Search

Your search keyword '"Edefonti, Valeria"' showing total 13 results
Start Over Author "Edefonti, Valeria" Publication Type Electronic Resources

Refine your results

13 results on '"Edefonti, Valeria"'

1. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE Consortium

Author

Goyal, Neerav, Hennessy, Max, Lehman, Erik, Lin, Wenxue, Agudo, Antonio, Ahrens, Wolfgang, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kanda, Jossy L, Kelsey, Karl, Hansen, Bo T, Koifman, Rosalina, Lagiou, Pagona, La Vecchia, Carlo, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Mendoza López, Rossana, Luce, Danièle, Macfarlane, Gary, Mates, Dana, Matsuo, Keitaro, Mcclean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moysich, Kirsten, Negri, Eva, Olshan, Andrew F, Pandics, Tama, Polesel, Jerry, Purdue, Mark, Radoi, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Świątkowska, Beata, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Winn, Deborah M, Wunsch-Filho, Victor, Yu, Guo-Pei, Zevallos, Jose P, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Muscat, Joshua E, Boccia, Stefania (ORCID:0000-0002-1864-749X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Goyal, Neerav, Hennessy, Max, Lehman, Erik, Lin, Wenxue, Agudo, Antonio, Ahrens, Wolfgang, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kanda, Jossy L, Kelsey, Karl, Hansen, Bo T, Koifman, Rosalina, Lagiou, Pagona, La Vecchia, Carlo, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Mendoza López, Rossana, Luce, Danièle, Macfarlane, Gary, Mates, Dana, Matsuo, Keitaro, Mcclean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moysich, Kirsten, Negri, Eva, Olshan, Andrew F, Pandics, Tama, Polesel, Jerry, Purdue, Mark, Radoi, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Świątkowska, Beata, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Winn, Deborah M, Wunsch-Filho, Victor, Yu, Guo-Pei, Zevallos, Jose P, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Muscat, Joshua E, Boccia, Stefania (ORCID:0000-0002-1864-749X), and Cadoni, Gabriella (ORCID:0000-0001-8244-784X)

Abstract

Objective: We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries. Subjects and methods: The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared. Results: The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites. Conclusion: These findings suggest the degree of industrialization and economic development affects the relationship between smoking-and alcohol with head and neck cancer.

Published
2022

2. Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium.

Author

Chang, Chun-Pin, Chang, Chun-Pin, La Vecchia, Carlo, Serraino, Diego, Olshan, Andrew F, Zevallos, Jose P, Morgenstern, Hal, Levi, Fabio, Garavello, Werner, Kelsey, Karl, McClean, Michael, Chen, Chu, Schwartz, Stephen M, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Parpinel, Maria, Augustin, Livia SA, Turati, Federica, Zhang, Zuo-Feng, Edefonti, Valeria, Chang, Chun-Pin, Chang, Chun-Pin, La Vecchia, Carlo, Serraino, Diego, Olshan, Andrew F, Zevallos, Jose P, Morgenstern, Hal, Levi, Fabio, Garavello, Werner, Kelsey, Karl, McClean, Michael, Chen, Chu, Schwartz, Stephen M, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Parpinel, Maria, Augustin, Livia SA, Turati, Federica, Zhang, Zuo-Feng, and Edefonti, Valeria

Abstract

High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.

Published
2020

3. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration.

