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173 results on '"Guglielmo, M."'

1. Progression of non-obstructive coronary plaque: a practical CCTA-based risk score from the PARADIGM registry

Author: Pontone, G, Rossi, A, Baggiano, A, Andreini, D, Conte, E, Fusini, L, Gebhard, C, Rabbat, M, Guaricci, A, Guglielmo, M, Muscogiuri, G, Mushtaq, S, Al-Mallah, M, Berman, D, Budoff, M, Cademartiri, F, Chinnaiyan, K, Choi, J, Chun, E, de Araujo Goncalves, P, Gottlieb, I, Hadamitzky, M, Kim, Y, Lee, B, Lee, S, Maffei, E, Marques, H, Samady, H, Shin, S, Sung, J, van Rosendael, A, Virmani, R, Bax, J, Leipsic, J, Lin, F, Min, J, Narula, J, Shaw, L, Chang, H, Pontone G., Rossi A., Baggiano A., Andreini D., Conte E., Fusini L., Gebhard C., Rabbat M. G., Guaricci A., Guglielmo M., Muscogiuri G., Mushtaq S., Al-Mallah M. H., Berman D. S., Budoff M. J., Cademartiri F., Chinnaiyan K., Choi J. H., Chun E. J., de Araujo Goncalves P., Gottlieb I., Hadamitzky M., Kim Y. J., Lee B. K., Lee S. -E., Maffei E., Marques H., Samady H., Shin S., Sung J. M., van Rosendael A., Virmani R., Bax J. J., Leipsic J. A., Lin F. Y., Min J. K., Narula J., Shaw L. J., Chang H. -J., Pontone, G, Rossi, A, Baggiano, A, Andreini, D, Conte, E, Fusini, L, Gebhard, C, Rabbat, M, Guaricci, A, Guglielmo, M, Muscogiuri, G, Mushtaq, S, Al-Mallah, M, Berman, D, Budoff, M, Cademartiri, F, Chinnaiyan, K, Choi, J, Chun, E, de Araujo Goncalves, P, Gottlieb, I, Hadamitzky, M, Kim, Y, Lee, B, Lee, S, Maffei, E, Marques, H, Samady, H, Shin, S, Sung, J, van Rosendael, A, Virmani, R, Bax, J, Leipsic, J, Lin, F, Min, J, Narula, J, Shaw, L, Chang, H, Pontone G., Rossi A., Baggiano A., Andreini D., Conte E., Fusini L., Gebhard C., Rabbat M. G., Guaricci A., Guglielmo M., Muscogiuri G., Mushtaq S., Al-Mallah M. H., Berman D. S., Budoff M. J., Cademartiri F., Chinnaiyan K., Choi J. H., Chun E. J., de Araujo Goncalves P., Gottlieb I., Hadamitzky M., Kim Y. J., Lee B. K., Lee S. -E., Maffei E., Marques H., Samady H., Shin S., Sung J. M., van Rosendael A., Virmani R., Bax J. J., Leipsic J. A., Lin F. Y., Min J. K., Narula J., Shaw L. J., and Chang H. -J.
Abstract: Objectives: No clear recommendations are endorsed by the different scientific societies on the clinical use of repeat coronary computed tomography angiography (CCTA) in patients with non-obstructive coronary artery disease (CAD). This study aimed to develop and validate a practical CCTA risk score to predict medium-term disease progression in patients at a low-to-intermediate probability of CAD. Methods: Patients were part of the Progression of AtheRosclerotic PlAque Determined by Computed Tomographic Angiography Imaging (PARADIGM) registry. Specifically, 370 (derivation cohort) and 219 (validation cohort) patients with two repeat, clinically indicated CCTA scans, non-obstructive CAD, and absence of high-risk plaque (≥ 2 high-risk features) at baseline CCTA were included. Disease progression was defined as the new occurrence of ≥ 50% stenosis and/or high-risk plaque at follow-up CCTA. Results: In the derivation cohort, 104 (28%) patients experienced disease progression. The median time interval between the two CCTAs was 3.3 years (2.7–4.8). Odds ratios for disease progression derived from multivariable logistic regression were as follows: 4.59 (95% confidence interval: 1.69–12.48) for the number of plaques with spotty calcification, 3.73 (1.46–9.52) for the number of plaques with low attenuation component, 2.71 (1.62–4.50) for 25–49% stenosis severity, 1.47 (1.17–1.84) for the number of bifurcation plaques, and 1.21 (1.02–1.42) for the time between the two CCTAs. The C-statistics of the model were 0.732 (0.676–0.788) and 0.668 (0.583–0.752) in the derivation and validation cohorts, respectively. Conclusions: The new CCTA-based risk score is a simple and practical tool that can predict mid-term CAD progression in patients with known non-obstructive CAD. Clinical relevance statement: The clinical implementation of this new CCTA-based risk score can help promote the management of patients with non-obstructive coronary disease in terms of timing of imaging follow-u
Published: 2024

2. Mitral Annular Disjunction in Idiopathic Ventricular Fibrillation Patients: Just a Bystander or a Potential Cause?

Author: Verheul, L.M., Guglielmo, M, Groeneveld, Sanne A, Kirkels, F P, Scrocco, C, Cramer, M J, Bootsma, M, Kapel, G. F.L., Alings, Marco A.M.W., Evertz, Reinder, Mulder, Bart A, Prakken, Niek H.J., Balt, Jippe C., Hirsch, Alexander, Yap, Sing-Chien, Volders, Paul G A, Verheul, L.M., Guglielmo, M, Groeneveld, Sanne A, Kirkels, F P, Scrocco, C, Cramer, M J, Bootsma, M, Kapel, G. F.L., Alings, Marco A.M.W., Evertz, Reinder, Mulder, Bart A, Prakken, Niek H.J., Balt, Jippe C., Hirsch, Alexander, Yap, Sing-Chien, and Volders, Paul G A
Abstract: Aims Previously, we demonstrated that inferolateral mitral annular disjunction (MAD) is more prevalent in patients with idiopathic ventricular fibrillation (IVF) than in healthy controls. In the present study, we advanced the insights into the prevalence and ventricular arrhythmogenicity by inferolateral MAD in an even larger IVF cohort. Methods and results This retrospective multi-centre study included 185 IVF patients [median age 39 (27, 52) years, 40% female]. Cardiac magnetic resonance images were analyzed for mitral valve and annular abnormalities and late gadolinium enhancement. Clinical characteristics were compared between patients with and without MAD. MAD in any of the 4 locations was present in 112 (61%) IVF patients and inferolateral MAD was identified in 24 (13%) IVF patients. Mitral valve prolapse (MVP) was found in 13 (7%) IVF patients. MVP was more prevalent in patients with inferolateral MAD compared with patients without inferolateral MAD (42 vs. 2%, P < 0.001). Pro-arrhythmic characteristics in terms of a high burden of premature ventricular complexes (PVCs) and non-sustained ventricular tachycardia (VT) were more prevalent in patients with inferolateral MAD compared to patients without inferolateral MAD (67 vs. 23%, P < 0.001 and 63 vs. 41%, P = 0.046, respectively). Appropriate implantable cardioverter defibrillator therapy during follow-up was comparable for IVF patients with or without inferolateral MAD (13 vs. 18%, P = 0.579). Conclusion A high prevalence of inferolateral MAD and MVP is a consistent finding in this large IVF cohort. The presence of inferolateral MAD is associated with a higher PVC burden and non-sustained VTs. Further research is needed to explain this potential interplay.[GRAPHICS]
Published: 2024

3. Terrestrial very-long-baseline atom interferometry : Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanic, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanic, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024
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4. Terrestrial very-long-baseline atom interferometry: Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaž, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belić, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojević, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, Rosendo, Esther del Pino, Deppner, Christian, Derevianko, Andrei, Rham, Claudia de, Roeck, Albert De, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelof, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fanì, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündoğan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanımeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglič, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, Monjaraz, Cristian López, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, ioğlu, Özgür E. Müstecapl, Ni, Wei-Tou, Noller, Johannes, Odžak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalčec, Kimberly, Tolley, Andrew. J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, Klitzing, Wolf von, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Cruzeiro, Emmanuel Zambrini, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanič, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaž, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belić, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojević, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, Rosendo, Esther del Pino, Deppner, Christian, Derevianko, Andrei, Rham, Claudia de, Roeck, Albert De, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelof, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fanì, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündoğan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanımeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglič, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, Monjaraz, Cristian López, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, ioğlu, Özgür E. Müstecapl, Ni, Wei-Tou, Noller, Johannes, Odžak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalčec, Kimberly, Tolley, Andrew. J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, Klitzing, Wolf von, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Cruzeiro, Emmanuel Zambrini, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanič, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024

5. Terrestrial very-long-baseline atom interferometry : Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanic, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanic, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024
Full Text: View/download PDF

6. Terrestrial very-long-baseline atom interferometry : Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanic, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanic, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024
Full Text: View/download PDF

7. Terrestrial very-long-baseline atom interferometry : Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanic, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanic, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024
Full Text: View/download PDF

8. Terrestrial very-long-baseline atom interferometry: Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaž, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belić, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojević, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, Rosendo, Esther del Pino, Deppner, Christian, Derevianko, Andrei, Rham, Claudia de, Roeck, Albert De, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelof, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fanì, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündoğan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanımeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglič, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, Monjaraz, Cristian López, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, ioğlu, Özgür E. Müstecapl, Ni, Wei-Tou, Noller, Johannes, Odžak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalčec, Kimberly, Tolley, Andrew. J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, Klitzing, Wolf von, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Cruzeiro, Emmanuel Zambrini, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanič, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaž, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belić, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojević, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, Rosendo, Esther del Pino, Deppner, Christian, Derevianko, Andrei, Rham, Claudia de, Roeck, Albert De, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelof, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fanì, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündoğan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanımeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglič, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, Monjaraz, Cristian López, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, ioğlu, Özgür E. Müstecapl, Ni, Wei-Tou, Noller, Johannes, Odžak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalčec, Kimberly, Tolley, Andrew. J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, Klitzing, Wolf von, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Cruzeiro, Emmanuel Zambrini, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanič, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024

9. Terrestrial very-long-baseline atom interferometry : Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanic, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanic, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024
Full Text: View/download PDF

10. Mitral annular disjunction in idiopathic ventricular fibrillation patients: Just a bystander or a potential cause?

Author: Team Onderzoek, Team Medisch, Circulatory Health, Arts Assistenten Cardiologie, Researchgr. Hart-brein as., Brain, Verheul, L. M., Guglielmo, M., Groeneveld, S. A., Kirkels, F. P., Scrocco, C., Cramer, M. J., Bootsma, M., Kapel, G. F.L., Alings, M., Evertz, R., Mulder, B. A., Prakken, N. H.J., Balt, J. C., Volders, P. G.A., Hirsch, A., Yap, S. C., Postema, P. G., Nijveldt, R., Velthuis, B. K., Behr, E. R., Wilde, A. A.M., Hassink, R. J., Team Onderzoek, Team Medisch, Circulatory Health, Arts Assistenten Cardiologie, Researchgr. Hart-brein as., Brain, Verheul, L. M., Guglielmo, M., Groeneveld, S. A., Kirkels, F. P., Scrocco, C., Cramer, M. J., Bootsma, M., Kapel, G. F.L., Alings, M., Evertz, R., Mulder, B. A., Prakken, N. H.J., Balt, J. C., Volders, P. G.A., Hirsch, A., Yap, S. C., Postema, P. G., Nijveldt, R., Velthuis, B. K., Behr, E. R., Wilde, A. A.M., and Hassink, R. J.
Published: 2024

11. Does the AVNeo valve reduce wall stress on the aortic wall? A cardiac magnetic resonance analysis with 4D-flow for the evaluation of aortic valve replacement with the Ozaki technique

Author: Pirola, S, Mastroiacovo, G, Bonomi, A, Manchester, E, Fisichella, S, Maragna, R, Baggiano, A, Mushtaq, S, Muscogiuri, G, Guglielmo, M, Xu, X, Pontone, G, Polvani, G, Pirola S., Mastroiacovo G., Bonomi A., Manchester E. L., Fisichella S. M., Maragna R., Baggiano A., Mushtaq S., Muscogiuri G., Guglielmo M., Xu X. Y., Pontone G., Polvani G., Pirola, S, Mastroiacovo, G, Bonomi, A, Manchester, E, Fisichella, S, Maragna, R, Baggiano, A, Mushtaq, S, Muscogiuri, G, Guglielmo, M, Xu, X, Pontone, G, Polvani, G, Pirola S., Mastroiacovo G., Bonomi A., Manchester E. L., Fisichella S. M., Maragna R., Baggiano A., Mushtaq S., Muscogiuri G., Guglielmo M., Xu X. Y., Pontone G., and Polvani G.
Abstract: OBJECTIVES: Aortic valve neocuspidalization aims to replace the 3 aortic cusps with autologous pericardium pre-treated with glutaraldehyde, and it is a surgical alternative to the classical aortic valve replacement (AVR). Image-based patient-specific computational fluid dynamics allows the derivation of shear stress on the aortic wall [wall shear stress (WSS)]. Previous studies support a potential link between increased WSS and histological alterations of the aortic wall. The aim of this study is to compare the WSS of the ascending aorta in patients undergoing aortic valve neocuspidalization versus AVR with biological prostheses. METHODS: This is a prospective nonrandomized clinical trial. Each patient underwent a 4D-flow cardiac magnetic resonance scan after surgery, which informed patient-specific computational fluid dynamics models to evaluate WSS at the ascending aortic wall. The adjusted variables were calculated by summing the residuals obtained from a multivariate linear model (with ejection fraction and left ventricle outflow tract-aorta angle as covariates) to the mean of the variables. RESULTS: Ten patients treated with aortic valve neocuspidalization were enrolled and compared with 10 AVR patients. The aortic valve neocuspidalization group showed a significantly lower WSS in the outer curvature segments of the proximal and distal ascending aorta as compared to AVR patients (P = 0.0179 and 0.0412, respectively). WSS levels remained significantly lower along the outer curvature of the proximal aorta in the aortic valve neocuspidalization population, even after adjusting the WSS for the ejection fraction and the left ventricle outflow tract-aorta angle [2.44 Pa (2.17-3.01) vs 1.94 Pa (1.72-2.01), P = 0.02]. CONCLUSIONS: Aortic valve neocuspidalization hemodynamical features are potentially associated with a lower WSS in the ascending aorta as compared to commercially available bioprosthetic valves.
Published: 2023

12. Editorial: Multimodality imaging in the assessment of ischemic chronic coronary syndrome

Author: Muscogiuri, G, Guglielmo, M, Muscogiuri G., Guglielmo M., Muscogiuri, G, Guglielmo, M, Muscogiuri G., and Guglielmo M.
Published: 2023

13. Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy: The DERIVATE–ICM International Registry

Author: Pontone, G, Guaricci, A, Fusini, L, Baggiano, A, Guglielmo, M, Muscogiuri, G, Volpe, A, Abete, R, Aquaro, G, Barison, A, Bogaert, J, Camastra, G, Carigi, S, Carrabba, N, Casavecchia, G, Censi, S, Cicala, G, De Cecco, C, De Lazzari, M, Di Giovine, G, Di Roma, M, Dobrovie, M, Focardi, M, Gaibazzi, N, Gismondi, A, Gravina, M, Lanzillo, C, Lombardi, M, Lorenzoni, V, Lozano-Torres, J, Martini, C, Marzo, F, Masi, A, Memeo, R, Moro, C, Nese, A, Palumbo, A, Pavon, A, Pedrotti, P, Marra, M, Pica, S, Pradella, S, Presicci, C, Rabbat, M, Raineri, C, Rodriguez-Palomares, J, Sbarbati, S, Schoepf, U, Squeri, A, Sverzellati, N, Symons, R, Tat, E, Timpani, M, Todiere, G, Valentini, A, Varga-Szemes, A, Masci, P, Schwitter, J, Pontone G., Guaricci A. I., Fusini L., Baggiano A., Guglielmo M., Muscogiuri G., Volpe A., Abete R., Aquaro G., Barison A., Bogaert J., Camastra G., Carigi S., Carrabba N., Casavecchia G., Censi S., Cicala G., De Cecco C. N., De Lazzari M., Di Giovine G., Di Roma M., Dobrovie M., Focardi M., Gaibazzi N., Gismondi A., Gravina M., Lanzillo C., Lombardi M., Lorenzoni V., Lozano-Torres J., Martini C., Marzo F., Masi A., Memeo R., Moro C., Nese A., Palumbo A., Pavon A. G., Pedrotti P., Marra M. P., Pica S., Pradella S., Presicci C., Rabbat M. G., Raineri C., Rodriguez-Palomares J. F., Sbarbati S., Schoepf U. J., Squeri A., Sverzellati N., Symons R., Tat E., Timpani M., Todiere G., Valentini A., Varga-Szemes A., Masci P. -G., Schwitter J., Pontone, G, Guaricci, A, Fusini, L, Baggiano, A, Guglielmo, M, Muscogiuri, G, Volpe, A, Abete, R, Aquaro, G, Barison, A, Bogaert, J, Camastra, G, Carigi, S, Carrabba, N, Casavecchia, G, Censi, S, Cicala, G, De Cecco, C, De Lazzari, M, Di Giovine, G, Di Roma, M, Dobrovie, M, Focardi, M, Gaibazzi, N, Gismondi, A, Gravina, M, Lanzillo, C, Lombardi, M, Lorenzoni, V, Lozano-Torres, J, Martini, C, Marzo, F, Masi, A, Memeo, R, Moro, C, Nese, A, Palumbo, A, Pavon, A, Pedrotti, P, Marra, M, Pica, S, Pradella, S, Presicci, C, Rabbat, M, Raineri, C, Rodriguez-Palomares, J, Sbarbati, S, Schoepf, U, Squeri, A, Sverzellati, N, Symons, R, Tat, E, Timpani, M, Todiere, G, Valentini, A, Varga-Szemes, A, Masci, P, Schwitter, J, Pontone G., Guaricci A. I., Fusini L., Baggiano A., Guglielmo M., Muscogiuri G., Volpe A., Abete R., Aquaro G., Barison A., Bogaert J., Camastra G., Carigi S., Carrabba N., Casavecchia G., Censi S., Cicala G., De Cecco C. N., De Lazzari M., Di Giovine G., Di Roma M., Dobrovie M., Focardi M., Gaibazzi N., Gismondi A., Gravina M., Lanzillo C., Lombardi M., Lorenzoni V., Lozano-Torres J., Martini C., Marzo F., Masi A., Memeo R., Moro C., Nese A., Palumbo A., Pavon A. G., Pedrotti P., Marra M. P., Pica S., Pradella S., Presicci C., Rabbat M. G., Raineri C., Rodriguez-Palomares J. F., Sbarbati S., Schoepf U. J., Squeri A., Sverzellati N., Symons R., Tat E., Timpani M., Todiere G., Valentini A., Varga-Szemes A., Masci P. -G., and Schwitter J.
Abstract: Background: Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation. Objectives: The DERIVATE-ICM registry (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy; NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM. Methods: A total of 861 patients with ICM (mean age 65 ± 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints. Results: During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P = 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P = 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P = 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P = 0.007). Conclusions: The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care.
Published: 2023

