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98 results on '"Cyclic ADP-Ribose pharmacology"'

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1. Synthesis and biological evaluation of novel photo-clickable adenosine and cyclic ADP-ribose analogs: 8-N 3 -2'-O-propargyladenosine and 8-N 3 -2'-O-propargyl-cADPR.

2. Probing the Ca 2+ mobilizing properties on primary cortical neurons of a new stable cADPR mimic.

3. CD38 and MGluR1 as possible signaling molecules involved in epileptogenesis: A potential role for NAD + homeostasis.

4. Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients.

5. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury.

6. Variable-Temperature NMR Spectroscopy, Conformational Analysis, and Thermodynamic Parameters of Cyclic Adenosine 5'-Diphosphate Ribose Agonists and Antagonists.

7. Inhibiting the CD38/cADPR pathway protected rats against sepsis associated brain injury.

8. Synthesis of 8-Substituted Analogues of Cyclic ADP-4-Thioribose and Their Unexpected Identification as Ca 2+ -Mobilizing Full Agonists.

9. Discrepancy in calcium release from the sarcoplasmic reticulum and intracellular acidic stores for the protection of the heart against ischemia/reperfusion injury.

10. Design, Synthesis, and Identification of 4″α-Azidoethyl-cyclic ADP-Carbocyclic-ribose as a Highly Potent Analogue of Cyclic ADP-Ribose, a Ca(2+)-Mobilizing Second Messenger.

11. Blocking NAD(+)/CD38/cADPR/Ca(2+) pathway in sepsis prevents organ damage.

12. Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation.

13. Propagation of Intracellular Ca2+ Signals in Aged Exocrine Cells.

14. CD38 mediates the intracellular ATP levels and cell survival of C6 glioma cells.

15. 'Click cyclic ADP-ribose': a neutral second messenger mimic.

16. Identification of a novel pathway of transforming growth factor-β1 regulation by extracellular NAD+ in mouse macrophages: in vitro and in silico studies.

17. Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications.

18. CD38 and its role in oxytocin secretion and social behavior.

19. Aberrant cyclization affords a C-6 modified cyclic adenosine 5'-diphosphoribose analogue with biological activity in Jurkat T cells.

20. NAD(P)H oxidase-dependent intracellular and extracellular O2•- production in coronary arterial myocytes from CD38 knockout mice.

21. Cyclic ADP ribose is a novel regulator of intracellular Ca2+ oscillations in human bone marrow mesenchymal stem cells.

22. Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle.

23. MCP-1-activated monocytes induce apoptosis in human retinal pigment epithelium.

24. Mechanisms of vasopressin-induced intracellular Ca2+ oscillations in rat inner medullary collecting duct.

25. Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel.

26. Intracellular calcium elevation induced by extracellular application of cyclic-ADP-ribose or oxytocin is temperature-sensitive in rodent NG108-15 neuronal cells with or without exogenous expression of human oxytocin receptors.

27. Ca(2+) release induced by cADP-ribose is mediated by FKBP12.6 proteins in mouse bladder smooth muscle.

28. Cyclic ADP-ribose links metabolism to multiple fission in the dinoflagellate Crypthecodinium cohnii.

29. Identification of a chemical probe for NAADP by virtual screening.

30. cADPR stimulates SERCA activity in Xenopus oocytes.

31. Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy.

32. Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils.

33. Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation.

34. 2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives.

35. Chemoenzymatic synthesis of 7-deaza cyclic adenosine 5'-diphosphate ribose analogues, membrane-permeant modulators of intracellular calcium release.

36. Cyclic ADP-ribose mediates formyl methionyl leucyl phenylalanine (fMLP)-induced intracellular Ca(2+) rise and migration of human neutrophils.

37. Regulation of store-operated Ca2+ entry by CD38 in human airway smooth muscle.

38. Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus.

39. Regulation of TRPM2 by extra- and intracellular calcium.

40. Composition of sea urchin egg homogenate determines its potency to inositol trisphosphate and cyclic ADPRibose-induced Ca2+ release.

41. Nitric oxide regulates growth cone filopodial dynamics via ryanodine receptor-mediated calcium release.

42. Dual effects of cyclic ADP-ribose on sarcoplasmic reticulum Ca2+ release and storage in cardiac myocytes isolated from guinea-pig and rat ventricle.

43. Role of cADPR in sodium nitroprusside-induced opossum esophageal longitudinal smooth muscle contraction.

44. Enhancement of Ca2+-induced Ca2+ release by cyclic ADP-ribose in frog motor nerve terminals.

45. Fertilization causes a single Ca2+ increase that fully depends on Ca2+ influx in oocytes of limpets (Phylum Mollusca, Class Gastropoda).

46. Substitution at the 8-position of 3''-deoxy-cyclic ADP-carbocyclic-ribose, a highly potent Ca2+-mobilizing agent, provides partial agonists.

47. Design, synthesis, and biological activity of carbocyclic analogues of cyclic ADP-ribose, a Ca2+-mobilizing second messenger.

48. Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives.

49. Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains.

50. FK506 induces biphasic Ca2+ release from microsomal vesicles of rat pancreatic acinar cells.

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