Author

Di Credico, Gioia, Di Credico, Gioia, Polesel, Jerry, Dal Maso, Luigino, Pauli, Francesco, Torelli, Nicola, Luce, Daniele, Radoï, Loredana, Matsuo, Keitaro, Serraino, Diego, Brennan, Paul, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Canova, Cristina, Richiardi, Lorenzo, Healy, Claire M, Kjaerheim, Kristina, Conway, David I, Macfarlane, Gary J, Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Franceschi, Silvia, Herrero, Rolando, Toporcov, Tatiana N, Moyses, Raquel A, Muscat, Joshua, Negri, Eva, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W, Koifman, Rosalina, Wunsch-Filho, Victor, Olshan, Andrew F, Zevallos, Jose P, Sturgis, Erich M, Li, Guojun, Levi, Fabio, Zhang, Zuo-Feng, Morgenstern, Hal, Smith, Elaine, Lazarus, Philip, La Vecchia, Carlo, Garavello, Werner, Chen, Chu, Schwartz, Stephen M, Zheng, Tongzhang, Vaughan, Thomas L, Kelsey, Karl, McClean, Michael, Benhamou, Simone, Hayes, Richard B, Purdue, Mark P, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Yuan-Chin, Amy Lee, Edefonti, Valeria, Di Credico, Gioia, Di Credico, Gioia, Polesel, Jerry, Dal Maso, Luigino, Pauli, Francesco, Torelli, Nicola, Luce, Daniele, Radoï, Loredana, Matsuo, Keitaro, Serraino, Diego, Brennan, Paul, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Canova, Cristina, Richiardi, Lorenzo, Healy, Claire M, Kjaerheim, Kristina, Conway, David I, Macfarlane, Gary J, Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Franceschi, Silvia, Herrero, Rolando, Toporcov, Tatiana N, Moyses, Raquel A, Muscat, Joshua, Negri, Eva, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W, Koifman, Rosalina, Wunsch-Filho, Victor, Olshan, Andrew F, Zevallos, Jose P, Sturgis, Erich M, Li, Guojun, Levi, Fabio, Zhang, Zuo-Feng, Morgenstern, Hal, Smith, Elaine, Lazarus, Philip, La Vecchia, Carlo, Garavello, Werner, Chen, Chu, Schwartz, Stephen M, Zheng, Tongzhang, Vaughan, Thomas L, Kelsey, Karl, McClean, Michael, Benhamou, Simone, Hayes, Richard B, Purdue, Mark P, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Yuan-Chin, Amy Lee, and Edefonti, Valeria

Abstract

BackgroundAlcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.MethodsData from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.ResultsFor all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).ConclusionsPresent results further encourage the reduction of alcohol intensity to mitigate HNC risk.

Published
2020

4. Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium.

Author

Chang, Chun-Pin, Chang, Chun-Pin, La Vecchia, Carlo, Serraino, Diego, Olshan, Andrew F, Zevallos, Jose P, Morgenstern, Hal, Levi, Fabio, Garavello, Werner, Kelsey, Karl, McClean, Michael, Chen, Chu, Schwartz, Stephen M, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Parpinel, Maria, Augustin, Livia SA, Turati, Federica, Zhang, Zuo-Feng, Edefonti, Valeria, Chang, Chun-Pin, Chang, Chun-Pin, La Vecchia, Carlo, Serraino, Diego, Olshan, Andrew F, Zevallos, Jose P, Morgenstern, Hal, Levi, Fabio, Garavello, Werner, Kelsey, Karl, McClean, Michael, Chen, Chu, Schwartz, Stephen M, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Parpinel, Maria, Augustin, Livia SA, Turati, Federica, Zhang, Zuo-Feng, and Edefonti, Valeria

Abstract

High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.

Published
2020

5. Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium.

Author

Chang, Chun-Pin, Chang, Chun-Pin, La Vecchia, Carlo, Serraino, Diego, Olshan, Andrew F, Zevallos, Jose P, Morgenstern, Hal, Levi, Fabio, Garavello, Werner, Kelsey, Karl, McClean, Michael, Chen, Chu, Schwartz, Stephen M, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Parpinel, Maria, Augustin, Livia SA, Turati, Federica, Zhang, Zuo-Feng, Edefonti, Valeria, Chang, Chun-Pin, Chang, Chun-Pin, La Vecchia, Carlo, Serraino, Diego, Olshan, Andrew F, Zevallos, Jose P, Morgenstern, Hal, Levi, Fabio, Garavello, Werner, Kelsey, Karl, McClean, Michael, Chen, Chu, Schwartz, Stephen M, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Parpinel, Maria, Augustin, Livia SA, Turati, Federica, Zhang, Zuo-Feng, and Edefonti, Valeria

Abstract

High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.

Published
2020

6. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration.

