Synthesis, spectral characterization and biological evaluation of carbamate and sulfonamide derivatives of cis-tramadol.

A series of new carbamates and sulfonamide derivatives of cis-tramadol 5(a-e) and 7(a-e) have been synthesized in high yields by the reaction of cis-tramadol with various chloroformates 4(a-e) and sulfonyl chlorides 6(a-e). All the newly synthesized compounds were characterized by IR, NMR (1H and 13C), mass and elemental analyses. The synthesized compounds were evaluated for their antibacterial and antifungal activities. Compounds 5a, 5b, 7a and 7c exhibited potent antibacterial and antifungal activity. [ABSTRACT FROM AUTHOR]