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1. Event generators for high-energy physics experiments

Author: Campbell, J, Diefenthaler, M, Hobbs, T, Hoche, S, Isaacson, J, Kling, F, Mrenna, S, Reuter, J, Alioli, S, Andersen, J, Andreopoulos, C, Ankowski, A, Aschenauer, E, Ashkenazi, A, Baker, M, Barrow, J, van Beekveld, M, Bewick, G, Bhattacharya, S, Bierlich, C, Bothmann, E, Bredt, P, Broggio, A, Buckley, A, Butter, A, Butterworth, J, Byrne, E, Calame, C, Chakraborty, S, Chen, X, Chiesa, M, Childers, J, Cruz-Martinez, J, Currie, J, Darvishi, N, Dasgupta, M, Denner, A, Dreyer, F, Dytman, S, El-Menoufi, B, Engel, T, Ravasio, S, Figueroa, D, Flower, L, Forshaw, J, Frederix, R, Friedland, A, Frixione, S, Gallagher, H, Gallmeister, K, Gardiner, S, Gauld, R, Gaunt, J, Gavardi, A, Gehrmann, T, De Ridder, A, Gellersen, L, Giele, W, Gieseke, S, Giuli, F, Glover, E, Grazzini, M, Grohsjean, A, Gutschow, C, Hamilton, K, Han, T, Hatcher, R, Heinrich, G, Helenius, I, Hen, O, Hirschi, V, Hofer, M, Holguin, J, Huss, A, Ilten, P, Jadach, S, Jentsch, A, Jones, S, Ju, W, Kallweit, S, Karlberg, A, Katori, T, Kerner, M, Kilian, W, Kirchgaesser, M, Klein, S, Knobbe, M, Krause, C, Krauss, F, Lang, J, Lee, G, Li, S, Lim, M, Lindert, J, Lombardi, D, Lonnblad, L, Loschner, M, Lurkin, N, Ma, Y, Machado, P, Magerya, V, Maier, A, Majer, I, Maltoni, F, Marcoli, M, Marinelli, G, Masouminia, M, Mastrolia, P, Mattelaer, O, Mazzitelli, J, Mcfayden, J, Medves, R, Meinzinger, P, Mo, J, Monni, P, Montagna, G, Morgan, T, Mosel, U, Nachman, B, Nadolsky, P, Nagar, R, Nagy, Z, Napoletano, D, Nason, P, Neumann, T, Nevay, L, Nicrosini, O, Niehues, J, Niewczas, K, Ohl, T, Ossola, G, Pandey, V, Papadopoulou, A, Papaefstathiou, A, Paz, G, Pellen, M, Pelliccioli, G, Peraro, T, Piccinini, F, Pickering, L, Pires, J, Placzek, W, Platzer, S, Plehn, T, Pozzorini, S, Prestel, S, Preuss, C, Price, A, Quackenbush, S, Re, E, Reichelt, D, Reina, L, Reuschle, C, Richardson, P, Rocco, M, Rocco, N, Roda, M, Garcia, A, Roiser, S, Rojo, J, Rottoli, L, Salam, G, Schonherr, M, Schuchmann, S, Schumann, S, Schurmann, R, Scyboz, L, Seymour, M, Siegert, F, Signer, A, Chahal, G, Siodmok, A, Sjostrand, T, Skands, P, Smillie, J, Sobczyk, J, Soldin, D, Soper, D, Soto-Ontoso, A, Soyez, G, Stagnitto, G, Tena-Vidal, J, Tomalak, O, Tramontano, F, Trojanowski, S, Tu, Z, Uccirati, S, Ullrich, T, Ulrich, Y, Utheim, M, Valassi, A, Verbytskyi, A, Verheyen, R, Wagman, M, Walker, D, Webber, B, Weinstein, L, White, O, Whitehead, J, Wiesemann, M, Wilkinson, C, Williams, C, Winterhalder, R, Wret, C, Xie, K, Yang, T, Yazgan, E, Zanderighi, G, Zanoli, S, Zapp, K, Campbell J. M., Diefenthaler M., Hobbs T. J., Hoche S., Isaacson J., Kling F., Mrenna S., Reuter J., Alioli S., Andersen J. R., Andreopoulos C., Ankowski A. M., Aschenauer E. C., Ashkenazi A., Baker M. D., Barrow J. L., van Beekveld M., Bewick G., Bhattacharya S., Bierlich C., Bothmann E., Bredt P., Broggio A., Buckley A., Butter A., Butterworth J. M., Byrne E. P., Calame C. M. C., Chakraborty S., Chen X., Chiesa M., Childers J. T., Cruz-Martinez J., Currie J., Darvishi N., Dasgupta M., Denner A., Dreyer F. A., Dytman S., El-Menoufi B. K., Engel T., Ravasio S. F., Figueroa D., Flower L., Forshaw J. R., Frederix R., Friedland A., Frixione S., Gallagher H., Gallmeister K., Gardiner S., Gauld R., Gaunt J., Gavardi A., Gehrmann T., De Ridder A. G., Gellersen L., Giele W., Gieseke S., Giuli F., Glover E. W. N., Grazzini M., Grohsjean A., Gutschow C., Hamilton K., Han T., Hatcher R., Heinrich G., Helenius I., Hen O., Hirschi V., Hofer M., Holguin J., Huss A., Ilten P., Jadach S., Jentsch A., Jones S. P., Ju W., Kallweit S., Karlberg A., Katori T., Kerner M., Kilian W., Kirchgaesser M. M., Klein S., Knobbe M., Krause C., Krauss F., Lang J., Lang J. -N., Lee G., Li S. W., Lim M. A., Lindert J. M., Lombardi D., Lonnblad L., Loschner M., Lurkin N., Ma Y., Machado P., Magerya V., Maier A., Majer I., Maltoni F., Marcoli M., Marinelli G., Masouminia M. R., Mastrolia P., Mattelaer O., Mazzitelli J., McFayden J., Medves R., Meinzinger P., Mo J., Monni P. F., Montagna G., Morgan T., Mosel U., Nachman B., Nadolsky P., Nagar R., Nagy Z., Napoletano D., Nason P., Neumann T., Nevay L. J., Nicrosini O., Niehues J., Niewczas K., Ohl T., Ossola G., Pandey V., Papadopoulou A., Papaefstathiou A., Paz G., Pellen M., Pelliccioli G., Peraro T., Piccinini F., Pickering L., Pires J., Placzek W., Platzer S., Plehn T., Pozzorini S., Prestel S., Preuss C. T., Price A. C., Quackenbush S., Re E., Reichelt D., Reina L., Reuschle C., Richardson P., Rocco M., Rocco N., Roda M., Garcia A. R., Roiser S., Rojo J., Rottoli L., Salam G. P., Schonherr M., Schuchmann S., Schumann S., Schurmann R., Scyboz L., Seymour M. H., Siegert F., Signer A., Chahal G. S., Siodmok A., Sjostrand T., Skands P., Smillie J. M., Sobczyk J. T., Soldin D., Soper D. E., Soto-Ontoso A., Soyez G., Stagnitto G., Tena-Vidal J., Tomalak O., Tramontano F., Trojanowski S., Tu Z., Uccirati S., Ullrich T., Ulrich Y., Utheim M., Valassi A., Verbytskyi A., Verheyen R., Wagman M., Walker D., Webber B. R., Weinstein L., White O., Whitehead J., Wiesemann M., Wilkinson C., Williams C., Winterhalder R., Wret C., Xie K., Yang T. -Z., Yazgan E., Zanderighi G., Zanoli S., Zapp K., Campbell, J, Diefenthaler, M, Hobbs, T, Hoche, S, Isaacson, J, Kling, F, Mrenna, S, Reuter, J, Alioli, S, Andersen, J, Andreopoulos, C, Ankowski, A, Aschenauer, E, Ashkenazi, A, Baker, M, Barrow, J, van Beekveld, M, Bewick, G, Bhattacharya, S, Bierlich, C, Bothmann, E, Bredt, P, Broggio, A, Buckley, A, Butter, A, Butterworth, J, Byrne, E, Calame, C, Chakraborty, S, Chen, X, Chiesa, M, Childers, J, Cruz-Martinez, J, Currie, J, Darvishi, N, Dasgupta, M, Denner, A, Dreyer, F, Dytman, S, El-Menoufi, B, Engel, T, Ravasio, S, Figueroa, D, Flower, L, Forshaw, J, Frederix, R, Friedland, A, Frixione, S, Gallagher, H, Gallmeister, K, Gardiner, S, Gauld, R, Gaunt, J, Gavardi, A, Gehrmann, T, De Ridder, A, Gellersen, L, Giele, W, Gieseke, S, Giuli, F, Glover, E, Grazzini, M, Grohsjean, A, Gutschow, C, Hamilton, K, Han, T, Hatcher, R, Heinrich, G, Helenius, I, Hen, O, Hirschi, V, Hofer, M, Holguin, J, Huss, A, Ilten, P, Jadach, S, Jentsch, A, Jones, S, Ju, W, Kallweit, S, Karlberg, A, Katori, T, Kerner, M, Kilian, W, Kirchgaesser, M, Klein, S, Knobbe, M, Krause, C, Krauss, F, Lang, J, Lee, G, Li, S, Lim, M, Lindert, J, Lombardi, D, Lonnblad, L, Loschner, M, Lurkin, N, Ma, Y, Machado, P, Magerya, V, Maier, A, Majer, I, Maltoni, F, Marcoli, M, Marinelli, G, Masouminia, M, Mastrolia, P, Mattelaer, O, Mazzitelli, J, Mcfayden, J, Medves, R, Meinzinger, P, Mo, J, Monni, P, Montagna, G, Morgan, T, Mosel, U, Nachman, B, Nadolsky, P, Nagar, R, Nagy, Z, Napoletano, D, Nason, P, Neumann, T, Nevay, L, Nicrosini, O, Niehues, J, Niewczas, K, Ohl, T, Ossola, G, Pandey, V, Papadopoulou, A, Papaefstathiou, A, Paz, G, Pellen, M, Pelliccioli, G, Peraro, T, Piccinini, F, Pickering, L, Pires, J, Placzek, W, Platzer, S, Plehn, T, Pozzorini, S, Prestel, S, Preuss, C, Price, A, Quackenbush, S, Re, E, Reichelt, D, Reina, L, Reuschle, C, Richardson, P, Rocco, M, Rocco, N, Roda, M, Garcia, A, Roiser, S, Rojo, J, Rottoli, L, Salam, G, Schonherr, M, Schuchmann, S, Schumann, S, Schurmann, R, Scyboz, L, Seymour, M, Siegert, F, Signer, A, Chahal, G, Siodmok, A, Sjostrand, T, Skands, P, Smillie, J, Sobczyk, J, Soldin, D, Soper, D, Soto-Ontoso, A, Soyez, G, Stagnitto, G, Tena-Vidal, J, Tomalak, O, Tramontano, F, Trojanowski, S, Tu, Z, Uccirati, S, Ullrich, T, Ulrich, Y, Utheim, M, Valassi, A, Verbytskyi, A, Verheyen, R, Wagman, M, Walker, D, Webber, B, Weinstein, L, White, O, Whitehead, J, Wiesemann, M, Wilkinson, C, Williams, C, Winterhalder, R, Wret, C, Xie, K, Yang, T, Yazgan, E, Zanderighi, G, Zanoli, S, Zapp, K, Campbell J. M., Diefenthaler M., Hobbs T. J., Hoche S., Isaacson J., Kling F., Mrenna S., Reuter J., Alioli S., Andersen J. R., Andreopoulos C., Ankowski A. M., Aschenauer E. C., Ashkenazi A., Baker M. D., Barrow J. L., van Beekveld M., Bewick G., Bhattacharya S., Bierlich C., Bothmann E., Bredt P., Broggio A., Buckley A., Butter A., Butterworth J. M., Byrne E. P., Calame C. M. C., Chakraborty S., Chen X., Chiesa M., Childers J. T., Cruz-Martinez J., Currie J., Darvishi N., Dasgupta M., Denner A., Dreyer F. A., Dytman S., El-Menoufi B. K., Engel T., Ravasio S. F., Figueroa D., Flower L., Forshaw J. R., Frederix R., Friedland A., Frixione S., Gallagher H., Gallmeister K., Gardiner S., Gauld R., Gaunt J., Gavardi A., Gehrmann T., De Ridder A. G., Gellersen L., Giele W., Gieseke S., Giuli F., Glover E. W. N., Grazzini M., Grohsjean A., Gutschow C., Hamilton K., Han T., Hatcher R., Heinrich G., Helenius I., Hen O., Hirschi V., Hofer M., Holguin J., Huss A., Ilten P., Jadach S., Jentsch A., Jones S. P., Ju W., Kallweit S., Karlberg A., Katori T., Kerner M., Kilian W., Kirchgaesser M. M., Klein S., Knobbe M., Krause C., Krauss F., Lang J., Lang J. -N., Lee G., Li S. W., Lim M. A., Lindert J. M., Lombardi D., Lonnblad L., Loschner M., Lurkin N., Ma Y., Machado P., Magerya V., Maier A., Majer I., Maltoni F., Marcoli M., Marinelli G., Masouminia M. R., Mastrolia P., Mattelaer O., Mazzitelli J., McFayden J., Medves R., Meinzinger P., Mo J., Monni P. F., Montagna G., Morgan T., Mosel U., Nachman B., Nadolsky P., Nagar R., Nagy Z., Napoletano D., Nason P., Neumann T., Nevay L. J., Nicrosini O., Niehues J., Niewczas K., Ohl T., Ossola G., Pandey V., Papadopoulou A., Papaefstathiou A., Paz G., Pellen M., Pelliccioli G., Peraro T., Piccinini F., Pickering L., Pires J., Placzek W., Platzer S., Plehn T., Pozzorini S., Prestel S., Preuss C. T., Price A. C., Quackenbush S., Re E., Reichelt D., Reina L., Reuschle C., Richardson P., Rocco M., Rocco N., Roda M., Garcia A. R., Roiser S., Rojo J., Rottoli L., Salam G. P., Schonherr M., Schuchmann S., Schumann S., Schurmann R., Scyboz L., Seymour M. H., Siegert F., Signer A., Chahal G. S., Siodmok A., Sjostrand T., Skands P., Smillie J. M., Sobczyk J. T., Soldin D., Soper D. E., Soto-Ontoso A., Soyez G., Stagnitto G., Tena-Vidal J., Tomalak O., Tramontano F., Trojanowski S., Tu Z., Uccirati S., Ullrich T., Ulrich Y., Utheim M., Valassi A., Verbytskyi A., Verheyen R., Wagman M., Walker D., Webber B. R., Weinstein L., White O., Whitehead J., Wiesemann M., Wilkinson C., Williams C., Winterhalder R., Wret C., Xie K., Yang T. -Z., Yazgan E., Zanderighi G., Zanoli S., and Zapp K.
Abstract: We provide an overview of the status of Monte-Carlo event generators for high-energy particle physics. Guided by the experimental needs and requirements, we highlight areas of active development, and opportunities for future improvements. Particular emphasis is given to physics models and algorithms that are employed across a variety of experiments. These common themes in event generator development lead to a more comprehensive understanding of physics at the highest energies and intensities, and allow models to be tested against a wealth of data that have been accumulated over the past decades. A cohesive approach to event generator development will allow these models to be further improved and systematic uncertainties to be reduced, directly contributing to future experimental success. Event generators are part of a much larger ecosystem of computational tools. They typically involve a number of unknown model parameters that must be tuned to experimental data, while maintaining the integrity of the underlying physics models. Making both these data, and the analyses with which they have been obtained accessible to future users is an essential aspect of open science and data preservation. It ensures the consistency of physics models across a variety of experiments.
Published: 2024

2. Early Childhood Longitudinal Study, Kindergarten Class of 1998-99 (ECLS-K): Third Grade Methodology Report. NCES 2005-018

