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Novel 1‐phenoxy‐3‐(piperazin‐1‐yl)propan‐2‐ol derivatives were designed and synthesized as potential triple reuptake inhibitors, which simultaneously inhibit serotonin, norepinephrine, and dopamine transporters (SERT, NET, and DAT, respectively). Through neurotransmitter transporter uptake assays, inhibitory activities of 1‐phenoxy‐3‐(piperazin‐1‐yl)propan‐2‐ol derivatives were evaluated. We discovered compound 19exhibited the most potent inhibitory activities against all three monoamine neurotransmitter transporters and the IC50values of 19against SERT, NET, and DAT were determined. In addition, binding modes of 19with SERT, NET, and DAT were predicted by docking studies. Novel 1‐phenoxy‐3‐(piperazin‐1‐yl)propan‐2‐ol derivatives exhibited potent inhibitory activities against serotonin, norepinephrine, and dopamine transporters (SERT, NET, and DAT, respectively) simultaneously and thus, 1‐phenoxy‐3‐(piperazin‐1‐yl)propan‐2‐ol derivatives possessed potential as triple reuptake inhibitors. Compound 19possessed the most potent combination of SERT, NET, and DAT inhibitory activity with inhibition values greater than 60% for all three monoamine transporters.

The modified-solvothermal method has been used to synthesize pure anatase and anatase-rutile mixed-phase TiO2nanomaterials using titanium isopropoxide, sodium hydroxide, and triethylamine as primary sources with different calcination temperatures (500 °C and 700 °C). The effect of the precipitating agent, capping agent, and calcination temperatures on the properties, such as structural, morphological, and optical of the resultant nanomaterials has been investigated through several techniques including X-ray diffraction (XRD), Raman spectroscopy, Transmission electron microscopy (TEM), UV–Vis absorption spectroscopy, Scanning electron microscopy (SEM), selected area electron diffraction (SAED), and high-resolution transmission electron microscopy (HRTEM). XRD and Raman spectra confirmed the pure anatase and anatase-rutile mixed structures of the prepared nanomaterials at 500 °C and 700 °C. Furthermore, the Raman active modes confirmed the formation of TiO2. It is noticed that the crystallite size of the nanomaterials increased with increasing calcination temperature of the XRD pattern. The morphologies of the prepared samples were displayed using SEM and TEM micrographs, which are almost the same in shape (cubic and cubic rod mixed). The particle size increased with an increase in calcination temperature and was found to be between 10 and 20 nm, which is similar to the crystallite size. The lattice fringes (d) from HRTEM images are assigned to the XRD plane (101) and (110) plane of anatase and anatase-rutile TiO2, respectively. The SAED exhibited well crystalline nature and confirmed the polycrystalline nature of the prepared nanomaterials by the bright points and the ring patterns. The optical band gap decreased with an increase in temperature and the optical properties are affected by calcination temperature and triethylamine.

•Heat stress causes serious damage to wheat production.•Wheat sensitive to heat at vegetative and reproductive stages.•Trait-based phenotyping is promising for understanding heat response.•Genomic provides heat responsive genetic variations.•Functional phenomics and genomics crucial for heat tolerance wheat cultivars.

Transport of materials and information across cellular boundaries, such as plasma, mitochondrial and nuclear membranes, happens mainly through varieties of ion channels and pumps. Various biophysical and biochemical processes play vital roles. The underlying mechanisms and associated phenomenological lipid membrane transports are linked directly or indirectly to the cell health condition. Mitochondrial membranes (mitochondrial outer membrane (MOM) and mitochondrial inner membrane (MIM)) host crucial cellular processes. Their malfunction is often found responsible for the rise of cell-originated diseases, including cancer, Alzheimers, neurodegenerative disease, etc. A large number of ion channels active across MOM and MIM are known to belong to vital cell-based structures found to be linked directly to cellular signaling. Hence, their malfunctions are often found to contribute to abnormalities in intracellular communication, which may even be associated with the rise of various diseases. This article aims to pinpoint ion channels that are directly or indirectly linked to especially aging and related abnormalities in health conditions. An attempt has been made to address the natural structures of these channels, their mutated conditions, and the ways we may cause interventions in their malfunctioning. The malfunction of ion channel subunits, especially various proteins, involved directly in channel formation and/or indirectly in channel stabilization leads to the rise of various channel-specific diseases, which are known as channelopathies. Channelopathies in aging will be discussed briefly. This mini-review may be found as an important reference for drug discovery scientists dealing with aging-related diseases.

