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We aimed to analyze the factors associated with decreased morbidity and mortality from malignant neoplasms of the lip, oral cavity and pharynx (LOCPN). A cross-sectional, ecological, descriptive and analytical study was conducted based on records of the SUS Hospital Information System, e-Gestor Basic Care and Atlas of Human Development in Brazil. Data were collected from the 27 federative units of Brazil regarding morbidity and mortality by neoplasm (2010-2020), Municipal Human Development Index (Census 2010), per capita income (Census 2010), General Population (Census 2022) and Primary Care Coverage (2010-2020). Cox regression was used to analyze the factors associated with increased morbidity and mortality of LOCPN (p < 0.05). Regarding the increase in the number of hospitalizations, it was found that cities with primary care coverage higher than 70% have a lower risk associated with increased hospitalization rates and increased death rates. Among the variables evaluated, only primary care coverage is associated with the outcomes under study. Thus, increasing primary care coverage affects the reduction of morbidity and mortality by LOCPN. [ABSTRACT FROM AUTHOR]

BACKGROUND: The likelihood of infection with SARS-COV-2 (COVID-19) in the dental office is considered high. OBJECTIVES: Assessing the impact of the COVID-19 on dental practices and anxiety levels in risk group Brazilian dentists. METHODS: A cross-sectional study was performed using an online questionnaire. The data obtained were analyzed using the IBM SPSS 25.0 software (Pearson's Chi-square association test, multivariate logistic regression, and Poisson multiple regression), with subsequent calculation of the odds ratio at a 95% confidence interval, with a significance level of 5%. RESULTS: Responses of 578 dentists distributed in all regions of Brazil were collected. Most of the dentists were female, with an average age of 35. Of the participants, 23.4% were part of the increased risk group for COVID-19. The professionals who belonged to the increased risk group had a greater chance of not feeling prepared to perform consultations (OR = 1.67) and were not performing any procedures during the pandemic (OR = 2.03). Belonging to the increased risk group did not influence anxiety levels among the dentists. The factors associated with increased anxiety were being female, being younger, working in the southeastern region of the country, being afraid of contracting COVID-19 while working, and being concerned for one's professional future. CONCLUSIONS: The pandemic has had a negative impact on the professional practice of individuals at risk, but the level of anxiety was like professionals who were not part of the increased risk group for COVID-19. [ABSTRACT FROM AUTHOR]

Aim: It was analyzed the efficacy of mouthwash and spray containing essential oil (EO) of Cinnamomum zeylanicum Blume for the treatment of oral candidiasis. Methods and results: A randomized, controlled, and blinded clinical trial was conducted with 36 individuals (probabilistic sample) with oral candidiasis who were divided into two treatment groups: C. zeylanicum (0.5 mg/mL), n = 18; nystatin (100,000IU/mL), n = 18. The efficacy of the products was evaluated by two parameters: (a) clinical evolution recorded by calibrated examiners (Kappa = 0.822) according to Newton's classification and (b) reduction of colony‐forming units/mL. Mycological and clinical parameters were analyzed before and at 15 days after treatment. Clinical examination of the mucosa showed that C. zeylanicum (p < 0.0339) and nystatin (p <.0139) had efficacy, resulting in a reduction of signs and symptoms (Mann‐Whitney test). Mycological analysis showed that C. zeylanicum caused a reduction of 61% and 33% of Candida spp., isolates oral mucosa and dentures, respectively. Candida tropicalis strains were eliminated after C. zeylanicum, in both sites. The participants reported a pleasant taste and few product‐related complaints. Conclusion: C. zeylanicum EO and nystatin exhibited clinical efficacy, according to the Newton classification, and reducing in Candida spp. The clinical trial has been registered (Registration number: NBR–33s6 × 5, ensaiosclinicos.gov.br). [ABSTRACT FROM AUTHOR]