Author: National Center for Education Statistics (ED), Washington, DC., Westat Research, Inc., Rockville, MD., Tourangeau, Karen, Brick, Mike, Byrne, Lauren, Le, Thanh, Nord, Christine, West, Jerry, and Hausken, Elvira Germino
Abstract: This methodology report provides technical information about the development, design, and conduct of the third grade data collection of the Early Childhood Longitudinal Study, Kindergarten Class of 1998-99 (ECLS-K). Detailed information on the development of the instruments, sample design, data collection methods, data preparation and editing, response rates, and weighting and variance estimation is included. This report is organized into the following chapters: (1) Introduction; (2) Development of Survey Instruments; (3) Sample Design and Implementation; (4) Data Collection Methods; (5) Data Preparation and Editing; (6) Response Rates; and (7) Weighting and Variance Estimation. Individual chapters contain references. (Contains 65 tables and 29 exhibits.)
Published: 2005

3. State of the World's Newborns: A Report from Saving Newborn Lives.

Author: Save the Children, Westport, CT., Costello, Anthony, Francis, Victoria, Byrne, Ali, and Puddephatt, Claire
Abstract: There has been little change in newborn mortality in the past 20 years, even through proven, cost-effective solutions exist to save many of these young lives. This report reviews the most recent data on the newborn, revealing the alarming poor health and quality of health care for mothers and newborns in virtually all impoverished countries. The report identifies infections, complications of prematurity, and birth asphyxia and injuries as the primary causes of newborn mortality, with low birth weight an important secondary factor. Another major cause of neonatal deaths in developing countries is identified as poor maternal health, especially during pregnancy. The report argues that many of these neonatal deaths can be prevented with three cost-effective solutions that do not depend on highly technical training or sophisticated equipment: (1) tetanus toxoid immunization; (2) skilled health care at delivery; and (3) immediate and exclusive breastfeeding. Further, the report maintains that policymakers, nongovernmental organizations, health care professionals, and community leaders need to collaborate in strengthening existing health care delivery systems to provide expectant mothers and their babies the care they need. A key part to this effort is advocating for and creating policies that address newborns' special needs. The report's appendices include tables providing information on newborn health status and on newborn health services and practices, by country, and as well as each country's rank on the Human Development Index, a composite indicator of development status that includes life expectancy at birth, educational achievement, and real gross domestic product per capita. (Contains 84 endnotes.) (KB)
Published: 2001

4. Illinois Higher Education: Building the Economy, Shaping Society.

Author: Illinois Univ., Urbana. Inst. of Government and Public Affairs., Illinois State Board of Higher Education, Springfield., Resek, Robert W., Merriman, David F., Hartter, Susan R., McCarthy, Diane M., and Byrne, Paul F.
Abstract: This report examines some of the costs of higher education and the benefits Illinois citizens receive in return. The study examines both public and private higher education and measures the impact on a state-wide basis. Data come from the Integrated Postsecondary Education Data System and data collected by the Illinois State Board of Higher Education. Data contain direct costs of higher education, including costs to taxpayers and students, and costs paid by donations and endowments. The report highlights seven benefits of higher education: monetary benefits to students, benefits from university spending, benefits from student and visitor spending, additional state and local tax revenue, nonmonetary benefits to students and society, added productivity to society, and public service and outreach programs. Ten appendixes include a list Illinois colleges and universities; lifetime value of additional earnings; enrollment in Illinois colleges and universities, fall 1997; degrees and certificates awarded, academic year 1996-97; expenditures by Illinois colleges and universities; faculty and staff at Illinois colleges and universities, fall 1997; visitor survey; total expenditures by visitors, fiscal year 1999; direct and indirect expenditures and employment generated by student and visitor spending, fiscal year 1996; and calculation of specific nonmonetary benefits. There are illustrative vignettes throughout the report. (Each section of the report contains endnotes.) (SM)
Published: 2000

5. Parents and the Internet: What Today's Parents Need To Know.

Author: Byrne, John J.
Abstract: This guide to the Internet is designed to help parents, especially urban parents, find information they will need to participate in school leadership and in their children's education. The following sections explain the Internet for parents: (1) "How To Use the Internet"; (2) "General Sites"; (3) "Education Related Sites for Parents"; (4) "Government Links"; (5) "My Favorite Site"; (6) "Must See Sites for Parents"; (7) "Urban Web"; (8) "Parents and School Reform"; (9) "Plain Old Fun for Parents and Kids"; and (10) "Index." Using the information superhighway is vital if parents want to participate fully and knowledgeably in constructing school policy. (SLD)
Published: 1998

6. Learning drivers : rural electrification regime building in Kenya and Tanzania

Author: Byrne, Robert P.
Subjects: 333.793, DT0433.5 Kenya, DT0436 Tanzania. Tanganyika. German East Africa, TK3001 Distribution or transmission of electric power, TK5101 Telecommunication Including telegraphy, telephone, radio, radar, television
Abstract: Rural electrification has been a long-standing objective in many developing countries. For decades, the assumption and practice has been to build centralised generating capacity and transmit the electricity over national grids. More recently, interest has grown in using PV (photovoltaic) technology as a solution to the problem of rural electrification. A private household market for PV has been developing in Kenya since 1984 and now has more than 200,000 systems installed, sold through this private market. Consequently, it is widely hailed as a success story among developing countries. Until recently, Tanzania had almost no household PV market, despite interest from a number of actors, including some of those who have been involved in enabling the rapid growth of the market in Kenya. However, sales of PV began to grow quite rapidly from the early 2000s and the trend appears to be gaining pace, with an estimated 285 kWp sold in 2007, having risen by 57% in one year. At the time of the research, there were two large donor-funded PV projects underway in the country. The research attempts to explain the dynamics of the two PV niches over the past 25 years using strategic niche management as its theoretical framework. It finds that the Kenyan niche has benefited more from donor support than is usually acknowledged. The thesis also makes theoretical and methodological contributions. It offers a way to connect first and second-order learning to expectations and visions concepts; dimensions expectations and visions; and presents a tool for systematic investigation of socio-technical trajectory developments. The thesis also suggests a number of ways in which the strategic niche management framework could be enhanced. These include stronger theorising about learning, and the incorporation of power, politics and risk into the theory.
Published: 2011

7. Modification of layered silicates for PET nanocomposites

Author: Byrne, C. P.
Subjects: 620.5
Published: 2006

8. ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.

Author: Balmanno, Kathryn, Balmanno, Kathryn, Kidger, Andrew M, Byrne, Dominic P, Sale, Matthew J, Nassman, Nejma, Eyers, Patrick A, Cook, Simon J, Balmanno, Kathryn, Balmanno, Kathryn, Kidger, Andrew M, Byrne, Dominic P, Sale, Matthew J, Nassman, Nejma, Eyers, Patrick A, and Cook, Simon J
Abstract: Innate or acquired resistance to small molecule BRAF or MEK1/2 inhibitors (BRAFi or MEKi) typically arises through mechanisms that sustain or reinstate ERK1/2 activation. This has led to the development of a range of ERK1/2 inhibitors (ERKi) that either inhibit kinase catalytic activity (catERKi) or additionally prevent the activating pT-E-pY dual phosphorylation of ERK1/2 by MEK1/2 (dual-mechanism or dmERKi). Here, we show that eight different ERKi (both catERKi or dmERKi) drive the turnover of ERK2, the most abundant ERK isoform, with little or no effect on ERK1. Thermal stability assays show that ERKi do not destabilise ERK2 (or ERK1) in vitro, suggesting that ERK2 turnover is a cellular consequence of ERKi binding. ERK2 turnover is not observed upon treatment with MEKi alone, suggesting it is ERKi binding to ERK2 that drives ERK2 turnover. However, MEKi pre-treatment, which blocks ERK2 pT-E-pY phosphorylation and dissociation from MEK1/2, prevents ERK2 turnover. ERKi treatment of cells drives the poly-ubiquitylation and proteasome-dependent turnover of ERK2 and pharmacological or genetic inhibition of Cullin-RING E3 ligases prevents this. Our results suggest that ERKi, including current clinical candidates, act as 'kinase degraders', driving the proteasome-dependent turnover of their major target, ERK2. This may be relevant to the suggestion of kinase-independent effects of ERK1/2 and the therapeutic use of ERKi.
Published: 2023

9. Author Correction : Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Author: van Rheenen, Wouter, van der Spek, Rick A. A., Bakker, Mark K., van Vugt, Joke J. F. A., Hop, Paul J., Zwamborn, Ramona A. J., de Klein, Niek, Westra, Harm-Jan, Bakker, Olivier B., Deelen, Patrick, Shireby, Gemma, Hannon, Eilis, Moisse, Matthieu, Baird, Denis, Restuadi, Restuadi, Dolzhenko, Egor, Dekker, Annelot M., Gawor, Klara, Westeneng, Henk-Jan, Tazelaar, Gijs H. P., van Eijk, Kristel R., Kooyman, Maarten, Byrne, Ross P., Doherty, Mark, Heverin, Mark, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Ticozzi, Nicola, Cooper-Knock, Johnathan, Smith, Bradley N., Gromicho, Marta, Chandran, Siddharthan, Pal, Suvankar, Morrison, Karen E., Shaw, Pamela J., Hardy, John, Orrell, Richard W., Sendtner, Michael, Meyer, Thomas, Başak, Nazli, van der Kooi, Anneke J., Ratti, Antonia, Fogh, Isabella, Gellera, Cinzia, Lauria, Giuseppe, Corti, Stefania, Cereda, Cristina, Sproviero, Daisy, D'Alfonso, Sandra, Sorarù, Gianni, Siciliano, Gabriele, Filosto, Massimiliano, Padovani, Alessandro, Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Canosa, Antonio, Grassano, Maurizio, Beghi, Ettore, Pupillo, Elisabetta, Logroscino, Giancarlo, Nefussy, Beatrice, Osmanovic, Alma, Nordin, Angelica, Lerner, Yossef, Zabari, Michal, Gotkine, Marc, Baloh, Robert H., Bell, Shaughn, Vourc'h, Patrick, Corcia, Philippe, Couratier, Philippe, Millecamps, Stéphanie, Meininger, Vincent, Salachas, François, Mora Pardina, Jesus S., Assialioui, Abdelilah, Rojas-Garcia, Ricard, Dion, Patrick A., Ross, Jay P., Ludolph, Albert C., Weishaupt, Jochen H., Brenner, David, Freischmidt, Axel, Bensimon, Gilbert, Brice, Alexis, Durr, Alexandra, Payan, Christine A. M., Saker-Delye, Safa, Wood, Nicholas W., Topp, Simon, Rademakers, Rosa, Tittmann, Lukas, Lieb, Wolfgang, Franke, Andre, Ripke, Stephan, Braun, Alice, Kraft, Julia, Whiteman, David C., Olsen, Catherine M., Uitterlinden, André G, Hofman, Albert, Rietschel, Marcella, Cichon, Sven, Nöthen, Markus M., Amouyel, Philippe, Traynor, Bryan J., Singleton, Andrew B., Mitne Neto, Miguel, Cauchi, Ruben J., Ophoff, Roel A., Wiedau-Pazos, Martina, Lomen-Hoerth, Catherine, van Deerlin, Vivianna M., Grosskreutz, Julian, Roediger, Annekathrin, Gaur, Nayana, Jörk, Alexander, Barthel, Tabea, Theele, Erik, Ilse, Benjamin, Stubendorff, Beatrice, Witte, Otto W., Steinbach, Robert, Hübner, Christian A., Graff, Caroline, Brylev, Lev, Fominykh, Vera, Demeshonok, Vera, Ataulina, Anastasia, Rogelj, Boris, Koritnik, Blaž, Zidar, Janez, Ravnik-Glavač, Metka, Glavač, Damjan, Stević, Zorica, Drory, Vivian, Povedano, Monica, Blair, Ian P., Kiernan, Matthew C., Benyamin, Beben, Henderson, Robert D., Furlong, Sarah, Mathers, Susan, McCombe, Pamela A., Needham, Merrilee, Ngo, Shyuan T., Nicholson, Garth A., Pamphlett, Roger, Rowe, Dominic B., Steyn, Frederik J., Williams, Kelly L., Mather, Karen A., Sachdev, Perminder S., Henders, Anjali K., Wallace, Leanne, De Carvalho, Mamede, Pinto, Susana, Petri, Susanne, Weber, Markus, Rouleau, Guy A., Silani, Vincenzo, Curtis, Charles J., Breen, Gerome, Glass, Jonathan D., Brown, Robert H., Landers, John E., Shaw, Christopher E., Andersen, Peter Munch, Groen, Ewout J. N., van Es, Michael A., Pasterkamp, R. Jeroen, Fan, Dongsheng, Garton, Fleur C., McRae, Allan F., Smith, George Davey, Gaunt, Tom R., Eberle, Michael A., Mill, Jonathan, McLaughlin, Russell L., Hardiman, Orla, Kenna, Kevin P., Wray, Naomi R., Tsai, Ellen, Runz, Heiko, Franke, Lude, Al-Chalabi, Ammar, Van Damme, Philip, van den Berg, Leonard H., Veldink, Jan H., Universitat Autònoma de Barcelona, van Rheenen, Wouter, van der Spek, Rick A. A., Bakker, Mark K., van Vugt, Joke J. F. A., Hop, Paul J., Zwamborn, Ramona A. J., de Klein, Niek, Westra, Harm-Jan, Bakker, Olivier B., Deelen, Patrick, Shireby, Gemma, Hannon, Eilis, Moisse, Matthieu, Baird, Denis, Restuadi, Restuadi, Dolzhenko, Egor, Dekker, Annelot M., Gawor, Klara, Westeneng, Henk-Jan, Tazelaar, Gijs H. P., van Eijk, Kristel R., Kooyman, Maarten, Byrne, Ross P., Doherty, Mark, Heverin, Mark, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Ticozzi, Nicola, Cooper-Knock, Johnathan, Smith, Bradley N., Gromicho, Marta, Chandran, Siddharthan, Pal, Suvankar, Morrison, Karen E., Shaw, Pamela J., Hardy, John, Orrell, Richard W., Sendtner, Michael, Meyer, Thomas, Başak, Nazli, van der Kooi, Anneke J., Ratti, Antonia, Fogh, Isabella, Gellera, Cinzia, Lauria, Giuseppe, Corti, Stefania, Cereda, Cristina, Sproviero, Daisy, D'Alfonso, Sandra, Sorarù, Gianni, Siciliano, Gabriele, Filosto, Massimiliano, Padovani, Alessandro, Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Canosa, Antonio, Grassano, Maurizio, Beghi, Ettore, Pupillo, Elisabetta, Logroscino, Giancarlo, Nefussy, Beatrice, Osmanovic, Alma, Nordin, Angelica, Lerner, Yossef, Zabari, Michal, Gotkine, Marc, Baloh, Robert H., Bell, Shaughn, Vourc'h, Patrick, Corcia, Philippe, Couratier, Philippe, Millecamps, Stéphanie, Meininger, Vincent, Salachas, François, Mora Pardina, Jesus S., Assialioui, Abdelilah, Rojas-Garcia, Ricard, Dion, Patrick A., Ross, Jay P., Ludolph, Albert C., Weishaupt, Jochen H., Brenner, David, Freischmidt, Axel, Bensimon, Gilbert, Brice, Alexis, Durr, Alexandra, Payan, Christine A. M., Saker-Delye, Safa, Wood, Nicholas W., Topp, Simon, Rademakers, Rosa, Tittmann, Lukas, Lieb, Wolfgang, Franke, Andre, Ripke, Stephan, Braun, Alice, Kraft, Julia, Whiteman, David C., Olsen, Catherine M., Uitterlinden, André G, Hofman, Albert, Rietschel, Marcella, Cichon, Sven, Nöthen, Markus M., Amouyel, Philippe, Traynor, Bryan J., Singleton, Andrew B., Mitne Neto, Miguel, Cauchi, Ruben J., Ophoff, Roel A., Wiedau-Pazos, Martina, Lomen-Hoerth, Catherine, van Deerlin, Vivianna M., Grosskreutz, Julian, Roediger, Annekathrin, Gaur, Nayana, Jörk, Alexander, Barthel, Tabea, Theele, Erik, Ilse, Benjamin, Stubendorff, Beatrice, Witte, Otto W., Steinbach, Robert, Hübner, Christian A., Graff, Caroline, Brylev, Lev, Fominykh, Vera, Demeshonok, Vera, Ataulina, Anastasia, Rogelj, Boris, Koritnik, Blaž, Zidar, Janez, Ravnik-Glavač, Metka, Glavač, Damjan, Stević, Zorica, Drory, Vivian, Povedano, Monica, Blair, Ian P., Kiernan, Matthew C., Benyamin, Beben, Henderson, Robert D., Furlong, Sarah, Mathers, Susan, McCombe, Pamela A., Needham, Merrilee, Ngo, Shyuan T., Nicholson, Garth A., Pamphlett, Roger, Rowe, Dominic B., Steyn, Frederik J., Williams, Kelly L., Mather, Karen A., Sachdev, Perminder S., Henders, Anjali K., Wallace, Leanne, De Carvalho, Mamede, Pinto, Susana, Petri, Susanne, Weber, Markus, Rouleau, Guy A., Silani, Vincenzo, Curtis, Charles J., Breen, Gerome, Glass, Jonathan D., Brown, Robert H., Landers, John E., Shaw, Christopher E., Andersen, Peter Munch, Groen, Ewout J. N., van Es, Michael A., Pasterkamp, R. Jeroen, Fan, Dongsheng, Garton, Fleur C., McRae, Allan F., Smith, George Davey, Gaunt, Tom R., Eberle, Michael A., Mill, Jonathan, McLaughlin, Russell L., Hardiman, Orla, Kenna, Kevin P., Wray, Naomi R., Tsai, Ellen, Runz, Heiko, Franke, Lude, Al-Chalabi, Ammar, Van Damme, Philip, van den Berg, Leonard H., Veldink, Jan H., and Universitat Autònoma de Barcelona
Published: 2022