There is a huge potential for recycling animal manure in agricultural farms, but fecal microorganisms from land-applied animal manure can join shallow groundwater through leaching especially in alluvial formations. Thus, this study investigated the leaching rate of total viable count (TVC) below a 1.1-m soil depth in a field lysimeter planted with rice–maize–rice rotation, where the rotation received different treatments, i.e., chemical fertilizer, dry manure, fresh manure, alternate wetting and drying (AWD) irrigation, and traditional irrigation. Leachate samples of six major irrigation/rainfall events were collected and analyzed for TVC concentration. In the Aman rice season, manure application had a significantly higher TVC leaching (5.5 × 106colony forming units (CFU) per milliliter) than the no-manure treatment (8.2 × 104 CFU/mL). In the maize season, manure application increased more than one log-scale of TVC leaching concentration. A higher concentration of TVC leaching (3 × 105 CFU/mL) was observed even after 93 d of fresh manure application. The fresh manure had a higher TVC load, and it possibly helped microorganisms survive longer by providing a more manure-like environment in the soil. In the Boro rice season, manure application increased the TVC leaching up to 3–4 log-scale compared with the control treatment. The AWD irrigation increased TVC leaching compared with the continuous irrigation because the desiccation fractures developed in the AWD irrigation helped TVC bypass the organic-rich topsoil. The Boro rice fields had higher TVC leaching than the maize fields with higher manure doses. The study suggests that there is scope to improve manure management to protect the groundwater quality.

A proposal has been made to identify tuberculosis cells using a novel compact sensor based on photonic crystal fiber: PCF in accordance with hexagonal spectroscopy. This proposed structure, which consists of a closely packed hexagonal air hole in the cladding region and a hollow-core area, possesses a very low loss of 6.30 × 10−8 dB/m and an exceptionally high sensitivity of up to 91.75 % (tuberculosis cell for 1.345). Numerous optical parameters have been identified and assessed, comprised of the numerical aperture, the V-parameter, or normalized frequency (Veff), and the effective area (Aeff). The operational wavelength range is defined as 0.80–3.0 THz. The numerical investigation of the properties of the proposed TB sensors is performed within the environment of COMSOL Multiphysics (Version 5.3) using FV-FEM stands for the full vector finite element method. PCF sensors composed of hexagonal lattice in a circular form with ZEONEX as the backdrop material is intended to boost the sensitivity response in comparison to the earlier works. Additionally, the sensor that is being displayed achieves a single modality throughout its whole operational wavelength range. This proposed sensor may play a significant role in identifying tuberculosis thanks to its superior sensitivity response and extremely minimal confinement loss. So, it is clearly seen that this sensor could be used to bio-medical sectors with process of terahertz (THz) wave pulse.

In modern wearable electronics, textile-based supercapacitors have attracted significant attention in the field of energy storage systems owing to their flexibility, wearability, and stretchability, and have worked as an alternative emerging energy source for non-renewable energies besides meeting the daily energy demand. The review summarized the state of the art in textile-based supercapacitors and added new knowledge about emerging electrode materials, electrolytes, separators, and textile current collectors to help us understand how these components contribute to the development of high-rate supercapacitors. In order to improve the electrochemical performance of the textile-based supercapacitor, we begin by reviewing the fundamentals of different electrode materials, such as MXene, polyoxometalate, black phosphorus, metal-organic frameworks, and functionalized materials such as Schiff base ligand doped and co-doping agents. Then, appropriate electrolytes—including aqueous, non-aqueous, ionic, and redox mediator gel polymers—are added to widen the potential window, as discussed in the next section. Following that, the flexible separator (such as gel polymer, woven and nonwoven textiles, and cellulose), which prevents the short circuit, and the engineering of textile structures of one dimension (1D), two dimensions (2D), and three dimensions (3D) were also studied. Finally, the current challenges and prospects of this emerging field are also highlighted.