14. The Role of Non-Invasive Multimodality Imaging in Chronic Coronary Syndrome: Anatomical and Functional Pathways

Author: Bergamaschi, L, Pavon, A, Angeli, F, Tuttolomondo, D, Belmonte, M, Armillotta, M, Sansonetti, A, Foa, A, Paolisso, P, Baggiano, A, Mushtaq, S, De Zan, G, Carriero, S, Cramer, M, Teske, A, Broekhuizen, L, van der Bilt, I, Muscogiuri, G, Sironi, S, Leo, L, Gaibazzi, N, Lovato, L, Pontone, G, Pizzi, C, Guglielmo, M, Bergamaschi L., Pavon A. G., Angeli F., Tuttolomondo D., Belmonte M., Armillotta M., Sansonetti A., Foa A., Paolisso P., Baggiano A., Mushtaq S., De Zan G., Carriero S., Cramer M. -J., Teske A. J., Broekhuizen L., van der Bilt I., Muscogiuri G., Sironi S., Leo L. A., Gaibazzi N., Lovato L., Pontone G., Pizzi C., Guglielmo M., Bergamaschi, L, Pavon, A, Angeli, F, Tuttolomondo, D, Belmonte, M, Armillotta, M, Sansonetti, A, Foa, A, Paolisso, P, Baggiano, A, Mushtaq, S, De Zan, G, Carriero, S, Cramer, M, Teske, A, Broekhuizen, L, van der Bilt, I, Muscogiuri, G, Sironi, S, Leo, L, Gaibazzi, N, Lovato, L, Pontone, G, Pizzi, C, Guglielmo, M, Bergamaschi L., Pavon A. G., Angeli F., Tuttolomondo D., Belmonte M., Armillotta M., Sansonetti A., Foa A., Paolisso P., Baggiano A., Mushtaq S., De Zan G., Carriero S., Cramer M. -J., Teske A. J., Broekhuizen L., van der Bilt I., Muscogiuri G., Sironi S., Leo L. A., Gaibazzi N., Lovato L., Pontone G., Pizzi C., and Guglielmo M.
Abstract: Coronary artery disease (CAD) is one of the major causes of mortality and morbidity worldwide, with a high socioeconomic impact. Currently, various guidelines and recommendations have been published about chronic coronary syndromes (CCS). According to the recent European Society of Cardiology guidelines on chronic coronary syndrome, a multimodal imaging approach is strongly recommended in the evaluation of patients with suspected CAD. Today, in the current practice, non-invasive imaging methods can assess coronary anatomy through coronary computed tomography angiography (CCTA) and/or inducible myocardial ischemia through functional stress testing (stress echocardiography, cardiac magnetic resonance imaging, single photon emission computed tomography—SPECT, or positron emission tomography—PET). However, recent trials (ISCHEMIA and REVIVED) have cast doubt on the previous conception of the management of patients with CCS, and nowadays it is essential to understand the limitations and strengths of each imaging method and, specifically, when to choose a functional approach focused on the ischemia versus a coronary anatomy-based one. Finally, the concept of a pathophysiology-driven treatment of these patients emerged as an important goal of multimodal imaging, integrating ‘anatomical’ and ‘functional’ information. The present review aims to provide an overview of non-invasive imaging modalities for the comprehensive management of CCS patients.
Published: 2023

15. Exploring the EVolution in PrognOstic CapabiLity of MUltisequence Cardiac MagneTIc ResOnance in PatieNts Affected by Takotsubo Cardiomyopathy Based on Machine Learning Analysis: Design and Rationale of the EVOLUTION Study

Author: Cau, R, Muscogiuri, G, Pisu, F, Gatti, M, Velthuis, B, Loewe, C, Cademartiri, F, Pontone, G, Montisci, R, Guglielmo, M, Sironi, S, Esposito, A, Francone, M, Dacher, N, Peebles, C, Bastarrika, G, Salgado, R, Saba, L, Cau R., Muscogiuri G., Pisu F., Gatti M., Velthuis B., Loewe C., Cademartiri F., Pontone G., Montisci R., Guglielmo M., Sironi S., Esposito A., Francone M., Dacher N., Peebles C., Bastarrika G., Salgado R., Saba L., Cau, R, Muscogiuri, G, Pisu, F, Gatti, M, Velthuis, B, Loewe, C, Cademartiri, F, Pontone, G, Montisci, R, Guglielmo, M, Sironi, S, Esposito, A, Francone, M, Dacher, N, Peebles, C, Bastarrika, G, Salgado, R, Saba, L, Cau R., Muscogiuri G., Pisu F., Gatti M., Velthuis B., Loewe C., Cademartiri F., Pontone G., Montisci R., Guglielmo M., Sironi S., Esposito A., Francone M., Dacher N., Peebles C., Bastarrika G., Salgado R., and Saba L.
Abstract: Purpose: Takotsubo cardiomyopathy (TTC) is a transient but severe acute myocardial dysfunction with a wide range of outcomes from favorable to life-threatening. The current risk stratification scores of TTC patients do not include cardiac magnetic resonance (CMR) parameters. To date, it is still unknown whether and how clinical, trans-thoracic echocardiography (TTE), and CMR data can be integrated to improve risk stratification. Methods: EVOLUTION (Exploring the eVolution in prognOstic capabiLity of mUlti-sequence cardiac magneTIc resOnance in patieNts affected by Takotsubo cardiomyopathy) is a multicenter, international registry of TTC patients who will undergo a clinical, TTE, and CMR evaluation. Clinical data including demographics, risk factors, comorbidities, laboratory values, ECG, and results from TTE and CMR analysis will be collected, and each patient will be followed-up for in-hospital and long-term outcomes. Clinical outcome measures during hospitalization will include cardiovascular death, pulmonary edema, arrhythmias, stroke, or transient ischemic attack. Clinical long-term outcome measures will include cardiovascular death, pulmonary edema, heart failure, arrhythmias, sudden cardiac death, and major adverse cardiac and cerebrovascular events defined as a composite endpoint of death from any cause, myocardial infarction, recurrence of TTC, transient ischemic attack, and stroke. We will develop a comprehensive clinical and imaging score that predicts TTC outcomes and test the value of machine learning models, incorporating clinical and imaging parameters to predict prognosis. Conclusions: The main goal of the study is to develop a comprehensive clinical and imaging score, that includes TTE and CMR data, in a large cohort of TTC patients for risk stratification and outcome prediction as a basis for possible changes in patient management.
Published: 2023

16. The Non-Invasive Diagnosis of Chronic Coronary Syndrome: A Focus on Stress Computed Tomography Perfusion and Stress Cardiac Magnetic Resonance

Author: Groenhoff, L, De Zan, G, Costantini, P, Siani, A, Ostillio, E, Carriero, S, Muscogiuri, G, Bergamaschi, L, Patti, G, Pizzi, C, Sironi, S, Pavon, A, Carriero, A, Guglielmo, M, Groenhoff L., De Zan G., Costantini P., Siani A., Ostillio E., Carriero S., Muscogiuri G., Bergamaschi L., Patti G., Pizzi C., Sironi S., Pavon A. G., Carriero A., Guglielmo M., Groenhoff, L, De Zan, G, Costantini, P, Siani, A, Ostillio, E, Carriero, S, Muscogiuri, G, Bergamaschi, L, Patti, G, Pizzi, C, Sironi, S, Pavon, A, Carriero, A, Guglielmo, M, Groenhoff L., De Zan G., Costantini P., Siani A., Ostillio E., Carriero S., Muscogiuri G., Bergamaschi L., Patti G., Pizzi C., Sironi S., Pavon A. G., Carriero A., and Guglielmo M.
Abstract: Coronary artery disease is still a major cause of death and morbidity worldwide. In the setting of chronic coronary disease, demonstration of inducible ischemia is mandatory to address treatment. Consequently, scientific and technological efforts were made in response to the request for non-invasive diagnostic tools with better sensitivity and specificity. To date, clinicians have at their disposal a wide range of stress-imaging techniques. Among others, stress cardiac magnetic resonance (S-CMR) and computed tomography perfusion (CTP) techniques both demonstrated their diagnostic efficacy and prognostic value in clinical trials when compared to other non-invasive ischemia-assessing techniques and invasive fractional flow reserve measurement techniques. Standardized protocols for both S-CMR and CTP usually imply the administration of vasodilator agents to induce hyperemia and contrast agents to depict perfusion defects. However, both methods have their own limitations, meaning that optimizing their performance still requires a patient-tailored approach. This review focuses on the characteristics, drawbacks, and future perspectives of these two techniques.
Published: 2023

17. Coronary-specific quantification of myocardial deformation by strain echocardiography may disclose the culprit vessel in patients with non-ST-segment elevation acute coronary syndrome

Author: Guaricci, A, Chiarello, G, Gherbesi, E, Fusini, L, Soldato, N, Siena, P, Ursi, R, Ruggieri, R, Guglielmo, M, Muscogiuri, G, Baggiano, A, Rabbat, M, Memeo, R, Lepera, M, Favale, S, Pontone, G, Guaricci A. I., Chiarello G., Gherbesi E., Fusini L., Soldato N., Siena P., Ursi R., Ruggieri R., Guglielmo M., Muscogiuri G., Baggiano A., Rabbat M. G., Memeo R., Lepera M., Favale S., Pontone G., Guaricci, A, Chiarello, G, Gherbesi, E, Fusini, L, Soldato, N, Siena, P, Ursi, R, Ruggieri, R, Guglielmo, M, Muscogiuri, G, Baggiano, A, Rabbat, M, Memeo, R, Lepera, M, Favale, S, Pontone, G, Guaricci A. I., Chiarello G., Gherbesi E., Fusini L., Soldato N., Siena P., Ursi R., Ruggieri R., Guglielmo M., Muscogiuri G., Baggiano A., Rabbat M. G., Memeo R., Lepera M., Favale S., and Pontone G.
Abstract: Aims To compare the diagnostic accuracy of speckle tracking echocardiography technique using territorial longitudinal strain (TLS) for the detection of culprit vessel vs. vessel-specific wall motion score index (WMSI) in non-ST-segment elevation–acute coronary syndrome (NSTE-ACS) patients scheduled for invasive coronary angiography (ICA). Methods and results One hundred and eighty-three patients (mean age: 66 ± 12 years, male: 71%) diagnosed with NSTE-ACS underwent echocardiography evaluation at hospital admission and ICA within 24 h. Culprit vessels were left anterior descending (LAD), left circumflex (CX), and right coronary arteries (RCAs) in 38.5%, 39.6%, and 21.4%, respectively. An increase of affected vessels [1-, 2-, and 3-vessel coronary artery disease (CAD)] was associated with increased WMSI and TLS values. There was a statistically significant difference of both WMSI-LAD, WMSI-CX, WMSI-RCA and TLS-LAD, TLS-CX, TLS-RCA of myocardial segments with underlying severe CAD compared to no CAD (P = 0.001 and P < 0.001, respectively). Moreover, a significant difference of TLS-LAD, TLS-CX, TLS-RCA, and WMSI-CX of myocardial segments with an underlying culprit vessel compared to non-culprit vessels (P < 0.001, P < 0.001, P = 0.022, and P < 0.001, respectively) was identified. WMSI-LAD and WMSI-RCA did not show statistical significant differences. A regression model revealed that the combination of WMSI þ TLS was more accurate compared to WMSI alone in detecting the culprit vessel (LAD, P = 0.001; CX, P < 0.001; and RCA, P = 0.019). Conclusion Territorial longitudinal strain allows an accurate identification of the culprit vessel in NSTE-ACS patients. In addition to WMSI, TLS may be considered as part of routine echocardiography for better clinical assessment in this subset of patients.
Published: 2022

18. Advances in Multimodality Cardiovascular Imaging in the Diagnosis of Heart Failure With Preserved Ejection Fraction

Author: Del Torto, A, Guaricci, A, Pomarico, F, Guglielmo, M, Fusini, L, Monitillo, F, Santoro, D, Vannini, M, Rossi, A, Muscogiuri, G, Baggiano, A, Pontone, G, Del Torto A., Guaricci A. I., Pomarico F., Guglielmo M., Fusini L., Monitillo F., Santoro D., Vannini M., Rossi A., Muscogiuri G., Baggiano A., Pontone G., Del Torto, A, Guaricci, A, Pomarico, F, Guglielmo, M, Fusini, L, Monitillo, F, Santoro, D, Vannini, M, Rossi, A, Muscogiuri, G, Baggiano, A, Pontone, G, Del Torto A., Guaricci A. I., Pomarico F., Guglielmo M., Fusini L., Monitillo F., Santoro D., Vannini M., Rossi A., Muscogiuri G., Baggiano A., and Pontone G.
Abstract: Heart failure with preserved ejection fraction (HFpEF) is a syndrome defined by the presence of heart failure symptoms and increased levels of circulating natriuretic peptide (NP) in patients with preserved left ventricular ejection fraction and various degrees of diastolic dysfunction (DD). HFpEF is a complex condition that encompasses a wide range of different etiologies. Cardiovascular imaging plays a pivotal role in diagnosing HFpEF, in identifying specific underlying etiologies, in prognostic stratification, and in therapeutic individualization. Echocardiography is the first line imaging modality with its wide availability; it has high spatial and temporal resolution and can reliably assess systolic and diastolic function. Cardiovascular magnetic resonance (CMR) is the gold standard for cardiac morphology and function assessment, and has superior contrast resolution to look in depth into tissue changes and help to identify specific HFpEF etiologies. Differently, the most important role of nuclear imaging [i.e., planar scintigraphy and/or single photon emission CT (SPECT)] consists in the screening and diagnosis of cardiac transthyretin amyloidosis (ATTR) in patients with HFpEF. Cardiac CT can accurately evaluate coronary artery disease both from an anatomical and functional point of view, but tissue characterization methods have also been developed. The aim of this review is to critically summarize the current uses and future perspectives of echocardiography, nuclear imaging, CT, and CMR in patients with HFpEF.
Published: 2022

19. Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19

Author: Einstein, A, Hirschfeld, C, Williams, M, Vitola, J, Better, N, Villines, T, Cerci, R, Shaw, L, Choi, A, Dorbala, S, Karthikeyan, G, Lu, B, Sinitsyn, V, Ansheles, A, Kudo, T, Bucciarelli-Ducci, C, Norgaard, B, Maurovich-Horvat, P, Campisi, R, Milan, E, Louw, L, Allam, A, Bhatia, M, Sewanan, L, Malkovskiy, E, Cohen, Y, Randazzo, M, Narula, J, Morozova, O, Pascual, T, Pynda, Y, Dondi, M, Paez, D, Hinterleitner, G, Lu, Y, Xu, Z, Erinne, I, Shetty, M, Lopez-Mattei, J, Parwani, P, Goda, A, Shirka, E, Bouyoucef, S, Chelghoum, L, Mansouri, F, Medjahedi, A, Naili, Q, Ridouh, M, Alasia, D, Alberghina, L, Aramayo, N, Buchara, D, Busso, F, Bustos Rivadero, J, Camilletti, J, Campanelli, H, Castro, R, Daicz, M, del Riego, H, Dragonetti, L, Echazarreta, D, Erriest, J, Faccio, F, Facello, A, Gallegos, H, Geronazzo, R, Glait, H, Hasbani, V, Jager, V, Lewkowicz, J, Lotti, J, Maciel, N, Masoli, O, Mastrovito, E, Medus, M, Merani, M, Molteni, S, Montecinos, M, Parisi, G, Sueldo, C, Perez de Arenaza, D, Quintana, L, Radzinschi, A, Redruello, M, Rodriguez, M, Rojas, H, Acuna, A, Schere, D, Traverso, S, Vazquez, G, Zeffiro, S, Sakanyan, M, Beuzeville, S, Boktor, R, Crowley, M, Downie, D, Dwivedi, G, Elison, B, Farouque, O, Jasper, K, Joshi, S, Lee, J, Lee, K, Lui, E, Mcconachie, P, Meaker, J, Nandurkar, D, Neill, J, O'Rourke, E, O'Sullivan, P, Pandos, G, Premaratne, M, Prior, D, Rutherford, N, Saunders, C, Taubman, K, Tauro, A, Taylor, A, Theuerle, J, Thomas, P, Tow, J, Upton, A, Vamadevan, S, Wayne, V, Wegner, E, Wong, D, Younger, J, Beitzke, D, Feuchtner, G, Sommer, O, Weiss, K, Maroz-Vadalazhskaya, N, Tserakhau, U, Homans, F, Van De Heyning, C, Araujo, R, Soldat-Stankovic, V, Stankovic, S, Almeida, A, Anselmi, C, Azevedo, G, Bittencourt, M, Pianta, D, Cabeda, E, Carreira, L, Coelho, I, de Amorim Fernandes, F, de Lorenzo, A, Delgado, R, Erthal, F, Fernandes, F, Fernandes, J, Ferreira de Souza, T, Foppa, M, Matos Alves, W, Gontijo, C, Gottlieb, I, Grossman, G, Albernaz Siqueira, M, Nomura, C, Koga, K, Lima, R, Lopes, R, Marcal Filho, H, Masiero, P, Mastrocola, L, Menezes de Siqueira, M, Mesquita, C, Naves, D, Penna, F, Pinto, I, Rocha, T, Rocha, J, Rodrigues, A, Salioni, L, Sanches, A, Santos, M, Da Silva, L, Schvartzman, P, Matushita, C, Senra, T, Silva, M, Soares, C, Spiro, B, Suaide Silva, C, Torres, R, Monte, G, Vilela, A, Villa, A, Voss, T, Waltrick, R, Zapparoli, M, Naseer, H, Garcheva-Tsacheva, M, Ouattara, T, Thou, S, Varoeun, S, Abikhzer, G, Beanlands, R, Chetrit, M, Dabreo, D, Dennie, C, Friedrich, M, Hafez, M, Hanneman, K, Miller, R, Oikonomou, A, Roifman, I, Small, G, Tandon, V, Trivedi, A, White, J, Zukotynski, K, Alay, R, Concha, C, Massardo, T, Abad, P, Anzola, K, Arturo, H, Benitez, L, Cadena, A, Zamudio, C, Calderon, A, Gutierrez Villamil, C, Jaimes, C, Londono, J, Lopez, N, Merlano-Gaitan, S, Murgieitio-Cabrera, R, Valencia, M, Vergel, D, Santamaria, A, Solis, F, Batinic, T, Franceschi, M, Paar, M, Prpic, M, Felipe Batista, C, Cabrera, L, Peix, A, Pena, Y, Rochela Vazquez, L, Ntalas, I, Kaminek, M, Kincl, V, Lang, O, Abdulla, J, Bottcher, M, Busk, M, Geisler, U, Gormsen, L, Hansson, N, Hess, S, Hove, J, Jensen, L, Jensen, M, Kragholm, K, Ovrehus, K, Rasmussen, J, Ronnow Sand, N, Sondergaard, H, Zaremba, T, Speckter, H, Amores, N, Velez, M, Alrahman, T, Elsamad, S, Abdelfattah, A, Elkaffas, S, Hassan, M, Hussein, E, Ibrahim, A, Kandeel, A, Ali, M, Shaaban, M, Flores, C, Gomez Leiva, V, Liiver, A, Larikka, M, Uusitalo, V, Agostini, D, Berger, C, Dietz, M, Hyafil, F, Ohana, M, Prigent, K, Regaieg, H, Sarda-Mantel, L, H-Ici, D, Ayetey, H, Angelidis, G, Fragkaki, C, Fragkiadaki, C, Georgoulias, P, Koutelou, M, Kyrozi, E, Lama, N, Prassopoulos, V, Spartalis, M, Zaglavara, T, Gonzalez, C, Gutierrez, G, Maldonado, A, Martinez, Y, Kovacs, A, Szilveszter, B, Banthia, N, Bhat, V, Choudhury, P, Chowdekar, V, Christopher, J, Garg, T, Goyal, N, Gupta, R, Gupta, A, Hephzibah, J, Jain, S, Krupa, J, Kumar, P, Kumar, S, Lalchandani, A, Mishra, A, Mishra, V, Mohan, P, Ozair, A, Pandey, S, Parameswaran, R, Patel, C, Patel, T, Patel, S, Vimala, L, Kumar Sarangi, D, Sengupta, S, Sethi, A, Sharma, A, Sharma, P, Shrigiriwar, A, Singh, S, Singh, H, Sood, A, Verma, A, Vyas, A, Soeriadi, E, Bun, E, Hutomo, F, Syawaluddin, H, Yudistiro, R, Albadr, A, Assadi, M, Emami, F, Emami-Ardekani, A, Farzanehfar, S, Jafari, R, Manafi-Farid, R, Tajik, M, Arnson, Y, Fuchs, S, Goldkorn, R, Kennedy, J, Leitman, M, Shalev, A, Acampa, W, Albano, D, Alongi, P, Arnone, G, Assante, R, Baritussio, A, Bauckneht, M, Bianco, F, Bonfiglioli, R, Bovenzi, F, Bruno, I, Bruno, A, Busnardo, E, Califaretti, E, Casoni, R, Censullo, V, Chierichetti, F, Chiocchi, M, Cittanti, C, Clemente, A, Cuocolo, A, De Rimini, M, De Vincentis, G, Della Tommasina, V, Dellegrottaglie, S, Erba, P, Evangelista, L, Faggi, L, Faragasso, E, Florimonte, L, Frantellizzi, V, Gatti, M, Gaudiano, A, Gelardi, F, Gerali, A, Gimelli, A, Guglielmo, M, Leccisotti, L, Liga, 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V., Liiver A., Larikka M., Uusitalo V., Agostini D., Berger C., Dietz M., Hyafil F., Ohana M., Prigent K., Regaieg H., Sarda-Mantel L., H-Ici D. O., Ayetey H., Angelidis G., Fragkaki C., Fragkiadaki C., Georgoulias P., Koutelou M., Kyrozi E., Lama N., Prassopoulos V., Spartalis M., Zaglavara T., Gonzalez C., Gutierrez G., Maldonado A., Martinez Y., Kovacs A., Szilveszter B., Banthia N., Bhat V., Choudhury P., Chowdekar V. S., Christopher J., Garg T., Goyal N. K., Gupta R. K., Gupta A., Hephzibah J., Jain S., Krupa J., Kumar P., Kumar S., Lalchandani A., Mishra A., Mishra V. D., Mohan P., Ozair A., Pandey S., Parameswaran R., Patel C., Patel T., Patel S., Vimala L. R., Kumar Sarangi D. P., Sengupta S., Sethi A., Sharma A., Sharma A. K., Sharma P., Shrigiriwar A., Singh S., Singh H., Sood A., Verma A., Vyas A., Soeriadi E. A., Bun E., Hutomo F., Syawaluddin H., Yudistiro R., Albadr A., Assadi M., Emami F., Emami-Ardekani A., Farzanehfar S., Jafari R., Manafi-Farid R., Tajik M., Arnson Y., Fuchs S., Goldkorn R., Kennedy J., Leitman M., Shalev A., Acampa W., Albano D., Alongi P., Arnone G., Assante R., Baritussio A., Bauckneht M., Bianco F., Bonfiglioli R., Bovenzi F., Bruno I., Bruno A., Busnardo E., Califaretti E., Casoni R., Censullo V., Chierichetti F., Chiocchi M., Cittanti C., Clemente A., Cuocolo A., De Rimini M. L., De Vincentis G., Della Tommasina V., Dellegrottaglie S., Erba P. A., Evangelista L., Faggi L., Faragasso E., Florimonte L., Frantellizzi V., Gatti M., Gaudiano A., Gelardi F., Gerali A., Gimelli A., Guglielmo M., Leccisotti L., Liga R., Liguori C., Longo G., Maffione M., Marcassa C., Matassa G., Mele D., Mircoli L., Paccagnella A., Pacella S., Padovano F., Pellegrini D., Pergola V., Pugliese L., Quartuccio N., Rampin L., Ricci F., Rubini G., Russo V., Sambuceti G., Scatteia A., Sciagra R., Spidalieri G., Stefanelli A., Tedeschi C., Ventroni G., Baugh D., Madu E., Aikawa T., Asano H., Fujimoto S., Fujise K., Fukushima Y., Fukuyama K., Ichikawa Y., Ideguchi R., Iguchi N., Imai M., Ishimura H., Isobe S., Ito K., Izawa Y., Kadokami T., Kasai T., Kato T., Kawamoto T., Kiryu S., Kumita S., Manabe O., Maruno H., Matsumoto N., Miyagawa M., Moroi M., Nagamachi S., Nakajima K., Nakazato R., Nanasato M., Naya M., Norikane T., Ohta Y., Otomi Y., Otsuka H., Oyama-Manabe N., Saito M., Sarai M., Sato J., Sato D., Shiraishi S., Takanami K., Takehana K., Taniguchi Y., Teragawa H., Tomizawa N., Umeji K., Wakabayashi Y., Yamada S., Yamazaki S., Yoneyama T., Rawashdeh M., Dautov T., Makhdomi K., Abass M., Garashi M., Siraj Q., Kalnina M., Haidar M., Komiagiene R., Kviecinskiene G., Vajauskas D., Karim N. K. A., Doucoure M., Reichmuth L., Samuel A., Dieng M. L., Naojee A. S., Hernandez E. A., Alducin Tellez C. R., Alexanderson-Rosas E., Barragan E., Cabada M., Calderon D., Carvajal-Juarez I., Esparza J., Gama-Moreno M. G., Quinto V. G., Gonzalez N. C., Herrera-Zarza M. C., Meave A., Medina Verdugo J. G., Melendez G., Morales Murguia R. H., Navarro Quiroz C. S., Ornelas M., Preciado-Anaya A., Preciado-Gutierrez O. U., Puente A., Salazar A. R., Rosales Uvera S. G., Rosales-Uvera S., Serna Macias J. A., Sierra-Galan L., Sierra-Galan L. M., Tirado Alderete J. C., Vallejo E., Faraggi M., Sereegotov E., Ben Rais N., Alaoui N. I., Kyiphyu T., Oo S. T., Win S. M., Zar H., Ghimire R., Neupane M., Glaudemans A., Slart R., Verschure D., Allen B., Edmond J., Mckenzie C., Tie S., Van Pelt N., Worthington K., Young C., Soli I. A., Kana S., Onubogu U., Sani M., Braten A. T., Jorgensen A., Vassbotn H. -E., Al Dhuhli H., Jawa Z., Tag N., Fatima S., Imran M. B., Younis M. N., Saadullah M., Malo Y. H., Lenturut-Katal D., Castillo M., Ortellado J., Akhter A., Cader F. A., Hussain R., Khan S. R., Mandal T., Nasreen F., An Y., Cao D., Gong L., Hou Y., Jia C., Li T., Li C., Liu H., Liu W., Liu J., Ng M. -Y., Shi H., Tang C., Wang X., Wang Z., Wang Y., Wu J., Yi Y., Yuan L., Zhang T., Zhang L., Chavez E., Cruz C., Llontop C., Morales R., Abrihan P., Bustos-Barroso A., Duldulao-Ogbac M., Eduarte C., Obaldo J., Quinon A., San Juan B., San Juan C. J., Sauler-Gomez M. R., Uy M., Kostkiewicz M., Kunikowska J., Teresinska A., Urbanik T., Bettencourt N., Fontes-Carvalho R., Gavina C., Goncalves L., Macedo F., Moreno N., Sousa C., Timoteo A. T., Vidigal M. J., Al Heidous M., Ramanathan S., Arnous S., Aytani S., Byrne A., Gleeson T., Kerins D., O'Brien J., Bang J. -I., Bom H., Cheon M., Cheon G. J., Cho S. -G., Hong C. M., Jeong Y. H., Kang W. J., Kang Y. -K., Kim J. -Y., Oh S. W., So Y., Song H. -C., Won K. S., Yoo S. W., Mitevska I., Vavlukis M., Salobir B. G., Stalc M., Benedek T., Pop M., Stan C., Ansheles A., Dariy O., Gagarina N., Itskovich I., Karalkin A., Kokov A., Marina G., Migunova E., Pospelov V., Ryzhkova D., Sayfullina G., Sergienko V., Shurupova I., Vakhromeeva M., Valiullina N., Zavadovsky K., Zhuravlev K., Abazid R., Al Garni T., Alasnag M., Aljizeeri A., Amer H., Amro A., Hamdy H., Smettei O., Saranovic D. S., Vlajkovic M., Keng F., See J., Berecova Z., Mistinova J. P., Evbuomwan O., Govender N., Hack J., Hadebe B., Hlongwa K., Kaplan M., Lakhi H., Milos K., Modiselle M., More S., Muambadzi N., Scholtz L., Barreiro-Perez M., Blanco I., Broncano J., Camarero A., Casans-Tormo I., De Haro J., Flotats A., Garcia E., Mendiguchia C. G., Jimenez-Heffernan A., Leta R., Diaz J. L., Vega L. L., Manovel-Sanchez A., Monzonis A. M., Patrut B., Pubul V., Perez R. R., Zeidan N., Nanayakkara D., Suliman A., Engblom H., Murtadha M., Ostenfeld E., Simonsson M., Alkadhi H., Buechel R. R., Burger P., Grani C., Kamani C., Kawel-Bohm N., Klaeser B., Manka R., Prior J., Kaewchur T., Khiewvan B., Kositwattanarerk A., Namwongprom S., Thientunyakit T., Sayman H. B., Yuksel M., Sebikali M. J., Okello E., Korol P., Noverko I., Satyr M., Ahmad T., Alfakih K., Andrade I., Buckingham S., Bularga A., Carpenter J. -P., Cole G., Cusack D., David S., Davis P., Fairbairn T., Ghosh A., Ramkumar P. G., Hamilton M., Haque F., Hudson B., Johnstone A., Karthikeyan V. J., Kay M., Khan M. A., Kitt J., Low C. S., Mcalindon E., Mccreavy D., Morrissey B., Motwani M., Na D., Nicol E., Patel D., Rodrigues J., Rofe C., Schofield R., Semple T., Sheikh A., Sinha A., Subedi D., Topping W., Tweed K., Underwood S. R., Weir-Mccall J., Zuhairy H., Abbasi T., Abohashem S., Abramson S., Al-Mallah M., Kumar M. A., Balmer-Swain M., Berman D., Bernheim A., Bhatti S., Biederman R., Bieging E., Bingham S., Bloom S., Blue S., Borges A., Branch K., Bravo P., Buddhe S., Budoff M., Bullock-Palmer R., Cahill M., Candela C., Cao J., Chatterjee S., Chatzizisis Y., Chaudhuri N. R., Cheezum M., Chelliah A., Chen T., Chen M., Chen L., Chokshi A., Chung J., Danciu S., DeSisto W., Dilorenzo M., Doukky R., Duvall W., Ferencik M., Foster C., Fuisz A., Gannon M., German D., Gerson M., Geske J., Hage F., Haider A., Haider S., Hamirani Y., Hassen K., Hendel R., Henkel J., Horgan S., Hyun M., Janardhanan R., Jerome S., Kalra D., Kassop D., Kinkhabwala M., Kinzfogl G., Koch B., Koweek L., Krepp J., Kwon Y., Layer J., Lesser J., Leung S., Lisske B., Magurany K., Markowitz J., Mccullough B., Moalemi A., Moffitt C., Montanez J., Moore W., Morayati S., Mossa-Basha M., Mrsic Z., Murthy V., Nagpal P., Nelson K., Nijjar P., O'Quinn R., Passen E., Patil P., Pursnani A., Quachang N., Rabbat M., Ranjan P., Lozano P. R., Schemmer M., Seifried R., Shah N., Shah A., Shanbhag S., Sharma G., Skotnicki R., Sobczak M., Soman P., Sorrell V., Srichai M., Streeter J., Strickland L., Suliman S., Tebyanian N., Thomas D., Thompson R., Uretsky S., Vallurupalli S., Vandyck-Acquah M., Verma V., Villines T., Weinstein J., Wolinsky D., Zareba K., Zgaljardic M., Beretta M., Ferrando R., Kapitan M., Mut F., Djuraev O., Rozikhodjaeva G., Vera L., Duc B. D., Nguyen X. C., and Hiep Nguyen P. M.
Abstract: Background: The extent to which health care systems have adapted to the COVID-19 pandemic to provide necessary cardiac diagnostic services is unknown. Objectives: The aim of this study was to determine the impact of the pandemic on cardiac testing practices, volumes and types of diagnostic services, and perceived psychological stress to health care providers worldwide. Methods: The International Atomic Energy Agency conducted a worldwide survey assessing alterations from baseline in cardiovascular diagnostic care at the pandemic's onset and 1 year later. Multivariable regression was used to determine factors associated with procedure volume recovery. Results: Surveys were submitted from 669 centers in 107 countries. Worldwide reduction in cardiac procedure volumes of 64% from March 2019 to April 2020 recovered by April 2021 in high- and upper middle-income countries (recovery rates of 108% and 99%) but remained depressed in lower middle- and low-income countries (46% and 30% recovery). Although stress testing was used 12% less frequently in 2021 than in 2019, coronary computed tomographic angiography was used 14% more, a trend also seen for other advanced cardiac imaging modalities (positron emission tomography and magnetic resonance; 22%-25% increases). Pandemic-related psychological stress was estimated to have affected nearly 40% of staff, impacting patient care at 78% of sites. In multivariable regression, only lower-income status and physicians’ psychological stress were significant in predicting recovery of cardiac testing. Conclusions: Cardiac diagnostic testing has yet to recover to prepandemic levels in lower-income countries. Worldwide, the decrease in standard stress testing is offset by greater use of advanced cardiac imaging modalities. Pandemic-related psychological stress among providers is widespread and associated with poor recovery of cardiac testing.
Published: 2022

