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New Sesquiterpene Formamides from the Marine Sponge Axinyssa sp.
- Source :
- Helvetica Chimica Acta; Mar2008, Vol. 91 Issue 3, p426-434, 9p
- Publication Year :
- 2008
-
Abstract
- Chemical investigation of an extract of the marine sponge Axinyssa sp., collected from the South China Sea, led to the isolation and identification of two new sesquiterpene formamides, (4R*,5R*,10R*)-4-formamidoeudesm-7-ene (1) and (4R*,5R*,7S*,10R*)-4-formamidoeudesman-11-ol (2), together with the known 4α-formamidogorgon-11-ene (3). Their structures were elucidated by spectroscopic methods, including 1D- and 2D-NMR spectroscopy, high-resolution ESI-TOF mass spectrometry, as well as X-ray single-crystal diffraction experiments. Possible biosynthetic pathways for 1–3 were also proposed. The human nasopharyngeal cancer cell line CNE-2, human cervical cancer cell line HeLa, and human normal liver cell line L02 were used to examine the cytotoxic activities of 1–3in vitro. As the results, 1 showed significant cytotoxic activity against CNE-2, HeLa, and L02 cell lines with the IC50 values of 13.8, 7.5, and 38.0 4;μg/ml, resp. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0018019X
- Volume :
- 91
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Helvetica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 32119660
- Full Text :
- https://doi.org/10.1002/hlca.200890047