Author

Di Credico, Gioia, Di Credico, Gioia, Polesel, Jerry, Dal Maso, Luigino, Pauli, Francesco, Torelli, Nicola, Luce, Daniele, Radoï, Loredana, Matsuo, Keitaro, Serraino, Diego, Brennan, Paul, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Canova, Cristina, Richiardi, Lorenzo, Healy, Claire M, Kjaerheim, Kristina, Conway, David I, Macfarlane, Gary J, Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Franceschi, Silvia, Herrero, Rolando, Toporcov, Tatiana N, Moyses, Raquel A, Muscat, Joshua, Negri, Eva, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W, Koifman, Rosalina, Wunsch-Filho, Victor, Olshan, Andrew F, Zevallos, Jose P, Sturgis, Erich M, Li, Guojun, Levi, Fabio, Zhang, Zuo-Feng, Morgenstern, Hal, Smith, Elaine, Lazarus, Philip, La Vecchia, Carlo, Garavello, Werner, Chen, Chu, Schwartz, Stephen M, Zheng, Tongzhang, Vaughan, Thomas L, Kelsey, Karl, McClean, Michael, Benhamou, Simone, Hayes, Richard B, Purdue, Mark P, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Yuan-Chin, Amy Lee, Edefonti, Valeria, Di Credico, Gioia, Di Credico, Gioia, Polesel, Jerry, Dal Maso, Luigino, Pauli, Francesco, Torelli, Nicola, Luce, Daniele, Radoï, Loredana, Matsuo, Keitaro, Serraino, Diego, Brennan, Paul, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Canova, Cristina, Richiardi, Lorenzo, Healy, Claire M, Kjaerheim, Kristina, Conway, David I, Macfarlane, Gary J, Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Franceschi, Silvia, Herrero, Rolando, Toporcov, Tatiana N, Moyses, Raquel A, Muscat, Joshua, Negri, Eva, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W, Koifman, Rosalina, Wunsch-Filho, Victor, Olshan, Andrew F, Zevallos, Jose P, Sturgis, Erich M, Li, Guojun, Levi, Fabio, Zhang, Zuo-Feng, Morgenstern, Hal, Smith, Elaine, Lazarus, Philip, La Vecchia, Carlo, Garavello, Werner, Chen, Chu, Schwartz, Stephen M, Zheng, Tongzhang, Vaughan, Thomas L, Kelsey, Karl, McClean, Michael, Benhamou, Simone, Hayes, Richard B, Purdue, Mark P, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Yuan-Chin, Amy Lee, and Edefonti, Valeria

Abstract

BackgroundAlcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.MethodsData from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.ResultsFor all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).ConclusionsPresent results further encourage the reduction of alcohol intensity to mitigate HNC risk.

Published
2020

7. Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE).

Author

Chang, Chun-Pin, Chang, Chun-Pin, Chang, Shen-Chih, Chuang, Shu-Chun, Berthiller, Julien, Ferro, Gilles, Matsuo, Keitaro, Wünsch-Filho, Victor, Toporcov, Tatiana N, de Carvalho, Marcos Brasilino, La Vecchia, Carlo, Olshan, Andrew F, Zevallos, Jose P, Serraino, Diego, Muscat, Joshua, Sturgis, Erich M, Li, Guojun, Morgenstern, Hal, Levi, Fabio, Dal Maso, Luigino, Smith, Elaine, Kelsey, Karl, McClean, Michael, Vaughan, Thomas L, Lazarus, Philip, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Winn, Deborah M, Bosetti, Cristina, Edefonti, Valeria, Garavello, Werner, Negri, Eva, Hayes, Richard B, Purdue, Mark P, Boccia, Stefania, Cadoni, Gabriella, Shangina, Oxana, Koifman, Rosalina, Curado, Maria Paula, Vilensky, Marta, Swiatkowska, Beata, Herrero, Rolando, Franceschi, Silvia, Benhamou, Simone, Fernandez, Leticia, Menezes, Ana MB, Daudt, Alexander W, Mates, Dana, Schantz, Stimson, Yu, Guo-Pei, Lissowska, Jolanta, Brenner, Hermann, Fabianova, Eleonora, Rudnai, Peter, Brennan, Paul, Boffetta, Paolo, Zhang, Zuo-Feng, Hashibe, Mia, Lee, Yuan-Chin Amy, Chang, Chun-Pin, Chang, Chun-Pin, Chang, Shen-Chih, Chuang, Shu-Chun, Berthiller, Julien, Ferro, Gilles, Matsuo, Keitaro, Wünsch-Filho, Victor, Toporcov, Tatiana N, de Carvalho, Marcos Brasilino, La Vecchia, Carlo, Olshan, Andrew F, Zevallos, Jose P, Serraino, Diego, Muscat, Joshua, Sturgis, Erich M, Li, Guojun, Morgenstern, Hal, Levi, Fabio, Dal Maso, Luigino, Smith, Elaine, Kelsey, Karl, McClean, Michael, Vaughan, Thomas L, Lazarus, Philip, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Winn, Deborah M, Bosetti, Cristina, Edefonti, Valeria, Garavello, Werner, Negri, Eva, Hayes, Richard B, Purdue, Mark P, Boccia, Stefania, Cadoni, Gabriella, Shangina, Oxana, Koifman, Rosalina, Curado, Maria Paula, Vilensky, Marta, Swiatkowska, Beata, Herrero, Rolando, Franceschi, Silvia, Benhamou, Simone, Fernandez, Leticia, Menezes, Ana MB, Daudt, Alexander W, Mates, Dana, Schantz, Stimson, Yu, Guo-Pei, Lissowska, Jolanta, Brenner, Hermann, Fabianova, Eleonora, Rudnai, Peter, Brennan, Paul, Boffetta, Paolo, Zhang, Zuo-Feng, Hashibe, Mia, and Lee, Yuan-Chin Amy

