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If 2016 proves to be the pivotal year for big change in the active lifestyle industry, 2017 will represent the big shake out. That's the sentiment from more than 20 [...]

No one ever said retailing was easy. Despite an improving economy, active-lifestyle retail sales gains, and continued strength of the athleisure trend in fashion, numerous industry retailers began to falter [...]

Customers and elite athletes are going harder, faster, longer and stronger. This boost in activity has cleared the way for the recovery category to blossom, as more users visit retailers [...]

In November 2016... The thermometer read 70 degrees throughout much of the country. Retailers were hawking fleeces, puffies and winter boots. Vendors were taking next winter's orders before the first [...]

Camping isn't just for campsites anymore. 'The outdoor industry is trying to come to grips with the other ways people camp and use the equipment,' said Eureka Product Manager Paul [...]

Retail point-of-sale (POS) systems, which long ago made a big leap beyond the cash register, are again evolving to the next level. The latest technologies in the space not only [...]

Cell death and inflammation are closely linked arms of the innate immune response to combat infection and tissue malfunction. Recent advancements in our understanding of the intricate signals originating from dying cells have revealed that cell death serves as more than just an end point. It facilitates the exchange of information between the dying cell and cells of the tissue microenvironment, particularly immune cells, alerting and recruiting them to the site of disturbance. Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is emerging as a critical stress sentinel that functions as a molecular switch, governing cellular survival, inflammatory responses and immunogenic cell death signalling. Its tight regulation involves multiple layers of post-translational modifications. In this Review, we discuss the molecular mechanisms that regulate RIPK1 to maintain homeostasis and cellular survival in healthy cells, yet drive cell death in a context-dependent manner. We address how RIPK1 mutations or aberrant regulation is associated with inflammatory and autoimmune disorders and cancer. Moreover, we tease apart what is known about catalytic and non-catalytic roles of RIPK1 and discuss the successes and pitfalls of current strategies that aim to target RIPK1 in the clinic.

Wintersport goggle brands are beginning to pull back from some of the category's recent big trends--such as oversized lenses and integrated electronics--as consumers lean toward simpler models that bring performance [...]

[ILLUSTRATION OMITTED] [ILLUSTRATION OMITTED] Going back to his days at baselayer brands Duofold and I/O Bio, Robert Bernthal always thought the wool supply chain was 'clumsy and volatile.' The natural [...]

* Potential liabilities for promoters of tax exploitation schemes and implementers of schemes that are materially different to a product ruling * How ordinary tax advisers and in-house tax advisers [...]

The Asthma Impairment and Risk Questionnaire (AIRQ®) is a composite control assessment. Scores of 0-1 indicate well-controlled (WC), 2-4 not well-controlled (NWC), and 5-10 very poorly controlled (VPC) asthma. Asthma Checklist is a tool to facilitate implementation of guideline and expert report recommendations. We assessed the impact of implementing AIRQ and Asthma Checklist with patients in a coaching program provided by certified asthma educators (AE-C).

The article evaluates the architectural design of Gymnasium Wandsworth located in Hackney that was designed by Holland Harvey architectual firm.

Upcoming changes to the nation's overtime-pay rules have many businesses rushing to adjust pay structures and policies ahead of the rules going into effect December 1, 2016. Beyond the larger [...]

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Introduction Accurate, widely based morbidity data from general practice would be of great value in many kinds of epidemiological or health services research. In research on prescribing they would make [...]

Australia's coal mines are essential to steelmaking operations and electricity producers worldwide. It's a field where surveyors are in high demand--the collection and processing of survey data are crucial both [...]

Some of the nation's top clean energy entrepreneurs will gather Oct. 19-21 in Denver to pitch their business concepts at the National Renewable Energy Laboratory's 23rd Industry Growth Forum. The [...]

The influences of processing parameters and tool feature on the microstructure of AA1100 and AA3003 aluminium alloys were investigated using bobbin friction stir welding (BFSW). The research includes flow visualization and microstructural evolution of the weld texture using the metallographic measurement method. Results indicated that the operational parameters of the welding (e.g. feed rate, rotating speed) and the geometry of the tool can directly affect the flow patterns of the weld structure. The microscopic details revealed by the optical and electron microscope imply the dynamic recrystallization including grain refinement and precipitation mechanisms within the stirring zone of the weld region. The microscopic observations for the weld samples show a better performance of the fully-featured tool (tri-flat threaded pin and scrolled shoulders) compared to the simple tool without inscribed surface features. The fully-featured tool resulted in a more uniform thermomechanical plastic deformation within the weld structure along with the precipitation hardening and the homogeneity of the microstructure.

A variety of tool shoulder designs comprising three families i.e. blade, spiral and circular shaped scrolls, were produced to improve the material flow and restrictions to avoid the tunnel void. The bobbin tools were manufactured by 3D printing additive manufacturing technology using solid filament. The butt weld joint was produced by each tool using plasticine as the workpiece material. The apparent surface features and bi-colour cross-sections provided a physical flow comparison among the shoulder designs. For the bobbin friction stir welding (BFSW), the tool shoulder with a three-spiral design produced the most stability with the best combination of the flow patterns on surface and cross-sections. The circular family tools showed a suitable intermixing on the surface pattern, while the blade scrolls showed better flow features within the cross-sections. The flow-driven effect of the shoulder features of the bobbin-tool design (inscribed grooves) was replicated by the 3D-printed tools and the analogue modelling of the weld samples. Similar flow patterns were achieved by dissimilar aluminium-copper weld, validating the accuracy of the analogue plasticine for the flow visualization of the bobbin friction stir welding.

As performance apparel brands rush to gain authenticity with coveted millennial consumers, many are eyeing natural fabrics as a way to exude the category's traditional roots. Wool, which is often [...]