10. One-loop central-emission vertex for two gluons in $\mathcal{N}=4$ super Yang-Mills theory

Author: Byrne, Emmet P., Del Duca, Vittorio, Dixon, Lance J., Gardi, Einan, Smillie, Jennifer M., Byrne, Emmet P., Del Duca, Vittorio, Dixon, Lance J., Gardi, Einan, and Smillie, Jennifer M.
Abstract: A necessary ingredient for extending the BFKL equation to next-to-next-to-leading logarithmic (NNLL) accuracy is the one-loop central emission vertex (CEV) for two gluons which are not strongly ordered in rapidity. Here we consider the one-loop six-gluon amplitude in $\mathcal{N}=4$ super Yang-Mills (SYM) theory in a central next-to-multi-Regge kinematic (NMRK) limit, we show that its dispersive part factorises in terms of the two-gluon CEV, and we use it to extract the one-loop two-gluon CEV for any helicity configuration within this theory. This is a component of the two-gluon CEV in QCD. Although computed in the NMRK limit, both the colour structure and the kinematic dependence of the two-gluon CEV capture much of the complexity of the six-gluon amplitudes in general kinematics. In fact, the transcendental functions of the latter can be conveniently written in terms of impact factors, trajectories, single-emission CEVs and a remainder, which is a function of the conformally invariant cross ratios which characterise the six-gluon amplitudes in planar $\mathcal{N}=4$ SYM. Finally, as expected, in the MRK limit the two-gluon CEV neatly factorises in terms of two single-emission CEVs., Comment: 85 pages, 13 figures
Published: 2022

11. Event Generators for High-Energy Physics Experiments

Author: Campbell, J. M., Diefenthaler, M., Hobbs, T. J., Höche, S., Isaacson, J., Kling, F., Mrenna, S., Reuter, J., Alioli, S., Andersen, J. R., Andreopoulos, C., Ankowski, A. M., Aschenauer, E. C., Ashkenazi, A., Baker, M. D., Barrow, J. L., van Beekveld, M., Bewick, G., Bhattacharya, S., Bierlich, C., Bothmann, E., Bredt, P., Broggio, A., Buckley, A., Butter, A., Butterworth, J. M., Byrne, E. P., Chakraborty, S., Chen, X., Chiesa, M., Childers, J. T., Cruz-Martinez, J., Currie, J., Darvishi, N., Dasgupta, M., Denner, A., Dreyer, F. A., Dytman, S., El-Menoufi, B. K., Engel, T., Ravasio, S. Ferrario, Flower, L., Forshaw, J. R., Frederix, R., Friedland, A., Frixione, S., Gallagher, H., Gallmeister, K., Gardiner, S., Gauld, R., Gavardi, A., Gehrmann, T., Ridder, A. Gehrmann-De, Gellersen, L., Gieseke, S., Giuli, F., Glover, E. W. N., Grazzini, M., Grohsjean, A., Gütschow, C., Hamilton, K., Hatcher, R., Helenius, I., Han, T., Hen, O., Hirschi, V., Höfer, M., Holguin, J., Huss, A., Ilten, P., Jadach, S., Jentsch, A., Ju, W., Kallweit, S., Karlberg, A., Katori, T., Kilian, W., Kirchgaeßer, M. M., Knobbe, M., Krause, C., Krauss, F., Lang, J. -N., Lee, G., Li, S. W., Lim, M. A., Lindert, J. M., Lombardi, D., Lönnblad, L., Löschner, M., Lurkin, N., Ma, Y., Machado, P., Maier, A., Majer, I., Marcoli, M., Marinelli, G., Masouminia, M. R., Mattelaer, O., Mazzitelli, J., McFayden, J., Medves, R., Meinzinger, P., Mo, J., Monni, P. F., Morgan, T., Mosel, U., Nachman, B., Nadolsky, P., Nagar, R., Nagy, Z., Napoletano, D., Nason, P., Neumann, T., Nevay, L. J., Niehues, J., Niewczas, K., Ohl, T., Pandey, V., Papadopoulou, A., Paz, G., Pellen, M., Pelliccioli, G., Pickering, L., Pires, J., Plätzer, S., Plehn, T., Pozzorini, S., Prestel, S., Preuss, C. T., Price, A. C., Re, E., Reichelt, D., Richardson, P., Rocco, M., Rocco, N., Roda, M., Garcia, A. Rodriguez, Roiser, S., Rojo, J., Salam, G. P., Schönherr, M., Schuchmann, S., Schumann, S., Schürmann, R., Scyboz, L., Seymour, M. H., Siegert, F., Signer, A., Chahal, G. Singh, Siódmok, A., Sjöstrand, T., Skands, P., Smillie, J. M., Sobczyk, J. T., Soldin, D., Soper, D. E., Soto-Ontoso, A., Soyez, G., Stagnitto, G., Tena-Vidal, J., Tomalak, O., Trojanowski, S., Tu, Z., Uccirati, S., Ullrich, T., Ulrich, Y., Utheim, M., Valassi, A., Verbytskyi, A., Verheyen, R., Wagman, M., Walker, D., Webber, B. R., Weinstein, L., White, O., Whitehead, J., Wiesemann, M., Wilkinson, C., Williams, C., Winterhalder, R., Wret, C., Xie, K., Yang, T-Z., Yazgan, E., Zanderighi, G., Zanoli, S., Zapp, K., Campbell, J. M., Diefenthaler, M., Hobbs, T. J., Höche, S., Isaacson, J., Kling, F., Mrenna, S., Reuter, J., Alioli, S., Andersen, J. R., Andreopoulos, C., Ankowski, A. M., Aschenauer, E. C., Ashkenazi, A., Baker, M. D., Barrow, J. L., van Beekveld, M., Bewick, G., Bhattacharya, S., Bierlich, C., Bothmann, E., Bredt, P., Broggio, A., Buckley, A., Butter, A., Butterworth, J. M., Byrne, E. P., Chakraborty, S., Chen, X., Chiesa, M., Childers, J. T., Cruz-Martinez, J., Currie, J., Darvishi, N., Dasgupta, M., Denner, A., Dreyer, F. A., Dytman, S., El-Menoufi, B. K., Engel, T., Ravasio, S. Ferrario, Flower, L., Forshaw, J. R., Frederix, R., Friedland, A., Frixione, S., Gallagher, H., Gallmeister, K., Gardiner, S., Gauld, R., Gavardi, A., Gehrmann, T., Ridder, A. Gehrmann-De, Gellersen, L., Gieseke, S., Giuli, F., Glover, E. W. N., Grazzini, M., Grohsjean, A., Gütschow, C., Hamilton, K., Hatcher, R., Helenius, I., Han, T., Hen, O., Hirschi, V., Höfer, M., Holguin, J., Huss, A., Ilten, P., Jadach, S., Jentsch, A., Ju, W., Kallweit, S., Karlberg, A., Katori, T., Kilian, W., Kirchgaeßer, M. M., Knobbe, M., Krause, C., Krauss, F., Lang, J. -N., Lee, G., Li, S. W., Lim, M. A., Lindert, J. M., Lombardi, D., Lönnblad, L., Löschner, M., Lurkin, N., Ma, Y., Machado, P., Maier, A., Majer, I., Marcoli, M., Marinelli, G., Masouminia, M. R., Mattelaer, O., Mazzitelli, J., McFayden, J., Medves, R., Meinzinger, P., Mo, J., Monni, P. F., Morgan, T., Mosel, U., Nachman, B., Nadolsky, P., Nagar, R., Nagy, Z., Napoletano, D., Nason, P., Neumann, T., Nevay, L. J., Niehues, J., Niewczas, K., Ohl, T., Pandey, V., Papadopoulou, A., Paz, G., Pellen, M., Pelliccioli, G., Pickering, L., Pires, J., Plätzer, S., Plehn, T., Pozzorini, S., Prestel, S., Preuss, C. T., Price, A. C., Re, E., Reichelt, D., Richardson, P., Rocco, M., Rocco, N., Roda, M., Garcia, A. Rodriguez, Roiser, S., Rojo, J., Salam, G. P., Schönherr, M., Schuchmann, S., Schumann, S., Schürmann, R., Scyboz, L., Seymour, M. H., Siegert, F., Signer, A., Chahal, G. Singh, Siódmok, A., Sjöstrand, T., Skands, P., Smillie, J. M., Sobczyk, J. T., Soldin, D., Soper, D. E., Soto-Ontoso, A., Soyez, G., Stagnitto, G., Tena-Vidal, J., Tomalak, O., Trojanowski, S., Tu, Z., Uccirati, S., Ullrich, T., Ulrich, Y., Utheim, M., Valassi, A., Verbytskyi, A., Verheyen, R., Wagman, M., Walker, D., Webber, B. R., Weinstein, L., White, O., Whitehead, J., Wiesemann, M., Wilkinson, C., Williams, C., Winterhalder, R., Wret, C., Xie, K., Yang, T-Z., Yazgan, E., Zanderighi, G., Zanoli, S., and Zapp, K.
Abstract: We provide an overview of the status of Monte-Carlo event generators for high-energy particle physics. Guided by the experimental needs and requirements, we highlight areas of active development, and opportunities for future improvements. Particular emphasis is given to physics models and algorithms that are employed across a variety of experiments. These common themes in event generator development lead to a more comprehensive understanding of physics at the highest energies and intensities, and allow models to be tested against a wealth of data that have been accumulated over the past decades. A cohesive approach to event generator development will allow these models to be further improved and systematic uncertainties to be reduced, directly contributing to future experimental success. Event generators are part of a much larger ecosystem of computational tools. They typically involve a number of unknown model parameters that must be tuned to experimental data, while maintaining the integrity of the underlying physics models. Making both these data, and the analyses with which they have been obtained accessible to future users is an essential aspect of open science and data preservation. It ensures the consistency of physics models across a variety of experiments., Comment: 153 pages, 10 figures, contribution to Snowmass 2021
Published: 2022

12. SARS-CoV-2 infection is associated with post-acute self-reported neurocognitive symptoms

Author: PMB, Infectious Disease Clinical Research Program (IDCRP), Liana R. Andronescu, Stephanie A. Richard, Ann I. Scher, David A. Lindholm, Katrin Mende, Anuradha Ganesan, Nikhil Huprikar, Tahaniyat Lalani, Alfred Smith, Rupal M. Mody, Milissa U. Jones, Samantha E. Bazan, Rhonda E. Colombo, Christopher J. Colombo, Evan Ewers, Derek T. Larson, Ryan C. Maves, Catherine M. Berjohn, Carlos J Maldonado, Caroline English, Margaret Sanchez Edwards, Julia S. Rozman, Jennifer Rusiecki, Celia Byrne, Mark P. Simons, David Tribble, Timothy H Burgess, Simon D. Pollett, Brian K. Agan, PMB, Infectious Disease Clinical Research Program (IDCRP), Liana R. Andronescu, and Stephanie A. Richard, Ann I. Scher, David A. Lindholm, Katrin Mende, Anuradha Ganesan, Nikhil Huprikar, Tahaniyat Lalani, Alfred Smith, Rupal M. Mody, Milissa U. Jones, Samantha E. Bazan, Rhonda E. Colombo, Christopher J. Colombo, Evan Ewers, Derek T. Larson, Ryan C. Maves, Catherine M. Berjohn, Carlos J Maldonado, Caroline English, Margaret Sanchez Edwards, Julia S. Rozman, Jennifer Rusiecki, Celia Byrne, Mark P. Simons, David Tribble, Timothy H Burgess, Simon D. Pollett, Brian K. Agan
Abstract: Background Correspondence SARS-CoV-2 infection is associated with post-acute self-reported neurocognitive symptoms Liana R. Andronescu, PhD, MPH1,2, Stephanie A. Richard, PhD, MHS 1,2, Ann I. Scher, PhD3, David A. Lindholm, MD4,5, Katrin Mende, PhD1,2,5, Anuradha Ganesan, MBBS, MPH1,2,6, Nikhil Huprikar MD6, Tahaniyat Lalani, MBBS, MHS1,2,7, Alfred Smith MD7, Rupal M. Mody, MD8, Milissa U. Jones, MD9, Samantha E. Bazan, DNP, MS10, Rhonda E. Colombo, MD, MHS1,2,4,11, Christopher J. Colombo, MD4,11, Evan Ewers12, Derek T. Larson, DO12,13, Ryan C. Maves, MD1,13, Catherine M. Berjohn, MD, MPH1,4,13, Carlos J Maldonado, PhD14, Caroline English1,2, Margaret Sanchez Edwards, MS1,2, Julia S. Rozman, BS1,2, Jennifer Rusiecki, PhD3, Celia Byrne, PhD3, Mark P. Simons, PhD1, David Tribble, MD, DrPH1, Timothy H Burgess, MD, MPH1, Simon D. Pollett, MBBS1,2, Brian K. Agan, MD1,2 Objectives Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neurocognitive impairment on active-duty service members and other Military Health System (MHS) beneficiaries, it is important to characterize this post-infection phenotype and assess potential risk factors for poor neurocognitive outcomes. Email: landronescu@idcrp.org; liana.andronescu.ctr@usuhs.edu USU Infectious Disease Clinical Research Program (IDCRP), Department of Preventive Medicine and Biostatistics Henry M. Jackson Foundation for the Advancement of Military Medicine • Describe the prevalence of self-reported neurocognitive symptoms among SARS-CoV-2 positive vs negative subjects • Identify risk factors for self-reported neurocognitive symptoms among SARS-CoV-2 positive subjects Results 1Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 2Henry M. Jackso, RITM0027659, Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neurocognitive impairment on active-duty service members and other Military Health System (MHS) beneficiaries, it is important to characterize this post-infection phenotype and assess potential risk factors for poor neurocognitive outcomes.
Published: 2022

13. Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology (Nature Genetics, (2021), 53, 12, (1636-1648), 10.1038/s41588-021-00973-1)

