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We describe an experiment that explores the contribution of auditory and other features to the illusion of plausibility in a virtual environment that depicts the performance of a string quartet. 'Plausibility' refers to the component of presence that is the illusion that the perceived events in the virtual environment are really happening. The features studied were: Gaze (the musicians ignored the participant, the musicians sometimes looked towards and followed the participant's movements), Sound Spatialization (Mono, Stereo, Spatial), Auralization (no sound reflections, reflections corresponding to a room larger than the one perceived, reflections that exactly matched the virtual room), and Environment (no sound from outside of the room, birdsong and wind corresponding to the outside scene). We adopted the methodology based on color matching theory, where 20 participants were first able to assess their feeling of plausibility in the environment with each of the four features at their highest setting. Then five times participants started from a low setting on all features and were able to make transitions from one system configuration to another until they matched their original feeling of plausibility. From these transitions a Markov transition matrix was constructed, and also probabilities of a match conditional on feature configuration. The results show that Environment and Gaze were individually the most important factors influencing the level of plausibility. The highest probability transitions were to improve Environment and Gaze, and then Auralization and Spatialization. We present this work as both a contribution to the methodology of assessing presence without questionnaires, and showing how various aspects of a musical performance can influence plausibility.

Music is a potent mood regulator that can induce relaxation and reduce anxiety in different situations. While several studies demonstrate that certain types of music have a subjective anxiolytic effect, the reported results from physiological responses are less conclusive. Virtual reality allows us to study diverse scenarios of real life under strict experimental control while preserving high ecological validity. We aimed to study the modulating effect of music on the anxiety responses triggered by an immersive virtual reality scenario designed to induce fear of heights. Subjects experienced a virtual scenario depicting an exterior elevator platform ascending and descending the total height of its 350 meters tall supporting structure. Participants were allocated to either a group that experienced the elevator ride with background music or without, in a between-groups design. Furthermore, each group included participants with different degrees of fear of heights, ranging from low to high fear. Recordings of heart rate, galvanic skin response, body balance, and head movements were obtained during the experiments. Subjective anxiety was measured by means of three questionnaires. The scenario produced significant changes in subjective and physiological measures, confirming its efficacy as a stressor. A significant increase in state anxiety was found between pre and post-assessment in the silence group, but not in the music group, indicating that post-stress recovery was faster in the musical group. Results suggest that music can ameliorate the subjective anxiety produced by fear of heights.

Background/Objectives: Gait retraining is widely used in orthopedic rehabilitation to address abnormal movement patterns. However, retaining walking modifications can be challenging without guidance from physical therapists. Real-time auditory biofeedback can help patients learn and maintain gait alterations. This study piloted the feasibility of the musification of feedback to medialize the center of pressure (COP). Methods: To provide musical feedback, COP and plantar pressure were captured in real time at 100 Hz from a wireless 16-sensor pressure insole. Twenty healthy subjects (29 ± 5 years old, 75.9 ± 10.5 Kg, 1.73 ± 0.07 m) were recruited to walk using this system and were further analyzed via marker-based motion capture. A lowpass filter muffled a pre-selected music playlist when the real-time center of pressure exceeded a predetermined lateral threshold. The only instruction participants received was to adjust their walking to avoid the muffling of the music. Results: All participants significantly medialized their COP (−9.38% ± 4.37, range −2.3% to −19%), guided solely by musical feedback. Participants were still able to reproduce this new walking pattern when the musical feedback was removed. Importantly, no significant changes in cadence or walking speed were observed. The results from a survey showed that subjects enjoyed using the system and suggested that they would adopt such a system for rehabilitation. Conclusions: This study highlights the potential of musical feedback for orthopedic rehabilitation. In the future, a portable system will allow patients to train at home, while clinicians could track their progress remotely through cloud-enabled telemetric health data monitoring. [ABSTRACT FROM AUTHOR]

Sense of body ownership has been studied using rubber hand illusion (RHI) and full-body illusion (FBI). It has recently become clear that consciously interpreting a fake body as one's own in a top-down manner influences these body illusions. Furthermore, a study interestingly found that the influence of top-down interpretation was moderated by the degree of depersonalization, which was a symptom of a lack of sense of body ownership. In a case study on depersonalization, the top-down interpretation of one's body was suggested to be a negative physical state that made it difficult to feel a sense of body ownership. However, this has not been examined. We examined the influence of negative top-down interpretation using an FBI procedure. A fake body was instructed to be viewed as a negative self-body ("view the virtual body's back while regarding the virtual body as your own experiencing abdominal pain"). To examine the influence of a negative top-down interpretation, participants were instructed to interpret the body as their own (neutral self-body) as a control condition. We used skin conductance responses to a fearful stimulus presented after an illusion procedure to measure the degree of FBI experienced. Results indicated a significant difference in the skin conductance response between the synchronous and asynchronous presentation of visual-tactile stimuli in the control condition, which confirmed the occurrence of the illusion. However, the occurrence of the illusion was not confirmed when the participants were instructed to interpret the virtual body as their own in a negative physical state, and the degree of FBI was smaller than the control condition. Our finding that an FBI was inhibited by manipulation of the top-down interpretation suggested that it could be a factor that inhibited the creation of a sense of body ownership. [ABSTRACT FROM AUTHOR]

