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'Click cyclic ADP-ribose': a neutral second messenger mimic.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2014 Mar 07; Vol. 50 (19), pp. 2458-61. Date of Electronic Publication: 2014 Jan 23. - Publication Year :
- 2014
-
Abstract
- Analogues of the potent Ca(2+) releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca(2+) release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 50
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 24452494
- Full Text :
- https://doi.org/10.1039/c3cc49249d