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2023 NOV 6 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators publish new report on Nanotechnology - Nanofibers. According to news reporting out of [...]

2021 DEC 18 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on osteoarthritis. According to news originating from Bari, [...]

Bioelectronic bone implants are being widely recognized as a promising technology for highly personalized bone/implant interface sensing and biophysical therapeutic stimulation. Such bioelectronic devices are based on an innovative concept with the ability to be applied to a wide range of implants, including in fixation and prosthetic systems. Recently, biointerface sensing using capacitive patterns was proposed to overcome the limitations of standard imaging technologies and other non-imaging technologies; moreover, electric stimulation using capacitive patterns was proposed to overcome the limitations of non-instrumented implants. We here provide an innovative low-power miniaturized electronic system with ability to provide both therapeutic stimulation and bone/implant interface monitoring using network-architectured capacitive interdigitated patterns. It comprises five modules: sensing, electric stimulation, processing, communication and power management. This technology was validated using in vitrotests: concerning the sensing system, its ability to detect biointerface changes ranging from tiny to severe bone-implant interface changes in target regions was validated; concerning the stimulation system, its ability to significantly enhance bone cells’ full differentiation, including matrix maturation and mineralization, was also confirmed. This work provides an impactful contribution and paves the way for the development of the new generation of orthopaedic biodevices.

2019 JUN 1 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Engineering - Precision Engineering and Manufacturing are discussed in [...]

2019 FEB 2 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Biophysics are discussed in a new report. According to [...]

A recent report from researchers at IRCCS Istituto Ortopedico Rizzoli in Bologna, Italy, discusses the role of biophysical stimulation in the multimodal management of vertebral compression fractures (VCF). VCF is a common type of fragility fracture associated with osteoporosis and reduced bone density. The report highlights the importance of a comprehensive workup to assess the underlying causes of VCF and outlines the multimodal treatment approach, which includes brace, pain management, bone metabolism evaluation, osteoporosis medication, and biophysical stimulation. The use of biophysical stimulation has shown promising results in promoting bone recovery, reducing the need for surgery, and improving patients' quality of life. [Extracted from the article]

2017 SEP 25 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators publish new report on Biomedical Engineering - Tissue Engineering. According to news originating [...]

2017 AUG 19 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Cardiology. According to news originating from Toronto, [...]

A recent report from the University of Maribor discusses the potential of molecular biophysical stimulation therapy (MBST) in the treatment of chronic musculoskeletal disorders. The researchers highlight the limitations of current treatments and the need for advanced technologies to improve bone density and cartilage regeneration. MBST, specifically nuclear magnetic resonance therapy, has shown promising results in the conservative treatment of musculoskeletal disorders. The aim of the review is to provide an overview of the current evidence of MBST's efficacy in managing chronic musculoskeletal disorders. [Extracted from the article]

Actin filaments also develop in parallel with the microtubules, facilitating actin-microtubule crosstalks. Keywords: Cheonan; South Korea; Asia; Biophysics; Cellular Structures; Cytoplasm; Cytoplasmic Structures; Cytoskeleton; Electromagnet; Electronics; Emerging Technologies; Intracellular Space; Microtubules; Nanofibers; Nanotechnology; Stem Cell Research EN Cheonan South Korea Asia Biophysics Cellular Structures Cytoplasm Cytoplasmic Structures Cytoskeleton Electromagnet Electronics Emerging Technologies Intracellular Space Microtubules Nanofibers Nanotechnology Stem Cell Research 45 45 1 11/06/23 20231109 NES 231109 2023 NOV 6 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators publish new report on Nanotechnology - Nanofibers. Cytoplasmic Structures, Cytoskeleton, Electromagnet, Electronics, Emerging Technologies, Intracellular Space, Microtubules, Nanofibers, Nanotechnology, Stem Cell Research, Cheonan, South Korea, Asia, Biophysics, Cellular Structures, Cytoplasm. [Extracted from the article]