Age-induced alterations in human immunity are often considered deleterious and are referred to as immunosenescence. The immune system monitors the number of senescent cells in the body, while immunosenescence may represent the initiation of systemic aging. Immune cells, particularly T cells, are the most impacted and involved in age-related immune function deterioration, making older individuals more prone to different age-related diseases. T-cell senescence can impact the effectiveness of immunotherapies that rely on the immune system's function, including vaccines and adoptive T-cell therapies. The research and practice of using senescent T cells as therapeutic targets to intervene in age-related diseases are in their nascent stages. Therefore, in this review, we summarize recent related literature to investigate the characteristics of senescent T cells as well as their formation mechanisms, relationship with various aging-related diseases, and means of intervention. The primary objective of this article is to explore the prospects and possibilities of therapeutically targeting senescent T cells, serving as a valuable resource for the development of immunotherapy and treatment of age-related diseases. [ABSTRACT FROM AUTHOR]

Simulating the experience of flight is a key objective of virtual reality (VR) technology. To enhance the sense of flying and immersion, we developed Drone Rider, a VR system that simulates free-flight atop a drone. In this study, we investigated whether delivering vibratory stimuli to the user's feet could improve these sensations. While high-frequency drone propeller vibrations typically induce sensory numbness, alternative vibration patterns were explored. In Experiment 1, participants rated 13 different vibration patterns derived from various mechanical sounds, such as those from chainsaws, motorcycles, and washing machines. The motorcycle-based vibrations were most effective in enhancing both the sense of flight and immersion. In Experiment 2, we synthesized new vibration patterns by superimposing the highest-rated vibrations from Experiment 1, but no combination outperformed the original motorcycle vibration. These findings suggest that vibrations with multiple components below 100 Hz may reduce sensory adaptation and enhance the sense of flight and immersion in VR. This work provides valuable insights for developers aiming to optimize haptic feedback in VR flight simulators. [ABSTRACT FROM AUTHOR]

Humans' sense of the passage of time is subjective and determined by psychophysiological responses to the environment. The passing of time has been perceived to significantly slow in stressful situations, such as accidents or virtual threats. The current study will explore distortions in the perception of passage of time when threat is simulated using virtual reality (VR). 44 participants negotiated a large (13.6 × 8.4 m) virtual environment designed to maximise the realism of a physical threat by exposing participants to a virtual height of 200m. Subjective perception of passage of time and time estimation were used as independent variables, whereas the movement of participants, and ambulatory psychophysiology, e.g., electrodermal activity (EDA), heart rate, served as dependent variables. The independent variables were examined in relation to the dependent variables through a regression analysis, which allowed for the identification of the specific weight of each variable. Our analyses revealed that passage of time was perceived to decrease (i.e., time slowed down) for those participants who exhibited the higher levels of skin conductance (SCL). It is argued that this finding can be explained by individual differences in self-regulatory strategies during the task and the effectiveness of VR as means to simulate threat. [ABSTRACT FROM AUTHOR]

Studies on the potential benefits of conveying biofeedback stimulus using a musical signal have appeared in recent years with the intent of harnessing the strong effects that music listening may have on subjects. While results are encouraging, the fundamental question has yet to be addressed, of how combined music and biofeedback compares to the already established use of either of these elements separately. This experiment, involving young adults (N = 24), compared the effectiveness at modulating participants' states of physiological arousal of each of the following conditions: A) listening to pre-recorded music, B) sonification biofeedback of the heart rate, and C) an algorithmically modulated musical feedback signal conveying the subject's heart rate. Our hypothesis was that each of the conditions (A), (B) and (C) would differ from the other two in the extent to which it enables participants to increase and decrease their state of physiological arousal, with (C) being more effective than (B), and both more than (A). Several physiological measures and qualitative responses were recorded and analyzed. Results show that using musical biofeedback allowed participants to modulate their state of physiological arousal at least equally well as sonification biofeedback, and much better than just listening to music, as reflected in their heart rate measurements, controlling for respiration-rate. Our findings indicate that the known effects of music in modulating arousal can therefore be beneficially harnessed when designing a biofeedback protocol., (Copyright © 2013 Elsevier B.V. All rights reserved.)

It has been shown that it is possible to generate perceptual illusions of ownership in immersive virtual reality (IVR) over a virtual body seen from first person perspective, in other words over a body that visually substitutes the person's real body. This can occur even when the virtual body is quite different in appearance from the person's real body. However, investigation of the psychological, behavioral and attitudinal consequences of such body transformations remains an interesting problem with much to be discovered. Thirty six Caucasian people participated in a between-groups experiment where they played a West-African Djembe hand drum while immersed in IVR and with a virtual body that substituted their own. The virtual hand drum was registered with a physical drum. They were alongside a virtual character that played a drum in a supporting, accompanying role. In a baseline condition participants were represented only by plainly shaded white hands, so that they were able merely to play. In the experimental condition they were represented either by a casually dressed dark-skinned virtual body (Casual Dark-Skinned - CD) or by a formal suited light-skinned body (Formal Light-Skinned - FL). Although participants of both groups experienced a strong body ownership illusion towards the virtual body, only those with the CD representation showed significant increases in their movement patterns for drumming compared to the baseline condition and compared with those embodied in the FL body. Moreover, the stronger the illusion of body ownership in the CD condition, the greater this behavioral change. A path analysis showed that the observed behavioral changes were a function of the strength of the illusion of body ownership towards the virtual body and its perceived appropriateness for the drumming task. These results demonstrate that full body ownership illusions can lead to substantial behavioral and possibly cognitive changes depending on the appearance of the virtual body. This could be important for many applications such as learning, education, training, psychotherapy and rehabilitation using IVR.