Abstract

BackgroundTobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk.MethodsWe analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models.ResultsWithout adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR<10 years vs. ≥30 years: 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR<10 years vs. ≥30 years: 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed.ConclusionsResults from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.

Published
2019

8. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach.

Author

Di Credico, Gioia, Di Credico, Gioia, Edefonti, Valeria, Polesel, Jerry, Pauli, Francesco, Torelli, Nicola, Serraino, Diego, Negri, Eva, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Brennan, Paul, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W, Koifman, Rosalina, Wunsch-Filho, Victor, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Simonato, Lorenzo, Richiardi, Lorenzo, Healy, Claire, Kjaerheim, Kristina, Conway, David I, Macfarlane, Tatiana V, Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Boaventura Rios, Leonardo F, Toporcov, Tatiana N, Franceschi, Silvia, Herrero, Rolando, Muscat, Joshua, Olshan, Andrew F, Zevallos, Jose P, La Vecchia, Carlo, Winn, Deborah M, Sturgis, Erich M, Li, Guojun, Fabianova, Eleonora, Lissowska, Jolanda, Mates, Dana, Rudnai, Peter, Shangina, Oxana, Swiatkowska, Beata, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Smith, Elaine, Lazarus, Philip, Bosetti, Cristina, Garavello, Werner, Kelsey, Karl, McClean, Michael, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Vaughan, Thomas L, Zheng, Tongzhang, Menvielle, Gwenn, Boccia, Stefania, Cadoni, Gabriella, Hayes, Richard B, Purdue, Mark, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Brenner, Hermann, D'Souza, Gypsyamber, Gross, Neil D, Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Dal Maso, Luigino, Di Credico, Gioia, Di Credico, Gioia, Edefonti, Valeria, Polesel, Jerry, Pauli, Francesco, Torelli, Nicola, Serraino, Diego, Negri, Eva, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Brennan, Paul, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W, Koifman, Rosalina, Wunsch-Filho, Victor, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Simonato, Lorenzo, Richiardi, Lorenzo, Healy, Claire, Kjaerheim, Kristina, Conway, David I, Macfarlane, Tatiana V, Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Boaventura Rios, Leonardo F, Toporcov, Tatiana N, Franceschi, Silvia, Herrero, Rolando, Muscat, Joshua, Olshan, Andrew F, Zevallos, Jose P, La Vecchia, Carlo, Winn, Deborah M, Sturgis, Erich M, Li, Guojun, Fabianova, Eleonora, Lissowska, Jolanda, Mates, Dana, Rudnai, Peter, Shangina, Oxana, Swiatkowska, Beata, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Smith, Elaine, Lazarus, Philip, Bosetti, Cristina, Garavello, Werner, Kelsey, Karl, McClean, Michael, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Vaughan, Thomas L, Zheng, Tongzhang, Menvielle, Gwenn, Boccia, Stefania, Cadoni, Gabriella, Hayes, Richard B, Purdue, Mark, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Brenner, Hermann, D'Souza, Gypsyamber, Gross, Neil D, Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Dal Maso, Luigino