In the competitive markets, effective management of supply chain and realisation of customer expectations are crucial factors for the better performance of an organisation. In the modern era, performance measurement has a significant role to get the competitive advantage. Quality function deployment (QFD) methodology is the most reliable and proved method to identify customer-based strategy. The objective of this research is to determine critical customer requirements and prioritise them to determine the critical supply chain factors to improve supply chain performances. This is a case study on six-selected garments accessories industries (GAI) in Bangladesh with respect to 17 readymade garments industries and buying house as a customer. This paper shows a new system of supply chain performance evaluation using transformation matrix called quality function deployment. By this system, it is possible to measure supply chain performance of any kind of manufacturing industry. Research findings can be used for the selection of manufacturing industries supply chain strategy.

Aim: The aim of this review is to update the knowledge about the Kawasaki disease (KD) which includes the way of early detection and latest treatment plan for the disease. Method: A number of literatures were reviewed and latest information about the etiology, diagnosis, laboratory investigation, treatment and outcome of the disease was collected and depicted in the review article. Result: Kawasaki disease is a multisystem vasculitis mainly affecting medium sized blood vessels. It is the second most common cause of vasculitis after Henoch Scholein Purpura (HSP) in children. Etiology of the disease is still unknown. Auto-immunity with genetic influence is thought to associate with the disease. Many physicians are ignorant of the disease. The pediatrician must be aware of the disease and suspect this condition in less than 5 year old children presenting with more than 5 days fever. the number of methods on the basis of criteria is set for the diagnosis of the disease. Latest treatment plan is set up for the disease which reduces the morbidity and mortality to a great extent. Conclusion: Physicians must have consciousness and comprehensive knowledge for the early suspicion of this disease. Any child presenting with fever for more than 5 days should not be ignored and other criteria of KD have to be evaluated by the physician. Early diagnosis and updated treatment are imperative for the prevention of morbidity and mortality for the disease.

Interactions between membrane proteins (MPs)/antimicrobial peptides (AMPs) and lipids play important roles in the creation and function of membrane transport events like ion channels, defects, etc. Energetics based on these interactions have been found to explain various aspects of general drug effects on cell membranes. We have used various membrane active agents (MAAs) such as peptides, chemotherapy drugs, amphipathic molecules, amphiphiles, etc. to observe the complexes created between them and lipids in bilayers that often serve as membrane transport events in order to better understand the underlying mechanism(s). We find that the structures and functions of MAAs-lipids complexes are very specific to the respective MAAs. However, the underlying mechanisms originating from some common types of interactions are found to depend on physical properties of both MAAs and lipids. Specifically, the stability and functions of MAAs-lipid complexes depend primarily on the electrostatic energy coupling between MAAs and lipids. The mechanical energy coupling between MAAs and lipids, depending mainly on the bilayer elastic profiles, contributes just secondary effects into the stability and functions of the complexes. Both of these electrostatic and mechanical energetic couplings emerge from a unique interaction energy expression appearing from screened Coulomb interaction treatment between MAAs and lipids, mainly depending on the localized charge profiles and on other physical properties of both MAAs and lipids. This review will address the functions and underlying molecular mechanisms of membrane transport events, membrane effects of general drugs, etc. and thus will open up avenues leading to novel drug discovery.

Nanoparticles have received much attention in biomedical applications due to their unique physicochemical properties. The metal/metal oxide nanoparticles are involved in various applications, including drug delivery, therapy, and diagnosis. Subsequently, many hazardous chemicals and organic solvents were utilized to synthesize the metallic nanoparticles. Therefore, the green synthesis came into the limelight to overcome the economic and environmental burden. The green synthesis represents the production of nanoparticles that reduce or terminate the use of hazardous materials and solvents that encourages environmental safety. The frequently utilized green materials in numerous metallic nanoparticle syntheses include microbes, plants, fruits, and other food sources. However, the burden on global food security and limited natural resources creates distress over environmental sustainability. Thus, adopting bio-waste materials to produce highly efficient, biocompatible, economic, and eco-friendly metallic nanoparticles could support waste valorization and lead to environmental sustainability. Therefore, the present review focuses on the various bio-waste materials adopted to synthesize metal/metal oxide nanoparticles. We have thoroughly discussed the potential of chemicals-mediated metal/metal oxide nanoparticles in different drug delivery applications such as tumor targeting, brain targeting, stimuli-responsive drug release followed by large molecules delivery. Consequently, this can open a new road for researchers to explore drug delivery applications using bio-waste mediated green synthesized metallic nanoparticles. Finally, the cytotoxicity aspects of such nanoparticles are meticulously discussed compared to chemically synthesized counterparts.