Author: van Rheenen W., van Rheenen, W, van der Spek, R, Bakker, M, van Vugt, J, Hop, P, Zwamborn, R, de Klein, N, Westra, H, Bakker, O, Deelen, P, Shireby, G, Hannon, E, Moisse, M, Baird, D, Restuadi, R, Dolzhenko, E, Dekker, A, Gawor, K, Westeneng, H, Tazelaar, G, van Eijk, K, Kooyman, M, Byrne, R, Doherty, M, Heverin, M, Al Khleifat, A, Iacoangeli, A, Shatunov, A, Ticozzi, N, Cooper-Knock, J, Smith, B, Gromicho, M, Chandran, S, Pal, S, Morrison, K, Shaw, P, Hardy, J, Orrell, R, Sendtner, M, Meyer, T, Basak, N, van der Kooi, A, Ratti, A, Fogh, I, Gellera, C, Lauria, G, Corti, S, Cereda, C, Sproviero, D, D'Alfonso, S, Soraru, G, Siciliano, G, Filosto, M, Padovani, A, Chio, A, Calvo, A, Moglia, C, Brunetti, M, Canosa, A, Grassano, M, Beghi, E, Pupillo, E, Logroscino, G, Nefussy, B, Osmanovic, A, Nordin, A, Lerner, Y, Zabari, M, Gotkine, M, Baloh, R, Bell, S, Vourc'H, P, Corcia, P, Couratier, P, Millecamps, S, Meininger, V, Salachas, F, Mora Pardina, J, Assialioui, A, Rojas-Garcia, R, Dion, P, Ross, J, Ludolph, A, Weishaupt, J, Brenner, D, Freischmidt, A, Bensimon, G, Brice, A, Durr, A, Payan, C, Saker-Delye, S, Wood, N, Topp, S, Rademakers, R, Tittmann, L, Lieb, W, Franke, A, Ripke, S, Braun, A, Kraft, J, Whiteman, D, Olsen, C, Uitterlinden, A, Hofman, A, Rietschel, M, Cichon, S, Nothen, M, Amouyel, P, Comi, G, Riva, N, Lunetta, C, Gerardi, F, Cotelli, M, Rinaldi, F, Chiveri, L, Guaita, M, Perrone, P, Ceroni, M, Diamanti, L, Ferrarese, C, Tremolizzo, L, Delodovici, M, Bono, G, Manera, U, Vasta, R, Bombaci, A, Casale, F, Fuda, G, Salamone, P, Iazzolino, B, Peotta, L, Cugnasco, P, De Marco, G, Torrieri, M, Palumbo, F, Gallone, S, Barberis, M, Sbaiz, L, Gentile, S, Mauro, A, Mazzini, L, De Marchi, F, Corrado, L, Bertolotto, A, Gionco, M, Leotta, D, Odddenino, E, Imperiale, D, Cavallo, R, Pignatta, P, De Mattei, M, Geda, C, Papurello, D, Gusmaroli, G, Comi, C, Labate, C, Ruiz, L, Ferrandi, D, Rota, E, Aguggia, M, Di Vito, N, Meineri, P, Ghiglione, P, Launaro, N, Dotta, M, Di Sapio, A, Giardini, G, Tiloca, C, Peverelli, S, Taroni, F, Pensato, V, Castellotti, B, Del Bo, R, Gagliardi, S, Raggi, F, Simoncini, C, Lo Gerfo, A, Inghilleri, M, Ferlini, A, Simone, I, Passarella, B, Guerra, V, Zoccolella, S, Nozzoli, C, Mundi, C, Leone, M, Zarrelli, M, Tamma, F, Valluzzi, F, Calabrese, G, Boero, G, Rini, A, Traynor, B, Singleton, A, Mitne Neto, M, Cauchi, R, Ophoff, R, Wiedau-Pazos, M, Lomen-Hoerth, C, van Deerlin, V, Grosskreutz, J, Roediger, A, Gaur, N, Jork, A, Barthel, T, Theele, E, Ilse, B, Stubendorff, B, Witte, O, Steinbach, R, Hubner, C, Graff, C, Brylev, L, Fominykh, V, Demeshonok, V, Ataulina, A, Rogelj, B, Koritnik, B, Zidar, J, Ravnik-Glavac, M, Glavac, D, Stevic, Z, Drory, V, Povedano, M, Blair, I, Kiernan, M, Benyamin, B, Henderson, R, Furlong, S, Mathers, S, Mccombe, P, Needham, M, Ngo, S, Nicholson, G, Pamphlett, R, Rowe, D, Steyn, F, Williams, K, Mather, K, Sachdev, P, Henders, A, Wallace, L, de Carvalho, M, Pinto, S, Petri, S, Weber, M, Rouleau, G, Silani, V, Curtis, C, Breen, G, Glass, J, Brown, R, Landers, J, Shaw, C, Andersen, P, Groen, E, van Es, M, Pasterkamp, R, Fan, D, Garton, F, Mcrae, A, Davey Smith, G, Gaunt, T, Eberle, M, Mill, J, Mclaughlin, R, Hardiman, O, Kenna, K, Wray, N, Tsai, E, Runz, H, Franke, L, Al-Chalabi, A, Van Damme, P, van den Berg, L, Veldink, J, van Rheenen W., van der Spek R. A. A., Bakker M. K., van Vugt J. J. F. A., Hop P. J., Zwamborn R. A. J., de Klein N., Westra H. -J., Bakker O. B., Deelen P., Shireby G., Hannon E., Moisse M., Baird D., Restuadi R., Dolzhenko E., Dekker A. M., Gawor K., Westeneng H. -J., Tazelaar G. H. P., van Eijk K. R., Kooyman M., Byrne R. P., Doherty M., Heverin M., Al Khleifat A., Iacoangeli A., Shatunov A., Ticozzi N., Cooper-Knock J., Smith B. N., Gromicho M., Chandran S., Pal S., Morrison K. E., Shaw P. J., Hardy J., Orrell R. W., Sendtner M., Meyer T., Basak N., van der Kooi A. J., Ratti A., Fogh I., Gellera C., Lauria G., Corti S., Cereda C., Sproviero D., D'Alfonso S., Soraru G., Siciliano G., Filosto M., Padovani A., Chio A., Calvo A., Moglia C., Brunetti M., Canosa A., Grassano M., Beghi E., Pupillo E., Logroscino G., Nefussy B., Osmanovic A., Nordin A., Lerner Y., Zabari M., Gotkine M., Baloh R. H., Bell S., Vourc'h P., Corcia P., Couratier P., Millecamps S., Meininger V., Salachas F., Mora Pardina J. S., Assialioui A., Rojas-Garcia R., Dion P. A., Ross J. P., Ludolph A. C., Weishaupt J. H., Brenner D., Freischmidt A., Bensimon G., Brice A., Durr A., Payan C. A. M., Saker-Delye S., Wood N. W., Topp S., Rademakers R., Tittmann L., Lieb W., Franke A., Ripke S., Braun A., Kraft J., Whiteman D. C., Olsen C. M., Uitterlinden A. G., Hofman A., Rietschel M., Cichon S., Nothen M. M., Amouyel P., Comi G., Riva N., Lunetta C., Gerardi F., Cotelli M. S., Rinaldi F., Chiveri L., Guaita M. C., Perrone P., Ceroni M., Diamanti L., Ferrarese C., Tremolizzo L., Delodovici M. L., Bono G., Manera U., Vasta R., Bombaci A., Casale F., Fuda G., Salamone P., Iazzolino B., Peotta L., Cugnasco P., De Marco G., Torrieri M. C., Palumbo F., Gallone S., Barberis M., Sbaiz L., Gentile S., Mauro A., Mazzini L., De Marchi F., Corrado L., Bertolotto A., Gionco M., Leotta D., Odddenino E., Imperiale D., Cavallo R., Pignatta P., De Mattei M., Geda C., Papurello D. M., Gusmaroli G., Comi C., Labate C., Ruiz L., Ferrandi D., Rota E., Aguggia M., Di Vito N., Meineri P., Ghiglione P., Launaro N., Dotta M., Di Sapio A., Giardini G., Tiloca C., Peverelli S., Taroni F., Pensato V., Castellotti B., Comi G. P., Del Bo R., Gagliardi S., Raggi F., Simoncini C., Lo Gerfo A., Inghilleri M., Ferlini A., Simone I. L., Passarella B., Guerra V., Zoccolella S., Nozzoli C., Mundi C., Leone M., Zarrelli M., Tamma F., Valluzzi F., Calabrese G., Boero G., Rini A., Traynor B. J., Singleton A. B., Mitne Neto M., Cauchi R. J., Ophoff R. A., Wiedau-Pazos M., Lomen-Hoerth C., van Deerlin V. M., Grosskreutz J., Roediger A., Gaur N., Jork A., Barthel T., Theele E., Ilse B., Stubendorff B., Witte O. W., Steinbach R., Hubner C. A., Graff C., Brylev L., Fominykh V., Demeshonok V., Ataulina A., Rogelj B., Koritnik B., Zidar J., Ravnik-Glavac M., Glavac D., Stevic Z., Drory V., Povedano M., Blair I. P., Kiernan M. C., Benyamin B., Henderson R. D., Furlong S., Mathers S., McCombe P. A., Needham M., Ngo S. T., Nicholson G. A., Pamphlett R., Rowe D. B., Steyn F. J., Williams K. L., Mather K. A., Sachdev P. S., Henders A. K., Wallace L., de Carvalho M., Pinto S., Petri S., Weber M., Rouleau G. A., Silani V., Curtis C. J., Breen G., Glass J. D., Brown R. H., Landers J. E., Shaw C. E., Andersen P. M., Groen E. J. N., van Es M. A., Pasterkamp R. J., Fan D., Garton F. C., McRae A. F., Davey Smith G., Gaunt T. R., Eberle M. A., Mill J., McLaughlin R. L., Hardiman O., Kenna K. P., Wray N. R., Tsai E., Runz H., Franke L., Al-Chalabi A., Van Damme P., van den Berg L. H., Veldink J. H., van Rheenen W., van Rheenen, W, van der Spek, R, Bakker, M, van Vugt, J, Hop, P, Zwamborn, R, de Klein, N, Westra, H, Bakker, O, Deelen, P, Shireby, G, Hannon, E, Moisse, M, Baird, D, Restuadi, R, Dolzhenko, E, Dekker, A, Gawor, K, Westeneng, H, Tazelaar, G, van Eijk, K, Kooyman, M, Byrne, R, Doherty, M, Heverin, M, Al Khleifat, A, Iacoangeli, A, Shatunov, A, Ticozzi, N, Cooper-Knock, J, Smith, B, Gromicho, M, Chandran, S, Pal, S, Morrison, K, Shaw, P, Hardy, J, Orrell, R, Sendtner, M, Meyer, T, Basak, N, van der Kooi, A, Ratti, A, Fogh, I, Gellera, C, Lauria, G, Corti, S, Cereda, C, Sproviero, D, D'Alfonso, S, Soraru, G, Siciliano, G, Filosto, M, Padovani, A, Chio, A, Calvo, A, Moglia, C, Brunetti, M, Canosa, A, Grassano, M, Beghi, E, Pupillo, E, Logroscino, G, Nefussy, B, Osmanovic, A, Nordin, A, Lerner, Y, Zabari, M, Gotkine, M, Baloh, R, Bell, S, Vourc'H, P, Corcia, P, Couratier, P, Millecamps, S, Meininger, V, Salachas, F, Mora Pardina, J, Assialioui, A, Rojas-Garcia, R, Dion, P, Ross, J, Ludolph, A, Weishaupt, J, Brenner, D, Freischmidt, A, Bensimon, G, Brice, A, Durr, A, Payan, C, Saker-Delye, S, Wood, N, Topp, S, Rademakers, R, Tittmann, L, Lieb, W, Franke, A, Ripke, S, Braun, A, Kraft, J, Whiteman, D, Olsen, C, Uitterlinden, A, Hofman, A, Rietschel, M, Cichon, S, Nothen, M, Amouyel, P, Comi, G, Riva, N, Lunetta, C, Gerardi, F, Cotelli, M, Rinaldi, F, Chiveri, L, Guaita, M, Perrone, P, Ceroni, M, Diamanti, L, Ferrarese, C, Tremolizzo, L, Delodovici, M, Bono, G, Manera, U, Vasta, R, Bombaci, A, Casale, F, Fuda, G, Salamone, P, Iazzolino, B, Peotta, L, Cugnasco, P, De Marco, G, Torrieri, M, Palumbo, F, Gallone, S, Barberis, M, Sbaiz, L, Gentile, S, Mauro, A, Mazzini, L, De Marchi, F, Corrado, L, Bertolotto, A, Gionco, M, Leotta, D, Odddenino, E, Imperiale, D, Cavallo, R, Pignatta, P, De Mattei, M, Geda, C, Papurello, D, Gusmaroli, G, Comi, C, Labate, C, Ruiz, L, Ferrandi, D, Rota, E, Aguggia, M, Di Vito, N, Meineri, P, Ghiglione, P, Launaro, N, Dotta, M, Di Sapio, A, Giardini, G, Tiloca, C, Peverelli, S, Taroni, F, Pensato, V, Castellotti, B, Del Bo, R, Gagliardi, S, Raggi, F, Simoncini, C, Lo Gerfo, A, Inghilleri, M, Ferlini, A, Simone, I, Passarella, B, Guerra, V, Zoccolella, S, Nozzoli, C, Mundi, C, Leone, M, Zarrelli, M, Tamma, F, Valluzzi, F, Calabrese, G, Boero, G, Rini, A, Traynor, B, Singleton, A, Mitne Neto, M, Cauchi, R, Ophoff, R, Wiedau-Pazos, M, Lomen-Hoerth, C, van Deerlin, V, Grosskreutz, J, Roediger, A, Gaur, N, Jork, A, Barthel, T, Theele, E, Ilse, B, Stubendorff, B, Witte, O, Steinbach, R, Hubner, C, Graff, C, Brylev, L, Fominykh, V, Demeshonok, V, Ataulina, A, Rogelj, B, Koritnik, B, Zidar, J, Ravnik-Glavac, M, Glavac, D, Stevic, Z, Drory, V, Povedano, M, Blair, I, Kiernan, M, Benyamin, B, Henderson, R, Furlong, S, Mathers, S, Mccombe, P, Needham, M, Ngo, S, Nicholson, G, Pamphlett, R, Rowe, D, Steyn, F, Williams, K, Mather, K, Sachdev, P, Henders, A, Wallace, L, de Carvalho, M, Pinto, S, Petri, S, Weber, M, Rouleau, G, Silani, V, Curtis, C, Breen, G, Glass, J, Brown, R, Landers, J, Shaw, C, Andersen, P, Groen, E, van Es, M, Pasterkamp, R, Fan, D, Garton, F, Mcrae, A, Davey Smith, G, Gaunt, T, Eberle, M, Mill, J, Mclaughlin, R, Hardiman, O, Kenna, K, Wray, N, Tsai, E, Runz, H, Franke, L, Al-Chalabi, A, Van Damme, P, van den Berg, L, Veldink, J, van Rheenen W., van der Spek R. A. A., Bakker M. K., van Vugt J. J. F. A., Hop P. J., Zwamborn R. A. J., de Klein N., Westra H. -J., Bakker O. B., Deelen P., Shireby G., Hannon E., Moisse M., Baird D., Restuadi R., Dolzhenko E., Dekker A. M., Gawor K., Westeneng H. -J., Tazelaar G. H. P., van Eijk K. R., Kooyman M., Byrne R. P., Doherty M., Heverin M., Al Khleifat A., Iacoangeli A., Shatunov A., Ticozzi N., Cooper-Knock J., Smith B. N., Gromicho M., Chandran S., Pal S., Morrison K. E., Shaw P. J., Hardy J., Orrell R. W., Sendtner M., Meyer T., Basak N., van der Kooi A. J., Ratti A., Fogh I., Gellera C., Lauria G., Corti S., Cereda C., Sproviero D., D'Alfonso S., Soraru G., Siciliano G., Filosto M., Padovani A., Chio A., Calvo A., Moglia C., Brunetti M., Canosa A., Grassano M., Beghi E., Pupillo E., Logroscino G., Nefussy B., Osmanovic A., Nordin A., Lerner Y., Zabari M., Gotkine M., Baloh R. H., Bell S., Vourc'h P., Corcia P., Couratier P., Millecamps S., Meininger V., Salachas F., Mora Pardina J. S., Assialioui A., Rojas-Garcia R., Dion P. A., Ross J. P., Ludolph A. C., Weishaupt J. H., Brenner D., Freischmidt A., Bensimon G., Brice A., Durr A., Payan C. A. M., Saker-Delye S., Wood N. W., Topp S., Rademakers R., Tittmann L., Lieb W., Franke A., Ripke S., Braun A., Kraft J., Whiteman D. C., Olsen C. M., Uitterlinden A. G., Hofman A., Rietschel M., Cichon S., Nothen M. M., Amouyel P., Comi G., Riva N., Lunetta C., Gerardi F., Cotelli M. S., Rinaldi F., Chiveri L., Guaita M. C., Perrone P., Ceroni M., Diamanti L., Ferrarese C., Tremolizzo L., Delodovici M. L., Bono G., Manera U., Vasta R., Bombaci A., Casale F., Fuda G., Salamone P., Iazzolino B., Peotta L., Cugnasco P., De Marco G., Torrieri M. C., Palumbo F., Gallone S., Barberis M., Sbaiz L., Gentile S., Mauro A., Mazzini L., De Marchi F., Corrado L., Bertolotto A., Gionco M., Leotta D., Odddenino E., Imperiale D., Cavallo R., Pignatta P., De Mattei M., Geda C., Papurello D. M., Gusmaroli G., Comi C., Labate C., Ruiz L., Ferrandi D., Rota E., Aguggia M., Di Vito N., Meineri P., Ghiglione P., Launaro N., Dotta M., Di Sapio A., Giardini G., Tiloca C., Peverelli S., Taroni F., Pensato V., Castellotti B., Comi G. P., Del Bo R., Gagliardi S., Raggi F., Simoncini C., Lo Gerfo A., Inghilleri M., Ferlini A., Simone I. L., Passarella B., Guerra V., Zoccolella S., Nozzoli C., Mundi C., Leone M., Zarrelli M., Tamma F., Valluzzi F., Calabrese G., Boero G., Rini A., Traynor B. J., Singleton A. B., Mitne Neto M., Cauchi R. J., Ophoff R. A., Wiedau-Pazos M., Lomen-Hoerth C., van Deerlin V. M., Grosskreutz J., Roediger A., Gaur N., Jork A., Barthel T., Theele E., Ilse B., Stubendorff B., Witte O. W., Steinbach R., Hubner C. A., Graff C., Brylev L., Fominykh V., Demeshonok V., Ataulina A., Rogelj B., Koritnik B., Zidar J., Ravnik-Glavac M., Glavac D., Stevic Z., Drory V., Povedano M., Blair I. P., Kiernan M. C., Benyamin B., Henderson R. D., Furlong S., Mathers S., McCombe P. A., Needham M., Ngo S. T., Nicholson G. A., Pamphlett R., Rowe D. B., Steyn F. J., Williams K. L., Mather K. A., Sachdev P. S., Henders A. K., Wallace L., de Carvalho M., Pinto S., Petri S., Weber M., Rouleau G. A., Silani V., Curtis C. J., Breen G., Glass J. D., Brown R. H., Landers J. E., Shaw C. E., Andersen P. M., Groen E. J. N., van Es M. A., Pasterkamp R. J., Fan D., Garton F. C., McRae A. F., Davey Smith G., Gaunt T. R., Eberle M. A., Mill J., McLaughlin R. L., Hardiman O., Kenna K. P., Wray N. R., Tsai E., Runz H., Franke L., Al-Chalabi A., Van Damme P., van den Berg L. H., and Veldink J. H.
Abstract: In the version of this article initially published, the affiliation for Nazli Başak appeared incorrectly. Nazli Başak is at Koç University, School of Medicine, KUTTAM-NDAL, Istanbul, Turkey, and not Bogazici University. The error has been corrected in the HTML and PDF versions of the article.
Published: 2022

