1. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
- Author
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Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., Sampaziotis, F., Worlock, K. B., Yoshida, M., Barnes, J. L., Banovich, N. E., Barbry, P., Brazma, A., Collin, J., Desai, T. J., Duong, T. E., Eickelberg, O., Falk, C., Farzan, M., Glass, I., Gupta, R. K., Haniffa, M., Horvath, P., Hubner, N., Hung, D., Kaminski, N., Krasnow, M., Kropski, J. A., Kuhnemund, M., Lako, M., Lee, H., Leroy, S., Linnarson, S., Lundeberg, Joakim, Meyer, K. B., Miao, Z., Misharin, A. V., Nawijn, M. C., Nikolic, M. Z., Noseda, M., Ordovas-Montanes, J., Oudit, G. Y., Pe’er, D., Powell, J., Quake, S., Rajagopal, J., Tata, P. R., Rawlins, E. L., Regev, A., Reyfman, P. A., Rozenblatt-Rosen, O., Saeb-Parsy, K., Samakovlis, Christos, Schiller, H. B., Schultze, J. L., Seibold, M. A., Seidman, C. E., Seidman, J. G., Shalek, A. K., Shepherd, D., Spence, J., Spira, A., Sun, X., Teichmann, S. A., Theis, F. J., Tsankov, A. M., Vallier, L., van den Berge, M., Whitsett, J., Xavier, R., Xu, Y., Zaragosi, L. -E, Zerti, D., Zhang, H., Zhang, K., Rojas, M., Figueiredo, F., Network, HCA Lung Biological, Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., Sampaziotis, F., Worlock, K. B., Yoshida, M., Barnes, J. L., Banovich, N. E., Barbry, P., Brazma, A., Collin, J., Desai, T. J., Duong, T. E., Eickelberg, O., Falk, C., Farzan, M., Glass, I., Gupta, R. K., Haniffa, M., Horvath, P., Hubner, N., Hung, D., Kaminski, N., Krasnow, M., Kropski, J. A., Kuhnemund, M., Lako, M., Lee, H., Leroy, S., Linnarson, S., Lundeberg, Joakim, Meyer, K. B., Miao, Z., Misharin, A. V., Nawijn, M. C., Nikolic, M. Z., Noseda, M., Ordovas-Montanes, J., Oudit, G. Y., Pe’er, D., Powell, J., Quake, S., Rajagopal, J., Tata, P. R., Rawlins, E. L., Regev, A., Reyfman, P. A., Rozenblatt-Rosen, O., Saeb-Parsy, K., Samakovlis, Christos, Schiller, H. B., Schultze, J. L., Seibold, M. A., Seidman, C. E., Seidman, J. G., Shalek, A. K., Shepherd, D., Spence, J., Spira, A., Sun, X., Teichmann, S. A., Theis, F. J., Tsankov, A. M., Vallier, L., van den Berge, M., Whitsett, J., Xavier, R., Xu, Y., Zaragosi, L. -E, Zerti, D., Zhang, H., Zhang, K., Rojas, M., Figueiredo, F., and Network, HCA Lung Biological
- Abstract
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org., QC 20200625
- Published
- 2020
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