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The human brain has its own microbiome, consisting of bacteria, viruses, and fungi, which has the potential to reverse symptoms of neurodegenerative diseases like dementia. Research has shown that certain pathogens, such as the herpes simplex virus and bacteria associated with gum disease, are prevalent in the brains of people with dementia. The brain's microbiome may play a role in other neurological conditions as well, such as Parkinson's disease. Potential treatments include antiviral medications and vaccines, which have shown promise in reducing the risk of developing dementia. However, there is still much to learn about the brain's microbiome and its impact on health. [Extracted from the article]

A quiz concerning the topics from the Monthly Test Drive: Series 5 on Strategies for Enhancement in Food Production and Microbes in Human Welfare, including questions related to natural insecticides, triticale hybridization, microbial products, and more.

Ten novel meroterpenoids, dryoptins/11″- epi -dryoptins A~E (1 ~ 10) with an unprecedented skeleton consisting of dimeric or trimeric acylphloroglucinols and dehydrotheonelline, two undescribed acylphloroglucinol-nerolidol meroterpenoids (11 ~ 12), and ten known acylphloroglucinol derivatives (13 ~ 22), were isolated from D. crassirhizoma. The novel structures including absolute configurations were established by comprehensive spectroscopic analyses and quantum chemical electronic circular dichroism (ECD) calculations. A biosynthetic pathway of 1 ~ 10 was assumed. The trimeric acylphloroglucinol meroterpenoids 7 / 8 showed significant antifungal activity against standard Candida albicans with a MIC50 value of 1.61 µg/mL [fluconazole (FLC): 3.41 µg/mL], and when combined with FLC, the principal components 20 and 21 exhibited strong antifungal activities against FLC-resistant C. albicans with MIC50 values of 8.39 and 7.16 µg/mL (FLC: > 100 µg/mL), respectively. Moreover, compounds 2, 5 / 6, 18, 19 , and 21 exhibited inhibitory effects against several pathogenic fungi and bacteria, with MIC50 values of 6.25 ~ 50 µg/mL. [ABSTRACT FROM AUTHOR]

Researchers at Nankai University in China have developed a new nanoplatform, MSNP-EAP1Ab, to target Candida albicans, a fungus that causes life-threatening systemic infections. This platform, composed of mesoporous silica nanoparticles grafted with antibodies, showed promising results in inhibiting fungal immune escape and enhancing phagocytosis by immune cells. The study suggests that this innovative approach could be effective in combating systemic fungal infections, particularly in immunocompromised individuals. [Extracted from the article]

A recent study published in the journal Sexually Transmitted Infections suggests that a change in policy may be contributing to the rise in treatment-resistant vaginal thrush. The study found an increase in non-albicans Candida species and fluconazole-resistant C albicans between 2018 and 2021. Researchers noted that the shift towards empirical treatment based on symptoms alone, rather than confirmatory lab tests, may be a factor in the rise of resistant infections. This trend raises concerns about the challenges in treating these infections effectively, as some strains show reduced sensitivity to multiple antifungal medications. [Extracted from the article]

Researchers at the University of Tennessee have discovered that the protein encoded by the uncharacterized gene C1_01140C, and not the previously annotated C. albicans Gac1p, plays a major role in regulating glycogen synthesis in Candida albicans. This finding sheds light on the molecular events driving synthase activation in the human fungal pathogen. The study, funded by various organizations including the National Institutes of Health, highlights the importance of C1_01140Cp as the functional ortholog of the PPP1R subunit ScGac1p in C. albicans. [Extracted from the article]

This article discusses a study on the oral microbiome in severe early childhood caries (S-ECC). The study examined the bacterial-fungal dynamics in 61 children aged 3-4 years with S-ECC and evaluated environmental factors such as saliva pH, buffering capacity, and trace elements. The findings revealed significant shifts in bacterial diversity in S-ECC saliva samples, with increased abundance of cariogenic species like Streptococcus mutans. Candida albicans was also found to be more prevalent in the S-ECC group. The study highlights the complex interactions between bacteria and fungi in S-ECC and suggests potential microbial taxa associated with reduced saliva pH. [Extracted from the article]

