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Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production
- Source :
- Sencio , V , Barthelemy , A , Tavares , L P , Machado , M G , Soulard , D , Cuinat , C , Queiroz-Junior , C M , Noordine , M L , Salomé-Desnoulez , S , Deryuter , L , Foligné , B , Wahl , C , Frisch , B , Vieira , A T , Paget , C , Milligan , G , Ulven , T , Wolowczuk , I , Faveeuw , C , Le Goffic , R , Thomas , M , Ferreira , S , Teixeira , M M & Trottein , F 2020 , ' Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production ' , Cell Reports , vol. 30 , no. 9 , pp. 2934-2947.e6 .
- Publication Year :
- 2020
-
Abstract
- Sencio et al. provide insights into the mechanisms that underlie bacterial superinfection post-influenza. The authors demonstrate that influenza infection remotely alters the production of short-chain fatty acids (SCFAs) by the gut microbiota. Supplementation with acetate or pharmacological activation of the SCFA receptor FFAR2 reduces susceptibility to secondary bacterial infection.
Details
- Database :
- OAIster
- Journal :
- Sencio , V , Barthelemy , A , Tavares , L P , Machado , M G , Soulard , D , Cuinat , C , Queiroz-Junior , C M , Noordine , M L , Salomé-Desnoulez , S , Deryuter , L , Foligné , B , Wahl , C , Frisch , B , Vieira , A T , Paget , C , Milligan , G , Ulven , T , Wolowczuk , I , Faveeuw , C , Le Goffic , R , Thomas , M , Ferreira , S , Teixeira , M M & Trottein , F 2020 , ' Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production ' , Cell Reports , vol. 30 , no. 9 , pp. 2934-2947.e6 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1263226077
- Document Type :
- Electronic Resource