FAM20C, a member of the family with sequence similarity 20, is involved in many physiological functions. Obesity, characterized by excessive accumulation of adipose tissue, has attracted more and more attention as a worldwide health problem. Here we generated adipocyte‐specific FAM20C knockout mice to investigate the role of FAM20C in adipose tissue expansion and obesity. Our results demonstrate that knockout mice are protected against high fat diet‐induced obesity, adiposity, and fatty liver disease. Additionally, knockout mice exhibited improved metabolic phenotypes, including enhanced glucose tolerance and insulin sensitivity compared with control mice. Furthermore, we observed reduced inflammatory infiltration and collagen deposition in the adipose tissues of knockout mice. Taken together, our results indicate that targeting FAM20C in adipocytes may be a promising strategy for the treatment of obesity and associated metabolic disorders. [ABSTRACT FROM AUTHOR]

The metaverse offers new technological possibilities for conducting 3D immersive meetings with head-mounted displays that can enrich virtual teamwork. To conceptualize this new interaction space, we synthesize interdisciplinary findings from human-computer interaction literature, group research, and meeting science. We develop a conceptual framework of 3D immersive group meetings that integrates technological design characteristics, subjective attendee experiences, mediating mechanisms, and meeting outcomes. As a first empirical glimpse into this framework, we include a pilot study of group member's self-reported experiences and observed group dynamics in the metaverse. Building on our framework and first empirical insights, we discuss implications for future investigations of group dynamics in the metaverse. [ABSTRACT FROM AUTHOR]

In virtual reality (VR), users can embody a wide variety of avatars, fromdigital replicas of themselves through diverse human body styles and appearances to non-humanoid representations. Although choosing a body to inhabit is part of what makes VR such an engaging experience, various studies have shown how embodiment may change the way we perceive ourselves and others both inside and outside VR. In our study, we explored whether first-person versus third-person avatar customization would lead to changes in embodiment. Furthermore, participants were embodied in larger-sized avatars based on the hypothesis that embodiment would lead to a change in implicit bias toward larger-sized people. Our results show that third-person avatar customization led to a decrease in the perceived embodiment of the larger-sized avatar and that, on the contrary, higher embodiment was associated with a reduction in implicit biases toward larger-sized people in the first-person avatar customization mode. These findings suggest that third-person avatar customization leads to reduced feelings of embodiment, while first-person avatar customization may support more radical body changes. [ABSTRACT FROM AUTHOR]

The article is a book review of David Chalmers' "Reality+: Virtual Worlds and the Problems of Philosophy." It praises the book's inclusive approach to philosophy and its exploration of virtual reality. However, it criticizes the book for not delving into the practical aspects of current VR technology and suggests that philosophers and technologists should collaborate to address philosophical questions in existing VR systems. The article emphasizes the importance of considering software and hardware development, socio-political environments, and ethical concerns in virtual spaces. It concludes that the book may be interesting for general readers but lacks depth for specialists. [Extracted from the article]

The multifaceted nature of body experience, encompassing affective, cognitive, and perceptual components, plays a critical role in the development and persistence of conditions such as anorexia nervosa (AN). Recent research attempted to address such disturbance to improve therapeutical effectiveness, using mirror exposure (ME) and body‐swapping (BS) techniques in immersive virtual reality (VR). Procedures from a third‐person perspective—as mirror‐like experiences—were primarily used to address bodily cognitive and affective components, whereas first‐person ones—as BS—were used to correct distorted body perception. This study investigated the effect of spatial reference frame on body self‐consciousness and body perception during BS. Data revealed two main findings: Even though embodiment was significantly enhanced when participants engaged with a virtual body from a first‐person viewpoint, both egocentric and allocentric perspectives influenced body size estimation (BSE), suggesting that both spatial perspectives critically form and sustain body self‐perception. We discussed predictive coding theory to explain spatial perspective influence on body experience, highlighting the potential therapeutic benefits of incorporating first and third‐person perspectives on body illusions (BIs) for more effective interventions targeting body‐related disturbances. [ABSTRACT FROM AUTHOR]

Glucocorticoids (GC) and parathyroid hormone (PTH) are widely used therapeutic endocrine hormones where their effects on bone and joint arise from actions on multiple skeletal cell types. In osteocytes, GC and PTH exert opposing effects on perilacunar canalicular remodeling (PLR). Suppressed PLR can impair bone quality and joint homeostasis, including in GC-induced osteonecrosis. However, combined effects of GC and PTH on PLR are unknown. Given the untapped potential to target osteocytes to improve skeletal health, this study sought to test the feasibility of therapeutically mitigating PLR suppression. Focusing on subchondral bone and joint homeostasis, we hypothesize that PTH(1-34), a PLR agonist, could rescue GC-suppressed PLR. The skeletal effects of GC and PTH(1-34), alone or combined, were examined in male and female mice by microcomputed tomography, mechanical testing, histology, and gene expression analysis. For each outcome, females were more responsive to GC and PTH(1-34) than males. GC and PTH(1-34) exerted regional differences, with GC increasing trabecular bone volume but reducing cortical bone thickness, stiffness, and ultimate force. Despite PTH(1-34)'s anabolic effects on trabecular bone, it did not rescue GC's catabolic effects on cortical bone. Likewise, cartilage integrity and subchondral bone apoptosis, tartrate-resistant acid phosphatase (TRAP) activity, and osteocyte lacunocanalicular networks showed no evidence that PTH(1-34) could offset GCdependent effects. Rather, GC and PTH(1-34) each increased cortical bone gene expression implicated in bone resorption by osteoclasts and osteocytes, including Acp5, Mmp13, Atp6v0d2, Ctsk, differences maintained when GC and PTH(1-34) were combined. Since PTH(1-34) is insufficient to rescue GC's effects on young female mouse bone, future studies are needed to determine if osteocyte PLR suppression, due to GC, aging, or other factors, can be offset by a PLR agonist. [ABSTRACT FROM AUTHOR]

