Pharmacologically Active Amine Boranes.

The use of amine boranes to inhibit the inflammation process is disclosed. These boranes, which are boron analogs of a-amino acids, effectively block the following: general inflammation, induced arthritis, and the writhing reflex associated with pleurisy is also inhibited. The boron analogs are shown in vitro to inhibit the release of lysosomal enzymes from liver and polymor-phonuclear neutrophils (PMNs). Further, prostaglandin synthesis is blocked by these compounds at a low concentration, viz, 10-6M. Liver oxidative phosphorylation processes are also uncoupled by these compounds, but PMN migration is unaltered at 10-4M.
Supersedes PAT-APPL-068 356-79.