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Tmprss6siRNA Treatment in Mice Stops Hepcidin Reduction across Pregnancy
- Source :
- Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p2471-2471, 1p
- Publication Year :
- 2023
-
Abstract
- Aim:Hepcidin levels are suppressed during human and murine pregnancy. It is unknown whether hepcidin levels are primarily the result of iron deficiency/utilisation or whether there is a pregnancy-specific mechanism for hepcidin suppression. We reasoned that Tmprss6inhibition would cause constitutive BMP-SMAD signalling and help determine the mechanism of antenatal hepcidin suppression.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 142
- Issue :
- 1, Number 1 Supplement 1
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs64700717
- Full Text :
- https://doi.org/10.1182/blood-2023-191263