A recent study conducted at Zarqa University in Jordan examined the genotypes and antifungal susceptibility of Candida albicans strains isolated from women with vaginal candidiasis (VC). The study analyzed 312 isolates of candida species recovered from women with VC and found that C. albicans was the most dominant species causing VC in the studied population. The genotypic analysis revealed three different subtypes of C. albicans at the 25S rDNA gene and nine distinct subtypes based on the RPS region. The study also found variations in the susceptibility of different genotypes to antifungal drugs, with genotype A being more susceptible to certain drugs. This research provides valuable insights into the genetic diversity and antifungal susceptibility of C. albicans strains causing VC in Jordanian women. [Extracted from the article]

A recent study conducted by researchers from the Medical University of Lublin in Poland highlights the challenges posed by fungal infections in pediatric patients with acute lymphoblastic leukemia (ALL). Despite the use of antifungal prophylaxis, these infections still contribute to approximately 20% of cases in children undergoing treatment for ALL. The study presents a case report of a 5-year-old pediatric patient who developed Candida albicans and Aspergillus spp. infections during the consolidation phase of ALL treatment. The researchers emphasize the importance of accurate diagnosis and prompt initiation of targeted therapy in managing these infections in leukemia patients. [Extracted from the article]

A recent study conducted at Prince of Songkla University in Thailand explored the aggregation and adhesion abilities of various probiotic strains and Candida species in relation to oral health. The study found that certain probiotic strains, such as Lacticaseibacillus rhamnosus SD4, Limosilactobacillus fermentum SD7, and L. rhamnosus SD11, exhibited high adhesion to human oral keratinocytes and showed potential in preventing and treating oral candidiasis. The research also revealed that the adhesion abilities of probiotics were strongly related to their autoaggregation, cell surface charges, and hydrophobicity. The findings suggest that oral probiotics may be beneficial in inhibiting Candida adhesion and infection progression. [Extracted from the article]

A recent study conducted at Rivers State University Teaching Hospital in Nigeria examined the prevalence and antifungal susceptibility of Candida species in patients. Candida species are responsible for a range of human infections known as Candidiasis, and non-albicans Candida species have become significant opportunistic pathogens. The study found that out of 206 clinical specimens, 44 isolates (21.4%) were identified, with the majority coming from high vaginal swabs. The most prevalent Candida species was Candida albicans, and the study also highlighted the increasing prevalence of non-albicans Candida species and the growing resistance of Candida isolates to commonly used antifungal drugs. The researchers emphasized the importance of accurate diagnosis and sensitivity testing for effective treatment, particularly for hospitalized patients with severe underlying illnesses. [Extracted from the article]

A recent study conducted by researchers at the London School of Hygiene and Tropical Medicine focused on understanding the host response to infection by opportunistic fungal pathogens, including Cryptococcus neoformans, Cryptococcus gattii, and Candida albicans. The researchers captured the transcriptional signature of immune cells from South African volunteers when exposed to these fungal infections. They found that the transcriptional response to cryptococcal stimuli was lower compared to Candida albicans, and unique expression signatures were observed for all three fungal stimuli. This research provides a starting point for further studies to identify biomarkers of disease severity and potential treatment targets for cryptococcal disease. [Extracted from the article]

Researchers from Sidi Mohamed Ben Abdellah University in Fez, Morocco have conducted a study on the antifungal properties of Streptomyces sp. DS104 against Candida albicans, a fungus that causes infections. The researchers isolated bioactive fractions from the strain and found that they exhibited high inhibition against C. albicans. The fractions contained various compounds, including carboxylic acids and pyrrolopyrazine derivatives, some of which had not been previously detected in the Streptomyces genus. The study suggests that Streptomyces sp. DS104 has potential as a candidate for the development of antifungal drugs. [Extracted from the article]

A recent study conducted by researchers at University Vale Paraiba UNIVAP in Sao Jose dos Campos, Brazil, has found that Organoselenium Compounds (OCs) have the potential to inhibit the development of dual-species biofilms of Candida albicans and Candida krusei. These biofilms are known to contribute to antimicrobial resistance and are a significant factor in infections caused by non-albicans Candida species. The study demonstrated that OCs, particularly (p-MeOPhSe)(2), were able to reduce the metabolic activity and cell number of these biofilms. This research highlights the potential of OCs as effective antifungal drugs and the need for the development of new treatments for fungal infections. [Extracted from the article]