Tissue engineering is a promising therapeutic strategy to regenerate skeletal muscle. However, ex vivocultivation methods typically result in a low differentiation efficiency of stem cells as well as grafts that resemble the native tissues morphologically, but lack contractile function. The application of biomimetic tensile strain provides a potent stimulus for enhancing myogenic differentiation and engineering functional skeletal muscle grafts. We reviewed integrin-dependent mechanisms that potentially link mechanotransduction pathways to the upregulation of myogenic genes. Yet, gaps in our understanding make it challenging to use these pathways to theoretically determine optimal ex vivostrain regimens. A multitude of strain protocols have been applied to in vitrocultures for the cultivation of myogenic progenitors (adipose- and bone marrow-derived stem cells and satellite cells) and transformed murine myoblasts, C2C12s. Strain regimens are characterized by orientation, amplitude, and time-dependent factors (effective frequency, duration, and the rest period between successive strain cycles). Analysis of published data has identified possible minimum/maximum values for these parameters and suggests that uniaxial strains may be more potent than biaxial strains, possibly because they more closely mimic physiologic strain profiles. The application of these biophysical stimuli for engineering 3D skeletal muscle grafts is nontrivial and typically requires custom-designed bioreactors used in combination with biomaterial scaffolds. Consideration of the physical properties of these scaffolds is critical for effective transmission of the applied strains to encapsulated cells. Taken together, these studies demonstrate that biomimetic tensile strain generally results in improved myogenic outcomes in myogenic progenitors and differentiated myoblasts. However, for 3D systems, the optimization of the strain regimen may require the entire system including cells, biomaterials, and bioreactor, to be considered in tandem.

Background:Osteochondral lesions of the talus (OLT) frequently occur after ankle sprains in young patients participating in sports activities. These injuries may lead to chronic pain, joint swelling, and finally osteoarthritis, therefore, surgical repair is frequently needed. A collagen scaffold seeded with bone marrow–derived cells (BMDCs) harvested from patient’s iliac crest and implanted into the OLT through a single arthroscopic procedure has been recently proposed as an effective treatment option. Nevertheless, BMDCs, embedded in an inflammatory environment, tend to differentiate toward a fibroblast phenotype with a consequential loss of mechanical characteristics. Biophysical stimulation with pulsed electromagnetic fields (PEMFs) has been shown to promote anabolic chondrocyte activity, stimulate proteoglycan synthesis, and reduce the release of the most relevant pro-inflammatory cytokines. The aim of this randomized controlled trial was to evaluate the effects of PEMFs on clinical outcome in patients who underwent BMDCs transplantation for OLT.Methods:Thirty patients affected by grade III and IV Outerbridge OLT underwent BMDCs transplantation. After surgery, patients were randomly assigned to either experimental group (PEMFs 4 hours per day for 60 days starting within 3 days after operation) or control group. Clinical outcome was evaluated with (American Orthopaedic Foot and Ankle Society) AOFAS score, Visual Analog Scale (VAS), and Short Form-36 (SF-36).Results:Significantly higher AOFAS score was recorded in the experimental group both at 6 or 12 months follow-up. At 60 days and 6 and 12 months follow-up, significant lower pain was observed in the experimental group. No significant difference was found in SF-36 between groups.Conclusion:A superior clinical outcome was found in the experimental group with more than 10 points higher AOFAS score at final follow-up. Biophysical stimulation started soon after surgery aided patient recovery leading to pain control and a better clinical outcome with these improvements lasting more than 1 year after surgery.Level of Evidence:Level II, prospective comparative study.