20. Application of AI in cardiovascular multimodality imaging

Author: Muscogiuri, G, Volpato, V, Cau, R, Chiesa, M, Saba, L, Guglielmo, M, Senatieri, A, Chierchia, G, Pontone, G, Dell'Aversana, S, Schoepf, U, Andrews, M, Basile, P, Guaricci, A, Marra, P, Muraru, D, Badano, L, Sironi, S, Muscogiuri G., Volpato V., Cau R., Chiesa M., Saba L., Guglielmo M., Senatieri A., Chierchia G., Pontone G., Dell'Aversana S., Schoepf U. J., Andrews M. G., Basile P., Guaricci A. I., Marra P., Muraru D., Badano L., Sironi S., Muscogiuri, G, Volpato, V, Cau, R, Chiesa, M, Saba, L, Guglielmo, M, Senatieri, A, Chierchia, G, Pontone, G, Dell'Aversana, S, Schoepf, U, Andrews, M, Basile, P, Guaricci, A, Marra, P, Muraru, D, Badano, L, Sironi, S, Muscogiuri G., Volpato V., Cau R., Chiesa M., Saba L., Guglielmo M., Senatieri A., Chierchia G., Pontone G., Dell'Aversana S., Schoepf U. J., Andrews M. G., Basile P., Guaricci A. I., Marra P., Muraru D., Badano L., and Sironi S.
Abstract: Technical advances in artificial intelligence (AI) in cardiac imaging are rapidly improving the reproducibility of this approach and the possibility to reduce time necessary to generate a report. In cardiac computed tomography angiography (CCTA) the main application of AI in clinical practice is focused on detection of stenosis, characterization of coronary plaques, and detection of myocardial ischemia. In cardiac magnetic resonance (CMR) the application of AI is focused on post-processing and particularly on the segmentation of cardiac chambers during late gadolinium enhancement. In echocardiography, the application of AI is focused on segmentation of cardiac chambers and is helpful for valvular function and wall motion abnormalities. The common thread represented by all of these techniques aims to shorten the time of interpretation without loss of information compared to the standard approach. In this review we provide an overview of AI applications in multimodality cardiac imaging.
Published: 2022

21. Diagnostic performance of deep learning algorithm for analysis of computed tomography myocardial perfusion

Author: Muscogiuri, G, Chiesa, M, Baggiano, A, Spadafora, P, De Santis, R, Guglielmo, M, Scafuri, S, Fusini, L, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Mancini, M, Ricci, F, Ariano, F, Spiritigliozzi, L, Babbaro, M, Mollace, R, Maragna, R, Giacari, C, Andreini, D, Guaricci, A, Colombo, G, Rabbat, M, Pepi, M, Sardanelli, F, Pontone, G, Muscogiuri G, Chiesa M, Baggiano A, Spadafora P, De Santis R, Guglielmo M, Scafuri S, Fusini L, Mushtaq S, Conte E, Annoni A, Formenti A, Mancini ME, Ricci F, Ariano FP, Spiritigliozzi L, Babbaro M, Mollace R, Maragna R, Giacari CM, Andreini D, Guaricci AI, Colombo GI, Rabbat MG, Pepi M, Sardanelli F, Pontone G., Muscogiuri, G, Chiesa, M, Baggiano, A, Spadafora, P, De Santis, R, Guglielmo, M, Scafuri, S, Fusini, L, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Mancini, M, Ricci, F, Ariano, F, Spiritigliozzi, L, Babbaro, M, Mollace, R, Maragna, R, Giacari, C, Andreini, D, Guaricci, A, Colombo, G, Rabbat, M, Pepi, M, Sardanelli, F, Pontone, G, Muscogiuri G, Chiesa M, Baggiano A, Spadafora P, De Santis R, Guglielmo M, Scafuri S, Fusini L, Mushtaq S, Conte E, Annoni A, Formenti A, Mancini ME, Ricci F, Ariano FP, Spiritigliozzi L, Babbaro M, Mollace R, Maragna R, Giacari CM, Andreini D, Guaricci AI, Colombo GI, Rabbat MG, Pepi M, Sardanelli F, and Pontone G.
Abstract: Purpose: To evaluate the diagnostic accuracy of a deep learning (DL) algorithm predicting hemodynamically significant coronary artery disease (CAD) by using a rest dataset of myocardial computed tomography perfusion (CTP) as compared to invasive evaluation. Methods: One hundred and twelve consecutive symptomatic patients scheduled for clinically indicated invasive coronary angiography (ICA) underwent CCTA plus static stress CTP and ICA with invasive fractional flow reserve (FFR) for stenoses ranging between 30 and 80%. Subsequently, a DL algorithm for the prediction of significant CAD by using the rest dataset (CTP-DLrest) and stress dataset (CTP-DLstress) was developed. The diagnostic accuracy for identification of significant CAD using CCTA, CCTA + CTP stress, CCTA + CTP-DLrest, and CCTA + CTP-DLstress was measured and compared. The time of analysis for CTP stress, CTP-DLrest, and CTP-DLStress was recorded. Results: Patient-specific sensitivity, specificity, NPV, PPV, accuracy, and area under the curve (AUC) of CCTA alone and CCTA + CTPStress were 100%, 33%, 100%, 54%, 63%, 67% and 86%, 89%, 89%, 86%, 88%, 87%, respectively. Patient-specific sensitivity, specificity, NPV, PPV, accuracy, and AUC of CCTA + DLrest and CCTA + DLstress were 100%, 72%, 100%, 74%, 84%, 96% and 93%, 83%, 94%, 81%, 88%, 98%, respectively. All CCTA + CTP stress, CCTA + CTP-DLRest, and CCTA + CTP-DLStress significantly improved detection of hemodynamically significant CAD compared to CCTA alone (p < 0.01). Time of CTP-DL was significantly lower as compared to human analysis (39.2 ± 3.2 vs. 379.6 ± 68.0 s, p < 0.001). Conclusion: Evaluation of myocardial ischemia using a DL approach on rest CTP datasets is feasible and accurate. This approach may be a useful gatekeeper prior to CTP stress..
Published: 2022

22. Preoperative Ozaki technique measures on tridimensional engineered root

Author: Pirola, S, Mastroiacovo, G, Mostardini, G, Bonomi, A, Guglielmo, M, Muscogiuri, G, Baggiano, A, Montisci, A, Pontone, G, Polvani, G, Pirola S, Mastroiacovo G, Mostardini G, Bonomi A, Guglielmo M, Muscogiuri G, Baggiano A, Montisci A, Pontone G, Polvani G., Pirola, S, Mastroiacovo, G, Mostardini, G, Bonomi, A, Guglielmo, M, Muscogiuri, G, Baggiano, A, Montisci, A, Pontone, G, Polvani, G, Pirola S, Mastroiacovo G, Mostardini G, Bonomi A, Guglielmo M, Muscogiuri G, Baggiano A, Montisci A, Pontone G, and Polvani G.
Abstract: Background: The aortic valve neocuspidalization (AVNeo) is an innovative surgical technique aiming at the reconstruction of the aortic valve using autologous pericardium. One of the main criticisms to AVNeo is the longer duration of the aortic clamping time (ACT) as compared to standard aortic valve replacement due to the sizing of the valve neocusps. Methods: We retrospectively enrolled 30 consecutives patients underwent AVNeo. For each patient we developed a 3D aortic root model (ARM) based on CT-scan datasets. We retrospectively compared the leaflets measurements performed during surgery with those obtained on the corresponding ARMs. Results: In 100% of cases no difference between the in vitro and in vivo measurements exceeded the acceptable error limit of 2 mm. The correlation of each single in vitro versus in vivo measurements demonstrates a strong coincidence between the two different methods of sizing (r > 0,9, p < .0001). By analyzing the data considering the annulus perimeter and not the single cusp size, the perfect coincidence was to be found in 89.9% with a slight acceptable discrepancy (2 mm on total) in the remaining 10.1%. Conclusions: 3D-ARMs, printed from CT-scan, represent a reproducible process to obtain overlapping cusp sizes compared to those measured in-vivo, possibly reducing the ACT.
Published: 2022

23. Multimodality Imaging in Ischemic Chronic Cardiomyopathy

Author: Muscogiuri, G, Guglielmo, M, Serra, A, Gatti, M, Volpato, V, Schoepf, U, Saba, L, Cau, R, Faletti, R, Mcgill, L, De Cecco, C, Pontone, G, Dell'Aversana, S, Sironi, S, Muscogiuri G, Guglielmo M, Serra A, Gatti M, Volpato V, Schoepf UJ, Saba L, Cau R, Faletti R, McGill LJ, De Cecco CN, Pontone G, Dell'Aversana S, Sironi S, Muscogiuri, G, Guglielmo, M, Serra, A, Gatti, M, Volpato, V, Schoepf, U, Saba, L, Cau, R, Faletti, R, Mcgill, L, De Cecco, C, Pontone, G, Dell'Aversana, S, Sironi, S, Muscogiuri G, Guglielmo M, Serra A, Gatti M, Volpato V, Schoepf UJ, Saba L, Cau R, Faletti R, McGill LJ, De Cecco CN, Pontone G, Dell'Aversana S, and Sironi S
Abstract: Ischemic chronic cardiomyopathy (ICC) is still one of the most common cardiac diseases leading to the development of myocardial ischemia, infarction, or heart failure. The application of several imaging modalities can provide information regarding coronary anatomy, coronary artery disease, myocardial ischemia and tissue characterization. In particular, coronary computed tomography angiography (CCTA) can provide information regarding coronary plaque stenosis, its composition, and the possible evaluation of myocardial ischemia using fractional flow reserve CT or CT perfusion. Cardiac magnetic resonance (CMR) can be used to evaluate cardiac function as well as the presence of ischemia. In addition, CMR can be used to characterize the myocardial tissue of hibernated or infarcted myocardium. Echocardiography is the most widely used technique to achieve information regarding function and myocardial wall motion abnormalities during myocardial ischemia. Nuclear medicine can be used to evaluate perfusion in both qualitative and quantitative assessment. In this review we aim to provide an overview regarding the different noninvasive imaging techniques for the evaluation of ICC, providing information ranging from the anatomical assessment of coronary artery arteries to the assessment of ischemic myocardium and myocardial infarction. In particular this review is going to show the different noninvasive approaches based on the specific clinical history of patients with ICC.
Published: 2022

24. Cardiac Magnetic Resonance Tissue Characterization in Ischemic Cardiomyopathy

Author: Muscogiuri, G, Ricci, F, Scafuri, S, Guglielmo, M, Baggiano, A, De Stasio, V, Di Donna, C, Spiritigliozzi, L, Chiocchi, M, Lee, S, De Cecco, C, van Assen, M, Rabbat, M, Pontone, G, Muscogiuri G, Ricci F, Scafuri S, Guglielmo M, Baggiano A, De Stasio V, Di Donna C, Spiritigliozzi L, Chiocchi M, Lee SJ, De Cecco CN, van Assen M, Rabbat MG, Pontone G, Muscogiuri, G, Ricci, F, Scafuri, S, Guglielmo, M, Baggiano, A, De Stasio, V, Di Donna, C, Spiritigliozzi, L, Chiocchi, M, Lee, S, De Cecco, C, van Assen, M, Rabbat, M, Pontone, G, Muscogiuri G, Ricci F, Scafuri S, Guglielmo M, Baggiano A, De Stasio V, Di Donna C, Spiritigliozzi L, Chiocchi M, Lee SJ, De Cecco CN, van Assen M, Rabbat MG, and Pontone G
Abstract: Ischemic cardiomyopathy (ICM) is one of the most common causes of congestive heart failure. In patients with ICM, tissue characterization with cardiac magnetic resonance imaging (CMR) allows for evaluation of myocardial abnormalities in acute and chronic settings. Myocardial edema, microvascular obstruction (MVO), intracardiac thrombus, intramyocardial hemorrhage, and late gadolinium enhancement of the myocardium are easily depicted using standard CMR sequences. In the acute setting, tissue characterization is mainly focused on assessment of ventricular thrombus and MVO, which are associated with poor prognosis. Conversely, in chronic ICM, it is important to depict late gadolinium enhancement and myocardial ischemia using stress perfusion sequences. Overall, with CMR's ability to accurately characterize myocardial tissue in acute and chronic ICM, it represents a valuable diagnostic and prognostic imaging method for treatment planning. In particular, tissue characterization abnormalities in the acute setting can provide information regarding the patients that may develop major adverse cardiac event and show the presence of ventricular thrombus; in the chronic setting, evaluation of viable myocardium can be fundamental for planning myocardial revascularization. In this review, the main findings on tissue characterization are illustrated in acute and chronic settings using qualitative and quantitative tissue characterization.
Published: 2022

25. Prediction of myocardial blood flow under stress conditions by means of a computational model

Author: Di Gregorio, S, Vergara, C, Pelagi, G, Baggiano, A, Zunino, P, Guglielmo, M, Fusini, L, Muscogiuri, G, Rossi, A, Rabbat, M, Quarteroni, A, Pontone, G, Di Gregorio S, Vergara C, Pelagi GM, Baggiano A, Zunino P, Guglielmo M, Fusini L, Muscogiuri G, Rossi A, Rabbat MG, Quarteroni A, Pontone G., Di Gregorio, S, Vergara, C, Pelagi, G, Baggiano, A, Zunino, P, Guglielmo, M, Fusini, L, Muscogiuri, G, Rossi, A, Rabbat, M, Quarteroni, A, Pontone, G, Di Gregorio S, Vergara C, Pelagi GM, Baggiano A, Zunino P, Guglielmo M, Fusini L, Muscogiuri G, Rossi A, Rabbat MG, Quarteroni A, and Pontone G.
Abstract: Purpose: Quantification of myocardial blood flow (MBF) and functional assessment of coronary artery disease (CAD) can be achieved through stress myocardial computed tomography perfusion (stress-CTP). This requires an additional scan after the resting coronary computed tomography angiography (cCTA) and administration of an intravenous stressor. This complex protocol has limited reproducibility and non-negligible side effects for the patient. We aim to mitigate these drawbacks by proposing a computational model able to reproduce MBF maps. Methods: A computational perfusion model was used to reproduce MBF maps. The model parameters were estimated by using information from cCTA and MBF measured from stress-CTP (MBFCTP) maps. The relative error between the computational MBF under stress conditions (MBFCOMP) and MBFCTP was evaluated to assess the accuracy of the proposed computational model. Results: Applying our method to 9 patients (4 control subjects without ischemia vs 5 patients with myocardial ischemia), we found an excellent agreement between the values of MBFCOMP and MBFCTP. In all patients, the relative error was below 8% over all the myocardium, with an average-in-space value below 4%. Conclusion: The results of this pilot work demonstrate the accuracy and reliability of the proposed computational model in reproducing MBF under stress conditions. This consistency test is a preliminary step in the framework of a more ambitious project which is currently under investigation, i.e., the construction of a computational tool able to predict MBF avoiding the stress protocol and potential side effects while reducing radiation exposure.
Published: 2022

26. Computed tomography predictors of structural valve degeneration in patients undergoing transcatheter aortic valve implantation with balloon-expandable prostheses