• SiO 2 /Ag nanofibers were successfully produced by Solution Blow Spinning (SBS). • The incorporation of SiO 2 /Ag nanofibers improved the microhardness of the composite. • The flexural strength was maintained after simulated ageing for 30 days in water. • Silanization of the nanofibers affected the final properties of the composite. This work aimed at producing silica-blow-spun nanofibers containing silver nanoparticles (SiO 2 /Ag) and investigating the effect of their incorporation in different proportions, with or without pre-treatment with a silane coupling agent, on the mechanical, physicochemical, and biological properties of a commercial composite low-viscosity bulk-fill resin. The production of SiO 2 /Ag nanofibers was confirmed by transmission electron microscopy (TEM) and energy dispersive X-ray analysis (EDX). A portion of the produced nanofibers was silanized. Scanning electronic microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), contact angle measurements, and agar diffusion tests against Streptococcus mutans were used to verify the differences between silanized and non-silanized nanofibers. Different proportions (0.5 wt% and 1 wt%) of silanized (SiO 2 /Ag-0.5S and SiO 2 /Ag-1S) and non-silanized (SiO 2 /Ag-0.5NS and SiO 2 /Ag-1NS) nanofibers were incorporated into the bulk-fill composite (Opus Bulk Fill Flow, FGM). A commercial composite was used as the control. Evaluation of the color parameters (L*, a*, and b*), radiopacity, contact angle, antimicrobial activity, Vickers microhardness, surface roughness (Sa and Sq), flexural strength, and SEM of the fractured surfaces were performed. The data were analyzed using the Mann–Whitney U test (fiber morphology), Kruskal-Wallis tests, with Dunn's post hoc test (antimicrobial activity of the specimen against S. mutans), Student's t -test (disk diffusion), one-way ANOVA and Tukey (color, radiopacity, and contact angle), and two-way ANOVA and Tukey (microhardness, surface roughness, and flexural strength) tests. All statistical analyses were performed at a significance level of 1% (α = 0.01). Porous nanometric SiO 2 /Ag fibers were successfully produced. The silanization process, confirmed by FTIR, increased the diameter and contact angle and reduced the growth inhibition halos of the nanofibers (p < 0.01). After the incorporation of nanofibers into the dental composite, all color parameters were altered in all the experimental groups (p < 0.01). All the groups presented adequate radiopacity values. No statistical difference was observed in the contact angles of the experimental composites (p > 0.01). The lowest microbial counts were obtained in the SiO 2 /Ag-0.5S group; although no significant difference was observed with the control group (p < 0.01). The SiO 2 /Ag-1S, SiO 2 /Ag-0.5S, and SiO 2 /Ag-0.5NS groups exhibited higher microhardness after 30 d of immersion in water (p < 0.01). The surface roughness (Sa-μm) resembled that of the control at baseline, except for the SiO 2 /Ag-1NS group. For the baseline evaluation of flexural strength, all the experimental groups exhibited lower values than the control, except for SiO 2 /Ag-0.5NS and SiO 2 /Ag-0.5S, but after 30 d of immersion in water, there was no difference (p < 0.01). The incorporation of 0.5% wt. of silanized nanofibers in the commercial composite (SiO 2 /Ag-0.5S) seemed to be promising, especially for its greater inhibition of S. mutans , adequate roughness, and flexural strength, in addition to high hardness, even after aging in water. [ABSTRACT FROM AUTHOR]

Aim: It was analyzed the efficacy of mouthwash and spray containing essential oil (EO) of Cinnamomum zeylanicum Blume for the treatment of oral candidiasis., Methods and Results: A randomized, controlled, and blinded clinical trial was conducted with 36 individuals (probabilistic sample) with oral candidiasis who were divided into two treatment groups: C. zeylanicum (0.5 mg/mL), n = 18; nystatin (100,000IU/mL), n = 18. The efficacy of the products was evaluated by two parameters: (a) clinical evolution recorded by calibrated examiners (Kappa = 0.822) according to Newton's classification and (b) reduction of colony-forming units/mL. Mycological and clinical parameters were analyzed before and at 15 days after treatment. Clinical examination of the mucosa showed that C. zeylanicum (p < 0.0339) and nystatin (p < .0139) had efficacy, resulting in a reduction of signs and symptoms (Mann-Whitney test). Mycological analysis showed that C. zeylanicum caused a reduction of 61% and 33% of Candida spp., isolates oral mucosa and dentures, respectively. Candida tropicalis strains were eliminated after C. zeylanicum, in both sites. The participants reported a pleasant taste and few product-related complaints., Conclusion: C. zeylanicum EO and nystatin exhibited clinical efficacy, according to the Newton classification, and reducing in Candida spp. The clinical trial has been registered (Registration number: NBR-33s6 × 5, ensaiosclinicos.gov.br)., (© 2021 Special Care Dentistry Association and Wiley Periodicals LLC.)

The aim of this study was to develop polymeric nanofibers for controlled administration of Amphotericin B (AmpB), using the solution centrifugation technique, characterizing its microstructural and physical properties, release rate, and activity against Leishmania and Candida species. The core-shell nanofibers incorporated with AmpB were synthesized by Solution Blow Spinning (SBS) and characterized by scanning electron microscopy (SEM), differential scanning calorimetry, X-Ray diffraction, and drug release assay. In vitro leishmanicidal and antifungal activity were also evaluated. Fibrous membranes with uniform morphology and smooth surfaces were produced. The intensity of the diffraction peaks becomes slightly more pronounced, assuming the increased crystallization in PLA/PEG at high AmpB loadings. Drug release occurred and the solutions with nanofibers to encourage greater incorporation of AmpB showed a higher concentration. In the results of the experiment with promastigotes, the wells treated with nanofibers containing concentrations of AmpB at 0.25, 0.5, and 1%, did not have any viable cells, similar to the positive control. Various concentrations of AmpB improved the inhibition of fungal growth. The delivery system based on PLA/PEG nanofibers was properly developed for AmpB, presenting a controlled release and a successful encapsulation, as well as antifungal and antileishmanial activity., (Copyright © 2020 Gonçalves, Rocha, Pires, Muniz, Maciel, de Lima, dos Santos, Batista, de Medeiros, de Medeiros, de Oliveira, Goulart, Bonan and Castellano.)