1. The impact of ageing on trauma-related bleeding and coagulopathy
- Author
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Henna, Wong, Stanworth, Simon, Curry, Nicola, and Yu, Ly-Mee
- Subjects
Blood--Coagulation ,Aging ,Hemorrhage ,Traumatology - Abstract
The epidemiology of major injury is changing as the population ages, revealing gaps in our understanding of the management of older patients with trauma-related bleeding. Physiology and haemostasis alter with normal ageing and could attenuate the response to bleeding in an older person. The aim of this thesis was to explore the impact of the ageing trauma demographic on the presentation and management of bleeding and coagulopathy in trauma. I conducted a systematic review to explore the evidence across age for the use of blood transfusion strategies in acute trauma haemorrhage. I identified 10 randomised controlled trials; older patients were not well represented. There were no randomised trials in older people or trials that evaluated interventions for different age groups. A Delphi study was undertaken to develop a new consensus research definition for major bleeding in trauma. This definition was applied to the Trauma Audit Research Network registry to assess the effect of age on risk factors for major bleeding. I found older patients with bleeding were less likely to present with tachycardia than younger patients. Multivariable logistic regression using seven risk factors (age, male gender, penetrating injury, mechanism of injury, hypotension and tachycardia and unstable pelvis) showed all were independently significantly associated with bleeding. I also identified a negative interaction between age and penetrating injury, and age and mechanism of injury. Multiple imputation was used to handle missing data and the significance of the risk factors in the imputation model was broadly similar to the complete case analysis model. The effect of age on coagulation and fibrinolytic parameters was assessed in a multicentre cohort study. In patients who did not receive tranexamic acid, after adjusting for key covariates including presence of bleeding and injury severity, I found older age was associated with heightened fibrinolytic activity and fibrinogen levels compared with younger age. The programme of work in this thesis has provided new data showing that age has a significant effect on the clinical presentation and risk factors for bleeding. Furthermore, coagulation and fibrinolytic parameters appear altered across age. These data are exploratory and hypothesis-generating. They inform future research areas to assess the effectiveness of different interventions including tranexamic acid across age, develop age-adapted transfusion protocols and prediction models for bleeding that take age into consideration.
- Published
- 2020