Abstract

ObjectivesThis study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.Materials and methodsWe pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.ResultsFor oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.ConclusionReferring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

Published
2019

9. Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Author

Edefonti, Valeria, Edefonti, Valeria, Hashibe, Mia, Parpinel, Maria, Turati, Federica, Serraino, Diego, Matsuo, Keitaro, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Kelsey, Karl, McClean, Michael, Bosetti, Cristina, Galeone, Carlotta, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Amy Lee, Yuan-Chin, Chuang, Shu-Chun, La Vecchia, Carlo, Decarli, Adriano, Edefonti, Valeria, Edefonti, Valeria, Hashibe, Mia, Parpinel, Maria, Turati, Federica, Serraino, Diego, Matsuo, Keitaro, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Kelsey, Karl, McClean, Michael, Bosetti, Cristina, Galeone, Carlotta, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Amy Lee, Yuan-Chin, Chuang, Shu-Chun, La Vecchia, Carlo, and Decarli, Adriano

Abstract

Evidence of associations between single nutrients and head and neck cancer (HNC) is still more limited and less consistent than that for fruit and vegetables. However, clarification of the protective mechanisms of fruit and vegetables is important to our understanding of HNC etiology. We investigated the association between vitamin C intake from natural sources and cancer of the oral cavity/pharynx and larynx using individual-level pooled data from ten case-control studies (5,959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. After harmonization of study-specific exposure information via the residual method, adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models on quintile categories of 'non-alcohol energy-adjusted' vitamin C intake. In the presence of heterogeneity of the estimated ORs among studies, we derived those estimates from generalized linear mixed models. Higher intakes of vitamin C were inversely related to oral and pharyngeal (OR = 0.54, 95% CI: 0.45-0.65, for the fifth quintile category versus the first one, p for trend<0.001) and laryngeal cancers (OR = 0.52, 95% CI: 0.40-0.68, p for trend = 0.006), although in the presence of heterogeneity among studies for both sites. Inverse associations were consistently observed for the anatomical subsites of oral and pharyngeal cancer, and across strata of age, sex, education, body mass index, tobacco, and alcohol, for both cancer sites. The inverse association of vitamin C intake from foods with HNC may reflect a protective effect on these cancers; however, we cannot rule out other explanations.

Published
2015

10. Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium.

Author

Kawakita, Daisuke, Kawakita, Daisuke, Lee, Yuan-Chin Amy, Turati, Federica, Parpinel, Maria, Decarli, Adriano, Serraino, Diego, Matsuo, Keitaro, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Kelsey, Karl, McClean, Michael, Bosetti, Cristina, Garavello, Werner, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Chuang, Shu-Chun, Hashibe, Mia, Ferraroni, Monica, La Vecchia, Carlo, Edefonti, Valeria, Kawakita, Daisuke, Kawakita, Daisuke, Lee, Yuan-Chin Amy, Turati, Federica, Parpinel, Maria, Decarli, Adriano, Serraino, Diego, Matsuo, Keitaro, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Kelsey, Karl, McClean, Michael, Bosetti, Cristina, Garavello, Werner, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Chuang, Shu-Chun, Hashibe, Mia, Ferraroni, Monica, La Vecchia, Carlo, and Edefonti, Valeria

Abstract

The possible role of dietary fiber in the etiology of head neck cancers (HNCs) is unclear. We used individual-level pooled data from ten case-control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non-alcohol energy-adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders. Fiber intake was inversely associated with oral and pharyngeal cancer combined (OR for 5th vs. 1st quintile category = 0.49, 95% CI: 0.40-0.59; p for trend <0.001) and with laryngeal cancer (OR = 0.66, 95% CI: 0.54-0.82, p for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral and pharyngeal cancer combined. Nonetheless, inverse associations were consistently observed for the subsites of oral and pharyngeal cancers and within most strata of the considered covariates, for both cancer sites. Our findings from a multicenter large-scale pooled analysis suggest that, although in the presence of between-study heterogeneity, a greater intake of fiber may lower HNC risk.