Author: Guglielmo, M, Fusini, L, Muratori, M, Tamborini, G, Mantegazza, V, Andreini, D, Annoni, A, Babbaro, M, Baggiano, A, Conte, E, Carriero, S, Formenti, A, Guaricci, A, Mancini, E, Mollace, R, Muscogiuri, G, Mushtaq, S, Ricci, F, Rossi, A, Scafuri, S, Alushi, B, Cau, C, Cau, R, Cesarano, M, Saba, L, Rabbat, M, Pepi, M, Pontone, G, Guglielmo M., Fusini L., Muratori M., Tamborini G., Mantegazza V., Andreini D., Annoni A., Babbaro M., Baggiano A., Conte E., Carriero S., Formenti A., Guaricci A. I., Mancini E., Mollace R., Muscogiuri G., Mushtaq S., Ricci F., Rossi A., Scafuri S., Alushi B., Cau C., Cau R., Cesarano M., Saba L., Rabbat M., Pepi M., Pontone G., Guglielmo, M, Fusini, L, Muratori, M, Tamborini, G, Mantegazza, V, Andreini, D, Annoni, A, Babbaro, M, Baggiano, A, Conte, E, Carriero, S, Formenti, A, Guaricci, A, Mancini, E, Mollace, R, Muscogiuri, G, Mushtaq, S, Ricci, F, Rossi, A, Scafuri, S, Alushi, B, Cau, C, Cau, R, Cesarano, M, Saba, L, Rabbat, M, Pepi, M, Pontone, G, Guglielmo M., Fusini L., Muratori M., Tamborini G., Mantegazza V., Andreini D., Annoni A., Babbaro M., Baggiano A., Conte E., Carriero S., Formenti A., Guaricci A. I., Mancini E., Mollace R., Muscogiuri G., Mushtaq S., Ricci F., Rossi A., Scafuri S., Alushi B., Cau C., Cau R., Cesarano M., Saba L., Rabbat M., Pepi M., and Pontone G.
Abstract: Objectives: Computed tomography (CT) provides excellent anatomy assessment of the aortic annulus (AoA) and is utilized for pre-procedural planning of transcatheter aortic valve implantation (TAVI). We sought to investigate if geometrical characteristics of the AoA determined by CT may represent predictors of structural valve degeneration (SVD) in patients undergoing TAVI with balloon-expandable valves. Methods: This is a retrospective study on 124 consecutive patients (mean age: 79 ± 7 years; female: 61%) undergoing balloon-expandable TAVI prospectively enrolled in a registry. AoA maximum diameter (Dmax), minimum diameter (Dmin), and area were assessed using pre-procedural CT. SVD was identified during follow-up with transthoracic echocardiography documenting structural prosthetic valve abnormalities with or without hemodynamic changes. Results: The mean follow-up was 5.9 ± 1.7 years. SVD was found in 48 out of 124 patients (38%). AoA Dmax, Dmin, and area were significantly smaller in patients with SVD compared to patients without SVD (25.6 ± 2.2 mm vs. 27.1 ± 2.8 mm, p = 0.012; 20.5 ± 2.1 mm vs. 21.8 ± 2.1 mm, p = 0.001 and 419 ± 77 mm2 vs. 467 ± 88 mm2, p = 0.002, respectively). At univariable analysis, female sex, BSA, 23-mm prosthetic valve size, Dmax < 27.1 mm, and a Dmin < 19.9 mm were associated with SVD, whereas at multivariable analysis, only Dmin < 19.9 mm (OR = 2.873, 95% CI: 1.191–6.929, p = 0.019) and female sex (OR = 2.659, 95% CI: 1.095–6.458, p = 0.031) were independent predictors of SVD. Conclusions: Female sex and AoA Dmin < 19.9 mm are associated with SVD in patients undergoing TAVI with balloon-expandable valves. When implanting large prostheses in order to avoid paraprosthetic regurgitation, caution should be observed due to the risk of excessive stretching of the AoA Dmin, which may play a role in SVD. Key Points: • Long-term durability is a concern for transcatheter aortic valve bioprosthesis. • CT provides an excellent assessment
Published: 2022

27. Plaque assessment by coronary CT angiography may predict cardiac events in high risk and very high risk diabetic patients: A long-term follow-up study

Author: Andreini, D, Conte, E, Mushtaq, S, Magatelli, M, Traversari, F, Gigante, C, Belmonte, M, Gaudenzi-Asinelli, M, Annoni, A, Formenti, A, Mancini, M, Guglielmo, M, Baggiano, A, Melotti, E, Muscogiuri, G, Rondinelli, M, Pontone, G, Bartorelli, A, Pepi, M, Genovese, S, Andreini D, Conte E, Mushtaq S, Magatelli M, Traversari F, Gigante C, Belmonte M, Gaudenzi-Asinelli M, Annoni A, Formenti A, Mancini ME, Guglielmo M, Baggiano A, Melotti E, Muscogiuri G, Rondinelli M, Pontone G, Bartorelli AL, Pepi M, Genovese S., Andreini, D, Conte, E, Mushtaq, S, Magatelli, M, Traversari, F, Gigante, C, Belmonte, M, Gaudenzi-Asinelli, M, Annoni, A, Formenti, A, Mancini, M, Guglielmo, M, Baggiano, A, Melotti, E, Muscogiuri, G, Rondinelli, M, Pontone, G, Bartorelli, A, Pepi, M, Genovese, S, Andreini D, Conte E, Mushtaq S, Magatelli M, Traversari F, Gigante C, Belmonte M, Gaudenzi-Asinelli M, Annoni A, Formenti A, Mancini ME, Guglielmo M, Baggiano A, Melotti E, Muscogiuri G, Rondinelli M, Pontone G, Bartorelli AL, Pepi M, and Genovese S.
Abstract: Background and aims: The aim of the present study is to evaluate whether advanced coronary atherosclerosis analysis by CCTA may improve prognostic stratification among diabetic patients at high cardiovascular risk (CV risk). Methods and results: The study population consisted of 265 consecutive diabetic patients at high CV risk who underwent CCTA for suspected CAD between January 2011 and December 2016. For every patients both traditional and advanced, qualitative and quantitative coronary plaque analysis were performed. The occurrence of cardiac death, ACS, and non-urgent revascularization were recorded at follow-up. Among the 265 patients enrolled, 21 were lost to follow-up, whereas 244 (92%) had a complete follow-up (mean 45 ± 22 months) and were classified at high (n = 67) or very high cardiovascular risk (n = 177), according to ESC Guidelines. A total of 63 events were recorded (3 Cardiac Death, 3 NSTEMI, 8 unstable angina, 36 late non-urgent revascularization and 13 non-cardiac death) in 57 different patients. Elevated fibro-fatty plaque volume was the only predictor of events over age, gender and traditional risk factor when ACS and MACE were considered as end-points [HR (95% CI) 6.01 (1.65–21.87), p = 0.006 and 3.46 (2.00–5.97); p < 0.001]. Conclusion: The present study confirms the prognostic role of advance coronary atherosclerosis evaluation beyond risk factors and stenosis severity, even in diabetics. Despite the very high cardiovascular risk of study population, a not negligible portion (23%) of patients exhibited totally normal coronaries.
Published: 2022

28. Aortic regurgitation: A multimodality approach

Author: Siani, A, Perone, F, Costantini, P, Rodolfi, S, Muscogiuri, G, Sironi, S, Carriero, S, Pavon, A, van der Bilt, I, van Rosendael, P, Broekhuizen, L, Teske, A, Cramer, M, Guglielmo, M, Siani A., Perone F., Costantini P., Rodolfi S., Muscogiuri G., Sironi S., Carriero S., Pavon A. G., van der Bilt I., van Rosendael P., Broekhuizen L., Teske A., Cramer M. J., Guglielmo M., Siani, A, Perone, F, Costantini, P, Rodolfi, S, Muscogiuri, G, Sironi, S, Carriero, S, Pavon, A, van der Bilt, I, van Rosendael, P, Broekhuizen, L, Teske, A, Cramer, M, Guglielmo, M, Siani A., Perone F., Costantini P., Rodolfi S., Muscogiuri G., Sironi S., Carriero S., Pavon A. G., van der Bilt I., van Rosendael P., Broekhuizen L., Teske A., Cramer M. J., and Guglielmo M.
Abstract: Aortic regurgitation (AR) is a common valvular pathology. Multimodality noninvasive cardiovascular imaging is routinely used to assess the mechanism of AR, degree, and its hemodynamic impact on the cardiovascular system. Collecting this information is crucial in establishing the prognosis and in guiding patient management and follow-up. While echocardiography remains the primary test to assess AR, a comprehensive assessment of this valvulopathy can be obtained by combining the information from different techniques. This state-of-the-art review is intended to provide an update ed overview of the applications, strengths, and limits of transthoracic echocardiography, cardiac magnetic resonance, and cardiac computed tomography in patients with AR.
Published: 2022

29. Multimodality Imaging of the Neglected Valve: Role of Echocardiography, Cardiac Magnetic Resonance and Cardiac Computed Tomography in Pulmonary Stenosis and Regurgitation

Author: Costantini, P, Perone, F, Siani, A, Groenhoff, L, Muscogiuri, G, Sironi, S, Marra, P, Carriero, S, Pavon, A, Guglielmo, M, Costantini P., Perone F., Siani A., Groenhoff L., Muscogiuri G., Sironi S., Marra P., Carriero S., Pavon A. G., Guglielmo M., Costantini, P, Perone, F, Siani, A, Groenhoff, L, Muscogiuri, G, Sironi, S, Marra, P, Carriero, S, Pavon, A, Guglielmo, M, Costantini P., Perone F., Siani A., Groenhoff L., Muscogiuri G., Sironi S., Marra P., Carriero S., Pavon A. G., and Guglielmo M.
Abstract: The pulmonary valve (PV) is the least imaged among the heart valves. However, pulmonary regurgitation (PR) and pulmonary stenosis (PS) can occur in a variety of patients ranging from fetuses, newborns (e.g., tetralogy of Fallot) to adults (e.g., endocarditis, carcinoid syndrome, complications of operated tetralogy of Fallot). Due to their complexity, PR and PS are studied using multimodality imaging to assess their mechanism, severity, and hemodynamic consequences. Multimodality imaging is crucial to plan the correct management and to follow up patients with pulmonary valvulopathy. Echocardiography remains the first line methodology to assess patients with PR and PS, but the information obtained with this technique are often integrated with cardiac magnetic resonance (CMR) and computed tomography (CT). This state-of-the-art review aims to provide an updated overview of the usefulness, strengths, and limits of multimodality imaging in patients with PR and PS.
Published: 2022

30. Technology roadmap for cold-atoms based quantum inertial sensor in space

Author: Abend, Sven, Allard, Baptiste, Arnold, Aidan S., Ban, Ticijana, Barry, Liam, Battelier, Baptiste, Bawamia, Ahmad, Beaufils, Quentin, Bernon, Simon, Bertoldi, Andrea, Bonnin, Alexis, Bouyer, Philippe, Bresson, Alexandre, Burrow, Oliver S., Canuel, Benjamin, Desruelle, Bruno, Drougakis, Giannis, Forsberg, René, Gaaloul, Naceur, Gauguet, Alexandre, Gersemann, Matthias, Griffin, Paul F., Heine, Hendrik, Henderson, Victoria A., Herr, Waldemar, Kanthak, Simon, Krutzik, Markus, Lachmann, Maike D., Lammegger, Roland, Magnes, Werner, Mileti, Gaetano, Mitchell, Morgan W., Mottini, Sergio, Papazoglou, Dimitris, Pereira dos Santos, Franck, Peters, Achim, Rasel, Ernst, Riis, Erling, Schubert, Christian, Seidel, Stephan Tobias, Tino, Guglielmo M., Van Den Bossche, Mathias, von Klitzing, Wolf, Wicht, Andreas, Witkowski, Marcin, Zahzam, Nassim, Zawada, Michał, Abend, Sven, Allard, Baptiste, Arnold, Aidan S., Ban, Ticijana, Barry, Liam, Battelier, Baptiste, Bawamia, Ahmad, Beaufils, Quentin, Bernon, Simon, Bertoldi, Andrea, Bonnin, Alexis, Bouyer, Philippe, Bresson, Alexandre, Burrow, Oliver S., Canuel, Benjamin, Desruelle, Bruno, Drougakis, Giannis, Forsberg, René, Gaaloul, Naceur, Gauguet, Alexandre, Gersemann, Matthias, Griffin, Paul F., Heine, Hendrik, Henderson, Victoria A., Herr, Waldemar, Kanthak, Simon, Krutzik, Markus, Lachmann, Maike D., Lammegger, Roland, Magnes, Werner, Mileti, Gaetano, Mitchell, Morgan W., Mottini, Sergio, Papazoglou, Dimitris, Pereira dos Santos, Franck, Peters, Achim, Rasel, Ernst, Riis, Erling, Schubert, Christian, Seidel, Stephan Tobias, Tino, Guglielmo M., Van Den Bossche, Mathias, von Klitzing, Wolf, Wicht, Andreas, Witkowski, Marcin, Zahzam, Nassim, and Zawada, Michał
Abstract: Recent developments in quantum technology have resulted in a new generation of sensors for measuring inertial quantities, such as acceleration and rotation. These sensors can exhibit unprecedented sensitivity and accuracy when operated in space, where the free-fall interrogation time can be extended at will and where the environment noise is minimal. European laboratories have played a leading role in this field by developing concepts and tools to operate these quantum sensors in relevant environment, such as parabolic flights, free-fall towers, or sounding rockets. With the recent achievement of Bose-Einstein condensation on the International Space Station, the challenge is now to reach a technology readiness level sufficiently high at both component and system levels to provide "off the shelf"payload for future generations of space missions in geodesy or fundamental physics. In this roadmap, we provide an extensive review on the status of all common parts, needs, and subsystems for the application of atom-based interferometers in space, in order to push for the development of generic technology components.
Published: 2023

31. Terrestrial Very-Long-Baseline Atom Interferometry: Workshop Summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araujo, Henrique, Arduini, Gianluigi, Arnold, Aidan, Aßmann, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles, Quentin, Beaufils, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo, Cui, Yanou, Da Ros, Elisa, Davies, Gavin, Rosendo, Esther del Pino, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran, Dobrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelof, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fanì, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian Francesco, Glasbrenner, Eric, Gündogan, Mustafa, Haehnelt, Martin G., Hakulinen, Timo, Hammerer, Klemens, Hanımeli, Ekim Taylan, Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria, Herrmann, Sven, Hird, Thomas, Hogan, Jason, Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglič, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Laemmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Lafitte, Christophe Le Poncin, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, López, Luis, Asamar, Elias López, Monjaraz, Cristian López, Luciano, Gaetano, Mohammed, Mohammed Mahmoud, Maleknejad, Azadeh, Markus, Krutzik, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin, Müller, Jürgen, Müstecaplıoğlu, Özgür, Ni, Wei-Tou, Noller, Johannes, Odžak, Senad, Oi, Daniel, Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Santos, Franck Pereira dos, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst Maria, Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan, Safronova, Marianna, Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang, Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro, Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan, Mircea, Ovidiu Tintareanu, Tkalčec, Kimberly, Tolley, Andrew, Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Aceves, Veronica Vazquez, Vitanov, Nikolay, Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windapssinger, Patrcik, Wolf, Peter, Wörner, Lisa, Xuereb, André, Yahia, Mohamed, Cruzeiro, Emmanuel Zambrini, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanič, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araujo, Henrique, Arduini, Gianluigi, Arnold, Aidan, Aßmann, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles, Quentin, Beaufils, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo, Cui, Yanou, Da Ros, Elisa, Davies, Gavin, Rosendo, Esther del Pino, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran, Dobrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelof, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fanì, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian Francesco, Glasbrenner, Eric, Gündogan, Mustafa, Haehnelt, Martin G., Hakulinen, Timo, Hammerer, Klemens, Hanımeli, Ekim Taylan, Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria, Herrmann, Sven, Hird, Thomas, Hogan, Jason, Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglič, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Laemmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Lafitte, Christophe Le Poncin, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, López, Luis, Asamar, Elias López, Monjaraz, Cristian López, Luciano, Gaetano, Mohammed, Mohammed Mahmoud, Maleknejad, Azadeh, Markus, Krutzik, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin, Müller, Jürgen, Müstecaplıoğlu, Özgür, Ni, Wei-Tou, Noller, Johannes, Odžak, Senad, Oi, Daniel, Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Santos, Franck Pereira dos, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst Maria, Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan, Safronova, Marianna, Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang, Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro, Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan, Mircea, Ovidiu Tintareanu, Tkalčec, Kimberly, Tolley, Andrew, Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Aceves, Veronica Vazquez, Vitanov, Nikolay, Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windapssinger, Patrcik, Wolf, Peter, Wörner, Lisa, Xuereb, André, Yahia, Mohamed, Cruzeiro, Emmanuel Zambrini, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanič, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more km-scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions., Comment: Summary of the Terrestrial Very-Long-Baseline Atom Interferometry Workshop held at CERN: https://indico.cern.ch/event/1208783
Published: 2023

