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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Authors :
Sungnak, W.
Huang, N.
Bécavin, C.
Berg, M.
Queen, R.
Litvinukova, M.
Talavera-López, C.
Maatz, H.
Reichart, D.
Sampaziotis, F.
Worlock, K. B.
Yoshida, M.
Barnes, J. L.
Banovich, N. E.
Barbry, P.
Brazma, A.
Collin, J.
Desai, T. J.
Duong, T. E.
Eickelberg, O.
Falk, C.
Farzan, M.
Glass, I.
Gupta, R. K.
Haniffa, M.
Horvath, P.
Hubner, N.
Hung, D.
Kaminski, N.
Krasnow, M.
Kropski, J. A.
Kuhnemund, M.
Lako, M.
Lee, H.
Leroy, S.
Linnarson, S.
Lundeberg, Joakim
Meyer, K. B.
Miao, Z.
Misharin, A. V.
Nawijn, M. C.
Nikolic, M. Z.
Noseda, M.
Ordovas-Montanes, J.
Oudit, G. Y.
Pe’er, D.
Powell, J.
Quake, S.
Rajagopal, J.
Tata, P. R.
Rawlins, E. L.
Regev, A.
Reyfman, P. A.
Rozenblatt-Rosen, O.
Saeb-Parsy, K.
Samakovlis, Christos
Schiller, H. B.
Schultze, J. L.
Seibold, M. A.
Seidman, C. E.
Seidman, J. G.
Shalek, A. K.
Shepherd, D.
Spence, J.
Spira, A.
Sun, X.
Teichmann, S. A.
Theis, F. J.
Tsankov, A. M.
Vallier, L.
van den Berge, M.
Whitsett, J.
Xavier, R.
Xu, Y.
Zaragosi, L. -E
Zerti, D.
Zhang, H.
Zhang, K.
Rojas, M.
Figueiredo, F.
Network, HCA Lung Biological
Sungnak, W.
Huang, N.
Bécavin, C.
Berg, M.
Queen, R.
Litvinukova, M.
Talavera-López, C.
Maatz, H.
Reichart, D.
Sampaziotis, F.
Worlock, K. B.
Yoshida, M.
Barnes, J. L.
Banovich, N. E.
Barbry, P.
Brazma, A.
Collin, J.
Desai, T. J.
Duong, T. E.
Eickelberg, O.
Falk, C.
Farzan, M.
Glass, I.
Gupta, R. K.
Haniffa, M.
Horvath, P.
Hubner, N.
Hung, D.
Kaminski, N.
Krasnow, M.
Kropski, J. A.
Kuhnemund, M.
Lako, M.
Lee, H.
Leroy, S.
Linnarson, S.
Lundeberg, Joakim
Meyer, K. B.
Miao, Z.
Misharin, A. V.
Nawijn, M. C.
Nikolic, M. Z.
Noseda, M.
Ordovas-Montanes, J.
Oudit, G. Y.
Pe’er, D.
Powell, J.
Quake, S.
Rajagopal, J.
Tata, P. R.
Rawlins, E. L.
Regev, A.
Reyfman, P. A.
Rozenblatt-Rosen, O.
Saeb-Parsy, K.
Samakovlis, Christos
Schiller, H. B.
Schultze, J. L.
Seibold, M. A.
Seidman, C. E.
Seidman, J. G.
Shalek, A. K.
Shepherd, D.
Spence, J.
Spira, A.
Sun, X.
Teichmann, S. A.
Theis, F. J.
Tsankov, A. M.
Vallier, L.
van den Berge, M.
Whitsett, J.
Xavier, R.
Xu, Y.
Zaragosi, L. -E
Zerti, D.
Zhang, H.
Zhang, K.
Rojas, M.
Figueiredo, F.
Network, HCA Lung Biological
Publication Year :
2020

Abstract

We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.<br />QC 20200625

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1235046488
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1038.s41591-020-0868-6
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