Published
2017

11. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries.

Author

Conway, David I, Conway, David I, Brenner, Darren R, McMahon, Alex D, Macpherson, Lorna MD, Agudo, Antonio, Ahrens, Wolfgang, Bosetti, Cristina, Brenner, Hermann, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, Curioni, Otávio A, Dal Maso, Luigino, Daudt, Alexander W, de Gois Filho, José F, D'Souza, Gypsyamber, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Gillison, Maura, Hayes, Richard B, Healy, Claire M, Herrero, Rolando, Holcatova, Ivana, Jayaprakash, Vijayvel, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, La Vecchia, Carlo, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Tatiana V, Mates, Dana, Matos, Elena, McClean, Michael, Menezes, Ana M, Menvielle, Gwenn, Merletti, Franco, Morgenstern, Hal, Moysich, Kirsten, Müller, Heiko, Muscat, Joshua, Olshan, Andrew F, Purdue, Mark P, Ramroth, Heribert, Richiardi, Lorenzo, Rudnai, Peter, Schantz, Stimson, Schwartz, Stephen M, Shangina, Oxana, Simonato, Lorenzo, Smith, Elaine, Stucker, Isabelle, Sturgis, Erich M, Szeszenia-Dabrowska, Neonila, Talamini, Renato, Thomson, Peter, Vaughan, Thomas L, Wei, Qingyi, Winn, Deborah M, Wunsch-Filho, Victor, Yu, Guo-Pei, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Chuang, Shu-Chun, Ghodrat, Marianoosh, Amy Lee, Yuan-Chin, Hashibe, Mia, Brennan, Paul, Conway, David I, Conway, David I, Brenner, Darren R, McMahon, Alex D, Macpherson, Lorna MD, Agudo, Antonio, Ahrens, Wolfgang, Bosetti, Cristina, Brenner, Hermann, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, Curioni, Otávio A, Dal Maso, Luigino, Daudt, Alexander W, de Gois Filho, José F, D'Souza, Gypsyamber, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Gillison, Maura, Hayes, Richard B, Healy, Claire M, Herrero, Rolando, Holcatova, Ivana, Jayaprakash, Vijayvel, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, La Vecchia, Carlo, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Tatiana V, Mates, Dana, Matos, Elena, McClean, Michael, Menezes, Ana M, Menvielle, Gwenn, Merletti, Franco, Morgenstern, Hal, Moysich, Kirsten, Müller, Heiko, Muscat, Joshua, Olshan, Andrew F, Purdue, Mark P, Ramroth, Heribert, Richiardi, Lorenzo, Rudnai, Peter, Schantz, Stimson, Schwartz, Stephen M, Shangina, Oxana, Simonato, Lorenzo, Smith, Elaine, Stucker, Isabelle, Sturgis, Erich M, Szeszenia-Dabrowska, Neonila, Talamini, Renato, Thomson, Peter, Vaughan, Thomas L, Wei, Qingyi, Winn, Deborah M, Wunsch-Filho, Victor, Yu, Guo-Pei, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Chuang, Shu-Chun, Ghodrat, Marianoosh, Amy Lee, Yuan-Chin, Hashibe, Mia, and Brennan, Paul

Abstract

Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 - 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 - 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels.

Published
2015

12. Folate intake and the risk of oral cavity and pharyngeal cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology Consortium.