32. Technology roadmap for cold-atoms based quantum inertial sensor in space

Author: Abend, Sven, Allard, Baptiste, Arnold, Aidan S., Ban, Ticijana, Barry, Liam, Battelier, Baptiste, Bawamia, Ahmad, Beaufils, Quentin, Bernon, Simon, Bertoldi, Andrea, Bonnin, Alexis, Bouyer, Philippe, Bresson, Alexandre, Burrow, Oliver S., Canuel, Benjamin, Desruelle, Bruno, Drougakis, Giannis, Forsberg, René, Gaaloul, Naceur, Gauguet, Alexandre, Gersemann, Matthias, Griffin, Paul F., Heine, Hendrik, Henderson, Victoria A., Herr, Waldemar, Kanthak, Simon, Krutzik, Markus, Lachmann, Maike D., Lammegger, Roland, Magnes, Werner, Mileti, Gaetano, Mitchell, Morgan W., Mottini, Sergio, Papazoglou, Dimitris, Pereira Dos Santos, Franck, Peters, Achim, Rasel, Ernst, Riis, Erling, Schubert, Christian, Seidel, Stephan Tobias, Tino, Guglielmo M., Van Den Bossche, Mathias, Von Klitzing, Wolf, Wicht, Andreas, Witkowski, Marcin, Zahzam, Nassim, Zawada, Michał, Abend, Sven, Allard, Baptiste, Arnold, Aidan S., Ban, Ticijana, Barry, Liam, Battelier, Baptiste, Bawamia, Ahmad, Beaufils, Quentin, Bernon, Simon, Bertoldi, Andrea, Bonnin, Alexis, Bouyer, Philippe, Bresson, Alexandre, Burrow, Oliver S., Canuel, Benjamin, Desruelle, Bruno, Drougakis, Giannis, Forsberg, René, Gaaloul, Naceur, Gauguet, Alexandre, Gersemann, Matthias, Griffin, Paul F., Heine, Hendrik, Henderson, Victoria A., Herr, Waldemar, Kanthak, Simon, Krutzik, Markus, Lachmann, Maike D., Lammegger, Roland, Magnes, Werner, Mileti, Gaetano, Mitchell, Morgan W., Mottini, Sergio, Papazoglou, Dimitris, Pereira Dos Santos, Franck, Peters, Achim, Rasel, Ernst, Riis, Erling, Schubert, Christian, Seidel, Stephan Tobias, Tino, Guglielmo M., Van Den Bossche, Mathias, Von Klitzing, Wolf, Wicht, Andreas, Witkowski, Marcin, Zahzam, Nassim, and Zawada, Michał
Abstract: Recent developments in quantum technology have resulted in a new generation of sensors for measuring inertial quantities, such as acceleration and rotation. These sensors can exhibit unprecedented sensitivity and accuracy when operated in space, where the free-fall interrogation time can be extended at will and where the environment noise is minimal. European laboratories have played a leading role in this field by developing concepts and tools to operate these quantum sensors in relevant environment, such as parabolic flights, free-fall towers, or sounding rockets. With the recent achievement of Bose-Einstein condensation on the International Space Station, the challenge is now to reach a technology readiness level sufficiently high at both component and system levels to provide "off the shelf"payload for future generations of space missions in geodesy or fundamental physics. In this roadmap, we provide an extensive review on the status of all common parts, needs, and subsystems for the application of atom-based interferometers in space, in order to push for the development of generic technology components.
Published: 2023

33. Terrestrial Very-Long-Baseline Atom Interferometry: Workshop Summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araujo, Henrique, Arduini, Gianluigi, Arnold, Aidan, Aßmann, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles, Quentin, Beaufils, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo, Cui, Yanou, Da Ros, Elisa, Davies, Gavin, Rosendo, Esther del Pino, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran, Dobrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelof, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fanì, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian Francesco, Glasbrenner, Eric, Gündogan, Mustafa, Haehnelt, Martin G., Hakulinen, Timo, Hammerer, Klemens, Hanımeli, Ekim Taylan, Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria, Herrmann, Sven, Hird, Thomas, Hogan, Jason, Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglič, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Laemmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Lafitte, Christophe Le Poncin, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, López, Luis, Asamar, Elias López, Monjaraz, Cristian López, Luciano, Gaetano, Mohammed, Mohammed Mahmoud, Maleknejad, Azadeh, Markus, Krutzik, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin, Müller, Jürgen, Müstecaplıoğlu, Özgür, Ni, Wei-Tou, Noller, Johannes, Odžak, Senad, Oi, Daniel, Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Santos, Franck Pereira dos, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst Maria, Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan, Safronova, Marianna, Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang, Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro, Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan, Mircea, Ovidiu Tintareanu, Tkalčec, Kimberly, Tolley, Andrew, Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Aceves, Veronica Vazquez, Vitanov, Nikolay, Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windapssinger, Patrcik, Wolf, Peter, Wörner, Lisa, Xuereb, André, Yahia, Mohamed, Cruzeiro, Emmanuel Zambrini, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanič, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araujo, Henrique, Arduini, Gianluigi, Arnold, Aidan, Aßmann, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles, Quentin, Beaufils, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo, Cui, Yanou, Da Ros, Elisa, Davies, Gavin, Rosendo, Esther del Pino, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran, Dobrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelof, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fanì, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian Francesco, Glasbrenner, Eric, Gündogan, Mustafa, Haehnelt, Martin G., Hakulinen, Timo, Hammerer, Klemens, Hanımeli, Ekim Taylan, Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria, Herrmann, Sven, Hird, Thomas, Hogan, Jason, Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglič, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Laemmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Lafitte, Christophe Le Poncin, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, López, Luis, Asamar, Elias López, Monjaraz, Cristian López, Luciano, Gaetano, Mohammed, Mohammed Mahmoud, Maleknejad, Azadeh, Markus, Krutzik, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin, Müller, Jürgen, Müstecaplıoğlu, Özgür, Ni, Wei-Tou, Noller, Johannes, Odžak, Senad, Oi, Daniel, Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Santos, Franck Pereira dos, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst Maria, Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan, Safronova, Marianna, Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang, Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro, Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan, Mircea, Ovidiu Tintareanu, Tkalčec, Kimberly, Tolley, Andrew, Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Aceves, Veronica Vazquez, Vitanov, Nikolay, Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windapssinger, Patrcik, Wolf, Peter, Wörner, Lisa, Xuereb, André, Yahia, Mohamed, Cruzeiro, Emmanuel Zambrini, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanič, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more km-scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions., Comment: Summary of the Terrestrial Very-Long-Baseline Atom Interferometry Workshop held at CERN: https://indico.cern.ch/event/1208783
Published: 2023

34. Infezione disseminata da Mycobacterium avium complex con batteriemia persistente in un paziente AIDS-presenter [Disseminated Mycobacterium avium complex infection with persistent bacteremia in an AIDS-presenter patient]

Author: Mezzadri, L, Borghesi Maria, L, Caramma Ilaria, C, Bisi, L, Rossi, M, Lapadula, G, Migliorino Guglielmo, M, Carbone, M, Bonfanti, P, Mezzadri Luca, Borghesi Maria Lucia, Caramma Ilaria Chiara, Bisi Luca, Rossi Marianna, Lapadula Giuseppe, Migliorino Guglielmo Marco, Carbone Maurizio, Bonfanti Paolo, Mezzadri, L, Borghesi Maria, L, Caramma Ilaria, C, Bisi, L, Rossi, M, Lapadula, G, Migliorino Guglielmo, M, Carbone, M, Bonfanti, P, Mezzadri Luca, Borghesi Maria Lucia, Caramma Ilaria Chiara, Bisi Luca, Rossi Marianna, Lapadula Giuseppe, Migliorino Guglielmo Marco, Carbone Maurizio, and Bonfanti Paolo
Abstract: Negli ultimi decenni, l’incidenza di casi AIDS-presenter è calata drasticamente grazie alla diffusione della terapia antiretrovirale e al suo utilizzo sempre più precoce. Fra le patologie opportunistiche associate all’AIDS, l’infezione disseminata da micobatteri non tubercolari rappresenta una grave complicanza. La presentazione clinica aspecifica, così come il difficile work-up diagnostico, possono ritardarne il riconoscimento e il successivo avvio della terapia. Ad oggi, nonostante efficaci terapie anti-micobatteriche, il fattore determinante per il successo della terapia è rappresentato dall’immuno-ricostituzione conseguente alla introduzione di una terapia antiretrovirale efficace. Il caso qui descritto rappresenta un esempio di infezione di difficile trattamento con coinvolgimento midollare, esordito come sospetta patologica ematologica., In recent decades, the incidence of AIDS-presenter cases has drastically decreased thanks to the availability of highly active antiretroviral therapy (HAART) and its early use. Among the AIDS-associated opportunistic diseases, non-tuberculous mycobacteria (NTM) disseminated infection represents a serious complication. The nonspecific clinical presentation, as well as the difficult diagnostic work-up, can delay the recognition and the subsequent initiation of therapy. To date, despite effective antimycobacterial drugs, the determining factor for treatment outcome is immune reconstitution resulting from HAART introduction. The case described here represents an example of a difficult-to-treat infection with bone marrow invasion, which began as a suspected hematological disease.
Published: 2023

35. Changes in upper airways microbiota in ventilator-associated pneumonia

Author: Alagna, L, Mancabelli, L, Magni, F, Chatenoud, L, Bassi, G, Del Bianco, S, Fumagalli, R, Turroni, F, Mangioni, D, Migliorino, G, Milani, C, Muscatello, A, Nattino, G, Picetti, E, Pinciroli, R, Rossi, S, Tonetti, T, Vargiolu, A, Bandera, A, Ventura, M, Citerio, G, Gori, A, Alagna, Laura, Mancabelli, Leonardo, Magni, Federico, Chatenoud, Liliane, Bassi, Gabriele, Del Bianco, Silvia, Fumagalli, Roberto, Turroni, Francesca, Mangioni, Davide, Migliorino, Guglielmo M, Milani, Christian, Muscatello, Antonio, Nattino, Giovanni, Picetti, Edoardo, Pinciroli, Riccardo, Rossi, Sandra, Tonetti, Tommaso, Vargiolu, Alessia, Bandera, Alessandra, Ventura, Marco, Citerio, Giuseppe, Gori, Andrea, Alagna, L, Mancabelli, L, Magni, F, Chatenoud, L, Bassi, G, Del Bianco, S, Fumagalli, R, Turroni, F, Mangioni, D, Migliorino, G, Milani, C, Muscatello, A, Nattino, G, Picetti, E, Pinciroli, R, Rossi, S, Tonetti, T, Vargiolu, A, Bandera, A, Ventura, M, Citerio, G, Gori, A, Alagna, Laura, Mancabelli, Leonardo, Magni, Federico, Chatenoud, Liliane, Bassi, Gabriele, Del Bianco, Silvia, Fumagalli, Roberto, Turroni, Francesca, Mangioni, Davide, Migliorino, Guglielmo M, Milani, Christian, Muscatello, Antonio, Nattino, Giovanni, Picetti, Edoardo, Pinciroli, Riccardo, Rossi, Sandra, Tonetti, Tommaso, Vargiolu, Alessia, Bandera, Alessandra, Ventura, Marco, Citerio, Giuseppe, and Gori, Andrea
Abstract: Background: The role of upper airways microbiota and its association with ventilator-associated pneumonia (VAP) development in mechanically ventilated (MV) patients is unclear. Taking advantage of data collected in a prospective study aimed to assess the composition and over-time variation of upper airway microbiota in patients MV for non-pulmonary reasons, we describe upper airway microbiota characteristics among VAP and NO-VAP patients. Methods: Exploratory analysis of data collected in a prospective observational study on patients intubated for non-pulmonary conditions. Microbiota analysis (trough 16S-rRNA gene profiling) was performed on endotracheal aspirates (at intubation, T0, and after 72 h, T3) of patients with VAP (cases cohort) and a subgroup of NO-VAP patients (control cohort, matched according to total intubation time). Results: Samples from 13 VAP patients and 22 NO-VAP matched controls were analyzed. At intubation (T0), patients with VAP revealed a significantly lower microbial complexity of the microbiota of the upper airways compared to NO-VAP controls (alpha diversity index of 84 ± 37 and 160 ± 102, in VAP and NO_VAP group, respectively, p-value < 0.012). Furthermore, an overall decrease in microbial diversity was observed in both groups at T3 as compared to T0. At T3, a loss of some genera (Prevotella 7, Fusobacterium, Neisseria, Escherichia–Shigella and Haemophilus) was found in VAP patients. In contrast, eight genera belonging to the Bacteroidetes, Firmicutes and Fusobacteria phyla was predominant in this group. However, it is unclear whether VAP caused dysbiosis or dysbiosis caused VAP. Conclusions: In a small sample size of intubated patients, microbial diversity at intubation was less in patients with VAP compared to patients without VAP.
Published: 2023

36. The Potential Role of Cardiac CT in the Evaluation of Patients With Known or Suspected Cardiomyopathy: From Traditional Indications to Novel Clinical Applications

Author: Conte, E, Mushtaq, S, Muscogiuri, G, Formenti, A, Annoni, A, Mancini, E, Ricci, F, Melotti, E, Gigante, C, Lorenza, Z, Guglielmo, M, Baggiano, A, Maragna, R, Giacari, C, Carbucicchio, C, Catto, V, Pepi, M, Andreini, D, Pontone, G, Conte E., Mushtaq S., Muscogiuri G., Formenti A., Annoni A., Mancini E., Ricci F., Melotti E., Gigante C., Lorenza Z., Guglielmo M., Baggiano A., Maragna R., Giacari C. M., Carbucicchio C., Catto V., Pepi M., Andreini D., Pontone G., Conte, E, Mushtaq, S, Muscogiuri, G, Formenti, A, Annoni, A, Mancini, E, Ricci, F, Melotti, E, Gigante, C, Lorenza, Z, Guglielmo, M, Baggiano, A, Maragna, R, Giacari, C, Carbucicchio, C, Catto, V, Pepi, M, Andreini, D, Pontone, G, Conte E., Mushtaq S., Muscogiuri G., Formenti A., Annoni A., Mancini E., Ricci F., Melotti E., Gigante C., Lorenza Z., Guglielmo M., Baggiano A., Maragna R., Giacari C. M., Carbucicchio C., Catto V., Pepi M., Andreini D., and Pontone G.
Abstract: After 15 years from its advent in the clinical field, coronary computed tomography (CCTA) is now widely considered as the best first-step test in patients with low-to-moderate pre-test probability of coronary artery disease. Technological innovation was of pivotal importance for the extensive clinical and scientific interest in CCTA. Recently, the advent of last generation wide-coverage CT scans paved the way for new clinical applications of this technique beyond coronary arteries anatomy evaluation. More precisely, both biventricular volume and systolic function quantification and myocardial fibrosis identification appeared to be feasible with last generation CT. In the present review we would focus on potential applications of cardiac computed tomography (CCT), beyond CCTA, for a comprehensive assessment patients with newly diagnosed cardiomyopathy, from technical requirements to novel clinical applications.
Published: 2021

37. Additional diagnostic value of cardiac magnetic resonance feature tracking in patients with biopsy-proven arrhythmogenic cardiomyopathy

Author: Muscogiuri, G, Fusini, L, Ricci, F, Sicuso, R, Guglielmo, M, Baggiano, A, Gasperetti, A, Casella, M, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Mancini, M, Babbaro, M, Mollace, R, Collevecchio, A, Scafuri, S, Kukavica, D, Andreini, D, Basso, C, Rizzo, S, De Gaspari, M, Priori, S, Dello Russo, A, Tondo, C, Pepi, M, Sommariva, E, Rabbat, M, Guaricci, A, Pontone, G, Muscogiuri G., Fusini L., Ricci F., Sicuso R., Guglielmo M., Baggiano A., Gasperetti A., Casella M., Mushtaq S., Conte E., Annoni A., Formenti A., Mancini M. E., Babbaro M., Mollace R., Collevecchio A., Scafuri S., Kukavica D., Andreini D., Basso C., Rizzo S., De Gaspari M., Priori S., Dello Russo A., Tondo C., Pepi M., Sommariva E., Rabbat M., Guaricci A. I., Pontone G., Muscogiuri, G, Fusini, L, Ricci, F, Sicuso, R, Guglielmo, M, Baggiano, A, Gasperetti, A, Casella, M, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Mancini, M, Babbaro, M, Mollace, R, Collevecchio, A, Scafuri, S, Kukavica, D, Andreini, D, Basso, C, Rizzo, S, De Gaspari, M, Priori, S, Dello Russo, A, Tondo, C, Pepi, M, Sommariva, E, Rabbat, M, Guaricci, A, Pontone, G, Muscogiuri G., Fusini L., Ricci F., Sicuso R., Guglielmo M., Baggiano A., Gasperetti A., Casella M., Mushtaq S., Conte E., Annoni A., Formenti A., Mancini M. E., Babbaro M., Mollace R., Collevecchio A., Scafuri S., Kukavica D., Andreini D., Basso C., Rizzo S., De Gaspari M., Priori S., Dello Russo A., Tondo C., Pepi M., Sommariva E., Rabbat M., Guaricci A. I., and Pontone G.
Abstract: Background: We aim to evaluate the value of Cardiac magnetic resonance (CMR) feature tracking (CMR-FT) in addition to Task Force Criteria(TFC) in patients with (arrhythmogenic cardiomyopathy) AC biopsy-proved. Methods: Thirty-five patients with AC histologically proven who performed CMR with late gadolinium enhancement (LGE) acquisition were enrolled. The study population was divided in Group1 (negative CMR TFC and LV ejection fraction≥55%) and Group2 (positive CMR TFC and/or LVEF<55%) and compared to an age and gender-matched control group. CMR datasets of all patients were analyzed to calculate LV indexed end-diastolic (LVEDi) and end-systolic (LVESi) volumes and RV indexed end-diastolic (RVEDi) and end-systolic (RVESi) volumes, both LV ejection fraction (LVEF) and RV ejection fraction (RVEF). Moreover, LV and RV global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were measured. Results: The AC patients showed both higher LVEDi (p:0.002) and RVEDi (p:0.017) and lower LVEF (p: 0.016) as compared to control patients. Moreover, AC patients showed impaired LV-GLS (p < 0.001), LV-GRS (p < 0.001), LV-GCS (p < 0.001) and RV-GRS (p:0.026) as compared to control subjects. Group1 patients showed a significant reduction of LV-GRS (p < 0.05) and LV-GCS p < 0.01) as compared to control subjects. At univariate analysis LV-GCS was the most discriminatory parameter between Group1 vs heathy subjects with an optimal cut-off of −15.8 (Sensitivity: 74%; Specificity: 10%). Conclusions: In patients with AC biopsy-proven, CMR-FT could improve the diagnostic yield in the subset of patients who results negative for imaging TFC criteria resulting as useful gatekeeper for indication of myocardial biopsy in case of equivocal clinical and imaging presentation.
Published: 2021