14. Thoracic Electrical Impedance Tomography—The 2022 Veterinary Consensus Statement

Author: Brabant, Olivia A, Byrne, David P, Sacks, Muriel, Moreno Martinez, Fernando, Raisis, Anthea L, Araos, Joaquin B, Waldmann, Andreas D, Schramel, Johannes P, Ambrosio, Aline, Hosgood, Giselle, Braun, Christina, Auer, Ulrike, Bleul, Ulrike, Herteman, Nicolas; https://orcid.org/0000-0001-8851-7714, Secombe, Cristy J, Schoster, Angelika; https://orcid.org/0000-0002-2162-6550, Soares, Joao, Beazley, Shannon, Meira, Carolina, Adler, Andy, Mosing, Martina; https://orcid.org/0000-0002-6190-5642, Brabant, Olivia A, Byrne, David P, Sacks, Muriel, Moreno Martinez, Fernando, Raisis, Anthea L, Araos, Joaquin B, Waldmann, Andreas D, Schramel, Johannes P, Ambrosio, Aline, Hosgood, Giselle, Braun, Christina, Auer, Ulrike, Bleul, Ulrike, Herteman, Nicolas; https://orcid.org/0000-0001-8851-7714, Secombe, Cristy J, Schoster, Angelika; https://orcid.org/0000-0002-2162-6550, Soares, Joao, Beazley, Shannon, Meira, Carolina, Adler, Andy, and Mosing, Martina; https://orcid.org/0000-0002-6190-5642
Abstract: Electrical impedance tomography (EIT) is a non-invasive real-time non-ionising imaging modality that has many applications. Since the first recorded use in 1978, the technology has become more widely used especially in human adult and neonatal critical care monitoring. Recently, there has been an increase in research on thoracic EIT in veterinary medicine. Real-time imaging of the thorax allows evaluation of ventilation distribution in anesthetised and conscious animals. As the technology becomes recognised in the veterinary community there is a need to standardize approaches to data collection, analysis, interpretation and nomenclature, ensuring comparison and repeatability between researchers and studies. A group of nineteen veterinarians and two biomedical engineers experienced in veterinary EIT were consulted and contributed to the preparation of this statement. The aim of this consensus is to provide an introduction to this imaging modality, to highlight clinical relevance and to include recommendations on how to effectively use thoracic EIT in veterinary species. Based on this, the consensus statement aims to address the need for a streamlined approach to veterinary thoracic EIT and includes: an introduction to the use of EIT in veterinary species, the technical background to creation of the functional images, a consensus from all contributing authors on the practical application and use of the technology, descriptions and interpretation of current available variables including appropriate statistical analysis, nomenclature recommended for consistency and future developments in thoracic EIT. The information provided in this consensus statement may benefit researchers and clinicians working within the field of veterinary thoracic EIT. We endeavor to inform future users of the benefits of this imaging modality and provide opportunities to further explore applications of this technology with regards to perfusion imaging and pathology diagnosis.
Published: 2022

15. Scale Model of a Soil Aggregate and Associated Organisms: A Teaching Tool for Soil Ecology

Author: Bruns, Mary Ann and Byrne, Loren B.
Abstract: Soil is a complex habitat for diverse biota. A significant challenge in teaching soil ecology is our inability to observe organisms as they live and interact in the soil. The objective of this article is to describe an interactive class project to help students visualize the sizes of different groups of soil organisms and to relate these to soil structural components. This project was carried out by students in an upper-level undergraduate soil ecology class. It involved the design and construction of a 4000 (times) scale model of a soil aggregate and its associated organisms. The body of the model was made from inexpensive, lightweight materials and had a diameter of approximately 1 m to depict a 0.25-mm aggregate. Students identified and discussed appropriate size ranges and construction materials for the model's bacteria, fungi, nematodes, mites, springtails, and other components. Instructor guided questions addressed size and arrangement of sand, silt, and clay particles; pores; and organic matter in a typical soil aggregate. The model is a useful tool for conveying physical and ecological relationships among soil organisms and is adaptable for use at diverse educational levels. (Contains 2 tables and 2 figures.)
Published: 2004

16. 'Obasan': More Than One Telling/More Than One Reading.

Author: Byrne, Mary Ellen
Abstract: Discusses how in her 1981 novel "Obasan," Joy Kogawa recounts the saga of the internment and relocation of Japanese Canadians during and after the Second World War by juxtaposing the "factual" historic telling against the personal, "fictional" telling. Asks students to analyze a passage and consider such literary elements as point of view, structure, selection of details, and figurative language. (SG)
Published: 2002

17. Hot Air Balloons: How To Get Up There Using Hot Air.

Author: Byrne, Tim
Abstract: Explains how a balloon activity can be used to identify certain principles of flight. Describes where balloons fit in the science curriculum. (YDS)
Published: 2001

18. Early Intervention Program Resource Guide: Selected Readings from Programs for Young Disabled Children in Pennsylvania.

Author: Pennsylvania State Dept. of Public Welfare, Harrisburg. Office of Mental Retardation. and Byrne, Jane M.
Abstract: Intended as a guide for professionals and local administrators in initiating and developing early intervention programs for handicapped children, the volume provides descriptions of 10 models and techniques presently utilized in Pennsylvania. Included are reports with the following titles and authors: "A System of Open Learning" (P. Malone), "A Description of Intervention Strategies for Handicapped Infants and Toddlers" (M. Mostertz, et al), "New Beginnings: A Center-Based Training Program for Families of Developmentally Delayed Infants and Toddlers" (C. Lapidakis), "Early Intervention Project for Behaviorally Disordered Preschoolers" (J. Reisinger and F. Gray), "A Multidimensional Early Intervention Program Model" (K. O'Connor), "An Integrated Early Intervention Project" (A. Vogeding), "Educational Programming Consideration: The Medically Involved Child in a Community Residential Setting" (H. Lynch and D. Misner), "A Community System for Serving Young Children and Their Families" (K. Sims), "Cooperation with the Medical Community: The Key to Success of Early Intervention Programs" (M. Perrin and M. Sgro), and "An Innovative Approach for Community Education About Early Intervention" (L. Fiorentino, et al). A bibliography of 118 current readings in early intervention is provided, and addresses of the contributors are included. (IM)
Published: 1976

19. Length of Working Life for Men and Women, 1970. Special Labor Force Report 187. Revised.

Author: Bureau of Labor Statistics (DOL), Washington, DC., Fullerton, Howard N., and Byrne, James J.
Abstract: Noting that data from 1970 working life tables indicate that since 1960 worklife expectancy has continued to edge downward for men and to lengthen for women, this report briefly discusses continuing trends in the worklife of men and women from 1900 through 1970. Women's worklife is presented in terms of single women; mothers; widowed, divorced, separated women; childless women; and separations and accessions among women. The appendix comprises the majority of the report (13 pages) and includes a brief description of two measures of working life expectancy; and a six-page discussion of the working life table (its uses and a description which includes how data are computed for the number of persons living; percent of population in the labor force; number in the labor force; average number of remaining years of life, of working life for the population, of working life for the labor force, of nonlabor force activity for those in the labor force, and of nonlabor force activity for those in the population). The five 1970 working life tables are presented for men, single women, ever-married women to whom no children were ever born, ever-married women in the labor force after the birth of last child, and for divorced, widowed, and separated women. (SH)
Published: 1976

20. Super Sites for Teachers of English (Software).

Author: Byrne, John J.
Abstract: Discusses and reviews World Wide Web sites of use and interest to English teachers. Discusses particular sites to browse, such as ERIC, KIDLINK, and some teacher discussion forums. Notes particular sites on the Internet for use in English Humanities classes; books online; famous author home pages; library links; writing sites online; literature; periodicals; and search engines. (SR)
Published: 1998

21. Global Warming on the International Agenda. Teaching Strategy.

Author: Keenan-Byrne, Patricia and Malkasian, Mark
Abstract: Presents a lesson plan that teaches students the links between industrialization and global warming, and analyzes the conflicting values and priorities involved in the debate between economic development and environmental concerns. Students role play delegates from countries attending an environmental conference. Handouts provide background information and discussion questions. (MJP)
Published: 1997

22. Written Feedback on Student Assignments: Another Look.

Author: Byrne, Ros
Abstract: Describes a way to give word-processed feedback on business communication assignments. Describes some advantages of this mode over both handwritten and audio comments, and identifies limitations of this method. (SR)
Published: 1997

23. Teaching and Assessing Civic Competence.

Author: Byrne, Bonnie
Abstract: Maintains that the primary goal of social studies instruction is the development of civic competence. Describes a Vietnam War interview project incorporating oral history techniques. Includes a grading sheet, a project description sheet, a list of interview questions, and a sample interview. (CFR)
Published: 1993

24. Real Jobs for Real People. An Employer's Guide to Youth Apprenticeship.

Author: National Alliance of Business, Inc., Washington, DC. and Byrne, Sandra
Abstract: Based on the experience of the National Alliance of Business' youth apprenticeship program (the Quality Connection Consortium), this guide offers practical advice on how employers can begin a youth apprenticeship program that will serve their labor needs. It addresses the internal support that a business must generate and gives tips on choosing an educational partner. It includes a discussion of how to determine employee education and training needs and how to meet those needs through youth apprenticeship. The guide covers the three different types of skills that comprise a youth apprenticeship program: academic, technical, and employability skills. Approaches to classroom instruction and structured on-the-job instruction provided under the guidance of a trained mentor/advisor are discussed. Personnel policy issues such as pay, career ladders, recruitment, rotation as a part of on-the-job learning, liability, and certification are also addressed. Student recruitment, including strategies to overcome the negative image that vocational courses have in some high schools, and staff development are addressed. Finally, job placement for graduates is covered in the closing section of the guide. Appendixes provide a list of resources (government and private projects and councils with addresses) and 43 references. (KC)
Published: 1992

25. Kids Helping Kids Readathon, Grade 8.

Author: Kosair Children's Hospital, Louisville, KY. and Byrne, Shirley M.
Abstract: This booklet (one of a series of 10 booklets in a reading project to benefit Kosair Children's Hospital in Louisville, Kentucky) contains 10 stories especially written for eighth graders by educators. The stories are about: effects of teenage drug and alcohol use/abuse; accidents and accident prevention; the loss of a father to cancer; a sister's reaction to her small brother's leukemia; an adventurous boy's apparent suicide; and similar topics. Students read the stories in the booklet and answer comprehension questions, and pledges are made by parents and friends for each question answered. The stories or story topics may be used in the classroom for instructional purposes and are intended to integrate the language arts, social studies, health, and creative arts. (SR)
Published: 1990

26. Kids Helping Kids Readathon, Grade 5.

Author: Kosair Children's Hospital, Louisville, KY. and Byrne, Shirley M.
Abstract: This booklet (one of a series of 10 booklets in a reading project to benefit Kosair Children's Hospital in Louisville, Kentucky) contains 10 stories especially written for fifth graders by educators. The stories are about: chronic and life-threatening diseases and children's feelings about them; accidents with guns and accident prevention; a visit to an emergency room; children's reactions to drug use/alcoholism in the family; and similar topics. Students read the stories in the booklet and answer comprehension questions, and pledges are made by parents and friends for each question answered. The stories or story topics may be used in the classroom for instructional purposes and are intended to help integrate the language arts, social studies, health, and creative arts. (SR)
Published: 1990

27. Kids Helping Kids Readathon, Grade 6.

Author: Kosair Children's Hospital, Louisville, KY. and Byrne, Shirley M.
Abstract: This booklet (one of a series of 10 booklets in a reading project to benefit Kosair Children's Hospital in Louisville, Kentucky) contains 10 stories especially written for sixth graders by educators. The stories are about: a student's coping with a terminal illness and its effect on his classmates; a boy's feelings about his rheumatoid arthritis; children's reactions to various hospital experiences; a 12-year-old's problem with overweight; a son's facing up to the truth of his parents' divorce; how children and others deal with personal differences caused by illness or disability; and similar topics. Students read the stories in the booklet and answer comprehension questions, and pledges are made by parents and friends for each question answered. The stories or story topics may be used in the classroom for instructional purposes and are intended to integrate the language arts, social studies, health, and creative arts. (SR)
Published: 1990

28. Kids Helping Kids Readathon, Grade 7.

Author: Kosair Children's Hospital, Louisville, KY. and Byrne, Shirley M.
Abstract: This booklet (one of a series of 10 booklets in a reading project to benefit Kosair Children's Hospital in Louisville, Kentucky) contains 10 stories especially written for seventh graders by educators. The stories are about: young people with chronic conditions such as diabetes and epilepsy; accidents and accident prevention; children's reactions to various hospital experiences as well as to serious illnesses and deaths; attitudes toward personal differences caused by physical disabilities, birth defects, etc.; and similar topics. Students read the stories in the booklet and answer comprehension questions, and pledges are made by parents and friends for each question answered. The stories or story topics may be used in the classroom for instructional purposes and are intended to help integrate the language arts, social studies, health, and creative arts. (SR)
Published: 1990

