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Effects of Lycium barbarumon bacterial translocation in thioacetamide-induced liver injury in rats

Authors :
Bilgic, Y
Harputluoglu, MMM
Kutlu, O
Demirel, U
Gul, M
Otlu, B
Temel, I
Gursoy, S
Dertli, R
Selcuk, EB
Yilmaz, I
Kilis, T
Source :
European Journal of Inflammation; December 2015, Vol. 13 Issue: 3 p154-163, 10p
Publication Year :
2015

Abstract

Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum(LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats.Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarumwas administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum.Results: In our study, Lycium barbarumtreatment did not attenuate liver damage. Lycium barbarumtreatment decreased ileal E. colicounts and intestinal damage but it did not alter BT frequency.Conclusions: In conclusion, the effects of Lycium barbarumon BT may be related to ongoing severe liver damage in this model.

Details

Language :
English
ISSN :
1721727X
Volume :
13
Issue :
3
Database :
Supplemental Index
Journal :
European Journal of Inflammation
Publication Type :
Periodical
Accession number :
ejs42275512
Full Text :
https://doi.org/10.1177/1721727X15618413