1. Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production
- Author
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Sencio, Valentin, Barthelemy, Adeline, Tavares, Luciana P., Machado, Marina G., Soulard, Daphnée, Cuinat, Céline, Queiroz-Junior, Celso Martins, Noordine, Marie Louise, Salomé-Desnoulez, Sophie, Deryuter, Lucie, Foligné, Benoit, Wahl, Céline, Frisch, Benoit, Vieira, Angelica T., Paget, Christophe, Milligan, Graeme, Ulven, Trond, Wolowczuk, Isabelle, Faveeuw, Christelle, Le Goffic, Ronan, Thomas, Muriel, Ferreira, Stéphanie, Teixeira, Mauro M., Trottein, François, Sencio, Valentin, Barthelemy, Adeline, Tavares, Luciana P., Machado, Marina G., Soulard, Daphnée, Cuinat, Céline, Queiroz-Junior, Celso Martins, Noordine, Marie Louise, Salomé-Desnoulez, Sophie, Deryuter, Lucie, Foligné, Benoit, Wahl, Céline, Frisch, Benoit, Vieira, Angelica T., Paget, Christophe, Milligan, Graeme, Ulven, Trond, Wolowczuk, Isabelle, Faveeuw, Christelle, Le Goffic, Ronan, Thomas, Muriel, Ferreira, Stéphanie, Teixeira, Mauro M., and Trottein, François
- Abstract
Sencio et al. provide insights into the mechanisms that underlie bacterial superinfection post-influenza. The authors demonstrate that influenza infection remotely alters the production of short-chain fatty acids (SCFAs) by the gut microbiota. Supplementation with acetate or pharmacological activation of the SCFA receptor FFAR2 reduces susceptibility to secondary bacterial infection.
- Published
- 2020