessive eating) only at lower levels of OSES. The researchers suggest that future studies should examine the interaction between SSES and OSES in understanding socioeconomic disparities in children's body composition and eating behaviors. [Extracted from the article]

According to a preprint abstract from biorxiv.org, researchers have studied the time-dependent changes in feeding behavior and energy balance associated with weight gain in mice fed obesogenic diets. The study found that switching mice to obesogenic diets initially led to bouts of hyperphagia (excessive eating), followed by persistent caloric hyperphagia. Although energy expenditure increased, it was not enough to offset the increased caloric intake, resulting in a sustained net positive energy balance. The study also found that running wheel exercise delayed weight gain in male mice fed a high-fat diet by enhancing satiation and increasing energy expenditure, but these effects were no longer apparent after 2 weeks. The researchers suggest that investigating changes to satiation and satiety mechanisms during the initial 2 weeks of high-fat diet exposure can provide insights into the etiology of obesity. Please note that this preprint has not been peer-reviewed. [Extracted from the article]

This document provides information about a clinical trial for the drug carbetocin nasal spray in individuals with Prader-Willi syndrome (PWS). The trial is currently enrolling participants and is expected to be completed by June 2026. The eligibility criteria for participation are outlined, including age, genetic diagnosis, and medical history. The study is being conducted in the United States and is regulated by the U.S. FDA. The responsible party for the trial is ACADIA Pharmaceuticals Inc. The document also includes keywords related to obesity, genetics, and other relevant topics. [Extracted from the article]

Rhythm Pharmaceuticals, a commercial-stage biopharmaceutical company, announced that Great Britain's Medicines & Healthcare Products Regulatory Agency (MHRA) has granted marketing authorisation to Imcivree (setmelanotide) for the treatment of obesity and [...]

This article discusses a study that focuses on the prediction of diabetes in middle-aged adults using machine learning. The study analyzed data from 296 middle-aged adults aged 40 to 60 years, assessing the associations between symptoms and diabetes status and identifying the most efficient machine learning model for predicting diabetes. The results showed significant associations between diabetes status and symptoms such as polyuria, polydipsia, weakness, sudden weight loss, partial paresis, polyphagia, and visual blurring. The Random Forest model demonstrated the highest sensitivity and accuracy, making it the most efficient model for predicting diabetes in middle-aged adults. The study highlights the importance of using diabetes-related symptoms for early detection in this population and suggests further exploration of genetic, lifestyle, and environmental factors to enhance diagnostic accuracy. [Extracted from the article]

The article examines whether seasonal affective disorder (SAD) can be managed with food. Topics discussed include symptoms and causes of SAD, conventional wisdom from the early days of SAD-awareness in the 1990s about people with SAD, and priority for someone with SAD according to dietitian Anafer Barrera.

Eating hyper-palatable foods (foods with a certain hard-to-resist combination of fat, salt, sugar and/or carbohydrates) is one of three factors associated with overeating, according to researchers. In the study, 2,733 [...]

2021 MAR 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on pharmacology have been presented. According to news originating from [...]

The article reports on the obesity scientific model presented in the December 2021 issue of "The American Journal of Clinical Nutrition," which showed that reduced consumption of foods rich in calories and carbohydrates could be beneficial to heart's health. According to Doctor David Ludwig, losing weight by reducing calories is a battle between mind and metabolism. Other topics include how the body respond to processed carbohydrates and the biological mechanisms that promote weight gain.

The article talks about the intuitive eating approach that took from the book "Intuitive Eating: A Revolutionary Programs that Works" by Elyse Resch and Evelyn Tribole to helps stop counting about calories and embracing the pleasure of food. It mentions its focus on to reject the diet mentality; to make peace with food; and to discover the satisfaction factor.

