SARS-CoV-2 infection is associated with post-acute self-reported neurocognitive symptoms

Background Correspondence SARS-CoV-2 infection is associated with post-acute self-reported neurocognitive symptoms Liana R. Andronescu, PhD, MPH1,2, Stephanie A. Richard, PhD, MHS 1,2, Ann I. Scher, PhD3, David A. Lindholm, MD4,5, Katrin Mende, PhD1,2,5, Anuradha Ganesan, MBBS, MPH1,2,6, Nikhil Huprikar MD6, Tahaniyat Lalani, MBBS, MHS1,2,7, Alfred Smith MD7, Rupal M. Mody, MD8, Milissa U. Jones, MD9, Samantha E. Bazan, DNP, MS10, Rhonda E. Colombo, MD, MHS1,2,4,11, Christopher J. Colombo, MD4,11, Evan Ewers12, Derek T. Larson, DO12,13, Ryan C. Maves, MD1,13, Catherine M. Berjohn, MD, MPH1,4,13, Carlos J Maldonado, PhD14, Caroline English1,2, Margaret Sanchez Edwards, MS1,2, Julia S. Rozman, BS1,2, Jennifer Rusiecki, PhD3, Celia Byrne, PhD3, Mark P. Simons, PhD1, David Tribble, MD, DrPH1, Timothy H Burgess, MD, MPH1, Simon D. Pollett, MBBS1,2, Brian K. Agan, MD1,2 Objectives Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neurocognitive impairment on active-duty service members and other Military Health System (MHS) beneficiaries, it is important to characterize this post-infection phenotype and assess potential risk factors for poor neurocognitive outcomes. Email: landronescu@idcrp.org; liana.andronescu.ctr@usuhs.edu USU Infectious Disease Clinical Research Program (IDCRP), Department of Preventive Medicine and Biostatistics Henry M. Jackson Foundation for the Advancement of Military Medicine • Describe the prevalence of self-reported neurocognitive symptoms among SARS-CoV-2 positive vs negative subjects • Identify risk factors for self-reported neurocognitive symptoms among SARS-CoV-2 positive subjects Results 1Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 2Henry M. Jackso
RITM0027659
Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neurocognitive impairment on active-duty service members and other Military Health System (MHS) beneficiaries, it is important to characterize this post-infection phenotype and assess potential risk factors for poor neurocognitive outcomes.