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Your search keyword '"Liu, Zhi-Qiang"' showing total 1,551 results
Start Over Author "Liu, Zhi-Qiang" Publication Type Academic Journals
1,551 results on '"Liu, Zhi-Qiang"'

28. The interaction of Synapsin 2a and Synaptogyrin-3 regulates fear extinction in mice

Author

Shen, Xi-Ya, Zhang, Juan, Huang, He-Zhou, Li, Shao-Dan, Zhou, Ling, Wu, Shi-Ping, Tang, Cheng, Huang, Xian, Liu, Zhi-Qiang, Guo, Zi-Yuan, Li, Xiang, Man, Heng-Ye, Lu, You-Ming, Zhu, Ling-Qiang, and Liu, Dan

Subjects
Neurons -- Health aspects, Drug approval -- Health aspects, Health care industry
Abstract

The mechanisms behind a lack of efficient fear extinction in some individuals are unclear. Here, by employing a principal components analysis-based approach, we differentiated the mice into extinction- resistant and susceptible groups. We determined that elevated synapsin 2a (Syn2a) in the infralimbic cortex (IL) to basolateral amygdala (BLA) circuit disrupted presynaptic orchestration, leading to an excitatory/inhibitory imbalance in the BLA region and causing extinction resistance. Overexpression or silencing of Syn2a levels in IL neurons replicated or alleviated behavioral, electrophysiological, and biochemical phenotypes in resistant mice. We further identified that the proline-rich domain H in the C-terminus of Syn2a was indispensable for the interaction with synaptogyrin-3 (Syngr3) and demonstrated that disrupting this interaction restored extinction impairments. Molecular docking revealed that ritonavir, an FDA- approved HIV drug, could disrupt Syn2a- Syngr3 binding and rescue fear extinction behavior in Syn2a-elevated mice. In summary, the aberrant elevation of Syn2a expression and its interaction with Syngr3 at the presynaptic site were crucial in fear extinction resistance, suggesting a potential therapeutic avenue for related disorders., Introduction Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric disorder (1) with complicated psychological and neurobiological mechanisms involving varied brain circuits mediating stress and fear responses (2-4), as well as [...]

Published
2024
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31. Clinical and imaging characteristics of children with Dandy-Walker syndrome before and after peritoneal shunt

Author

LIU Zhi-qiang, CHEN Jin-tao, TANG Wen-long, WENG Chao-qun, ZHANG Jin-feng, and LIN Zhi-xiong

Subjects
dandy-walker syndrome, ventriculoperitoneal shunt, magnetic resonance imaging, child, Neurology. Diseases of the nervous system, RC346-429
Abstract

Objective To summarize the clinical and imaging characteristics with Dandy-Walker syndrome (DWS) in children before and after peritoneal shunt. Methods and Results All 6 children with DWS admitted to Fujian Sanbo Funeng Brain Hospital from January 2016 to January 2023 were selected as the objects of observation, including one case of Dandy-Walker malformation (DWM) and 5 cases of Dandy- Walker variant (DWV). Before surgery, the main manifestations were cerebellar vermis defect, upward movement of the tentorial and sinusional area, severe dilatation of the fourth ventricle, posterior cranial fossa cystic lesions, supratentorial ventricle dilatation and hydrocephalus (one case); or cerebellar vermis dysplasia, cerebellar hemisphere compression, the fourth ventricle dilatation, posterior cranial fossa cystic lesions, supratentorial ventricle dilatation and hydrocephalus (5 cases). Right lateral ventriculoperitoneal shunt (2 cases) or posterior cranial fossa cyst-peritoneal shunt (4 cases) were performed, and the operations were successful without surgery - related complications. After 2.31-7.00 years of follow - up, 6 cases of hydrocephalus and posterior cranial fossa cystic malformation were gradually relieved, 3 cases of good prognosis, cerebral hemisphere and cerebellum development, speech, movement and intelligence normal; there were 3 children with general prognosis, including cerebellar disequilibrium symptoms (one case), autism, claustrophobia (one case), and speech, motor and intellectual disorders (one case) complicated with neurocutaneous melanosis. Conclusions The brain structure of the children with DWS presented with hydrocephalus can be well developed after the hydrocephalus is corrected by single shunt. Among them, the cerebellar vermis of the DWV is well developed, while the development of the DWM presented with cerebellar vermis defect needs to be observed in more cases.

Published
2023
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