38. Magnetic resonance imaging and artificial intelligence

Author: Muscogiuri, G, Guglielmo, M, Baggiano, A, Fusini, L, Ricci, F, Cicala, G, Rabbat, M, Guaricci, A, Pontone, G, Muscogiuri G., Guglielmo M., Baggiano A., Fusini L., Ricci F., Cicala G., Rabbat M. G., Guaricci A. I., Pontone G., Muscogiuri, G, Guglielmo, M, Baggiano, A, Fusini, L, Ricci, F, Cicala, G, Rabbat, M, Guaricci, A, Pontone, G, Muscogiuri G., Guglielmo M., Baggiano A., Fusini L., Ricci F., Cicala G., Rabbat M. G., Guaricci A. I., and Pontone G.
Abstract: Cardiac magnetic resonance (CMR) is the best-suited cardiac imaging modality to provide reliable and reproducible information regarding cardiac volumes, function, and tissue characterization. In clinical practice, artificial intelligence (AI) in CMR can be applied to the whole process, ranging from sequence reconstruction, image analysis, and reporting of findings. In sequence reconstruction, the application of AI is mainly focused on the speed of reconstruction, while in image analysis and reporting AI is primarily aimed at automating the process of segmentation of both ventricles as well as fibrotic tissue. Within the realm of tissue characterization, AI can also be helpful in the depiction of tissue abnormalities from noncontrast images. Finally, AI can be useful for prognostic stratification.
Published: 2021

39. Feasibility of late gadolinium enhancement (LGE) in ischemic cardiomyopathy using 2D-multisegment LGE combined with artificial intelligence reconstruction deep learning noise reduction algorithm

Author: Muscogiuri, G, Martini, C, Gatti, M, Dell'Aversana, S, Ricci, F, Guglielmo, M, Baggiano, A, Fusini, L, Bracciani, A, Scafuri, S, Andreini, D, Mushtaq, S, Conte, E, Gripari, P, Annoni, A, Formenti, A, Mancini, M, Bonfanti, L, Guaricci, A, Janich, M, Rabbat, M, Pompilio, G, Pepi, M, Pontone, G, Muscogiuri G., Martini C., Gatti M., Dell'Aversana S., Ricci F., Guglielmo M., Baggiano A., Fusini L., Bracciani A., Scafuri S., Andreini D., Mushtaq S., Conte E., Gripari P., Annoni A. D., Formenti A., Mancini M. E., Bonfanti L., Guaricci A. I., Janich M. A., Rabbat M. G., Pompilio G., Pepi M., Pontone G., Muscogiuri, G, Martini, C, Gatti, M, Dell'Aversana, S, Ricci, F, Guglielmo, M, Baggiano, A, Fusini, L, Bracciani, A, Scafuri, S, Andreini, D, Mushtaq, S, Conte, E, Gripari, P, Annoni, A, Formenti, A, Mancini, M, Bonfanti, L, Guaricci, A, Janich, M, Rabbat, M, Pompilio, G, Pepi, M, Pontone, G, Muscogiuri G., Martini C., Gatti M., Dell'Aversana S., Ricci F., Guglielmo M., Baggiano A., Fusini L., Bracciani A., Scafuri S., Andreini D., Mushtaq S., Conte E., Gripari P., Annoni A. D., Formenti A., Mancini M. E., Bonfanti L., Guaricci A. I., Janich M. A., Rabbat M. G., Pompilio G., Pepi M., and Pontone G.
Abstract: Background: Despite the low spatial resolution of 2D-multisegment late gadolinium enhancement (2D-MSLGE) sequences, it may be useful in uncooperative patients instead of standard 2D single segmented inversion recovery gradient echo late gadolinium enhancement sequences (2D-SSLGE). The aim of the study is to assess the feasibility and comparison of 2D-MSLGE reconstructed with artificial intelligence reconstruction deep learning noise reduction (NR) algorithm compared to standard 2D-SSLGE in consecutive patients with ischemic cardiomyopathy (ICM). Methods: Fifty-seven patients with known ICM referred for a clinically indicated CMR were enrolled in this study. 2D-MSLGE were reconstructed using a growing level of NR (0%,25%,50%,75%and 100%). Subjective image quality, signal to noise ratio (SNR) and contrast to noise ratio (CNR) were evaluated in each dataset and compared to standard 2D-SSLGE. Moreover, diagnostic accuracy, LGE mass and scan time were compared between 2D-MSLGE with NR and 2D-SSLGE. Results: The application of NR reconstruction ≥50% to 2D-MSLGE provided better subjective image quality, CNR and SNR compared to 2D-SSLGE (p < 0.01). The best compromise in terms of subjective and objective image quality was observed for values of 2D-MSLGE 75%, while no differences were found in terms of LGE quantification between 2D-MSLGE versus 2D-SSLGE, regardless the NR applied. The sensitivity, specificity, negative predictive value, positive predictive value and accuracy of 2D-MSLGE NR 75% were 87.77%,96.27%,96.13%,88.16% and 94.22%, respectively. Time of acquisition of 2D-MSLGE was significantly shorter compared to 2D-SSLGE (p < 0.01). Conclusion: When compared to standard 2D-SSLGE, the application of NR reconstruction to 2D-MSLGE provides superior image quality with similar diagnostic accuracy.
Published: 2021

40. Cardiac care of non-covid-19 patients during the sars-cov-2 pandemic: The pivotal role of ccta

Author: Conte, E, Mushtaq, S, Mancini, M, Annoni, A, Formenti, A, Muscogiuri, G, Asinelli, M, Gigante, C, Collet, C, Sonck, J, Guglielmo, M, Baggiano, A, Cosentino, N, Denora, M, Belmonte, M, Agalbato, C, Esposito, A, Assanelli, E, Bartorelli, A, Pepi, M, Pontone, G, Andreini, D, Conte E., Mushtaq S., Mancini M. E., Annoni A., Formenti A., Muscogiuri G., Asinelli M. G., Gigante C., Collet C., Sonck J., Guglielmo M., Baggiano A., Cosentino N., Denora M., Belmonte M., Agalbato C., Esposito A. A., Assanelli E., Bartorelli A. L., Pepi M., Pontone G., Andreini D., Conte, E, Mushtaq, S, Mancini, M, Annoni, A, Formenti, A, Muscogiuri, G, Asinelli, M, Gigante, C, Collet, C, Sonck, J, Guglielmo, M, Baggiano, A, Cosentino, N, Denora, M, Belmonte, M, Agalbato, C, Esposito, A, Assanelli, E, Bartorelli, A, Pepi, M, Pontone, G, Andreini, D, Conte E., Mushtaq S., Mancini M. E., Annoni A., Formenti A., Muscogiuri G., Asinelli M. G., Gigante C., Collet C., Sonck J., Guglielmo M., Baggiano A., Cosentino N., Denora M., Belmonte M., Agalbato C., Esposito A. A., Assanelli E., Bartorelli A. L., Pepi M., Pontone G., and Andreini D.
Abstract: Aim: The aim of this study is to evaluate the potential use of coronary CT angiography (CCTA) as the sole available non-invasive diagnostic technique for suspected coronary artery disease (CAD) during the coronavirus disease 2019 (COVID-19) pandemic causing limited access to the hospital facilities. Methods and Results: A consecutive cohort of patients with suspected stable CAD and clinical indication to non-invasive test was enrolled in a hub hospital in Milan, Italy, from March 9 to April 30, 2020. Outcome measures were obtained as follows: cardiac death, ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), and unstable angina. All the changes in medical therapy following the result of CCTA were annotated. A total of 58 patients with a mean age of 64 ± 11 years (36 men and 22 women) were enrolled. CCTA showed no CAD in 14 patients (24.1%), non-obstructive CAD in 30 (51.7%) patients, and obstructive CAD in 14 (24.1%) patients. Invasive coronary angiography (ICA) was considered deferrable in 48 (82.8%) patients. No clinical events were recorded after a mean follow-up of 376.4 ± 32.1 days. Changes in the medical therapy were significantly more prevalent in patients with vs. those without CAD at CCTA. Conclusion: The results of the study confirm the capability of CCTA to safely defer ICA in the majority of symptomatic patients and to correctly identify those with critical coronary stenoses necessitating coronary revascularization. This characteristic could be really helpful especially when the hospital resources are limited
Published: 2021

41. Stress CMR in Known or Suspected CAD: Diagnostic and Prognostic Role

Author: Baessato, F, Guglielmo, M, Muscogiuri, G, Baggiano, A, Fusini, L, Scafuri, S, Babbaro, M, Mollace, R, Collevecchio, A, Guaricci, A, Pontone, G, Baessato F, Guglielmo M, Muscogiuri G, Baggiano A, Fusini L, Scafuri S, Babbaro M, Mollace R, Collevecchio A, Guaricci AI, Pontone G, Baessato, F, Guglielmo, M, Muscogiuri, G, Baggiano, A, Fusini, L, Scafuri, S, Babbaro, M, Mollace, R, Collevecchio, A, Guaricci, A, Pontone, G, Baessato F, Guglielmo M, Muscogiuri G, Baggiano A, Fusini L, Scafuri S, Babbaro M, Mollace R, Collevecchio A, Guaricci AI, and Pontone G
Abstract: The recently published 2019 guidelines on chronic coronary syndromes (CCS) focus on the need for noninvasive imaging modalities to accurately establish the diagnosis of coronary artery disease (CAD) and assess the risk of clinical scenario occurrence. Appropriate patient management should rely on controlling symptoms, improving prognosis, and guiding each therapeutic strategy as well as monitoring disease progress. Among the noninvasive imaging modalities, cardiovascular magnetic resonance (CMR) has gained broad acceptance in past years due to its unique features in providing a complete assessment of CAD through data on cardiac anatomy and function and myocardial viability, with high spatial and temporal resolution and without ionizing radiation. In detail, evaluation of the presence and extent of myocardial ischemia through stress CMR (S-CMR) has shown a high rule-in power in detecting functionally significant coronary artery stenosis in patients suspected of CCS. Moreover, S-CMR technique may add significant prognostic value, as demonstrated by different studies which have progressively evidenced the valuable power of this multiparametric imaging modality in predicting adverse cardiac events. The latest scientific progress supports a greater expansion of S-CMR with improvement of quantitative myocardial perfusion analysis, myocardial strain, and native mapping within the same examination. Although further study is warranted, these techniques, which are currently mostly restricted to the research field, are likely to become increasingly prevalent in the clinical setting with the scope of increasing accuracy in the selection of patients to be sent to invasive revascularization. This review investigates the diagnostic and prognostic role of S-CMR in the context of CAD, by analysing a strong, long-standing, scientific evidence together with an appraisal of new advanced techniques which may potentially enrich CAD management in the next future.
Published: 2021

42. Arrhythmic Mitral Valve Prolapse: Introducing an Era of Multimodality Imaging-Based Diagnosis and Risk Stratification

Author: Kukavica, D, Guglielmo, M, Baggiano, A, Muscogiuri, G, Fusini, L, Muratori, M, Tamborini, G, Mantegazza, V, Trancuccio, A, Arnò, C, Mazzanti, A, Pepi, M, Priori, S, Pontone, G, Kukavica D, Guglielmo M, Baggiano A, Muscogiuri G, Fusini L, Muratori M, Tamborini G, Mantegazza V, Trancuccio A, Arnò C, Mazzanti A, Pepi M, Priori SG, Pontone G, Kukavica, D, Guglielmo, M, Baggiano, A, Muscogiuri, G, Fusini, L, Muratori, M, Tamborini, G, Mantegazza, V, Trancuccio, A, Arnò, C, Mazzanti, A, Pepi, M, Priori, S, Pontone, G, Kukavica D, Guglielmo M, Baggiano A, Muscogiuri G, Fusini L, Muratori M, Tamborini G, Mantegazza V, Trancuccio A, Arnò C, Mazzanti A, Pepi M, Priori SG, and Pontone G
Abstract: Mitral valve prolapse is a common cardiac condition, with an estimated prevalence between 1% and 3%. Most patients have a benign course, but ever since its initial description mitral valve prolapse has been associated to sudden cardiac death. Although the causal relationship between mitral valve prolapse and sudden cardiac death has never been clearly demonstrated, different factors have been implicated in arrhythmogenesis in patients with mitral valve prolapse. In this work, we offer a comprehensive overview of the etiology and the genetic background, epidemiology, pathophysiology, and we focus on the state-of-the-art imaging-based diagnosis of mitral valve prolapse. Going beyond the classical, well-described clinical factors, such as young age, female gender and auscultatory findings, we investigate multimodality imaging features, such as alterations of anatomy and function of the mitral valve and its leaflets, the structural and contractile anomalies of the myocardium, all of which have been associated to sudden cardiac death.
Published: 2021

43. Epicardial fat and coronary artery disease: Role of cardiac imaging

Author: Guglielmo, M, Lin, A, Dey, D, Baggiano, A, Fusini, L, Muscogiuri, G, Pontone, G, Guglielmo M, Lin A, Dey D, Baggiano A, Fusini L, Muscogiuri G, Pontone G, Guglielmo, M, Lin, A, Dey, D, Baggiano, A, Fusini, L, Muscogiuri, G, Pontone, G, Guglielmo M, Lin A, Dey D, Baggiano A, Fusini L, Muscogiuri G, and Pontone G
Abstract: Epicardial adipose tissue (EAT) represents the fat depot located between the myocardium and the visceral pericardial layer. Far from being an inert tissue, EAT has been recognized as secreting a large amount of bioactive molecules called adipokines, which have numerous exocrine and paracrine effects. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) – the EAT directly surrounding the coronary arteries – has a complex bidirectional interaction with the underlying vascular wall. While in normal conditions this mutual cross-talk helps maintain the homeostasis of the vascular wall, dysfunctional PCAT produces deleterious pro-inflammatory adipokines involved in atherogenesis. Importantly, PCAT inflammation has been associated with coronary artery disease (CAD) and major cardiovascular events. This review aims to provide an overview of the imaging techniques used to assess EAT, with a specific focus on cardiac computed tomography (CCT), which has become the key modality in this field. In contrast to echocardiography and cardiac magnetic resonance (CMR), CCT is not only able to visualize and precisely quantify EAT, but also to assess the coronary arteries and the PCAT simultaneously. In recent years, several papers have shown the utility of using CCT-derived PCAT attenuation as a surrogate measure of coronary inflammation. This noninvasive imaging biomarker may potentially be used to monitor patient responses to new antinflammatory drugs for the treatment of CAD.
Published: 2021

44. State of the art paper: Cardiovascular CT for planning ventricular tachycardia ablation procedures

Author: Conte, E, Mushtaq, S, Carbucicchio, C, Piperno, G, Catto, V, Mancini, M, Formenti, A, Annoni, A, Guglielmo, M, Baggiano, A, Muscogiuri, G, Belmonte, M, Cattani, F, Pontone, G, Jereczek-Fossa, B, Orecchia, R, Tondo, C, Andreini, D, Conte E, Mushtaq S, Carbucicchio C, Piperno G, Catto V, Mancini ME, Formenti A, Annoni A, Guglielmo M, Baggiano A, Muscogiuri G, Belmonte M, Cattani F, Pontone G, Jereczek-Fossa BA, Orecchia R, Tondo C, Andreini D., Conte, E, Mushtaq, S, Carbucicchio, C, Piperno, G, Catto, V, Mancini, M, Formenti, A, Annoni, A, Guglielmo, M, Baggiano, A, Muscogiuri, G, Belmonte, M, Cattani, F, Pontone, G, Jereczek-Fossa, B, Orecchia, R, Tondo, C, Andreini, D, Conte E, Mushtaq S, Carbucicchio C, Piperno G, Catto V, Mancini ME, Formenti A, Annoni A, Guglielmo M, Baggiano A, Muscogiuri G, Belmonte M, Cattani F, Pontone G, Jereczek-Fossa BA, Orecchia R, Tondo C, and Andreini D.
Abstract: In the last 20 years coronary computed tomography angiography (CCTA) gained a pivotal role in the evaluation of patients with suspected coronary artery disease (CAD) as finally recognized by the ESC guidelines on stable CAD. Technological advances have progressively improved the temporal resolution of CT scanners, contemporary reducing acquisition time, radiation dose and contrast volume needed for the whole heart volume acquisition, further expanding the role of cardiac CT beyond coronary anatomy evaluation. Aim of the present review is to discuss use and benefit of cardiac CT for the planning and preparation of VT ablation.
Published: 2021