Researchers from Emory University School of Medicine have conducted a study on Candida albicans, an opportunistic fungal pathogen that causes life-threatening infections in immunocompromised patients. The study focused on the impact of sinefungin, a natural nucleoside analog of S-adenosyl methionine, on the virulence of C. albicans. The researchers found that sinefungin impairs various pathogenic traits of C. albicans, including hyphal morphogenesis, biofilm formation, adhesion to epithelial cells, and virulence towards Galleria mellonella. The study suggests that sinefungin could be a potential avenue for therapeutic intervention against C. albicans. Further exploration of post-transcriptional control mechanisms of pathogenicity is recommended for antifungal design. [Extracted from the article]

Researchers from Poltava, Ukraine have conducted a study to identify antifungal drugs that are effective against Candida albicans, a fungus that causes inflammatory diseases of the soft tissues. The study analyzed 17 clinical isolates of Candida albicans and tested their susceptibility to various antifungal drugs. The results showed that fluconazole had the lowest efficacy, while amphotericin B, itraconazole, micafungin, and posaconazole showed better results. Cluster analysis revealed that amphotericin B and posaconazole were the most effective against Candida albicans isolates. This research highlights the importance of monitoring resistance and selecting appropriate antifungal treatments for fungal infections. [Extracted from the article]

Researchers from Oles Honchar Dnipro National University in Ukraine have developed a new method for synthesizing dihydropyrimidinones/thiones/selenones, which are compounds with potential therapeutic applications. The reaction proceeds with high selectivity and yields up to 95%. The researchers also demonstrated the versatility of the synthesized compounds by using them to synthesize other important organic molecules. In addition, in silico assessment suggests that these compounds have favorable drug-like properties. The compounds also showed promising activity against various pathogens and diseases, including Candida albicans, Alphis gossypii, Tripomastigote Chagas, Tcruzi amastigota, Tcruzi epimastigota, Leishmania amazonensis, and Dengue larvicida. [Extracted from the article]

The article focuses on examining the clinical characteristics, risk factors, and outcomes of Candida albicans infections in the bloodstream and lower respiratory tract. Topics include the comparative analysis of infection types, the impact of underlying conditions like hematologic malignancy and cerebrovascular accidents on mortality, and the significance of timely intervention in managing Candida infections.

Researchers from the University of Bucharest conducted a study to identify resistance and virulence markers in Candida spp. strains isolated from community-acquired infections in Bucharest outpatients in 2021. The study utilized phenotypic and molecular methods to analyze the strains and also investigated the efficacy of alternative solutions using silver nanoparticles (AgNPs) against them. The results showed that the Candida strains had a moderate-to-high potential to produce virulence markers, highlighting the need for surveillance measures to prevent severe invasive infections. The research was funded by the Romanian Executive Agency For Higher Education, Research, Development, And Innovation. [Extracted from the article]

Researchers from the State University of New York (SUNY) Buffalo have made advances in understanding Candida albicans, a fungus that can cause oral and systemic candidiasis. The researchers focused on two enzymes, Dfg5 and Dcw1, which are involved in cell wall integrity and pathogenesis. They found that mutations in these enzymes affected chitin synthesis, hyphal morphogenesis, and the ability of C. albicans to cause oral candidiasis in mice. The study suggests that Dfg5 and Dcw1 could be potential targets for new antifungal drugs. [Extracted from the article]

A report from the University of California Davis discusses research findings on Candida albicans, a fungal infection. The study found that antibiotic treatment promotes the growth of C. albicans in the intestines, but the mechanisms behind this are not fully understood. The researchers discovered that oxygen is necessary for the expansion of C. albicans after antibiotic treatment. They also found that limited access to oxygen helps maintain resistance against C. albicans colonization. The study suggests that oxygen may play a crucial role in preventing fungal infections. [Extracted from the article]

A recent study conducted by researchers at the Swiss Federal Institute of Technology Lausanne (EPFL) has found that the combination of undecylenic acid (UDA) and farnesol (FAR) can effectively prevent the formation of Candida albicans biofilm on dentures made of poly(methyl methacrylate) (PMMA). This is significant because C. albicans biofilm is highly resistant to antifungal drugs. The researchers modified PMMA with UDA and FAR to create antifungal composites, and their experiments showed a reduction in biofilm formation on dentures. This study suggests that the modified PMMA could be a promising strategy for combating Candida infections. [Extracted from the article]

A recent research report from the University of Belgrade in Serbia explores the antimicrobial activity of newly synthesized nicotinamides against Candida albicans, a drug-resistant pathogen. The study investigates the structure and antibacterial and antifungal properties of seven nicotinic acid hydrazides. The results show that Pseudomonas aeruginosa was the most susceptible to the compounds, while Candida albicans was the least susceptible. One compound, NC 4, completely inhibited the growth of Candida albicans, suggesting potential for enhancing or restoring the activity of established antibiotics. [Extracted from the article]

The article focuses on a clinical trial comparing the efficacy of intralesional Triamcinolone versus Candida albicans antigen in treating alopecia areata. Topics include evaluating the effectiveness of both treatments; assessing clinical and trichoscopic responses; and monitoring adverse effects in patients with less than fifty scalp involvement.