Introduction: This study aims to assess the efficacy of traditional virtual reality (VR) and Immersive Multi-sensory Environments (IME) in mitigating anxiety levels among university students. The study can address the following research questions: 1) What disparities exist in anxiety levels before and after exposure to traditional VR and IME? 2) How do anxiety levels compare between participants exposed to IME and those in a VR environment? Methods: The research adopted a twophase approach involving participants exhibiting moderate to high-stress levels. In the second phase, participants were randomly assigned to either a VR group (solely visual stimulation) or an IME group (comprising visual, auditory, and olfactory stimuli). The State-Trait Anxiety Inventory (STAI) were utilized to assess stress and anxiety levels before and after each experiment. Results: The findings suggest that participants' experiences in both VR and IME environments effectively contributed to reducing anxiety levels and fostering a tranquil atmosphere. Both experimental groups reported a significantly heightened sense of relaxation post-experiments. Although the disparity was not statistically significant, the IME group displayed a more pronounced reduction in stress levels compared to the VR group. Discussion: The research underscores the significance of considering the built environment and sensory design in addressing mental health challenges among college students. Further exploration and integration of such approaches into educational settings could significantly contribute to establishing more supportive and conducive environments for student success. [ABSTRACT FROM AUTHOR]

Humans' inherent fascination for stories can be observed throughout most of our documented history. If, for a long time, narratives were told through paintings, songs, or literature, recent technological advances such as immersive virtual reality have made it possible for us to interact with storylines and characters in a completely new manner. With these new technologies came the need to study how people interact with them and how they affect their users. Notably, research in this area has revealed that users of virtual environments tend to display behaviors/attitudes that are congruent with the appearance of the avatars they embody; a phenomenon termed the Proteus effect. Since its introduction in the literature, many studies have demonstrated the Proteus effect in various contexts, attesting to the robustness of the effect. However, beyond the first articles on the subject, very few studies have sought to investigate the social, affective, and cognitive mechanisms underlying the effect. Furthermore, the current literature appears somewhat disjointed with different schools of thought, using different methodologies, contributing to this research topic. Therefore, this work aims to give an overview of the current state of the literature and its shortcomings. It also presents a critical analysis of multiple theoretical frameworks that may help explain the Proteus effect. Notably, this work challenges the use of self-perception theory to explain the Proteus effect and considers other approaches from social psychology. Finally, we present new perspectives for upcoming research that seeks to investigate the effect of avatars on user behavior. All in all, this work aims to bring more clarity to an increasingly popular research subject and, more generally, to contribute to a better understanding of the interactions between humans and virtual environments. [ABSTRACT FROM AUTHOR]

Copyright of Iraq Journal of Market Research & Consumer Protection / Al-Mağallaẗ al-ʿIrāqiyyaẗ li-Buḥūṯ al-Sūq wa-Ḥimāyaẗ al-Mustahlik is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Inflammasomes comprise a group of protein complexes with fundamental roles in the induction of inflammation. Upon sensing stress factors, their assembly induces the activation and release of the pro-inflammatory cytokines interleukin (IL)-1β and -18 and a lytic type of cell death, termed pyroptosis. Recently, CARD8 has joined the group of inflammasome sensors. The carboxy-terminal part of CARD8, consisting of a function-to-find-domain (FIIND) and a caspase activation and recruitment domain (CARD), resembles that of NLR family pyrin domain containing 1 (NLRP1), which is recognized as the main inflammasome sensor in human keratinocytes. The interaction with dipeptidyl peptidases 8 and 9 (DPP8/9) represents an activation checkpoint for both sensors. CARD8 and NLRP1 are activated by viral protease activity targeting their amino-terminal region. However, CARD8 also has some unique features compared to the established inflammasome sensors. Activation of CARD8 occurs independently of the inflammasome adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC), leading mainly to pyroptosis rather than the activation and secretion of pro-inflammatory cytokines. CARD8 was also shown to have anti-inflammatory and anti-apoptotic activity. It interacts with, and inhibits, several proteins involved in inflammation and cell death, such as the inflammasome sensor NLRP3, CARD-containing proteins caspase-1 and -9, nucleotide-binding oligomerization domain containing 2 (NOD2), or nuclear factor kappa B (NF-κB). Single nucleotide polymorphisms (SNPs) of CARD8, some of them occurring at high frequencies, are associated with various inflammatory diseases. The molecular mechanisms underlying the different pro- and anti-inflammatory activities of CARD8 are incompletely understood. Alternative splicing leads to the generation of multiple CARD8 protein isoforms. Although the functional properties of these isoforms are poorly characterized, there is evidence that suggests isoform-specific roles. The characterization of the functions of these isoforms, together with their cell- and disease-specific expression, might be the key to a better understanding of CARD8's different roles in inflammation and inflammatory diseases. [ABSTRACT FROM AUTHOR]

