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Effects of Lycium barbarumon bacterial translocation in thioacetamide-induced liver injury in rats
- Source :
- European Journal of Inflammation; December 2015, Vol. 13 Issue: 3 p154-163, 10p
- Publication Year :
- 2015
-
Abstract
- Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum(LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats.Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarumwas administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum.Results: In our study, Lycium barbarumtreatment did not attenuate liver damage. Lycium barbarumtreatment decreased ileal E. colicounts and intestinal damage but it did not alter BT frequency.Conclusions: In conclusion, the effects of Lycium barbarumon BT may be related to ongoing severe liver damage in this model.
Details
- Language :
- English
- ISSN :
- 1721727X
- Volume :
- 13
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- European Journal of Inflammation
- Publication Type :
- Periodical
- Accession number :
- ejs42275512
- Full Text :
- https://doi.org/10.1177/1721727X15618413