Hyaline cartilage lesions represent an important global health problem. Several approaches have been developed in the last decades to resolve this disability cause, including tissue engineering, but to date, there is not a definitive procedure that is able to promote a repair tissue with the same mechanical and functional characteristics of native cartilage, and to obtain its integration in the subchondral bone. The need of resolutive technologies to obtain a “more effective” tissue substitutes has led Butler to propose the “Functional Tissue Engineering” (FTE) paradigm, whose principles are outlined in a so-called FTE road map. It consists of a two-phase strategy: in vitrotissue engineering and clinically surgery evaluation. The first phase, based on construct development, should take into account not only the chondrocyte biology, as their sensitivity to biochemical and physical stimuli, the risk of dedifferentiation in culture, and the ability to produce extracellular matrix, but also the features of suitable scaffolds. The in vivo phaseanalyzes the inflammatory microenvironment where the construct will be placed, because the cytokines released by synoviocytes and chondrocytes could affect the construct integrity, and, in particular, cause matrix degradation. The use of pulsed electromagnetic fields (PEMFs) represents an innovative therapeutic approach, because it is demonstrated that this physical stimulus increases the anabolic activity of chondrocytes and cartilage explants with consequent increase of matrix synthesis, but, at the same time, PEMFs limit the catabolic effects of inflammatory cytokines, reducing the construct degradation inside the surgical microenvironment. PEMFs mediate an up-regulation of A2Aadenosine receptors and a potentiation of their anti-inflammatory effects.

To enhance bone implant osteointegration, many strategies for improving biomaterial properties have been developed which include optimization of implant material, implant design, surface morphology and osteogenetic coatings. Other methods that have been attempted to enhance endogenous bone healing around biomaterials are different forms of biophysical stimulations such as pulsed electromagnetic fields (PEMFs) and low intensity pulsed ultrasounds (LIPUS), which were initially developed to accelerate fracture healing. To aid in the use of adjuvant biophysical therapies in the management of bone-implant osteointegration, the present authors reviewed experimental and clinical studies published in the literature over the last 20 years on the combined use of biomaterials and PEMFs or LIPUS, and summarized the methodology, and the possible mechanism of action and effectiveness of the different biophysical stimulations for the enhancement of bone healing processes around bone implanted biomaterials.

Apoptotic bodies as plentiful extracellular vesicles generated from apoptotic cells play a central role in signal transduction and homeostasis regulation and simultaneously switch death to regeneration to a certain extent. Herein, we designed engineered apoptotic bodies derived from T cells to have the capacity of inflammation regulation and cartilage affinity. The engineered apoptotic bodies as a natural anti-inflammation factor were encapsulated into lubricating hydrogel microspheres to achieve an injectable microsphere complex for the treatment of osteoarthritis (OA). In the above therapeutic system, the engineered apoptotic bodies acted as a biochemical cue to regulate the inflammatory microenvironment and promote chondrocyte cartilage homeostasis, whereas the lubricating hydrogel microspheres served as a biophysical stimulation to effectively reduce the friction of the cartilage surface, restore the cartilage stress, and control the slow delivery of the encapsulated engineered apoptotic bodies by friction degradation. Consequently, the current work creates an injectable and multifunctional therapeutic microsphere to advance cartilage remodeling and OA therapy.

A clinical trial, NCT06330454, is underway to investigate the effects of I-ONE therapy on patients who have undergone painful total knee replacement surgery. The trial aims to assess the resolution of pain, reduced intake of NSAIDs, and improved joint function in patients receiving I-ONE therapy. The therapy utilizes biophysical stimulation to modulate cartilage metabolism and reduce inflammation. The text also discusses the use of I-ONE therapy in other clinical scenarios, such as cartilage lesions, autologous chondrocyte transplantation, osteochondral lesions, and knee or shoulder replacement surgeries. A prospective cohort study is currently recruiting patients with painful total knee replacement to evaluate the use of noninvasive therapy with I-ONE therapy. The study will assess pain and functional recovery using various evaluation tools. The study is being conducted in Italy and is expected to be completed by October 2025. [Extracted from the article]