Isomeric decays with multipolarity λ ≥ 3 are discussed. Parity changing E3, M4, E5 decays are more widespread within the nuclide chart when compared to parity conserving M3, E4 and M5 transitions, which is the consequence of the properties of the nuclear shell model. The E3 transitions around 208 Pb are classified depending on their origins. Systematics of M4 and E5 transitions are presented. These provide an excellent test to the study of shell evolution in different parts of the nuclide chart as well as the nature of the effective charges. [ABSTRACT FROM AUTHOR]

Power semiconductor device architectures require the inclusion of a diffusion barrier to suppress or at best prevent the interdiffusion between the copper metallization interconnects and the surrounding silicon substructure. The binary pseudo-alloy of titanium–tungsten (TiW), with >70 at. % W, is a well-established copper diffusion barrier but is prone to degradation via the out-diffusion of titanium when exposed to high temperatures (≥ 400 ° C). Here, the thermal stability of physical vapor deposited TiW/Cu bilayer thin films in Si/SiO 2 (50 nm)/TiW(300 nm)/Cu(25 nm) stacks were characterized in response to annealing at 400 ° C for 0.5 h and 5 h, using a combination of soft and hard x-ray photoelectron spectroscopy and transmission electron microscopy. Results show that annealing promoted the segregation of titanium out of the TiW and interdiffusion into the copper metallization. Titanium was shown to be driven toward the free copper surface, accumulating there and forming a titanium oxide overlayer upon exposure to air. Annealing for longer timescales promoted a greater out-diffusion of titanium and a thicker oxide layer to grow on the copper surface. However, interface measurements suggest that the diffusion is not significant enough to compromise the barrier integrity, and the TiW/Cu interface remains stable even after 5 h of annealing. [ABSTRACT FROM AUTHOR]

Purpose: A noninvasive method for evaluating the infiltration of CD8 + T cells in tumors is urgently needed to monitor the response to immunotherapy. This study investigated the performance of a [ 68 Ga]Ga-NODAGA-SNA006 in positron emission tomography (PET) imaging of CD8 + T cells in patients with solid malignancies., Methods: This human dose-escalation PET imaging study involved eleven patients (lung cancer, 8; gastric carcinoma, 1; esophageal carcinoma, 2). Approximately 150 MBq of [ 68 Ga]Ga-NODAGA-SNA006 with varying nanobody masses (100 µg, 300 µg, 500 µg, 800 µg) was administered, and PET/computed tomography (CT) scans were performed at 15-30, 60-90 and 120 min postinjection (p.i.). Data regarding biodistribution, pharmacokinetics and radiation dosimetry were evaluated. CD8 + T-cell infiltration in biopsy samples was also measured via immunohistochemistry (IHC) for correlation analysis with the tumor uptake of [ 68 Ga]Ga-NODAGA-SNA006 PET., Results: [ 68 Ga]Ga-NODAGA-SNA006 was well tolerated by all eleven subjects. The highest radioactive uptake was observed in the spleen, followed by the kidneys and bladder. Liver uptake decreased with increasing nanobody mass. Rapid clearance (t 1/2 <30 min) of [ 68 Ga]Ga-NODAGA-SNA006 from whole blood and serum was observed. Furthermore, 68 Ga uptake in tumors (SUVmean) exhibited a linear relationship with CD8 + T-cell infiltration in biopsy samples (R 2  = 0.757, p = 0.011), suggesting that the tumor uptake of [ 68 Ga]Ga-NODAGA-SNA006 may represent the degree of CD8 + T-cell infiltration in the tumor., Conclusion: The use of [ 68 Ga]Ga-NODAGA-SNA006 is safe, feasible, and well tolerated. [ 68 Ga]Ga-NONAGA-SNA006 PET imaging can accurately detect CD8 expression inside tumors with favorable pharmacokinetics, thus providing a feasible method for noninvasive quantitative assessment of CD8 + T-cell tumor infiltration and monitoring the response to immunotherapy., Trial Registration: NCT05126927 (19 November 2021, retrospectively registered)., Competing Interests: Declarations. Compliance with ethical standards: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the Helsinki Declaration. This study was approved by the Research Ethics Board of the First Affiliated Hospital of Soochow University (Date: October 12, 2021/No:288) and all patients signed a written informed consent form before study participation (ClinicalTrials.gov identifier NCT05126927). Consent to participate: All participants involved in the study provided written informed consent. Competing interests: The authors have no relevant financial or non-financial interests to disclose., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Atherosclerosis poses a significant threat to human health, impacting overall well-being and imposing substantial financial burdens. Current treatment strategies mainly focus on managing low-density lipids (LDL) and optimizing liver functions. However, it's crucial to recognize that Atherosclerosis involves more than just lipid accumulation; it entails a complex interplay of immune responses. Research highlights the pivotal role of lipid-laden macrophages in the formation of atherosclerotic plaques. These macrophages attract lymphocytes like CD4 and CD8 to the inflamed site, potentially intensifying the inflammatory response. γδ T lymphocytes, with their diverse functions in innate and adaptive immune responses, pathogen defense, antigen presentation, and inflammation regulation, have been implicated in the early stages of Atherosclerosis. However, our understanding of the roles of γδ T cells in Atherosclerosis remains limited. This mini-review aims to shed light on the characteristics and functions of γδ T cells in Atherosclerosis. By gaining insights into the roles of γδ T cells, we may uncover a promising strategy to mitigate plaque buildup and dampen the inflammatory response, thereby opening new avenues for effectively managing this condition. [ABSTRACT FROM AUTHOR]

