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Chemical investigation of an extract of the marine sponge Axinyssa sp., collected from the South China Sea, led to the isolation and identification of two new sesquiterpene formamides, (4R*,5R*,10R*)-4-formamidoeudesm-7-ene (1) and (4R*,5R*,7S*,10R*)-4-formamidoeudesman-11-ol (2), together with the known 4α-formamidogorgon-11-ene (3). Their structures were elucidated by spectroscopic methods, including 1D- and 2D-NMR spectroscopy, high-resolution ESI-TOF mass spectrometry, as well as X-ray single-crystal diffraction experiments. Possible biosynthetic pathways for 1–3 were also proposed. The human nasopharyngeal cancer cell line CNE-2, human cervical cancer cell line HeLa, and human normal liver cell line L02 were used to examine the cytotoxic activities of 1–3in vitro. As the results, 1 showed significant cytotoxic activity against CNE-2, HeLa, and L02 cell lines with the IC50 values of 13.8, 7.5, and 38.0 4;μg/ml, resp. [ABSTRACT FROM AUTHOR]

Vermistatin (=(3R)-4,6-dimethoxy-3-{4-oxo-6-[(1E)-prop-1-en-1-yl]-4H-pyran-3-yl}-2-benzofuran-1(3H)-one; 1) and two new vermistatin derivatives, compounds 2 and 3, were isolated from the fungal strain Guignardia sp. No. 4382 obtained from the South-China Sea. Their structures were elucidated by various methods, including circular dichroism (CD), 1D- and 2D-NMR, and HR-EI-MS. The structures of 1 and 2 were unequivocally corroborated by X-ray crystallography, and their absolute configurations were derived by CD spectroscopy based on a literature comparison. The in vitro cytotoxic and antifungal activities of 1 and 2 were tested. [ABSTRACT FROM AUTHOR]

The title compound, C9H10Br2N2O3, was synthesized by chloro­form reaction of glycine methyl ester with 4,5-di­bromo-1-methyl-2-(tri­chloro­acetyl)­pyrrole at room temperature and was obtained in 74.6% yield. The crystal structure was determined by X-ray diffraction. [ABSTRACT FROM AUTHOR]