A preprint abstract from biorxiv.org discusses the relationship between Candida albicans, a fungus commonly found in the human gut, and the host's regulation of colonization in the gut. The study found that the genes Duox2 and Duoxa2, which encode dual NADPH oxidase activity, are upregulated in response to C. albicans and that this induction requires the yeast-hyphal transition and the toxin candidalysin. The study also found that hosts lacking the IL-17 receptor failed to upregulate these genes, and that mice lacking intestinal DUOX2 activity had reduced fungal colonization and increased hyphal cells in the gut. The study highlights the complex interplay between fungal cells, candidalysin toxin, and the host IL-17-DUOX2 axis in regulating C. albicans colonization in the gut. [Extracted from the article]

A recent study conducted at the Medical University in Varna, Bulgaria, has investigated the synergistic activity of essential oils from oregano and thyme with antifungal drugs against Candida albicans. Candida albicans is a common fungal pathogen that can cause infections in healthy individuals and is considered a critical priority by the World Health Organization. The study found that the combination of thyme essential oil and nystatin showed the most powerful antifungal action, while oregano oil alone also significantly reduced the density of the microbial population. Further research is needed to explore the potential of these essential oils as anticandidal agents. [Extracted from the article]

A report from Istanbul University-Cerrahpasa in Turkey discusses the rise of Candida parapsilosis, a fungal infection, in pediatric patients. The study found that C. parapsilosis was the most common species isolated, followed by Candida albicans. Non-albicans Candida species showed higher resistance to antifungal drugs compared to C. albicans. The study highlights the prevalence of C. parapsilosis in younger children, possibly due to the use of total parenteral nutrition and central venous catheters. The research emphasizes the need to address the significant antifungal resistance observed in C. parapsilosis. [Extracted from the article]

A recent report discusses the potential of probiotic-based antifungal drugs in treating severe biofilm-associated infections caused by the fungus Candida albicans. Candidiasis, a potentially fatal systemic fungal disease, primarily affects the skin and mucous membranes. Conventional medications have become less effective in treating candidiasis, leading researchers to explore innovative approaches. The study highlights the biotherapeutic potential of the probiotic yeast Saccharomyces boulardii in inhibiting the growth and development of Candida biofilms. The research emphasizes the health benefits of probiotics on human health and suggests that probiotic-based treatments could be a promising avenue for managing Candidiasis. [Extracted from the article]

Researchers at Udayana University have published a new study on Candida albicans, a fungus that causes candidiasis. The study focuses on the potential of lactic acid bacteria (LAB) to control candidiasis infection in humans. The researchers isolated LAB from sources such as kimchi, honey, and vaginal secretions, and tested their ability to inhibit the growth of C. albicans. They found that 46 out of over 100 LAB isolates significantly inhibited the growth of C. albicans, and all showed resistance to the antifungal agent fluconazole. The most promising isolates were closely related to three LAB species: Lactobacillus paracasei, Lacticaseibacillus paracasei, and Pediococcus pentosaceus. This research suggests that LAB could be used as a novel alternative method to reduce the use of antifungal agents in the treatment of candidiasis. [Extracted from the article]

A recent study conducted at Harbin Medical University in China examined the antifungal susceptibility of Candida species isolated from pregnant women in Yemen. The study found that Candida albicans was the most common species, followed by Candida krusei, Candida Tropicalis, Candida Grabata, and Candida dubliniensis. The highest rate of Candida infections was observed among women aged 24-30 years, those who had finished primary school, and those in the third trimester of pregnancy. The study also found varying levels of resistance to different antifungal drugs among the Candida isolates. The researchers recommend health education interventions to increase awareness of vaginitis and its prevention, as well as individualized antifungal susceptibility testing to determine the most effective treatment for each patient. [Extracted from the article]