A new report from the University of Ferrara in Italy discusses the increasing use of biophysical stimulation therapy, specifically Pulsed Electromagnetic Fields (PEMFs) and Capacitively Coupled Electric Fields (CCEFs), in the last twenty years. The report highlights the effectiveness of these therapies in promoting bone healing, joint preservation, and symptom relief. Positive results have been observed in the treatment of inflammatory processes, chondroprotection, and osteoporosis. The researchers suggest that these therapies have potential applications in prosthetic surgery and sports medicine. [Extracted from the article]

A recent study published in Heliyon discusses advancements in tissue engineering for articular cartilage regeneration. The study highlights the challenges of treating articular cartilage injuries and the limitations of current treatment options. Tissue engineering, which involves using cultured and expanded tissue cells combined with suitable scaffold materials, is emerging as a promising approach for cartilage regeneration. The review article explores the latest advancements in seed cells, scaffolds, cytokines, genetic engineering techniques, biophysical stimulation, and bioreactor systems. The study also outlines the signaling pathways involved in cartilage regeneration, providing valuable insights for researchers in the field. [Extracted from the article]

Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged cartilage. Hydrogel is widely used because it could provide rapid defect filling and proper structure support, and is biocompatible for cell aggregation and matrix deposition. Efforts have been made to seek suitable scaffolds for cartilage tissue engineering. Here Alg-DA/Ac-β-CD/gelatin hydrogel was designed with the features of physical and chemical multiple crosslinking and self-healing properties. Gelation time, swelling ratio, biodegradability and biocompatibility of the hydrogels were systematically characterized, and the injectable self-healing adhesive hydrogel were demonstrated to exhibit ideal properties for cartilage repair. Furthermore, the new hydrogel design introduces a pre-gel state before photo-crosslinking, where increased viscosity and decreased fluidity allow the gel to remain in a semi-solid condition. This granted multiple administration routes to the hydrogels, which brings hydrogels the ability to adapt to complex clinical situations. Pulsed electromagnetic fields (PEMF) have been recognized as a promising solution to various health problems owing to their noninvasive properties and therapeutic potentials. PEMF treatment offers a better clinical outcome with fewer, if any, side effects, and wildly used in musculoskeletal tissue repair. Thereby we propose PEMF as an effective biophysical stimulation to be 4th key element in cartilage tissue engineering. In this study, the as-prepared Alg-DA/Ac-β-CD/gelatin hydrogels were utilized in the rat osteochondral defect model, and the potential application of PEMF in cartilage tissue engineering were investigated. PEMF treatment were proven to enhance the quality of engineered chondrogenic constructs in vitro, and facilitate chondrogenesis and cartilage repair in vivo. All of the results suggested that with the injectable self-healing adhesive hydrogel and PEMF treatment, this newly proposed tissue engineering strategy revealed superior clinical potential for cartilage defect treatment.

The biophysical cues of endogenous origin, i.e., shear stress and electric field, are known to significantly modulate cell functionality, in vitro. While this has been relatively well investigated in conventional petri dish culture, it is important to validate such important phenomenon in physiologically simulated cellular microenvironment. In this perspective, this review critically discusses the importance of lab-on-a-chip (LOC)-based microfluidic devices to probe into this aspect to develop an insight towards the application in regenerative medicine. While reviewing several literature reports, an emphasis has been placed to unravel the intriguing aspects of shear and electric field modulated differentiation of stem cells in the biomicrofluidics devices. The potential application focusing the stem cell culture was emphasized in this article as the stem cells are the foundation of tissue regeneration. Several challenges in tissue regeneration and introduction of personalized medicine could be addressed through microfluidic technology. Culturing of organ-specific multiple cell types within lab-on-a-chip and biophysical stimulation mediated activations of intracellular signal transduction under gradient shear/electric field are highlighted in this review. Conceptually, regenerative medicine is considered as an emerging approach for treating traumatized, malfunctional anatomical parts of the patients with stem cells to establish normal functionality of the tissue. The regenerated tissue should preferably be the patients’ autologous tissue, grown under artificially created in vivo physiological environment. Biomicrofluidic-based lab-on-a-chip technology enables to perform in vitro cell/tissue engineering under endogenous cues, like shear and electric field. Therefore, this review discusses two aspects of regenerative medicine in terms of autologous transplantation of cells/tissues to improvise personalized regenerative medicine and to recreate an organ-specific tissue under the influence of biophysical stimulation in an attempt to improve the physiological functionality. Graphical abstractBiomicrofluidics based Lab-on-a-Chip devices have improvised the tissue regenerative approaches towards into the direction of personalised medicine.