The phenomenon of one's walking speed being affected by that of other pedestrians on the street is often observed in real-world scenarios. However, the effects of the motion and familiarity of avatars on a user in virtual reality have not been thoroughly investigated. Therefore, this study explored how alterations in human avatars affect the walking speed and sensation of users. Furthermore, walking speed has been shown to be influenced not only by visual perception but also by cognition. However, few studies have investigated the relationships between visual perception, cognition, and behavior. Therefore, we examined the relationships between stereotypical words for older people, a representative example of cognition-induced changes in walking speed, and visual perception stimuli of avatars. The results revealed a significant interaction between the stereotype and avatar walking motion. In particular, in the absence of the stereotype, participants were strongly affected by the older walking motion of the avatar, and their walking speed decreased. We also found that the walking motion of avatars significantly affects participants walking speed and sensation. These findings provide pioneering insights into the psychological factors that regulate human walking speed and propose a new method for manipulating the user's walking speed and sensation in VR space. [ABSTRACT FROM AUTHOR]

As a typical application of human–machine fusion intelligence, the exoskeleton is an indispensable intelligent interaction device for virtual reality. At present, there are an increasing number of studies on virtual reality systems using exoskeleton technology, especially in the field of medical rehabilitation. In this paper, for the first time, a virtual reality system with the application of exoskeleton technology is considered as the research object. We refer to three key human–machine interaction processes: recognition, perception, and feedback. The virtual reality system that uses exoskeleton technology is divided into positioning technology, multisensory interaction, and feedback technology. First, this study conducts literature research and then summarizes the technical characteristics, system architecture, and research status for key content such as positioning technology, multisensory interaction, and feedback technology. Finally, the three research aspects of the virtual reality system applying exoskeleton technology are summarized, considered, and prospected. [ABSTRACT FROM AUTHOR]

Objective: Occlusal stabilization splints (OSSs) are first-line therapy for temporomandibular disorder (TMD) and sleep-related-bruxism (SRB). The main goal of this study was to quantify adherence rates to OSS therapy in TMD patients and among non-painful conditions such as clenching and bruxism. It was hypothesized that adherence rates would be similar to those for other chronic conditions. Method and materials: Medical records of 99 patients seen in the Orofacial Pain Clinic between 2006 and 2014 were reviewed. Patients meeting the inclusion criteria were interviewed over the telephone regarding OSS adherence. Results: Of the 99 patients interviewed, 80 had chronic orofacial pain related to TMD and 19 received OSS due to (non-painful) SRB. Patients were divided according to usage; the USER group (58 patients, 58.6%) used their OSS for more than 1 year; the NUSE group was the remaining 41 (41.4%) patients who used their device for less than 1 year. Of the patients with pain as the reason for OSS use, 50 (62.5%) were in the USER group and 30 (37.5%) were in the NUSE group. The most common diagnosis was masticatory muscle disorders (MMD) with a 71.4% adherence rate, representing 60.3% of the USER group, which was significantly higher than those with SRB and other facial pain (P = .039). The most common reasons for non-adherence were sleep difficulties with OSS (31.6%) and resolution of the problem (25%). Conclusions: Patients reporting mild to major pain reduction had higher adherence rates than those with complete pain relief or none at all. Patients with MMD exhibited higher adherence rates than those with other facial pain types and SRB. [ABSTRACT FROM AUTHOR]

The use of virtual reality (VR) has seen significant recent growth and presents opportunities for use in many domain areas. The use of head-mounted displays (HMDs) also presents unique opportunities for the implementation of audio feedback congruent with head and body movements, thus matching intuitive expectations. However, the use of audio in VR is still undervalued and there is a lack of consistency within audio-centedd research in VR. To address this shortcoming and present an overview of this area of research, we conducted a scoping review (n = 121) focusing on the use of audio in HMD-based VR and its effects on user/player experience. Results show a lack of standardisation for common measures such as pleasantness and emphasize the context-specific ability of audio to influence a variety of affective, cognitive, and motivational measures, but are mixed for presence and generally lacking for social experiences and descriptive research. [ABSTRACT FROM AUTHOR]