45. Multimodality imaging of a left circumflex artery to right atrium coronary artery fistula associated with giant aneurysm

Author: Guglielmo, M, Del Torto, A, Muscogiuri, G, Mostardini, G, Pontone, G, Guglielmo M, Del Torto A, Muscogiuri G, Mostardini G, Pontone G, Guglielmo, M, Del Torto, A, Muscogiuri, G, Mostardini, G, Pontone, G, Guglielmo M, Del Torto A, Muscogiuri G, Mostardini G, and Pontone G
Published: 2021

46. CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry

Author: Guaricci, A, Masci, P, Muscogiuri, G, Guglielmo, M, Baggiano, A, Fusini, L, Lorenzoni, V, Martini, C, Andreini, D, Pavon, A, Aquaro, G, Barison, A, Todiere, G, Rabbat, M, Tat, E, Raineri, C, Valentini, A, Varga-Szemes, A, Schoepf, U, De Cecco, C, Bogaert, J, Dobrovie, M, Symons, R, Focardi, M, Gismondi, A, Lozano-Torres, J, Rodriguez-Palomares, J, Lanzillo, C, Di Roma, M, Moro, C, Di Giovine, G, Margonato, D, De Lazzari, M, Perazzolo Marra, M, Nese, A, Casavecchia, G, Gravina, M, Marzo, F, Carigi, S, Pica, S, Lombardi, M, Censi, S, Squeri, A, Palumbo, A, Gaibazzi, N, Camastra, G, Sbarbati, S, Pedrotti, P, Masi, A, Carrabba, N, Pradella, S, Timpani, M, Cicala, G, Presicci, C, Puglisi, S, Sverzellati, N, Santobuono, V, Pepi, M, Schwitter, J, Pontone, G, Guaricci AI, Masci PG, Muscogiuri G, Guglielmo M, Baggiano A, Fusini L, Lorenzoni V, Martini C, Andreini D, Pavon AG, Aquaro GD, Barison A, Todiere G, Rabbat MG, Tat E, Raineri C, Valentini A, Varga-Szemes A, Schoepf UJ, De Cecco CN, Bogaert J, Dobrovie M, Symons R, Focardi M, Gismondi A, Lozano-Torres J, Rodriguez-Palomares JF, Lanzillo C, Di Roma M, Moro C, Di Giovine G, Margonato D, De Lazzari M, Perazzolo Marra M, Nese A, Casavecchia G, Gravina M, Marzo F, Carigi S, Pica S, Lombardi M, Censi S, Squeri A, Palumbo A, Gaibazzi N, Camastra G, Sbarbati S, Pedrotti P, Masi A, Carrabba N, Pradella S, Timpani M, Cicala G, Presicci C, Puglisi S, Sverzellati N, Santobuono VE, Pepi M, Schwitter J, Pontone G, Guaricci, A, Masci, P, Muscogiuri, G, Guglielmo, M, Baggiano, A, Fusini, L, Lorenzoni, V, Martini, C, Andreini, D, Pavon, A, Aquaro, G, Barison, A, Todiere, G, Rabbat, M, Tat, E, Raineri, C, Valentini, A, Varga-Szemes, A, Schoepf, U, De Cecco, C, Bogaert, J, Dobrovie, M, Symons, R, Focardi, M, Gismondi, A, Lozano-Torres, J, Rodriguez-Palomares, J, Lanzillo, C, Di Roma, M, Moro, C, Di Giovine, G, Margonato, D, De Lazzari, M, Perazzolo Marra, M, Nese, A, Casavecchia, G, Gravina, M, Marzo, F, Carigi, S, Pica, S, Lombardi, M, Censi, S, Squeri, A, Palumbo, A, Gaibazzi, N, Camastra, G, Sbarbati, S, Pedrotti, P, Masi, A, Carrabba, N, Pradella, S, Timpani, M, Cicala, G, Presicci, C, Puglisi, S, Sverzellati, N, Santobuono, V, Pepi, M, Schwitter, J, Pontone, G, Guaricci AI, Masci PG, Muscogiuri G, Guglielmo M, Baggiano A, Fusini L, Lorenzoni V, Martini C, Andreini D, Pavon AG, Aquaro GD, Barison A, Todiere G, Rabbat MG, Tat E, Raineri C, Valentini A, Varga-Szemes A, Schoepf UJ, De Cecco CN, Bogaert J, Dobrovie M, Symons R, Focardi M, Gismondi A, Lozano-Torres J, Rodriguez-Palomares JF, Lanzillo C, Di Roma M, Moro C, Di Giovine G, Margonato D, De Lazzari M, Perazzolo Marra M, Nese A, Casavecchia G, Gravina M, Marzo F, Carigi S, Pica S, Lombardi M, Censi S, Squeri A, Palumbo A, Gaibazzi N, Camastra G, Sbarbati S, Pedrotti P, Masi A, Carrabba N, Pradella S, Timpani M, Cicala G, Presicci C, Puglisi S, Sverzellati N, Santobuono VE, Pepi M, Schwitter J, and Pontone G
Abstract: Aims: The aim of this registry was to evaluate the additional prognostic value of a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in a large cohort of consecutive unselected non-ischaemic cardiomyopathy (NICM) patients. Methods and results: In the DERIVATE registry (www.clinicaltrials.gov/registration: RCT#NCT03352648), 1000 (derivation cohort) and 508 (validation cohort) NICM patients with chronic heart failure (HF) and left ventricular ejection fraction [removed]3 segments with midwall fibrosis on late gadolinium enhancement (LGE) were the only independent predictors of all-cause mortality (HR: 1.036, 95% CI: 1.0117-1.056, P < 0.001 and HR: 2.077, 95% CI: 1.211-3.562, P = 0.008, respectively). For MAACE, the independent predictors were male gender, left ventricular end-diastolic volume index by CMR (CMR-LVEDVi), and >3 segments with midwall fibrosis on LGE (HR: 2.131, 95% CI: 1.231-3.690, P = 0.007; HR: 3.161, 95% CI: 1.750-5.709, P < 0.001; and HR: 1.693, 95% CI: 1.084-2.644, P = 0.021, respectively). A composite clinical and CMR-based risk score provided a net reclassification improvement of 63.7% (P < 0.001) for MAACE occurrence when added to the model based on SOC evaluation. These findings were confirmed in the validation cohort. Conclusion: In a large multicentre, multivendor cohort registry reflecting daily clinical practice in NICM work-up, a composite clinical and CMR-based risk score provides incremental prognostic value beyond SOC evaluation, which may have impact on the indication of implantable cardioverter-defibrillator implantation.
Published: 2021

47. Quantitative Evaluation of COVID-19 Pneumonia Lung Extension by Specific Software and Correlation with Patient Clinical Outcome. Quantitative Evaluation of COVID-19 Pneumonia Lung Extension by Specific Software and Correlation with Patient Clinical Outcome

Author: Annoni, A, Conte, E, Mancini, M, Gigante, C, Agalbato, C, Formenti, A, Muscogiuri, G, Mushtaq, S, Guglielmo, M, Baggiano, A, Bonomi, A, Pepi, M, Pontone, G, Andreini, D, Annoni AD, Conte E, Mancini ME, Gigante C, Agalbato C, Formenti A, Muscogiuri G, Mushtaq S, Guglielmo M, Baggiano A, Bonomi A, Pepi M, Pontone G, Andreini D, Annoni, A, Conte, E, Mancini, M, Gigante, C, Agalbato, C, Formenti, A, Muscogiuri, G, Mushtaq, S, Guglielmo, M, Baggiano, A, Bonomi, A, Pepi, M, Pontone, G, Andreini, D, Annoni AD, Conte E, Mancini ME, Gigante C, Agalbato C, Formenti A, Muscogiuri G, Mushtaq S, Guglielmo M, Baggiano A, Bonomi A, Pepi M, Pontone G, and Andreini D
Abstract: Lung infection named as COVID-19 is an infectious disease caused by the most recently discovered coronavirus 2 (SARS-CoV-2). CT (computed tomography) has been shown to have good sensitivity in comparison with RT-PCR, particularly in early stages. However, CT findings appear to not always be related to a certain clinical severity. The aim of this study is to evaluate a correlation between the percentage of lung parenchyma volume involved with COVID-19 infection (compared to the total lung volume) at baseline diagnosis and correlated to the patient’s clinical course (need for ventilator assistance and or death). All patients with suspected COVID-19 lung disease referred to our imaging department for Chest CT from 24 February to 6 April 2020were included in the study. Specific CT features were assessed including the amount of high attenuation areas (HAA) related to lung infection. HAA, defined as the percentage of lung parenchyma above a predefined threshold of −650 (HAA%, HAA/total lung volume), was automatically calculated using a dedicated segmentation software. Lung volumes and CT findings were correlated with patient’s clinical course. Logistic regressions were performed to assess the predictive value of clinical, inflammatory and CT parameters for the defined outcome. In the overall population we found an average infected lung volume of 31.4 ± 26.3% while in the subgroup of patients who needed ventilator assistance and who died as well as the patients who died without receiving ventilator assistance the volume of infected lung was significantly higher 41.4 ± 28.5 and 72.7 ± 36.2 (p < 0.001). In logistic regression analysis best predictors for ventilation and death were the presence of air bronchogram (p = 0.006), crazy paving (p = 0.007), peripheral distribution (p < 0.001), age (p = 0.002), fever at admission (p = 0.007), dyspnea (p = 0.002) and cardiovascular comorbidities (p < 0.001). In multivariable analysis, quantitative CT parameters and features
Published: 2021

48. Role of computed tomography in COVID-19

Author: Pontone, G, Scafuri, S, Mancini, M, Agalbato, C, Guglielmo, M, Baggiano, A, Muscogiuri, G, Fusini, L, Andreini, D, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Gennari, A, Guaricci, A, Rabbat, M, Pompilio, G, Pepi, M, Rossi, A, Pontone G, Scafuri S, Mancini ME, Agalbato C, Guglielmo M, Baggiano A, Muscogiuri G, Fusini L, Andreini D, Mushtaq S, Conte E, Annoni A, Formenti A, Gennari AG, Guaricci AI, Rabbat MR, Pompilio G, Pepi M, Rossi A, Pontone, G, Scafuri, S, Mancini, M, Agalbato, C, Guglielmo, M, Baggiano, A, Muscogiuri, G, Fusini, L, Andreini, D, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Gennari, A, Guaricci, A, Rabbat, M, Pompilio, G, Pepi, M, Rossi, A, Pontone G, Scafuri S, Mancini ME, Agalbato C, Guglielmo M, Baggiano A, Muscogiuri G, Fusini L, Andreini D, Mushtaq S, Conte E, Annoni A, Formenti A, Gennari AG, Guaricci AI, Rabbat MR, Pompilio G, Pepi M, and Rossi A
Abstract: Coronavirus disease 2019 (COVID-19) has become a rapid worldwide pandemic. While COVID-19 primarily manifests as an interstitial pneumonia and severe acute respiratory distress syndrome, severe involvement of other organs has been documented. In this article, we will review the role of non-contrast chest computed tomography in the diagnosis, follow-up and prognosis of patients affected by COVID-19 pneumonia with a detailed description of the imaging findings that may be encountered. Given that patients with COVID-19 may also suffer from coagulopathy, we will discuss the role of CT pulmonary angiography in the detection of acute pulmonary embolism. Finally, we will describe more advanced applications of CT in the differential diagnosis of myocardial injury with an emphasis on ruling out acute coronary syndrome and myocarditis.
Published: 2021

49. T1 mapping and cardiac magnetic resonance feature tracking in mitral valve prolapse

Author: Guglielmo, M, Fusini, L, Muscogiuri, G, Baessato, F, Loffreno, A, Cavaliere, A, Rizzon, G, Baggiano, A, Rabbat, M, Muratori, M, Tamborini, G, Danza, L, Del Torto, A, Tonet, E, Viani, G, Mushtaq, S, Conte, E, Bonalumi, G, Gripari, P, Zanobini, M, Andreini, D, Alamanni, F, Pepi, M, Guaricci, A, Pontone, G, Guglielmo M, Fusini L, Muscogiuri G, Baessato F, Loffreno A, Cavaliere A, Rizzon G, Baggiano A, Rabbat MG, Muratori M, Tamborini G, Danza LML, Del Torto A, Tonet E, Viani G, Mushtaq S, Conte E, Bonalumi G, Gripari P, Zanobini M, Andreini D, Alamanni F, Pepi M, Guaricci AI, Pontone G, Guglielmo, M, Fusini, L, Muscogiuri, G, Baessato, F, Loffreno, A, Cavaliere, A, Rizzon, G, Baggiano, A, Rabbat, M, Muratori, M, Tamborini, G, Danza, L, Del Torto, A, Tonet, E, Viani, G, Mushtaq, S, Conte, E, Bonalumi, G, Gripari, P, Zanobini, M, Andreini, D, Alamanni, F, Pepi, M, Guaricci, A, Pontone, G, Guglielmo M, Fusini L, Muscogiuri G, Baessato F, Loffreno A, Cavaliere A, Rizzon G, Baggiano A, Rabbat MG, Muratori M, Tamborini G, Danza LML, Del Torto A, Tonet E, Viani G, Mushtaq S, Conte E, Bonalumi G, Gripari P, Zanobini M, Andreini D, Alamanni F, Pepi M, Guaricci AI, and Pontone G
Abstract: Objectives: T1 mapping (T1-map) and cardiac magnetic resonance feature tracking (CMR-FT) techniques have been introduced for the early detection of interstitial myocardial fibrosis and deformation abnormalities. We sought to demonstrate that T1-map and CMR-FT may identify the presence of subclinical myocardial structural changes in patients with mitral valve prolapse (MVP). Methods: Consecutive MVP patients with moderate-to-severe mitral regurgitation and comparative matched healthy subjects were prospectively enrolled and underwent CMR-FT analysis to calculate 2D global and segmental circumferential (CS) and radial strain (RS) and T1-map to determine global and segmental native T1 (nT1) values. Results: Seventy-three MVP patients (mean age, 57 ± 13 years old; male, 76%; regurgitant volume, 57 ± 21 mL) and 42 matched control subjects (mean age, 56 ± 18 years; male, 74%) were included. MVP patients showed a lower global CS (− 16.3 ± 3.4% vs. − 17.8 ± 1.9%, p = 0.020) and longer global nT1 (1124.9 ± 97.7 ms vs. 1007.4 ± 26.1 ms, p < 0.001) as compared to controls. Moreover, MVP patients showed lower RS and CS in basal (21.6 ± 12.3% vs. 27.6 ± 8.9%, p = 0.008, and − 13.0 ± 6.7% vs. − 14.9 ± 4.1%, p = 0.013) and mid-inferolateral (20.6 ± 10.7% vs. 28.4 ± 8.7%, p < 0.001, and − 12.8 ± 6.3% vs. − 16.5 ± 4.0%, p < 0.001) walls as compared to other myocardial segments. Similarly, MVP patients showed longer nT1 values in basal (1080 ± 68 ms vs. 1043 ± 43 ms, p < 0.001) and mid-inferolateral (1080 ± 77 ms vs. 1034 ± 37 ms, p < 0.001) walls as compared to other myocardial segments. Of note, nT1 values were significantly correlated with CS (r, 0.36; p < 0.001) and RS (r, 0.37; p < 0.001) but not with regurgitant volume. Conclusions: T1-map and CMR-FT identify subclinical left ventricle tissue changes in patients with MVP. Further studies are required to correlate these subclinical tissue changes with the outcome. Key Points: • T1 mapping (T1-map) and cardia
Published: 2021

50. Current evidence on the diagnostic and prognostic role of native T1 mapping in heart diseases

Author: Tonet, E, Baggiano, A, Pavasini, R, Guglielmo, M, Censi, S, Cossu, A, Rapezzi, C, Muscogiuri, G, Squeri, A, Campo, G, Pontone, G, Tonet E, Baggiano A, Pavasini R, Guglielmo M, Censi S, Cossu A, Rapezzi C, Muscogiuri G, Squeri A, Campo G, Pontone G., Tonet, E, Baggiano, A, Pavasini, R, Guglielmo, M, Censi, S, Cossu, A, Rapezzi, C, Muscogiuri, G, Squeri, A, Campo, G, Pontone, G, Tonet E, Baggiano A, Pavasini R, Guglielmo M, Censi S, Cossu A, Rapezzi C, Muscogiuri G, Squeri A, Campo G, and Pontone G.
Abstract: Tissue characterization represents a prerogative of cardiac magnetic resonance. Beside late gadolinium enhancement, native T1 mapping (nT1m) reveals tissue composition. It could represent a useful tool for example when contrast medium can't be administrated. The present review summarises current evidence about nT1m in main heart diseases.
Published: 2021

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