A recent preprint abstract discusses the genetic variation and migration patterns of yeast populations in recurrent vulvovaginal candidiasis (RVVC). The study found that while most infections of vulvovaginal candidiasis can be successfully treated with antifungal drugs, approximately 8% of cases lead to chronic RVVC, with half of these cases being idiopathic. The researchers isolated yeast samples from the vaginal and rectal areas of four individuals with a history of RVVC and conducted whole-genome sequencing and phenotyping. The study revealed frequent migration between sites and found that the genetic diversity of the yeast populations was largely driven by single nucleotide changes. The study emphasizes the need for comparable studies to understand the factors shaping fungal microbial communities in this context. [Extracted from the article]

A recent study conducted by researchers at the University of Brasilia focused on the effectiveness of combining the antifungal peptide ToAP2 with fluconazole in treating Candida albicans biofilms. Candida albicans is a fungus that can cause invasive candidiasis, a life-threatening disease commonly associated with hospitalization. The study found that the combination of ToAP2 and fluconazole demonstrated a synergistic effect in reducing the viability of C. albicans biofilms on various materials, such as 96-well plates and medical devices. The researchers also observed structural changes in the biofilms and changes in gene expression associated with membrane synthesis and efflux pumps. The findings suggest that this combination treatment has therapeutic potential and could be used to develop preventive tools for intravenous catheters. [Extracted from the article]

Researchers from the University of Nigeria have conducted a study on the antifungal properties of the methanol extract of Artemisia annua (A. annua) on Candida albicans isolates collected from three hospitals in Enugu State, Nigeria. The study found that the extract of A. annua had better antifungal activity against resistant C. albicans isolates compared to azole drugs. The researchers also genotypically characterized the resistant C. albicans species. This study provides valuable insights into potential alternative treatments for fungal infections caused by C. albicans. [Extracted from the article]

Researchers from the Universidade Federal do Para in Brazil have conducted a review of candidiasis in Choloepus sp., specifically focusing on the etiology, epidemiology, pathogenesis, clinical manifestations, diagnosis, treatment, and prevention strategies of the disease. The review highlights Candida albicans as the most commonly implicated species in candidiasis and discusses the prevalence of the infection in wild and captive Choloepus populations. The article also explores diagnostic methods, treatment options, and emphasizes the importance of maintaining optimal husbandry practices and regular health monitoring to reduce the incidence and impact of candidiasis in Choloepus populations. Further research is needed to enhance understanding and improve health outcomes for these animals. [Extracted from the article]

A 52-year-old man developed severe sepsis, Candida peritonitis, extranodal natural killer/T-cell lymphoma (ENKTL), and Epstein Barr virus (EBV) infection reactivation during treatment for peripheral T-cell lymphoma. Despite treatment with micafungin for the Candida peritonitis, the patient did not show improvement. He experienced multiple organ failure and was treated in the ICU, but ultimately passed away due to multiple organ failure. The complications were attributed to the medications used for the lymphoma treatment. [Extracted from the article]

A recent study conducted at Kwame Nkrumah University of Science and Technology in Ghana investigated the risk factors associated with vulvovaginal candidiasis (VVI) and the antifungal resistance patterns of Candida albicans isolates. The study found that vaginal infections were most prevalent among women in their reproductive age, and there was a significant association between VVI and risk factors such as sexual practices, antibiotic misuse, poor personal hygiene, and birth control methods. Out of the samples collected, 58% were identified as C. albicans, and these isolates showed resistance to various antifungal agents. The researchers recommend nationwide education on the risk factors of VVI and the use of antifungal agents after susceptibility testing. [Extracted from the article]

A recent study conducted at Anhui University of Chinese Medicine in the People's Republic of China explored the protective mechanism of Sodium houttuyfonate (SH) in ameliorating colitis exacerbated by Candida albicans. The researchers found that SH treatment improved the expression of certain microRNAs (miRNAs) and reduced inflammatory response and fungal burden in a colitis model with C. albicans infection. The study concluded that SH can alleviate the severity of colitis aggravated by C. albicans through the Dectin-1/NF-kappa B/miR-32-5p/NFKBIZ axis. This research provides insights into potential therapeutic strategies for colonic diseases and conditions. [Extracted from the article]