A recent study conducted by researchers at the National Taipei University of Technology in Taiwan explores the development of treatments for hair loss. The study focuses on the use of biophysical stimulation as a non-pharmacological treatment for hair regeneration. The researchers developed a cationic fabric that utilizes asymmetrical ionic flow to stimulate hair follicles and skin. The treatment showed promising results in increasing the number of hair follicles and improving immunoregulation in skin defect animals, with no adverse risks. The research has been peer-reviewed and provides potential insights into future hair loss treatments. [Extracted from the article]

Each spot, which is diffused at times, indicates a protein-secreting cell, and the size of the spot provides a qualitative and often vague estimate of the amount of protein secreted by the cell. Naturally, the concentrations of the target proteins in cell culture supernatants represent an ensemble average of the entire cell population (in vitro), thus masking the cell-to-cell heterogeneity and, more importantly, the locoregional correlation between biophysical stimulation and biochemical response. Extracellular proteins facilitate cell migration and differentiation in cells. The method improves on existing methods like ELISpot, such that instead of relying on a spot for indicating where a cell has secreted protein, individual fluorescent "dots" are revealed to indicate individual proteins within a "spot". [Extracted from the article]

The demand for artificial organs has greatly increased because of various aging-associated diseases and the wide need for organ transplants. A recent trend in tissue engineering is the precise reconstruction of tissues by the growth of cells adhering to bioscaffolds, which are three-dimensional (3D) structures that guide tissue and organ formation. Bioscaffolds used to fabricate bionic tissues should be able to not only guide cell growth but also regulate cell behaviors. Common regulation methods include biophysical and biochemical stimulations. Biophysical stimulation cues include matrix hardness, external stress and strain, surface topology, and electromagnetic field and concentration, whereas biochemical stimulation cues include growth factors, proteins, kinases, and magnetic nanoparticles. This review discusses bioink preparation, 3D bioprinting (including extrusion-based, inkjet, and ultraviolet-assisted 3D bioprinting), and regulation of cell behaviors. In particular, it provides an overview of state-of-the-art methods and devices for regulating cell growth and tissue formation and the effects of biophysical and biochemical stimulations on cell behaviors. In addition, the fabrication of bioscaffolds embedded with regulatory modules for biomimetic tissue preparation is explained. Finally, challenges in cell growth regulation and future research directions are presented.

Tendons and ligaments (TL) have poor healing capability, and for serious injuries like tears or ruptures, surgical intervention employing autografts or allografts is usually required. Current tissue replacements are nonideal and can lead to future problems such as high retear rates, poor tissue integration, or heterotopic ossification. Alternatively, tissue engineering strategies are being pursued using biodegradable scaffolds. As tendons connect muscle and bone and ligaments attach bones, the interface of TL with other tissues represent complex structures, and this intricacy must be considered in tissue engineered approaches. In this paper, we review recent biofabrication and signaling strategies for biodegradable polymeric scaffolds for TL interfacial tissue engineering. First, we discuss biodegradable polymeric scaffolds based on the fabrication techniques as well as the target tissue application. Next, we consider the effect of signaling factors, including cell culture, growth factors, and biophysical stimulation. Then, we discuss human clinical studies on TL tissue healing using commercial synthetic scaffolds that have occurred over the past decade. Finally, we highlight the challenges and future directions for biodegradable scaffolds in the field of TL and interface tissue engineering.