Water quality improvements in shallow eutrophic lakes are commonly delayed due to loading from legacy phosphorus (P)‐enriched sediments, even with reduced external nutrient loads. It is critical to understand the drivers of internal P loading to suppress or remove this source of P and meet water quality goals. We contrast the drivers of internal P loading in two shallow eutrophic systems (Lake Carmi and Missisquoi Bay). Legacy P dynamics in the unmanipulated systems were compared to Lake Carmi during aeration. In‐situ high frequency water column monitoring along with water and sediment sampling was used to study P dynamics in response to changing lake conditions and aeration. Despite both systems exhibiting P mobility controlled by iron redox cycling, we observed distinct differences in the spatial extent and drivers of internal P loading. Legacy P loading was controlled by seasonal drivers in Lake Carmi, but by spatially variable and highly transient wind driven forcing of hydrodynamics in Missisquoi Bay. Aeration altered the mixing regime of Lake Carmi and shifted loading dynamics to frequent wind‐driven pulses of legacy P to surface waters akin to those of Missisquoi Bay. Mean hypolimnetic dissolved oxygen increased with aeration, but greater oxygen demand rates and periods of anoxia under transient stratification still resulted in internal P loading. Surface P concentrations were higher in summer months with aeration compared to previous years. This research illustrates the dynamic nature of legacy P behavior within and between shallow eutrophic lakes and the challenges in addressing this common water resources threat. Plain Language Summary: Shallow lakes with high amounts of nutrients like phosphorus often experience worsening water quality and harmful algae blooms. Even if less phosphorus enters the lake from the watershed, phosphorus already in the lake can cycle between the water and sediment for decades. It is important to understand how phosphorus moves within lakes to make management decisions. We studied what causes the release of phosphorus from sediment in Lake Carmi and Missisquoi Bay, Lake Champlain. These observations were compared to Lake Carmi during 4 years of whole‐lake aeration designed to limit phosphorus release. We found that the release of phosphorus at both study sites was tied to chemical reactions of iron. The timing of this release was controlled by seasonal changes in Lake Carmi before aeration, and by frequent wind‐driven mixing in Missisquoi Bay. Aeration changed the timing of mixing in Lake Carmi but did not decrease the amount of phosphorus recycled from the sediment. Aeration also increased the rate of oxygen consumption in Lake Carmi which quickly led to phosphorus release during periods of calm wind. This research shows the highly dynamic nature of phosphorus behavior within shallow lakes which is important to understand when making management decisions. Key Points: Legacy phosphorus mobility was driven by either episodic wind‐mediated mixing or seasonal turnover in two proximal shallow eutrophic systemsAeration altered hydrodynamics to change from seasonal to wind‐driven internal loading of legacy phosphorus, but it was not suppressedHeterogeneous spatiotemporal controls on internal legacy phosphorus loading present challenges to achieving water quality goals [ABSTRACT FROM AUTHOR]

The sense of embodiment refers to the sensations of being inside, having, and controlling a body. In virtual reality, it is possible to substitute a person's body with a virtual body, referred to as an avatar. Modulations of the sense of embodiment through modifications of this avatar have perceptual and behavioural consequences on users that can influence the way users interact with the virtual environment. Therefore, it is essential to define metrics that enable a reliable assessment of the sense of embodiment in virtual reality to better understand its dimensions, the way they interact, and their influence on the quality of interaction in the virtual environment. In this review, we first introduce the current knowledge on the sense of embodiment, its dimensions (senses of agency, body ownership, and self-location), and how they relate the ones with the others. Then, we dive into the different methods currently used to assess the sense of embodiment, ranging from questionnaires to neurophysiological measures. We provide a critical analysis of the existing metrics, discussing their advantages and drawbacks in the context of virtual reality. Notably, we argue that real-time measures of embodiment, which are also specific and do not require double tasking, are the most relevant in the context of virtual reality. Electroencephalography seems a good candidate for the future if its drawbacks (such as its sensitivity to movement and practicality) are improved. While the perfect metric has yet to be identified if it exists, this work provides clues on which metric to choose depending on the context, which should hopefully contribute to better assessing and understanding the sense of embodiment in virtual reality. [ABSTRACT FROM AUTHOR]

Background: Adolescent idiopathic scoliosis (AIS) is often accompanied by osteopenia and osteoporosis, which can cause serious complications. The aim of this study was to determine the specific bone mineral density (BMD) of each vertebral body in patients with AIS using biomechanical finite element modeling based on three-dimensional (3D) reconstruction. Methods: This retrospective study involved 56 patients with AIS. Computed tomography (CT) and radiography were performed. Spinal vertebrae were segmented from the spinal CT images of patients with AIS to reconstruct 3D vertebral models. The vertebral models were meshed into tetrahedral finite elements to assess the BMD. Results: The mean main curve Cobb angle was 88.6 ± 36.7°, and the mean kyphosis angle was 36.8 ± 31.5°. The mean BMD of the global spine was 0.83 ± 0.15 g/cm2. The highest BMD was measured on the concave side of the apex (0.98 ± 0.16 g/cm2). Apical vertebral BMD was negatively correlated with age and height (r = − 0.490, p = 0.009 and r = − 0.478, p = 0.043, respectively). There were no significant differences in BMD values between the concave and convex sides (p > 0.05). Conclusions: The 3D finite element modeling of BMD in patients with AIS is a reliable and accurate BMD measurement method. Using this method, the overall BMD of patients with AIS was shown to gradually decrease from the top to the bottom of the spine. Our findings provide valuable insights for surgical planning, choice of screw trajectories, and additional biomechanical analyzes using finite element models in the context of scoliosis. [ABSTRACT FROM AUTHOR]

A combination of time-averaged mass spectroscopy (MS), time-averaged optical emission spectroscopy (OES), and plasma transport modeling was employed to understand the transport processes of ions and atoms in high-power impulse magnetron sputtering discharges resulting in changes in the stoichiometry of NbCx films during their deposition from a stoichiometric NbC compound target at different repetition frequencies and duty cycles. Mass spectrometry showed that the fluxes of ions originating from the elements of the target increase with increasing pulse power density (and decreasing pulse length) due to an increasing electron density and, thus, electron-impact ionization probability. Due to the higher ionization energy and much lower ionization cross section of C (compared to Nb), it was found that the contribution of C+ ions to the deposition flux is practically negligible. Additionally, OES tracked the densities of ions and atoms at different distances from the target. The OES analysis revealed that the atom densities decreased as the pulse power density increased. In contrast, the ion densities exhibited an increase, which is consistent with the findings of MS. Using the data from MS, OES, and modeling, we were able to estimate the fluxes of atoms to the substrate. Our observations demonstrated a transition from C-rich toward Nb-rich flux of film-forming species with increasing pulse power density, corresponding to changes in the film composition. We further discuss the role of internal plasma processes that are responsible for this transition. [ABSTRACT FROM AUTHOR]

