1. Effects of Lycium barbarumon bacterial translocation in thioacetamide-induced liver injury in rats
- Author
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Bilgic, Y, Harputluoglu, MMM, Kutlu, O, Demirel, U, Gul, M, Otlu, B, Temel, I, Gursoy, S, Dertli, R, Selcuk, EB, Yilmaz, I, and Kilis, T
- Abstract
Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum(LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats.Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarumwas administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum.Results: In our study, Lycium barbarumtreatment did not attenuate liver damage. Lycium barbarumtreatment decreased ileal E. colicounts and intestinal damage but it did not alter BT frequency.Conclusions: In conclusion, the effects of Lycium barbarumon BT may be related to ongoing severe liver damage in this model.
- Published
- 2015
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