29. Kids Helping Kids Readathon, Grade 4.

Author: Kosair Children's Hospital, Louisville, KY. and Byrne, Shirley M.
Abstract: This booklet (one of a series of 10 booklets in a reading project to benefit Kosair Children's Hospital in Louisville, Kentucky) contains 10 stories especially written for fourth graders by educators. The stories are about: children's feelings about disease and treatment; accidents and accident proneness; children's reactions to the death by drowning of a classmate; a child's feelings about her Daddy's hunting; and similar topics. Students read the stories in the booklet and answer comprehension questions, and pledges are made by parents and friends for each question answered. The stories or story topics may be used in the classroom for instructional purposes and are intended to integrate the language arts, social studies, health, and creative arts. (SR)
Published: 1990

30. Kids Helping Kids Readathon, Grade 3.

Author: Kosair Children's Hospital, Louisville, KY. and Byrne, Shirley M.
Abstract: This booklet (one of a series of 10 booklets in a reading project to benefit Kosair Children's Hospital in Louisville, Kentucky) contains 10 stories especially written for third graders by educators. The stories are about: various kinds of disabilities; accidents and accident prevention; childhood illnesses; children's reactions to hospital stays; dealing with personal differences; and similar topics. Students read the stories in the booklet and answer comprehension questions, and pledges are made by parents and friends for each question answered. The stories or story topics may be used in the classroom for instructional purposes and are intended to help integrate arts, social studies, health, and creative arts. (MG)
Published: 1990

31. Kids Helping Kids Readathon, Grade 2.

Author: Kosair Children's Hospital, Louisville, KY. and Byrne, Shirley M.
Abstract: This booklet (one of a series of 10 booklets in a reading project to benefit Kosair Children's Hospital in Louisville, Kentucky) contains 10 stories especially written for second graders by educators. The stories are about: illness and accidents; accident prevention; children's reactions to hospital stays; the death of a pet; a child's view of adoption; a child's reaction to his first pair of glasses; and similar topics. Students read the stories in the booklet and answer comprehension questions, and pledges are made by parents and friends for each question answered. The stories or story topics may be used in the classroom for instructional purposes, and are intended to integrate the language arts, social studies, health, and creative arts. (MG)
Published: 1990

32. Kids Helping Kids Readathon, Grade 1.

Author: Kosair Children's Hospital, Louisville, KY. and Byrne, Shirley M.
Abstract: This booklet (one of a series of 10 booklets in a reading project to benefit Kosair Children's Hospital in Louisville, Kentucky) contains nine stories especially written for first graders by educators. The stories are about: illness and accidents; accident prevention; children's reactions to hospital stays; the first day of school; a death in the family; dealing with personal relationships; and similar topics. Students read the stories in the booklet and answer comprehension questions, and pledges are made by parents and friends for each question answered. The stories or story topics, which may be used in the classroom for instructional purposes and are intended to help integrate the language arts, social studies, health, and creative arts. (MG)
Published: 1990

33. Kids Helping Kids Readathon, Grade K.

Author: Kosair Children's Hospital, Louisville, KY. and Byrne, Shirley M.
Abstract: This booklet (one of a series of 10 booklets in a reading project to benefit Kosair Children's Hospital in Louisville, Kentucky) contains five stories especially written for kindergarten children by educators. The stories are about: the importance of using a seatbelt; a child's first experience of a hospital; a visit to an emergency room; a 5-year-old's feelings about his new brother; and a child who mistakes a mothball for a marshmallow. Students read the stories in the booklet and answer comprehension questions, and pledges are made by parents and friends for each question answered. The stories or story topics, which may be used in the classroom for instructional purposes, are intended to integrate the language arts, social studies, health, and creative arts. (MG)
Published: 1990

34. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Author: van Rheenen, Wouter, van der Spek, Rick A. A., Bakker, Mark K., van Vugt, Joke J. F. A., Hop, Paul J., Zwamborn, Ramona A. J., de Klein, Niek, Westra, Harm-Jan, Bakker, Olivier B., Deelen, Patrick, Shireby, Gemma, Hannon, Eilis, Moisse, Matthieu, Baird, Denis, Restuadi, Restuadi, Dolzhenko, Egor, Dekker, Annelot M., Gawor, Klara, Westeneng, Henk-Jan, Tazelaar, Gijs H. P., van Eijk, Kristel R., Kooyman, Maarten, Byrne, Ross P., Doherty, Mark, Heverin, Mark, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Ticozzi, Nicola, Cooper-Knock, Johnathan, Smith, Bradley N., Gromicho, Marta, Chandran, Siddharthan, Pal, Suvankar, Morrison, Karen E., Shaw, Pamela J., Hardy, John, Orrell, Richard W., Sendtner, Michael, Meyer, Thomas, Başak, Nazli, van der Kooi, Anneke J., Ratti, Antonia, Fogh, Isabella, Gellera, Cinzia, Lauria, Giuseppe, Corti, Stefania, Cereda, Cristina, Sproviero, Daisy, D'Alfonso, Sandra, Sorarù, Gianni, Siciliano, Gabriele, Filosto, Massimiliano, Padovani, Alessandro, Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Canosa, Antonio, Grassano, Maurizio, Beghi, Ettore, Pupillo, Elisabetta, Logroscino, Giancarlo, Nefussy, Beatrice, Osmanovic, Alma, Nordin, Angelica, Lerner, Yossef, Zabari, Michal, Gotkine, Marc, Baloh, Robert H., Bell, Shaughn, Vourc'h, Patrick, Corcia, Philippe, Couratier, Philippe, Millecamps, Stéphanie, Meininger, Vincent, Salachas, François, Mora Pardina, Jesus S., Assialioui, Abdelilah, Rojas-García, Ricard, Dion, Patrick A., Ross, Jay P., Ludolph, Albert C., Weishaupt, Jochen H., Brenner, David, Freischmidt, Axel, Bensimon, Gilbert, Brice, Alexis, Durr, Alexandra, Payan, Christine A. M., Saker-Delye, Safa, Wood, Nicholas W., Topp, Simon, Rademakers, Rosa, Tittmann, Lukas, Lieb, Wolfgang, Franke, Andre, Ripke, Stephan, Braun, Alice, Kraft, Julia, Whiteman, David C., Olsen, Catherine M., Uitterlinden, André G, Hofman, Albert, Rietschel, Marcella, Cichon, Sven, Nöthen, Markus M., Amouyel, Philippe, Traynor, Bryan J., Singleton, Andrew B., Mitne Neto, Miguel, Cauchi, Ruben J., Ophoff, Roel A., Wiedau-Pazos, Martina, Lomen-Hoerth, Catherine, van Deerlin, Vivianna M., Grosskreutz, Julian, Roediger, Annekathrin, Gaur, Nayana, Jörk, Alexander, Barthel, Tabea, Theele, Erik, Ilse, Benjamin, Stubendorff, Beatrice, Witte, Otto W., Steinbach, Robert, Hübner, Christian A., Graff, Caroline, Brylev, Lev, Fominykh, Vera, Demeshonok, Vera, Ataulina, Anastasia, Rogelj, Boris, Koritnik, Blaž, Zidar, Janez, Ravnik-Glavač, Metka, Glavač, Damjan, Stević, Zorica, Drory, Vivian, Povedano, Monica, Blair, Ian P., Kiernan, Matthew C., Benyamin, Beben, Henderson, Robert D., Furlong, Sarah, Mathers, Susan, McCombe, Pamela A., Needham, Merrilee, Ngo, Shyuan T., Nicholson, Garth A., Pamphlett, Roger, Rowe, Dominic B., Steyn, Frederik J., Williams, Kelly L., Mather, Karen A., Sachdev, Perminder S., Henders, Anjali K., Wallace, Leanne, de Carvalho, Mamede, Pinto, Susana, Petri, Susanne, Weber, Markus, Rouleau, Guy A., Silani, Vincenzo, Curtis, Charles J., Breen, Gerome, Glass, Jonathan D., Brown, Robert H., Landers, John E., Shaw, Christopher E., Andersen, Peter Munch, Groen, Ewout J. N., van Es, Michael A., Pasterkamp, R. Jeroen, Fan, Dongsheng, Garton, Fleur C., McRae, Allan F., Smith, George Davey, Gaunt, Tom R., Eberle, Michael A., Mill, Jonathan, McLaughlin, Russell L., Hardiman, Orla, Kenna, Kevin P., Wray, Naomi R., Tsai, Ellen, Runz, Heiko, Franke, Lude, Al-Chalabi, Ammar, Van Damme, Philip, van den Berg, Leonard H., Veldink, Jan H., Universitat Autònoma de Barcelona, van Rheenen, Wouter, van der Spek, Rick A. A., Bakker, Mark K., van Vugt, Joke J. F. A., Hop, Paul J., Zwamborn, Ramona A. J., de Klein, Niek, Westra, Harm-Jan, Bakker, Olivier B., Deelen, Patrick, Shireby, Gemma, Hannon, Eilis, Moisse, Matthieu, Baird, Denis, Restuadi, Restuadi, Dolzhenko, Egor, Dekker, Annelot M., Gawor, Klara, Westeneng, Henk-Jan, Tazelaar, Gijs H. P., van Eijk, Kristel R., Kooyman, Maarten, Byrne, Ross P., Doherty, Mark, Heverin, Mark, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Ticozzi, Nicola, Cooper-Knock, Johnathan, Smith, Bradley N., Gromicho, Marta, Chandran, Siddharthan, Pal, Suvankar, Morrison, Karen E., Shaw, Pamela J., Hardy, John, Orrell, Richard W., Sendtner, Michael, Meyer, Thomas, Başak, Nazli, van der Kooi, Anneke J., Ratti, Antonia, Fogh, Isabella, Gellera, Cinzia, Lauria, Giuseppe, Corti, Stefania, Cereda, Cristina, Sproviero, Daisy, D'Alfonso, Sandra, Sorarù, Gianni, Siciliano, Gabriele, Filosto, Massimiliano, Padovani, Alessandro, Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Canosa, Antonio, Grassano, Maurizio, Beghi, Ettore, Pupillo, Elisabetta, Logroscino, Giancarlo, Nefussy, Beatrice, Osmanovic, Alma, Nordin, Angelica, Lerner, Yossef, Zabari, Michal, Gotkine, Marc, Baloh, Robert H., Bell, Shaughn, Vourc'h, Patrick, Corcia, Philippe, Couratier, Philippe, Millecamps, Stéphanie, Meininger, Vincent, Salachas, François, Mora Pardina, Jesus S., Assialioui, Abdelilah, Rojas-García, Ricard, Dion, Patrick A., Ross, Jay P., Ludolph, Albert C., Weishaupt, Jochen H., Brenner, David, Freischmidt, Axel, Bensimon, Gilbert, Brice, Alexis, Durr, Alexandra, Payan, Christine A. M., Saker-Delye, Safa, Wood, Nicholas W., Topp, Simon, Rademakers, Rosa, Tittmann, Lukas, Lieb, Wolfgang, Franke, Andre, Ripke, Stephan, Braun, Alice, Kraft, Julia, Whiteman, David C., Olsen, Catherine M., Uitterlinden, André G, Hofman, Albert, Rietschel, Marcella, Cichon, Sven, Nöthen, Markus M., Amouyel, Philippe, Traynor, Bryan J., Singleton, Andrew B., Mitne Neto, Miguel, Cauchi, Ruben J., Ophoff, Roel A., Wiedau-Pazos, Martina, Lomen-Hoerth, Catherine, van Deerlin, Vivianna M., Grosskreutz, Julian, Roediger, Annekathrin, Gaur, Nayana, Jörk, Alexander, Barthel, Tabea, Theele, Erik, Ilse, Benjamin, Stubendorff, Beatrice, Witte, Otto W., Steinbach, Robert, Hübner, Christian A., Graff, Caroline, Brylev, Lev, Fominykh, Vera, Demeshonok, Vera, Ataulina, Anastasia, Rogelj, Boris, Koritnik, Blaž, Zidar, Janez, Ravnik-Glavač, Metka, Glavač, Damjan, Stević, Zorica, Drory, Vivian, Povedano, Monica, Blair, Ian P., Kiernan, Matthew C., Benyamin, Beben, Henderson, Robert D., Furlong, Sarah, Mathers, Susan, McCombe, Pamela A., Needham, Merrilee, Ngo, Shyuan T., Nicholson, Garth A., Pamphlett, Roger, Rowe, Dominic B., Steyn, Frederik J., Williams, Kelly L., Mather, Karen A., Sachdev, Perminder S., Henders, Anjali K., Wallace, Leanne, de Carvalho, Mamede, Pinto, Susana, Petri, Susanne, Weber, Markus, Rouleau, Guy A., Silani, Vincenzo, Curtis, Charles J., Breen, Gerome, Glass, Jonathan D., Brown, Robert H., Landers, John E., Shaw, Christopher E., Andersen, Peter Munch, Groen, Ewout J. N., van Es, Michael A., Pasterkamp, R. Jeroen, Fan, Dongsheng, Garton, Fleur C., McRae, Allan F., Smith, George Davey, Gaunt, Tom R., Eberle, Michael A., Mill, Jonathan, McLaughlin, Russell L., Hardiman, Orla, Kenna, Kevin P., Wray, Naomi R., Tsai, Ellen, Runz, Heiko, Franke, Lude, Al-Chalabi, Ammar, Van Damme, Philip, van den Berg, Leonard H., Veldink, Jan H., and Universitat Autònoma de Barcelona
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons. A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology.
Published: 2021

35. Logarithmic corrections for jet production at the LHC

Author: Byrne, Emmet P. and Byrne, Emmet P.
Abstract: Several important processes and analyses at the LHC are sensitive to higher-order perturbative corrections beyond what can currently be calculated at fixed order. One important class of logarithmic corrections are those which appear when the centre-of-mass energy of a QCD collision is much larger than the transverse momenta of the observed jets. We describe the High Energy Jets (HEJ) framework, which includes the dominant high-energy logarithms to provide all-order predictions for several LHC processes including Higgs, $W$, or $Z$ boson production in association with jets. We will summarise some recent developments, in particular the first matching of HEJ to a NLO calculation., Comment: Proceedings of 50th International Symposium on Multiparticle Dynamics (ISMD2021)
Published: 2021

36. Enzyme-catalyzed synthesis of malonate polyesters and their use as metal chelating materials

Author: Byrne, Fergal P., Assemat, Jamie M. Z., Stanford, Amy E., Farmer, Thomas J., Comerford, James W., Pellis, Alessandro, Byrne, Fergal P., Assemat, Jamie M. Z., Stanford, Amy E., Farmer, Thomas J., Comerford, James W., and Pellis, Alessandro
Abstract: Following the environmental problems caused by non-degradable plastics there is a need to synthesise greener and more sustainable polymers. In this work we describe, for the first time, the facile enzyme-catalysed synthesis of linear polyesters using dimethyl malonate as the diester. These polymers, containing a different aliphatic diol component (C4, C6 or C8), were synthesised in solventless conditions using immobilized Candida antarctica lipase B as the biocatalyst. The potential of enzymes for catalysing this reaction is compared with the unsuccessful antimony- and titanium-catalysed synthesis (T > 150 °C). The application of the synthesized polymers as effective metal chelators in biphasic, green solvent systems was also described, together with the characterisation of the synthesised materials.
Published: 2021

37. 2,2,5,5-Tetramethyloxolane (TMO) as a Solvent for Buchwald–Hartwig Aminations

Author: Trowse, Benjamin R., Byrne, Fergal P., Sherwood, James, O’Brien, Peter, Murray, Jane, Farmer, Thomas J., Trowse, Benjamin R., Byrne, Fergal P., Sherwood, James, O’Brien, Peter, Murray, Jane, and Farmer, Thomas J.
Abstract: Buchwald–Hartwig amination is one of the most important methods for the synthesis of N-arylamines and is widely employed for the synthesis of potential pharmaceuticals, natural products, and other fine chemicals. The reaction usually uses a Pd(0) catalyst such as Pd(dba)2 and (±)-BINAP in the presence of a base, and toluene is the most commonly used solvent. However, there are significant safety, toxicological, and environmental hazards associated with the use of toluene. Herein, we demonstrate the successful application of 2,2,5,5-tetramethyloxolane (TMO), a solvent with a similar property profile to toluene, for Buchwald–Hartwig amination reactions for coupling a wide range of primary and secondary amines with aryl bromides. When NaOt-Bu was used as the base, similar yields were obtained in toluene and TMO. In contrast, using Cs2CO3, TMO outperformed toluene significantly for electron-deficient aryl bromides that could be susceptible to nucleophilic attack. To showcase the use of TMO as a solvent for Buchwald–Hartwig aminations, the synthesis of a key intermediate in the route to smoothened (SMO) receptor antagonist drug candidate SEN826 was successfully accomplished in TMO. Improved metrics and reduction in residual palladium in the isolated amines demonstrate further benefits in the substitution of toluene with TMO in Buchwald–Hartwig aminations.
Published: 2021

