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There exist three principal types of neutral heterocyclic pyrazole ( = Hpz) derivatives containing two four-coordinate annular boron atoms. The pyrazaboles of type 1 have been known for more than two decades. They contain the skeleton >B(mu-pz)2B< and almost 100 different B- and/or C-substituted derivatives have been described. Triply bridged pyrazaboles of type 2 with X=- OBRO- were accidentally discovered in recent studies on the interaction of boroxins, (-RBO-)3, with pyrazole, and only one additional representative of this type 2 (with X = SS) has since been reported. In addition, several dibora monocations of the structural type 2 where X = pz have been described.

The use of amine boranes to inhibit the inflammation process is disclosed. These boranes, which are boron analogs of a-amino acids, effectively block the following: general inflammation, induced arthritis, and the writhing reflex associated with pleurisy is also inhibited. The boron analogs are shown in vitro to inhibit the release of lysosomal enzymes from liver and polymor-phonuclear neutrophils (PMNs). Further, prostaglandin synthesis is blocked by these compounds at a low concentration, viz, 10-6M. Liver oxidative phosphorylation processes are also uncoupled by these compounds, but PMN migration is unaltered at 10-4M., Supersedes PAT-APPL-068 356-79.