Pretreatment using various types of biophysical stimuli could provide appropriate potential to cells during construction of the engineered tissue in vitro. We hypothesized that multiple combinations of these biophysical stimuli could enhance osteogenic differentiation in vitroand bone formation in vivo. Cyclic strain, an electromagnetic field, and ultrasound were selected and combined as effective stimuli for osteogenic differentiation using a developed bioreactor. Here we report the experimental evaluation of the osteogenic effects of various combinations of three different biophysical stimuli in vitroand in vivousing human adipose-derived stem cells (ASCs). Osteogenic differentiation of ASCs was accelerated by multiple-combination biophysical stimulation in vitro. However, both single stimulation and double-combination stimulation were sufficient to accelerate bone regeneration in vivo, while the osteogenic marker expression of those groups was not as high as that of triple-combination stimulation in vitro. We inferred from these data that ASCs appropriately differentiated into the osteogenic lineage by biophysical stimulation could be a better option for accelerating bone formation in vivothan relatively undifferentiated or completely differentiated ASCs. Although many questions remain about the mechanisms of combined effects of various biophysical stimuli, this approach could be a more powerful tool for bone tissue regeneration.

Novoheart International Limited in Hong Kong has been granted a patent for devices that include organoid chambers to culture, maintain, monitor, or test organoids. These devices aim to provide more accurate models of human heart disease for drug development and testing, addressing the limitations of existing models. The patent describes a bioreactor system that enhances the fabrication, culture, and testing of organoid chambers, such as cardiac organoid chambers, to improve drug development and disease modeling. The devices are designed to mimic the physiology of hollow organs and tissues more closely, allowing for better monitoring and testing of living materials. [Extracted from the article]

A recent research study from Duke University Medical Center focused on nonoperative management of knee cartilage injuries, aiming to establish consensus statements through a Delphi process. Seventy-nine surgeons from 17 countries participated in generating eight questions on this topic, with varying levels of consensus achieved. The study highlighted areas of agreement and disagreement regarding indications, contraindications, and prognostic factors for nonoperative management of knee cartilage injuries. For more information, the full article can be accessed for free through the Journal of Cartilage & Joint Preservation. [Extracted from the article]

A study conducted by researchers at the Indian Institute of Technology (IIT) Bhu in Varanasi, India, explores the interplay between electrical stimulation, piezoelectric biomaterials, and cell functionality in tissue engineering and regenerative medicine. The study highlights the potential of smart piezoelectric biomaterials, which generate electric charges under mechanical stress, in guiding cell behavior and promoting the development of functional tissue-engineered constructs. The researchers also discuss the integration of data science approaches to optimize the design of piezoelectric scaffolds for specific tissue engineering applications. The study has been peer-reviewed and provides valuable insights into the field of regenerative bioelectronics. [Extracted from the article]

The objective of this study was to identify a combination of growth factors that could be used with hydrostatic pressure (HP) stimulation to enhance the functional development of cartilaginous grafts engineered using human infrapatellar fat pad derived stem cells (FPSCs) isolated from osteoarthritic patients. Agarose hydrogels were first seeded with FPSCs at different seeding densities and maintained in a chondrogenic media supplemented with TGF-β3. It was found that chondrogenesis of human FPSCs in hydrogel culture is dependent on the cell seeding density (10 versus30 million cells per ml), with greater sulphated glycosaminoglycan (sGAG) and collagen synthesis (normalised to DNA content) observed at higher seeding densities. Additional supplementation with BMP-6 was found to augment cartilage-specific matrix synthesis, also in a cell seeding density dependent manner, increasing both cell proliferation and sGAG synthesis in constructs seeded at higher densities, but having no significant effect at lower cell seeding densities. The application of cyclic HP to FPSC seeded constructs cultured in the presence of both TGF-β3 and BMP-6 had no significant effect on DNA content or sGAG accumulation, however it did improve the dynamic modulus of the engineered tissue. These tissues stained strongly for both alcian blue and type II collagen and negatively for type X collagen. The results of this study point to the benefits of combining both biochemical and biophysical stimulation to engineer functional cartilage grafts using diseased human FPSCs.

