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1. Synthesis, spectral characterization and biological evaluation of carbamate and sulfonamide derivatives of cis-tramadol.

Author

Reddy, S. Venkata Lakshmi, Varalakshmi, Mavallur, Reddy, Kiran Yerragudibathal, Chinthala, Swaroopa, Katla, Venkata Ramana, and NagaRaju, Chamarthi

Subjects
*CARBAMATE derivatives, *SULFONYL chlorides, *CHEMICAL synthesis, *ANTIBACTERIAL agents, *CHEMICAL yield, *ELEMENTAL analysis
Abstract

A series of new carbamates and sulfonamide derivatives of cis-tramadol 5(a-e) and 7(a-e) have been synthesized in high yields by the reaction of cis-tramadol with various chloroformates 4(a-e) and sulfonyl chlorides 6(a-e). All the newly synthesized compounds were characterized by IR, NMR (1H and 13C), mass and elemental analyses. The synthesized compounds were evaluated for their antibacterial and antifungal activities. Compounds 5a, 5b, 7a and 7c exhibited potent antibacterial and antifungal activity. [ABSTRACT FROM AUTHOR]

Published
2023
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