Author

Galeone, Carlotta, Galeone, Carlotta, Edefonti, Valeria, Parpinel, Maria, Leoncini, Emanuele, Matsuo, Keitaro, Talamini, Renato, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Jayaprakash, Vijayvel, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Bosetti, Cristina, Kelsey, Karl, McClean, Michael, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Lee, Yuan-Chin Amy, Hashibe, Mia, La Vecchia, Carlo, Boccia, Stefania, Galeone, Carlotta, Galeone, Carlotta, Edefonti, Valeria, Parpinel, Maria, Leoncini, Emanuele, Matsuo, Keitaro, Talamini, Renato, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Jayaprakash, Vijayvel, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Bosetti, Cristina, Kelsey, Karl, McClean, Michael, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Lee, Yuan-Chin Amy, Hashibe, Mia, La Vecchia, Carlo, and Boccia, Stefania

Abstract

There are suggestions of an inverse association between folate intake and serum folate levels and the risk of oral cavity and pharyngeal cancers (OPCs), but most studies are limited in sample size, with only few reporting information on the source of dietary folate. Our study aims to investigate the association between folate intake and the risk of OPC within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. We analyzed pooled individual-level data from ten case-control studies participating in the INHANCE consortium, including 5,127 cases and 13,249 controls. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated for the associations between total folate intake (natural, fortification and supplementation) and natural folate only, and OPC risk. We found an inverse association between total folate intake and overall OPC risk (the adjusted OR for the highest vs. the lowest quintile was 0.65, 95% CI: 0.43-0.99), with a stronger association for oral cavity (OR = 0.57, 95% CI: 0.43-0.75). A similar inverse association, though somewhat weaker, was observed for folate intake from natural sources only in oral cavity cancer (OR = 0.64, 95% CI: 0.45-0.91). The highest OPC risk was observed in heavy alcohol drinkers with low folate intake as compared to never/light drinkers with high folate (OR = 4.05, 95% CI: 3.43-4.79); the attributable proportion (AP) owing to interaction was 11.1% (95% CI: 1.4-20.8%). Lastly, we reported an OR of 2.73 (95% CI:2.34-3.19) for those ever tobacco users with low folate intake, compared with nevere tobacco users and high folate intake (AP of interaction =10.6%, 95% CI: 0.41-20.8%). Our project of a large pool of case-control studies supports a protective effect of total folate intake on OPC risk.

Published
2015

13. Vitamin D status among male late adolescents living in southern Switzerland: role of body composition and lifestyle

Author

Rabufetti, Andrea, Milani, Gregorio P., Lava, Sebastiano A. G., Edefonti, Valeria, Bianchetti, Mario G., Stettbacher, Andreas, Muggli, Franco, Simonetti, Giacomo, Rabufetti, Andrea, Milani, Gregorio P., Lava, Sebastiano A. G., Edefonti, Valeria, Bianchetti, Mario G., Stettbacher, Andreas, Muggli, Franco, and Simonetti, Giacomo

Abstract

Background: Poor vitamin D status is a worldwide health problem. Yet, knowledge about vitamin D status among adolescents in Southern Europe is limited. This study investigated concentrations and modulating factors of vitamin D in a healthy population of male late adolescents living in Southern Switzerland. Methods: All apparently healthy subjects attending for the medical evaluation before the compulsory military service in Southern Switzerland during 2014-2016 were eligible. Dark-skin subjects, subjects on vitamin D supplementation or managed with diseases or drugs involved in vitamin D metabolism were excluded. Anthropometric measurements (body height, weight, fat percentage, mid-upper arm and waist circumference) and blood sampling for total 25-hydroxy-vitamin D, total cholesterol and ferritin concentrations testing, were collected. Participants filled in a structured questionnaire addressing their lifestyle. Characteristics of the subjects with adequate (≥50 nmol/L–≤250 nmol/L) and insufficient (<50 nmol/L) vitamin D values were compared by Kruskal-Wallis test or χ2 test. Odds ratios for 25-hydroxy-vitamin D insufficiency were calculated by univariate and AIC-selected multiple logistic regression models. Results: A total of 1045 subjects volunteered to participate in the study. Insufficient concentrations of vitamin D were detected in 184 (17%). The season of measurement was the most significant factor associated with vitamin D levels and approximately 40% of subjects presented insucient vitamin D concentrations in winter. After model selection, body fat percentage, frequency and site of recreational physical activity, and the seasonality were significantly associated with the risk of vitamin D insufficiency. Conclusions: Among healthy male late adolescents in Southern Switzerland, about one every fourth subject presents a poor vitamin D status in non-summer seasons. Body fat percentage, frequent and outdoor recreational physical activity are modulating factors

Catalog

Books, media, physical & digital resources
See catalog results