Armed with a smart phone and weather app, today's consumer is ready for what Mother Nature serves up... down to the minute. That information, in conjunction with real-time traffic reports, [...]

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Electron Backscatter Diffraction (EBSD) was used to determine microstructural evolution in AA6082-T6 welds processed by the Bobbin Friction Stir Welding (BFSW). This revealed details of grain-boundaries in different regions of the weld microstructure. Different polycrystalline transformations were observed through the weld texture. The Stirring Zone (SZ) underwent severe grain fragmentation and a uniform Dynamic Recrystallisation (DRX). The transition region experienced stored strain which changed the grain size and morphology via sub-grain-boundary transformations. Other observations were of micro-cracks, the presence of oxidization, and the presence of strain hardening associated with precipitates. Flow-arms in welds are caused by DRX processes including shear, and low and high angle grain boundaries. Welding variables affect internal flow which affects microstructural integrity. The shear deformation induced by the pin causes a non-uniform thermal and strain gradient across the weld region, leading to formation of mixed state transformation of grain morphologies through the polycrystalline structure. The grain boundary mapping represents the differences in DRX mechanism I different regions of the weld, elucidates by the consequences of the thermomechanical nature of the weld. The EBSD micrographs indicated that the localised stored strain at the boundary regions of the weld (e.g. flow-arms) has a more distinct effect in emergence of thermomechanical nonuniformities within the DRX microstructure.

The purpose of this study is to elucidate the flow features of the dissimilar Al-Cu welded plates. The welding method used is Bobbin Friction Stir Welding (BFSW), and the joint is between two dissimilar materials, aluminium alloy (AA6082-T6) and pure copper. Weld samples were cut from along the weld line, and the cross-sections were polished and observed under an optical microscope (OM). Particular regions of interest were examined under a scanning electron microscope (SEM) and analysed with Energy Dispersive X-ray Spectroscopy (EDS) using the AZtec software from Oxford Instruments. The results and images attained were compared to other similar studies. The reason for fracture was mainly attributed to the welding parameters used; a higher rotational speed may be required to achieve a successful BFSW between these two materials. The impact of welding parameters on the Al-Cu flow bonding and evolution of the intermetallic compounds were identified by studying the interfacial microstructure at the location of the tool action. The work makes an original contribution to identifying the solid-phase hybrid bonding in Al-Cu joints to improve the understanding of the flow behaviours during the BFSW welding process. The microstructural evolution of the dissimilar weld has made it possible to develop a physical model proposed for the flow failure mechanism.

The flow-inducing effect of the bobbin-tool features (tri-flat pin and scrolled shoulder) were replicated by a simple analogue model for aluminium welds by layered plasticine samples. Flow patterns of the weld zone were clarified by a typical stereomicroscopy instrument assisted by dark-field/bright-field illumination. The effects of the pin features, specifically threads and flats in centre of bond zone and scrolled shoulder in sides of stirred zone, were identified. This study shows that internal flow features for BFSW welds is transferable from the friction stir welding process to the functional metal forming processes such where the shearing can extensively affect the microstructure. The similarity between the flow pattern of the provided aluminium samples and the plasticine analogue can validate the accuracy of the flow model presented in this work.

Currently in wintersport helmets, everyone is talking NFL football ... even our European friends. No, don't expect to see Smith, K2 and POC Sports outfitting the Pittsburgh Steelers or Arizona [...]

To quantify the childhood infectious disease burden and antibiotic use in the Northern Territory’s East Arnhem region through synthesis and analysis of historical data resources.

A new year always means new resolutions, and at most businesses, it also means new budgets and strategic planning. You know the drill: revenue, costs, profit--what's the bottomline? But within [...]

Warmer-than-normal weather put a dent in outdoor sales for fall and early winter 2015 at retail--largely due to a drop in outwear sales--but a curious bright spot came in footwear, [...]

Aim:Hepcidin levels are suppressed during human and murine pregnancy. It is unknown whether hepcidin levels are primarily the result of iron deficiency/utilisation or whether there is a pregnancy-specific mechanism for hepcidin suppression. We reasoned that Tmprss6inhibition would cause constitutive BMP-SMAD signalling and help determine the mechanism of antenatal hepcidin suppression.

Buckling Restrained Braces (BRB’s) have become common in seismic frames in earthquake areas. If a BRB performs as desired the steel core may yield but it is not easy to know the degree of yielding, or how much of the BRB earthquake life has been used up. To determine whether such a brace should remain as is, or whether it needs to be replaced, an inexpensive and simple measuring device that reports the deformations undergone is required. This paper discusses a study undertaken to develop such a device. Firstly, a literature study was undertaken and candidate devices were selected. Using Subjective Quantitative Analysis (SQA) and specific performance objectives the most appropriate of these was chosen. This device was then constructed and tested in a controlled environment. This mechanical device performed well through various stimulated earthquake cycles and events, is cheap, simple to install, and small. It provides cumulative and maximum displacement estimations and will be beneficial to the industry in post-event decision making.

In this article, I discuss the situation of trans people within the Church of England. I outline instances of legal and institutional discrimination in the following situations: the Equality Act 2010 in the context of employment, promotion and training; trans candidates for ordination; and marriage involving (a) trans person(s). I discuss some theology relating to this discrimination. I explain the impact of disadvantage and discrimination for minority groups with reference to minority stress, and clarify the microaggressive messages contained in differential institutional treatment for trans people. I suggest that the harm done by Church discrimination against trans people is real and significant, and ought to be recognised and addressed.

The usage of well-known architects as a way of marketing buildings is examined in detail. There are both benefits and drawbacks to using such architects.