Biophysical stimuli may be an effective therapy to counteract age-related changes in bone structure that affect the primary stability of implants used in joint replacement or fracture fixation. The influence of controlled mechanical loading on osseointegration was investigated using an in vivodevice implanted in the distal lateral femur of 12 male rabbits. Compressive loads (1 MPa, 1 Hz, 50 cycles/day, 4 weeks) were applied to a porous titanium foam implant and the underlying cancellous bone. The contralateral limbs served as nonloaded controls. Backscattered electron imaging indicated that the amount of bone ingrowth was significantly greater in the loaded limb than in the nonloaded control limb, whereas the amount of underlying cancellous periprosthetic bone was similar. No significant difference in the mineral apposition rate of the bone ingrowth or periprosthetic bone was measured in the loaded compared to the control limb. Histological analysis demonstrated newly formed woven bone in direct apposition to the implant coating, with a lack of fibrous tissue at the implant–periprosthetic bone interface in both loaded and nonloaded implants. The lack of fibrous tissue demonstrates that mechanical stimulation using this model significantly enhanced cancellous bone ingrowth without the detrimental effects of micromotion. These results suggest that biophysical therapy should be further investigated to augment current treatments to enhance long-term fixation of orthopedic devices. Additionally, this novel in vivoloading model can be used to further investigate the influence of biophysical stimulation on other tissue engineering approaches requiring bone ingrowth into both metallic and nonmetallic cell-seeded scaffolds.

In experimental research-driven biomaterials science, the influence of different material properties (elastic stiffness, surface energy, etc.) and, to a relatively lesser extent, biophysical stimulation (electric/magnetic) on cell–material interactions has been extensively investigated. Despite the central importance of protein adsorption on cell–material interactions, the quantitative analysis to probe into the role of physicochemical factors in protein adsorption remains largely unexplored in biomaterials science. In recent studies, the critical role of electric field stimulation toward the modulation of cell functionality in implantable biomaterials has been experimentally demonstrated. Given this background, we investigated the influence of external electric field stimulation (upto 1.00 V/nm) on fibronectin (FN) adsorption on a hydroxyapatite (HA) (001) surface at 300 K using the all-atom molecular dynamics (MD) simulation method. FN adsorption was found to be governed by attractive electrostatic interactions, which changed with the electric field strength. Nonmonotonous changes in the structural integrity of FN were recorded with the change in the field strength and direction. This can be attributed to the spatial rearrangement of the positions of local charges and the global structural changes of proteins. The dipole moment vectors of FN, water, and HA quantitatively exhibited a similar pattern of orienting themselves parallel to the field direction, with field strength-dependent increase in their magnitudes. No significant change has been recorded for the radial distribution function of water surrounding FN. Field-dependent variation in the salt bridge nets and the number of hydrogen bonds between FN and HA were also examined. One of the important results in the context of cell–material interaction is that the RGD (Arg-Gly-Asp) sequence of FN was exposed to the solvent side when the field was applied along an outward direction perpendicular to the HA (001) surface. In summary, the present study provides molecular insights into the influence of electric field stimulation on phenomenological interactions involved in FN adsorption on the HA surface.