A 64-year-old man with intellectual disability experienced various toxicities and off-label use of medications. He was being treated with risperidone, quetiapine, and levomepromazine for his intellectual disability, as well as off-label treatment with oxcarbazepine for impulsivity. However, he developed stiffness, hyperphagia, and auto-aggressiveness as a result of the treatment. After discontinuing oxcarbazepine, his symptoms rapidly improved and his serum sodium levels returned to normal. [Extracted from the article]

A case report published in Reactions Weekly describes a 2-year-old girl who exhibited lack of efficacy while being treated with metformin for obesity. The girl had rapid weight gain since infancy and presented with global developmental delay, macrocephaly, dysmorphic facial features, and small hands and feet. Despite lifestyle modifications, her hyperphagia and rapid weight gain persisted. Metformin was discontinued due to lack of effect, and the girl was subsequently treated with Topiramate and Lisdexamfetamine, which resulted in some weight gain attenuation and ultimately a decrease in body weight. The medications were well-tolerated with no significant adverse effects. [Extracted from the article]

For more information on this research see: Associations Between Hyperphagia, Symptoms of Sleep Breathing Disorder, Behaviour Difficulties and Caregiver Well-being In Prader-willi Syndrome: a Preliminary Study. Keywords: Perth; Australia; Australia and New Zealand; Chromosome Disorders; Congenital Abnormalities; Health and Medicine; Hyperphagia; Mental Retardation; Nervous System Diseases and Conditions; Neurobehavioral Manifestations; Neurologic Manifestations; Nutrition Disorders; Nutritional and Metabolic Diseases and Conditions; Obesity; Overnutrition; Pediatrics; Prader-Willi Syndrome EN Perth Australia Australia and New Zealand Chromosome Disorders Congenital Abnormalities Health and Medicine Hyperphagia Mental Retardation Nervous System Diseases and Conditions Neurobehavioral Manifestations Neurologic Manifestations Nutrition Disorders Nutritional and Metabolic Diseases and Conditions Obesity Overnutrition Pediatrics Prader-Willi Syndrome 625 625 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- Researchers detail new data in Nutritional and Metabolic Diseases and Conditions - Prader-Willi Syndrome. [Extracted from the article]

Keywords: Bariatrics; Diet and Nutrition; Genetics; Health and Medicine; Hyperphagia; Nutrition Disorders; Nutritional and Metabolic Diseases and Conditions; Obesity; Overnutrition; Risk and Prevention EN Bariatrics Diet and Nutrition Genetics Health and Medicine Hyperphagia Nutrition Disorders Nutritional and Metabolic Diseases and Conditions Obesity Overnutrition Risk and Prevention 1492 1492 1 10/24/23 20231024 NES 231024 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on obesity. According to the news editors, the research concluded: "Gene mutations associated with obesity in patients with a BMI > 40 kg/m2 are common. [Extracted from the article]

Bariatrics, Central Nervous System Diseases and Conditions, Chromosome Disorders, Congenital Abnormalities, Diet and Nutrition, Health and Medicine, Hyperphagia, Movement Disorders, Musculoskeletal Diseases and Conditions, Nutrition Disorders, Nutritional and Metabolic Diseases and Conditions, Obesity, Overnutrition, Pediatrics, Risk and Prevention, Angelman Syndrome Keywords: Angelman Syndrome; Bariatrics; Central Nervous System Diseases and Conditions; Chromosome Disorders; Congenital Abnormalities; Diet and Nutrition; Health and Medicine; Hyperphagia; Movement Disorders; Musculoskeletal Diseases and Conditions; Nutrition Disorders; Nutritional and Metabolic Diseases and Conditions; Obesity; Overnutrition; Pediatrics; Risk and Prevention EN Angelman Syndrome Bariatrics Central Nervous System Diseases and Conditions Chromosome Disorders Congenital Abnormalities Diet and Nutrition Health and Medicine Hyperphagia Movement Disorders Musculoskeletal Diseases and Conditions Nutrition Disorders Nutritional and Metabolic Diseases and Conditions Obesity Overnutrition Pediatrics Risk and Prevention 1373 1373 1 10/09/23 20231014 NES 231014 2023 OCT 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Angelman syndrome are presented in a new report. [Extracted from the article]

2020 NOV 21 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on obesity. According to news originating from the [...]

2020 JUN 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Nutritional and Metabolic Diseases and Conditions - Obesity [...]

Soleno Therapeutics announced top-line results from the company's Phase III trial, DESTINY PWS, evaluating once-daily Diazoxide Choline Controlled Release, or DCCR, tablets for patients with Prader-Willi Syndrome, or PWS. The [...]

2020 MAY 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Nutritional and Metabolic Diseases and Conditions - Prader-Willi Syndrome [...]

2020 MAY 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Nutritional and Metabolic Diseases and Conditions - Obesity are [...]