38. 3-Methoxybutan-2-one as a sustainable bio-based alternative to chlorinated solvents

Author: Jin, Saimeng, Byrne, Fergal P., Clark, James H., McElroy, Con Robert, Quinn, Alex, Sherwood, James, Hunt, Andrew J., Jin, Saimeng, Byrne, Fergal P., Clark, James H., McElroy, Con Robert, Quinn, Alex, Sherwood, James, and Hunt, Andrew J.
Abstract: Methylation of acetoin with dimethyl carbonate was performed in a sustainable one-step process, with improved process mass intensity (PMI) and atom economy compared to previously published methods. The resulting product, 3-methoxybutan-2-one (MO) was successfully evaluated as a bio-based solvent, while both Kamlet–Taft solvatochromic parameters and Hansen solubility parameters demonstrate its potential viability in the substitution of chlorinated solvents. MO exhibited a low peroxide forming potential and a negative Ames mutagenicity test and was successfully used as a solvent in a Friedel–Crafts acylation (79% yield compared to 77% in dichloromethane) and for N-alkylations. MO is a renewable oxygenated solvent, with the potential ability to substitute carcinogenic halogenated solvents in some applications.
Published: 2021

39. The Conditional Volatility Premium on Currency Portfolios

Author: Byrne, Joseph P., Sakemoto, Ryuta, Byrne, Joseph P., and Sakemoto, Ryuta
Abstract: Our paper examines conditional risk-return relations in a number of currency investment strategies, while modeling economic states using a large number of underlying risk factors. We identify a time-varying relationship between currency returns and volatility risk for most currency portfolios. In particular, value and momentum portfolios present risk-return relationships which switch sign, depending upon economic states. The positive relationship for the value portfolio is associated with “flight to quality” periods and the mean reversion for nominal exchange rates during financial crises. The positive relationship for the momentum portfolio is linked to the US and global business cycles and investors require positive compensation for risk in recessions.
Published: 2021

40. Future global climate: scenario-based projections and near-term information

Author: Masson-Delmotte, V., Zhai, P., Pirani, A., Connors, S. L., Pean, C., Berger, S., Caud, N., Chen, Y., Goldfarb, L., Gomis, M. I., Huang, M., Leitzell, K., Lonnoy, E., Matthews, J. B. R., Maycock, T. K., Waterfield, T., Yelekçi, O., Yu, R., Zhou, B., Lee, June-Yi, Marotzke, Jochem, Bala, Govindasamy, Cao, Long, Corti, Susanna, Dunne, John P., Engelbrecht, Francois, Fischer, Erich, Fyfe, John C., Jones, Christopher, Maycock, Amanda, Mutemi, Joseph, Ndiaye, Ousmane, Panickal, Swapna, Zhou, Tianjun, Milinski, Sebastian, Yun, Kyung-Sook, Armour, Kyle, Bellouin, Nicolas, Bethke, Ingo, Byrne, Michael P., Cassou, Christophe, Chen, Deliang, Cherchi, Annalisa, Christensen, Hannah M., Connors, Sarah L., Di Luca, Alejandro, Drijfhout, Sybren S., Fletcher, Christopher G., Forster, Piers, Garcia-Serrano, Javier, Gillett, Nathan P., Kaufmann, Darrell S., Keller, David P., Kravitz, Ben, Li, Hongmei, Liang, Yongxiao, MacDougall, Andrew H., Malinina, Elizaveta, Menary, Matthew, Merryfield, William J., Min, Seung-Ki, Nicholls, Zebedee R. J., Notz, Dirk, Pearson, Brodie, Priestley, Matthew D. K., Quaas, Johannes, Ribes, Aurelien, Ruane, Alex C., Sallee, Jean-Baptiste, Sanchez-Gomez, Emilia, Seneviratne, Sonia I., Slangen, Aimee B. A., Smith, Chris, Stuecker, Malte F., Swaminathan, Ranjini, Thorne, Peter W., Tokarska, Katarzyna B., Toohey, Matthew, Turner, Andrew, Volpi, Danila, Xiao, Cunde, Zappa, Giuseppe, Masson-Delmotte, V., Zhai, P., Pirani, A., Connors, S. L., Pean, C., Berger, S., Caud, N., Chen, Y., Goldfarb, L., Gomis, M. I., Huang, M., Leitzell, K., Lonnoy, E., Matthews, J. B. R., Maycock, T. K., Waterfield, T., Yelekçi, O., Yu, R., Zhou, B., Lee, June-Yi, Marotzke, Jochem, Bala, Govindasamy, Cao, Long, Corti, Susanna, Dunne, John P., Engelbrecht, Francois, Fischer, Erich, Fyfe, John C., Jones, Christopher, Maycock, Amanda, Mutemi, Joseph, Ndiaye, Ousmane, Panickal, Swapna, Zhou, Tianjun, Milinski, Sebastian, Yun, Kyung-Sook, Armour, Kyle, Bellouin, Nicolas, Bethke, Ingo, Byrne, Michael P., Cassou, Christophe, Chen, Deliang, Cherchi, Annalisa, Christensen, Hannah M., Connors, Sarah L., Di Luca, Alejandro, Drijfhout, Sybren S., Fletcher, Christopher G., Forster, Piers, Garcia-Serrano, Javier, Gillett, Nathan P., Kaufmann, Darrell S., Keller, David P., Kravitz, Ben, Li, Hongmei, Liang, Yongxiao, MacDougall, Andrew H., Malinina, Elizaveta, Menary, Matthew, Merryfield, William J., Min, Seung-Ki, Nicholls, Zebedee R. J., Notz, Dirk, Pearson, Brodie, Priestley, Matthew D. K., Quaas, Johannes, Ribes, Aurelien, Ruane, Alex C., Sallee, Jean-Baptiste, Sanchez-Gomez, Emilia, Seneviratne, Sonia I., Slangen, Aimee B. A., Smith, Chris, Stuecker, Malte F., Swaminathan, Ranjini, Thorne, Peter W., Tokarska, Katarzyna B., Toohey, Matthew, Turner, Andrew, Volpi, Danila, Xiao, Cunde, and Zappa, Giuseppe
Published: 2021

41. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Author: van Rheenen, W, van der Spek, R, Bakker, M, van Vugt, J, Hop, P, Zwamborn, R, de Klein, N, Westra, H, Bakker, O, Deelen, P, Shireby, G, Hannon, E, Moisse, M, Baird, D, Restuadi, R, Dolzhenko, E, Dekker, A, Gawor, K, Westeneng, H, Tazelaar, G, van Eijk, K, Kooyman, M, Byrne, R, Doherty, M, Heverin, M, Al Khleifat, A, Iacoangeli, A, Shatunov, A, Ticozzi, N, Cooper-Knock, J, Smith, B, Gromicho, M, Chandran, S, Pal, S, Morrison, K, Shaw, P, Hardy, J, Orrell, R, Sendtner, M, Meyer, T, Basak, N, van der Kooi, A, Ratti, A, Fogh, I, Gellera, C, Lauria, G, Corti, S, Cereda, C, Sproviero, D, D'Alfonso, S, Soraru, G, Siciliano, G, Filosto, M, Padovani, A, Chio, A, Calvo, A, Moglia, C, Brunetti, M, Canosa, A, Grassano, M, Beghi, E, Pupillo, E, Logroscino, G, Nefussy, B, Osmanovic, A, Nordin, A, Lerner, Y, Zabari, M, Gotkine, M, Baloh, R, Bell, S, Vourc'H, P, Corcia, P, Couratier, P, Millecamps, S, Meininger, V, Salachas, F, Mora Pardina, J, Assialioui, A, Rojas-Garcia, R, Dion, P, Ross, J, Ludolph, A, Weishaupt, J, Brenner, D, Freischmidt, A, Bensimon, G, Brice, A, Durr, A, Payan, C, Saker-Delye, S, Wood, N, Topp, S, Rademakers, R, Tittmann, L, Lieb, W, Franke, A, Ripke, S, Braun, A, Kraft, J, Whiteman, D, Olsen, C, Uitterlinden, A, Hofman, A, Rietschel, M, Cichon, S, Nothen, M, Amouyel, P, Traynor, B, Singleton, A, Mitne Neto, M, Cauchi, R, Ophoff, R, Wiedau-Pazos, M, Lomen-Hoerth, C, van Deerlin, V, Grosskreutz, J, Roediger, A, Gaur, N, Jork, A, Barthel, T, Theele, E, Ilse, B, Stubendorff, B, Witte, O, Steinbach, R, Hubner, C, Graff, C, Brylev, L, Fominykh, V, Demeshonok, V, Ataulina, A, Rogelj, B, Koritnik, B, Zidar, J, Ravnik-Glavac, M, Glavac, D, Stevic, Z, Drory, V, Povedano, M, Blair, I, Kiernan, M, Benyamin, B, Henderson, R, Furlong, S, Mathers, S, Mccombe, P, Needham, M, Ngo, S, Nicholson, G, Pamphlett, R, Rowe, D, Steyn, F, Williams, K, Mather, K, Sachdev, P, Henders, A, Wallace, L, de Carvalho, M, Pinto, S, Petri, S, Weber, M, Rouleau, G, Silani, V, Curtis, C, Breen, G, Glass, J, Brown, R, Landers, J, Shaw, C, Andersen, P, Groen, E, van Es, M, Pasterkamp, R, Fan, D, Garton, F, Mcrae, A, Davey Smith, G, Gaunt, T, Eberle, M, Mill, J, Mclaughlin, R, Hardiman, O, Kenna, K, Wray, N, Tsai, E, Runz, H, Franke, L, Al-Chalabi, A, Van Damme, P, van den Berg, L, Veldink, J, Ferrarese, C, van Rheenen W., van der Spek R. A. A., Bakker M. K., van Vugt J. J. F. A., Hop P. J., Zwamborn R. A. J., de Klein N., Westra H. -J., Bakker O. B., Deelen P., Shireby G., Hannon E., Moisse M., Baird D., Restuadi R., Dolzhenko E., Dekker A. M., Gawor K., Westeneng H. -J., Tazelaar G. H. P., van Eijk K. R., Kooyman M., Byrne R. P., Doherty M., Heverin M., Al Khleifat A., Iacoangeli A., Shatunov A., Ticozzi N., Cooper-Knock J., Smith B. N., Gromicho M., Chandran S., Pal S., Morrison K. E., Shaw P. J., Hardy J., Orrell R. W., Sendtner M., Meyer T., Basak N., van der Kooi A. J., Ratti A., Fogh I., Gellera C., Lauria G., Corti S., Cereda C., Sproviero D., D'Alfonso S., Soraru G., Siciliano G., Filosto M., Padovani A., Chio A., Calvo A., Moglia C., Brunetti M., Canosa A., Grassano M., Beghi E., Pupillo E., Logroscino G., Nefussy B., Osmanovic A., Nordin A., Lerner Y., Zabari M., Gotkine M., Baloh R. H., Bell S., Vourc'h P., Corcia P., Couratier P., Millecamps S., Meininger V., Salachas F., Mora Pardina J. S., Assialioui A., Rojas-Garcia R., Dion P. A., Ross J. P., Ludolph A. C., Weishaupt J. H., Brenner D., Freischmidt A., Bensimon G., Brice A., Durr A., Payan C. A. M., Saker-Delye S., Wood N. W., Topp S., Rademakers R., Tittmann L., Lieb W., Franke A., Ripke S., Braun A., Kraft J., Whiteman D. C., Olsen C. M., Uitterlinden A. G., Hofman A., Rietschel M., Cichon S., Nothen M. M., Amouyel P., Traynor B. J., Singleton A. B., Mitne Neto M., Cauchi R. J., Ophoff R. A., Wiedau-Pazos M., Lomen-Hoerth C., van Deerlin V. M., Grosskreutz J., Roediger A., Gaur N., Jork A., Barthel T., Theele E., Ilse B., Stubendorff B., Witte O. W., Steinbach R., Hubner C. A., Graff C., Brylev L., Fominykh V., Demeshonok V., Ataulina A., Rogelj B., Koritnik B., Zidar J., Ravnik-Glavac M., Glavac D., Stevic Z., Drory V., Povedano M., Blair I. P., Kiernan M. C., Benyamin B., Henderson R. D., Furlong S., Mathers S., McCombe P. A., Needham M., Ngo S. T., Nicholson G. A., Pamphlett R., Rowe D. B., Steyn F. J., Williams K. L., Mather K. A., Sachdev P. S., Henders A. K., Wallace L., de Carvalho M., Pinto S., Petri S., Weber M., Rouleau G. A., Silani V., Curtis C. J., Breen G., Glass J. D., Brown R. H., Landers J. E., Shaw C. E., Andersen P. M., Groen E. J. N., van Es M. A., Pasterkamp R. J., Fan D., Garton F. C., McRae A. F., Davey Smith G., Gaunt T. R., Eberle M. A., Mill J., McLaughlin R. L., Hardiman O., Kenna K. P., Wray N. R., Tsai E., Runz H., Franke L., Al-Chalabi A., Van Damme P., van den Berg L. H., Veldink J. H., Ferrarese C., van Rheenen, W, van der Spek, R, Bakker, M, van Vugt, J, Hop, P, Zwamborn, R, de Klein, N, Westra, H, Bakker, O, Deelen, P, Shireby, G, Hannon, E, Moisse, M, Baird, D, Restuadi, R, Dolzhenko, E, Dekker, A, Gawor, K, Westeneng, H, Tazelaar, G, van Eijk, K, Kooyman, M, Byrne, R, Doherty, M, Heverin, M, Al Khleifat, A, Iacoangeli, A, Shatunov, A, Ticozzi, N, Cooper-Knock, J, Smith, B, Gromicho, M, Chandran, S, Pal, S, Morrison, K, Shaw, P, Hardy, J, Orrell, R, Sendtner, M, Meyer, T, Basak, N, van der Kooi, A, Ratti, A, Fogh, I, Gellera, C, Lauria, G, Corti, S, Cereda, C, Sproviero, D, D'Alfonso, S, Soraru, G, Siciliano, G, Filosto, M, Padovani, A, Chio, A, Calvo, A, Moglia, C, Brunetti, M, Canosa, A, Grassano, M, Beghi, E, Pupillo, E, Logroscino, G, Nefussy, B, Osmanovic, A, Nordin, A, Lerner, Y, Zabari, M, Gotkine, M, Baloh, R, Bell, S, Vourc'H, P, Corcia, P, Couratier, P, Millecamps, S, Meininger, V, Salachas, F, Mora Pardina, J, Assialioui, A, Rojas-Garcia, R, Dion, P, Ross, J, Ludolph, A, Weishaupt, J, Brenner, D, Freischmidt, A, Bensimon, G, Brice, A, Durr, A, Payan, C, Saker-Delye, S, Wood, N, Topp, S, Rademakers, R, Tittmann, L, Lieb, W, Franke, A, Ripke, S, Braun, A, Kraft, J, Whiteman, D, Olsen, C, Uitterlinden, A, Hofman, A, Rietschel, M, Cichon, S, Nothen, M, Amouyel, P, Traynor, B, Singleton, A, Mitne Neto, M, Cauchi, R, Ophoff, R, Wiedau-Pazos, M, Lomen-Hoerth, C, van Deerlin, V, Grosskreutz, J, Roediger, A, Gaur, N, Jork, A, Barthel, T, Theele, E, Ilse, B, Stubendorff, B, Witte, O, Steinbach, R, Hubner, C, Graff, C, Brylev, L, Fominykh, V, Demeshonok, V, Ataulina, A, Rogelj, B, Koritnik, B, Zidar, J, Ravnik-Glavac, M, Glavac, D, Stevic, Z, Drory, V, Povedano, M, Blair, I, Kiernan, M, Benyamin, B, Henderson, R, Furlong, S, Mathers, S, Mccombe, P, Needham, M, Ngo, S, Nicholson, G, Pamphlett, R, Rowe, D, Steyn, F, Williams, K, Mather, K, Sachdev, P, Henders, A, Wallace, L, de Carvalho, M, Pinto, S, Petri, S, Weber, M, Rouleau, G, Silani, V, Curtis, C, Breen, G, Glass, J, Brown, R, Landers, J, Shaw, C, Andersen, P, Groen, E, van Es, M, Pasterkamp, R, Fan, D, Garton, F, Mcrae, A, Davey Smith, G, Gaunt, T, Eberle, M, Mill, J, Mclaughlin, R, Hardiman, O, Kenna, K, Wray, N, Tsai, E, Runz, H, Franke, L, Al-Chalabi, A, Van Damme, P, van den Berg, L, Veldink, J, Ferrarese, C, van Rheenen W., van der Spek R. A. A., Bakker M. K., van Vugt J. J. F. A., Hop P. J., Zwamborn R. A. J., de Klein N., Westra H. -J., Bakker O. B., Deelen P., Shireby G., Hannon E., Moisse M., Baird D., Restuadi R., Dolzhenko E., Dekker A. M., Gawor K., Westeneng H. -J., Tazelaar G. H. P., van Eijk K. R., Kooyman M., Byrne R. P., Doherty M., Heverin M., Al Khleifat A., Iacoangeli A., Shatunov A., Ticozzi N., Cooper-Knock J., Smith B. N., Gromicho M., Chandran S., Pal S., Morrison K. E., Shaw P. J., Hardy J., Orrell R. W., Sendtner M., Meyer T., Basak N., van der Kooi A. J., Ratti A., Fogh I., Gellera C., Lauria G., Corti S., Cereda C., Sproviero D., D'Alfonso S., Soraru G., Siciliano G., Filosto M., Padovani A., Chio A., Calvo A., Moglia C., Brunetti M., Canosa A., Grassano M., Beghi E., Pupillo E., Logroscino G., Nefussy B., Osmanovic A., Nordin A., Lerner Y., Zabari M., Gotkine M., Baloh R. H., Bell S., Vourc'h P., Corcia P., Couratier P., Millecamps S., Meininger V., Salachas F., Mora Pardina J. S., Assialioui A., Rojas-Garcia R., Dion P. A., Ross J. P., Ludolph A. C., Weishaupt J. H., Brenner D., Freischmidt A., Bensimon G., Brice A., Durr A., Payan C. A. M., Saker-Delye S., Wood N. W., Topp S., Rademakers R., Tittmann L., Lieb W., Franke A., Ripke S., Braun A., Kraft J., Whiteman D. C., Olsen C. M., Uitterlinden A. G., Hofman A., Rietschel M., Cichon S., Nothen M. M., Amouyel P., Traynor B. J., Singleton A. B., Mitne Neto M., Cauchi R. J., Ophoff R. A., Wiedau-Pazos M., Lomen-Hoerth C., van Deerlin V. M., Grosskreutz J., Roediger A., Gaur N., Jork A., Barthel T., Theele E., Ilse B., Stubendorff B., Witte O. W., Steinbach R., Hubner C. A., Graff C., Brylev L., Fominykh V., Demeshonok V., Ataulina A., Rogelj B., Koritnik B., Zidar J., Ravnik-Glavac M., Glavac D., Stevic Z., Drory V., Povedano M., Blair I. P., Kiernan M. C., Benyamin B., Henderson R. D., Furlong S., Mathers S., McCombe P. A., Needham M., Ngo S. T., Nicholson G. A., Pamphlett R., Rowe D. B., Steyn F. J., Williams K. L., Mather K. A., Sachdev P. S., Henders A. K., Wallace L., de Carvalho M., Pinto S., Petri S., Weber M., Rouleau G. A., Silani V., Curtis C. J., Breen G., Glass J. D., Brown R. H., Landers J. E., Shaw C. E., Andersen P. M., Groen E. J. N., van Es M. A., Pasterkamp R. J., Fan D., Garton F. C., McRae A. F., Davey Smith G., Gaunt T. R., Eberle M. A., Mill J., McLaughlin R. L., Hardiman O., Kenna K. P., Wray N. R., Tsai E., Runz H., Franke L., Al-Chalabi A., Van Damme P., van den Berg L. H., Veldink J. H., and Ferrarese C.
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons.
Published: 2021