Keywords: Applied Sciences; Bone Marrow; Bone Research; Electromagnet; Electronics; Health and Medicine; Science EN Applied Sciences Bone Marrow Bone Research Electromagnet Electronics Health and Medicine Science 90 90 1 05/29/23 20230530 NES 230530 2023 MAY 29 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- A new study on applied sciences is now available. Despite further high-quality studies on foot and ankle injuries are needed, PEMFs seem to be a valid aid to enhance the endogenous osteogenesis, to resolve the bone marrow edema, to inhibit the joint inflammation, preserving articular cartilage degeneration, and to relieve pain.". [Extracted from the article]

Osteoporosis is responsible for more than 1.5 million fractures annually, including: 300,000 hip fractures; 700,000 vertebral fractures; 250,000 wrist fractures; and 300,000 fractures at other sites. Keywords: Bone Diseases and Conditions; Bone Fractures; Bone Research; Business; Electromagnet; Electronics; Health and Medicine; Medrelief Inc.; Metabolic Bone Diseases and Conditions; Musculoskeletal Diseases and Conditions; Osteoporosis; Risk and Prevention; Ultrasound; Women's Health EN Bone Diseases and Conditions Bone Fractures Bone Research Business Electromagnet Electronics Health and Medicine Medrelief Inc. Metabolic Bone Diseases and Conditions Musculoskeletal Diseases and Conditions Osteoporosis Risk and Prevention Ultrasound Women's Health 499 499 1 04/24/23 20230425 NES 230425 2023 APR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Medrelief Inc. (Bethesda, Maryland, United States) has been issued patent number 11618874, according to news reporting originating out of Alexandria, Virginia, by NewsRx editors. Bone fracture repair and nerve re-growth potentials are typically faster than usual in the vicinity of a negative electrode but slower near a positive one, where in some cases tissue atrophy or necrosis may occur. [Extracted from the article]

Keywords: Hong Kong; People's Republic of China; Asia; Alcohols; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Electromagnet; Electronics; Emerging Technologies; Engineering; Health and Medicine; Hydrogel; Nanotechnology; Organic Chemicals; Polyethylene Glycols; Supramolecular; Tissue Engineering EN Hong Kong People's Republic of China Asia Alcohols Bioengineering Biomedical Engineering Biomedicine Biotechnology Electromagnet Electronics Emerging Technologies Engineering Health and Medicine Hydrogel Nanotechnology Organic Chemicals Polyethylene Glycols Supramolecular Tissue Engineering 227 227 1 04/03/23 20230406 NES 230406 2023 APR 6 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Fresh data on Biomedical Engineering - Tissue Engineering are presented in a new report. In this study, the as-prepared Alg-DA/Ac-beta-CD/gelatin hydrogels were utilized in the rat osteochondral defect model, and the potential application of PEMF in cartilage tissue engineering were investigated. [Extracted from the article]

Soft tissue plays an important role in the repair of bone trauma, and bone tissues without soft tissue coating may become necrotic after the bone trauma is healed. Furthermore, the amount of the regenerated bone increases as the BMP concentration increases, and even BMP and ECM in medium or low concentration can induce excess bone regeneration. [Extracted from the article]

2023 DEC 16 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Drug Research is now available. According to news [...]

2023 APR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Medrelief Inc. (Bethesda, Maryland, United States) has been issued patent number 11618874, according to [...]

2022 APR 25 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Researchers detail new data in mesenchymal stem cells. According to news originating from Columbia [...]

2022 FEB 7 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Current study results on artificial bone have been published. According to news reporting from [...]

2020 MAY 28 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- From Washington, D.C., NewsRx journalists report that a patent application by the inventors Kronberg, [...]

2020 MAY 18 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Researchers detail new data in Stem Cell Research - Mesenchymal Stem Cells. According to [...]

2020 FEB 13 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- MedRelief Inc. (Bethesda, Maryland, United States) has been issued patent number 10,544,388, according to [...]

2020 JAN 6 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Fresh data on Stem Cell Research - Mesenchymal Stem Cells are presented in a [...]

2017 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- A new study on Siloxanes is now available. According to news reporting originating in [...]

2016 SEP 26 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- New research on Stem Cell Research is the subject of a report. According to [...]