A 71-year-old woman with Adult Still's disease developed multiple infections, including Nocardia kroppenstedtii bacteremic pneumonia and empyema, Pneumocystis jirovecii, cytomegalovirus, Klebsiella pneumoniae, Epstein-Barr virus, and Candida albicans, while being treated with various medications. The woman initially responded well to methylprednisolone and dexamethasone, but later experienced a relapse of symptoms. She was subsequently treated with ciclosporin and tocilizumab, but her condition worsened, leading to respiratory failure and death. Despite receiving multiple antibiotics, her infections did not respond to treatment. [Extracted from the article]

An 81-year-old man with a history of recurrent adenocarcinoma of the gastroesophageal junction (GEJ) was treated with fluconazole for candida empyema. However, the treatment was not effective, and the patient experienced complications including right chest and abdominal pain, tachycardia, hypotension, and pleural effusion. Despite switching antibiotics and undergoing various procedures, the patient's condition worsened, leading to hematemesis, stupor, and hypotension. Ultimately, the patient died from candida empyema, indicating a lack of efficacy of fluconazole. [Extracted from the article]

A recent study conducted by researchers at the University of Iowa explores the role of protein kinases in the pathobiology of the fungus Candida albicans. Protein kinases are important regulatory proteins in both prokaryotes and eukaryotes and are potential drug targets for various human diseases. The researchers constructed a library of protein kinase mutants and studied their competitive fitness under different growth and stress conditions. They also investigated the mutants' impact on filamentation and biofilm formation, two critical virulence traits of C. albicans. The study highlights the environmentally contingent function of C. albicans protein kinases and provides a valuable genetic resource for future research. [Extracted from the article]

A recent study conducted at Kunming Medical University in Yunnan, China, explored the mechanism of vaginal epithelial cell pyroptosis induced by the Nlrp3 inflammasome in vulvovaginal candidiasis (VVC). VVC is a common mucosal fungal infection caused by Candida albicans. The study found that the WT C. albicans strain induced pyroptosis in vaginal epithelial cells, as indicated by the release of proinflammatory cytokines and the upregulation of pyroptosis-related proteins. However, the use of MCC950, a specific NLRP3 inhibitor, reversed these changes and reduced vaginal epithelial cell pyroptosis and the release of inflammatory cytokines. This research provides insights into the underlying mechanism of VVC and potential therapeutic targets for its treatment. [Extracted from the article]

Researchers from Griffith University in Australia have developed a wearable and discreet colorimetric platform for the detection of Candida albicans, a fungus that can cause infections in certain biological conditions. The platform, which can be adhered to existing feminine hygiene pads, is rapid, inexpensive, user-friendly, and disposable. It utilizes gold nanoparticles and thiolated aptamers to detect the presence of C. albicans, with the pads turning dark blue when the fungus is present. This proof-of-concept platform has the potential to significantly impact women's health globally. [Extracted from the article]

A study conducted by researchers at Sichuan University in Chengdu, China, explores the co-infection of Candida albicans and Staphylococcus aureus, which often leads to higher mortality rates. The researchers established a mouse model of subcutaneous infection to study the inflammation induced by co-infection. They found that S. aureus wraps around C. albicans and promotes its growth, while neutrophils primarily rely on phagocytosis to kill S. aureus. The study highlights the potential of neutrophil extracellular traps (NETs) as therapeutic targets for the treatment of co-infections. [Extracted from the article]

A recent study conducted by Kocaeli University in Turkey suggests that the fungus Candida albicans may be a risk factor for autism spectrum disorder. The researchers conducted a meta-analysis of studies involving children diagnosed with autism and found that the odds of Candida albicans presence were higher in those with autism compared to healthy individuals. The study concludes that Candida albicans may be an etiological factor for autistic behavior in children. Further research is needed to fully understand the relationship between Candida albicans and autism. [Extracted from the article]

Researchers from Mahidol University in Bangkok, Thailand have conducted a study on Candida albicans, a fungus known for causing candidiasis. The researchers synthesized farnesol-imprinted nanospheres (FINs) and found that they had a higher binding capacity for farnesol compared to control polymers. Treatment with FINs resulted in an increase in hyphae formation in C. albicans, indicating effective capture of farnesol by the FINs. The researchers suggest that FINs could be a potential compound to mitigate the severity of disseminated candidiasis by depleting yeast forms. The study was published in ChemistrySelect and was funded by the National Research Council of Thailand and Mahidol University. [Extracted from the article]