42. CMEs in the Heliosphere: III. A Statistical Analysis of the Kinematic Properties Derived from Stereoscopic Geometrical Modelling Techniques Applied to CMEs Detected in the Heliosphere from 2008 to 2014 by STEREO/HI-1

Author: Barnes, D., Davies, J. A., Harrison, R. A., Byrne, J. P., Perry, C. H., Bothmer, V., Eastwood, J. P., Gallagher, P. T., Kilpua, E. K. J., Möstl, C., Rodriguez, L., Rouillard, A. P., Odstrcil, D., Barnes, D., Davies, J. A., Harrison, R. A., Byrne, J. P., Perry, C. H., Bothmer, V., Eastwood, J. P., Gallagher, P. T., Kilpua, E. K. J., Möstl, C., Rodriguez, L., Rouillard, A. P., and Odstrcil, D.
Abstract: We present an analysis of coronal mass ejections (CMEs) observed by the Heliospheric Imagers (HIs) on board NASA's Solar Terrestrial Relations Observatory (STEREO) spacecraft. Between August 2008 and April 2014 we identify 273 CMEs that are observed simultaneously, by the HIs on both spacecraft. For each CME, we track the observed leading edge, as a function of time, from both vantage points, and apply the Stereoscopic Self-Similar Expansion (SSSE) technique to infer their propagation throughout the inner heliosphere. The technique is unable to accurately locate CMEs when their observed leading edge passes between the spacecraft, however, we are able to successfully apply the technique to 151, most of which occur once the spacecraft separation angle exceeds 180 degrees, during solar maximum. We find that using a small half-width to fit the CME can result in observed acceleration to unphysically high velocities and that using a larger half-width can fail to accurately locate the CMEs close to the Sun because the method does not account for CME over-expansion in this region. Observed velocities from SSSE are found to agree well with single-spacecraft (SSEF) analysis techniques applied to the same events. CME propagation directions derived from SSSE and SSEF analysis agree poorly because of known limitations present in the latter. This work was carried out as part of the EU FP7 HELCATS (Heliospheric Cataloguing, Analysis and Techniques Service) project (http://www.helcats-fp7.eu/).
Published: 2020
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43. A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily

Author: Chemical Biology and Drug Discovery, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Shrestha, Safal, Katiyar, Samiksha, Sanz-Rodriguez, Carlos E, Kemppinen, Nolan R, Kim, Hyun W, Kadirvelraj, Renuka, Panagos, Charalampos, Keyhaninejad, Neda, Colonna, Maxwell, Chopra, Pradeep, Byrne, Dominic P, Boons, Geert J, van der Knaap, Esther, Eyers, Patrick A, Edison, Arthur S, Wood, Zachary A, Kannan, Natarajan, Chemical Biology and Drug Discovery, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Shrestha, Safal, Katiyar, Samiksha, Sanz-Rodriguez, Carlos E, Kemppinen, Nolan R, Kim, Hyun W, Kadirvelraj, Renuka, Panagos, Charalampos, Keyhaninejad, Neda, Colonna, Maxwell, Chopra, Pradeep, Byrne, Dominic P, Boons, Geert J, van der Knaap, Esther, Eyers, Patrick A, Edison, Arthur S, Wood, Zachary A, and Kannan, Natarajan
Published: 2020

44. Combined subleading high-energy logarithms and NLO accuracy for W production in association with multiple jets

Author: Andersen, Jeppe R., Black, James A., Brooks, Helen M., Byrne, Emmet P., Maier, Andreas, Smillie, Jennifer M., Andersen, Jeppe R., Black, James A., Brooks, Helen M., Byrne, Emmet P., Maier, Andreas, and Smillie, Jennifer M.
Abstract: Large logarithmic corrections in $\hat s/p_t^2$ lead to substantial variations in the perturbative predictions for inclusive $W$-plus-dijet processes at the Large Hadron Collider. This instability can be cured by summing the leading-logarithmic contributions in $\hat s/p_t^2$ to all orders in $\alpha_s$. As expected though, leading logarithmic accuracy is insufficient to guarantee a suitable description in regions of phase space away from the high energy limit. We present (i) the first calculation of all partonic channels contributing at next-to-leading logarithmic order in $W$-boson production in association with at least two jets, and (ii) bin-by-bin matching to next-to-leading fixed-order accuracy. This new perturbative input is implemented in \emph{High Energy Jets}, and systematically improves the description of available experimental data in regions of phase space which are formally subleading with respect to $\hat s/p_t^2$., Comment: 54 pages, 23 figures. Journal version
Published: 2020
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45. Creep of cylindrical shells subject to axisymmetric loading

Author: Byrne, T. P.
Subjects: 620.1
Published: 1967

46. Transcriptional response to lactic acid stress in the hybrid yeast Zygosaccharomyces parabailii

Author: Ortiz-Merino, R, Kuanyshev, N, Byrne, K, Varela, J, Morrissey, J, Porro, D, Wolfe, K, Branduardi, P, Ortiz-Merino, Raúl A., KUANYSHEV, NURZHAN, Byrne, Kevin P., Varela, Javier A., Morrissey, John P., Porro, Danilo, Wolfe, Kenneth H., Branduardi, Paola, Ortiz-Merino, R, Kuanyshev, N, Byrne, K, Varela, J, Morrissey, J, Porro, D, Wolfe, K, Branduardi, P, Ortiz-Merino, Raúl A., KUANYSHEV, NURZHAN, Byrne, Kevin P., Varela, Javier A., Morrissey, John P., Porro, Danilo, Wolfe, Kenneth H., and Branduardi, Paola
Abstract: Lactic acid has a wide range of applications starting from its undissociated form, and its production using cell factories requires stress-tolerant microbial hosts. The interspecies hybrid yeast Zygosaccharomyces parabailii has great potential to be exploited as a novel host for lactic acid production, due to high organic acid tolerance at low pH and a fermentative metabolism with a high growth rate. Here we used mRNA sequencing (RNA-seq) to analyze Z. parabailii's transcriptional response to lactic acid added exogenously, and we explore the biological mechanisms involved in tolerance. Z. parabailii contains two homeologous copies of most genes. Under lactic acid stress, the two genes in each homeolog pair tend to diverge in expression to a significantly greater extent than under control conditions, indicating that stress tolerance is facilitated by interactions between the two gene sets in the hybrid. Lactic acid induces downregulation of genes related to cell wall and plasma membrane functions, possibly altering the rate of diffusion of lactic acid into cells. Genes related to iron transport and redox processes were upregulated, suggesting an important role for respiratory functions and oxidative stress defense. We found differences in the expression profiles of genes putatively regulated by Haa1 and Aft1/Aft2, previously described as lactic acid responsive in Saccharomyces cerevisiae. Furthermore, formate dehydrogenase (FDH) genes form a lactic acid-responsive gene family that has been specifically amplified in Z. parabailii in comparison to other closely related species. Our study provides a useful starting point for the engineering of Z. parabailii as a host for lactic acid production.
Published: 2018

47. Comparative Analysis of Oomycete Genome Evolution Using the Oomycete Gene Order Browser (OGOB)

Author: McGowan, Jamie, Byrne, Kevin P., Fitzpatrick, David A., McGowan, Jamie, Byrne, Kevin P., and Fitzpatrick, David A.
Abstract: The oomycetes are a class of microscopic, filamentous eukaryotes within the stramenopiles–alveolates–rhizaria eukaryotic supergroup. They include some of the most destructive pathogens of animals and plants, such as Phytophthora infestans, the causative agent of late potato blight. Despite the threat they pose to worldwide food security and natural ecosystems, there is a lack of tools and databases available to study oomycete genetics and evolution. To this end, we have developed the Oomycete Gene Order Browser (OGOB), a curated database that facilitates comparative genomic and syntenic analyses of oomycete species. OGOB incorporates genomic data for 20 oomycete species including functional annotations and a number of bioinformatics tools. OGOB hosts a robust set of orthologous oomycete genes for evolutionary analyses. Here, we present the structure and function of OGOB as well as a number of comparative genomic analyses we have performed to better understand oomycete genome evolution. We analyze the extent of oomycete gene duplication and identify tandem gene duplication as a driving force of the expansion of secreted oomycete genes. We identify core genes that are present and microsyntenically conserved (termed syntenologs) in oomycete lineages and identify the degree of microsynteny between each pair of the 20 species housed in OGOB. Consistent with previous comparative synteny analyses between a small number of oomycete species, our results reveal an extensive degree of microsyntenic conservation amongst genes with housekeeping functions within the oomycetes. OGOB is available at https://ogob.ie.
Published: 2018

48. CMEs in the Heliosphere: I. A Statistical Analysis of the Observational Properties of CMEs Detected in the Heliosphere from 2007 to 2017 by STEREO/HI-1

Author: Harrison, R. A., Davies, J. A., Barnes, D., Byrne, J. P., Perry, C. H., Bothmer, V., Eastwood, J. P., Gallagher, P. T., Kilpua, E. K. J., Möstl, C., Rodriguez, L., Rouillard, A. P., Odstrcil, D., Harrison, R. A., Davies, J. A., Barnes, D., Byrne, J. P., Perry, C. H., Bothmer, V., Eastwood, J. P., Gallagher, P. T., Kilpua, E. K. J., Möstl, C., Rodriguez, L., Rouillard, A. P., and Odstrcil, D.
Abstract: We present a statistical analysis of coronal mass ejections (CMEs) imaged by the Heliospheric Imager (HI) instruments aboard NASAs twin-spacecraft STEREO mission between April 2007 and August 2017 for STEREO-A and between April 2007 and September 2014 for STEREO-B. The analysis exploits a catalogue that was generated within the FP7 HELCATS project. Here, we focus on the observational characteristics of CMEs imaged in the heliosphere by the inner (HI-1) cameras. More specifically, in this paper we present distributions of the basic observational parameters - namely occurrence frequency, central position angle (PA) and PA span - derived from nearly 2000 detections of CMEs in the heliosphere by HI-1 on STEREO-A or STEREO-B from the minimum between Solar Cycles 23 and 24 to the maximum of Cycle 24; STEREO-A analysis includes a further 158 CME detections from the descending phase of Cycle 24, by which time communication with STEREO-B had been lost. We compare heliospheric CME characteristics with properties of CMEs observed at coronal altitudes, and with sunspot number. As expected, heliospheric CME rates correlate with sunspot number, and are not inconsistent with coronal rates once instrumental factors/differences in cataloguing philosophy are considered. As well as being more abundant, heliospheric CMEs, like their coronal counterparts, tend to be wider during solar maximum. Our results confirm previous coronagraph analyses suggesting that CME launch sites don't simply migrate to higher latitudes with increasing solar activity. At solar minimum, CMEs tend to be launched from equatorial latitudes while, at maximum, CMEs appear to be launched over a much wider latitude range; this has implications for understanding the CME/solar source association. Our analysis provides some supporting evidence for the systematic dragging of CMEs to lower latitude as they propagate outwards., Comment: 26 pages, 8 figures, in press at Solar Physics. The abstract has been shortened to comply with the allowed length at arxiv.org
Published: 2018
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49. Learner Needs, Teacher Skills and Classroom Resources.

Author: Byrne, Donn
Abstract: Proposes model of language teaching designed to balance teacher/learner input, whole class teaching vs. small group work, and teaching language as either form or function. Although amount of teacher intervention varies, all classroom activities are communicative, providing a situation where students are involved, contributing and interacting with each other, while teachers are providing direction, encouraging originality, and giving information. (SL)
Published: 1984

50. Dramatic Play, Childhood Drama and the Classroom.

Author: Kelly-Byrne, Diana
Abstract: Describes children's dramatic play behavior as a structured, recognizable phenomenon that is the result of careful nurturing by caregivers and a future tool to make vivid the actualities and potentialities of human experience. (CRH)
Published: 1984

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