The aim of the paper is to develop the concept of perceptual relation and to apply it to digital environments. First, the meaning of perceptual relation is phenomenologically analyzed and defined as the interaction between the whole and its parts, which is theorized by the founders of Gestalt psychology. However, this relation is not considered as an intrinsic, but as an extended one, implying also the relation with the surrounding world (Umwelt). Subsequently, this concept of extended relation is applied to a chosen object (a ball) as it is perceived in four different kinds of digital dimensions (on-screen, virtual, augmented, and hybrid). Through a phenomenological analysis, I argue that, whereas the whole-part configuration remains the same, some modes of appearance of the object (multisensoriality, figure-ground interaction, affordances, and persistence) are different. In order to define this dynamic, I have coined the concept of transdimensional analogy. [ABSTRACT FROM AUTHOR]

This study explores the unique properties of Pheophorbide a (Phed a) in the photodegradation of G-quadruplex DNA under anoxic conditions, emphasizing its potential for photodynamic therapy (PDT) in hypoxic tumor environments. We used electron spin resonance (ESR), circular dichroism (CD), and nuclear magnetic resonance (NMR) spectroscopies to assess the radical generation and DNA interaction capabilities of Phed a compared to Pyropheophorbide a (Pyro a) under both oxygenated and anoxic conditions. Our results reveal that Phed a effectively degrades G-quadruplex DNA in the absence of oxygen, whereas Pyro a does not. Under anoxic conditions, Phed a generates unique carbon-centered radicals, as indicated by distinctive ESR signals, which are not observed in aerobic environments or with Pyro a. These radicals facilitate DNA decomposition without relying on reactive oxygen species (ROS). Phed a's ability to degrade DNA independently of oxygen underscores its potential as a versatile and effective PDT agent, especially for hypoxic tumors where traditional photosensitizers are ineffective. This study paves the way for the development of new PDT agents that can operate under different oxygen levels. Phed a's radical generation and oxygen-independent DNA degradation mechanisms make it a promising candidate for future PDT applications., (© 2024 Wiley-VCH GmbH.)

The study characterized the temporal and spatial variability in greenhouse gas (GHG) fluxes (CO 2 , CH 4 , and N 2 O) between December 2020 and November 2021 and their regulating drivers in the subtropical wetland of the Indian Himalayan foothill. Five distinct habitats (M1-sloppy surface at swamp forest, M2-plain surface at swamp forest, M3-swamp surface with small grasses, M4-marshy land with dense macrophytes, and M5-marshy land with sparse macrophytes) were studied. We conducted in situ measurements of GHG fluxes, microclimate (AT, ST, and SMC (v/v) ), and soil properties (pH, EC, N, P, K, and SOC) in triplicates in all the habitat types. Across the habitats, CO 2 , CH 4 , and N 2 O fluxes ranged from 125 to 536 mg m -2  h -1 , 0.32 to 28.4 mg m -2  h -1 , and 0.16 to 3.14 mg m -2  h -1 , respectively. The habitats (M3 and M5) exhibited higher GHG fluxes than the others. The CH 4 flux followed the summer > autumn > spring > winter hierarchy. However, CO 2 and N 2 O fluxes followed the summer > spring > autumn > winter. CO 2 fluxes were primarily governed by ST and SOC. However, CH 4 and N 2 O fluxes were mainly regulated by ST and SMC (v/v) across the habitats. In the case of N 2 O fluxes, soil P and EC also played a crucial role across the habitats. AT was a universal driver controlling all GHG fluxes across the habitats. The results emphasize that long-term GHG flux monitoring in sub-tropical Himalayan Wetlands has become imperative to accurately predict the near-future GHG fluxes and their changing nature with the ongoing climate change., (© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Background. The protein equivalent of nitrogen appearance is an indirect index commonly used to assess dietary protein intake in patients on CAPD. Moreover it has been suggested that the ratio between nitrogen appearance and dietary nitrogen intake (fractional urea synthesis) can predict nitrogen balance in uraemic patients. Several formulae to directly calculate the protein equivalent of nitrogen appearance have been published. It has not been established, however, what formulae give the most appropriate estimate of protein intake and nitrogen appearance. Study design. Nitrogen balance studies were carried out in seven stable patients on CAPD. All of the patients were receiving a diet whose protein content (1.2 g/kg/body wt/day) and calorie content (35 kcal/kg/body wt/day) were rigorously controlled. Six formulae for calculating protein equivalent of nitrogen appearance and nitrogen appearance were tested and the agreement of the estimating formulae was evaluated by means of the Bland and Altman method. Results. Net nitrogen balance was 1.68±0.9 g/N day, protein intake (g/day) 81±19, protein intake (g/kg) 1.05±0.17. Differences in protein equivalent of nitrogen appearance of up to about 20% were found. The smallest differences between protein equivalent of nitrogen appearance and protein intake were obtained by the formulae of Bergstrom (1±7 g, limits of agreement −12 and +15 g) and Blumenkrantz (−2±5 g, limits of agreement −11 and +7 g). The formula of Bergstrom most closely estimated nitrogen appearance (−0.35±0.89 g). Using such formula, the fractional urea synthesis was 54±12%, giving evidence of positive nitrogen balances. Conclusion. For the routine monitoring of protein equivalent of nitrogen appearance in CAPD patients, we recommend Bergstrom's formula with the determination of dialysate protein losses. [ABSTRACT FROM PUBLISHER]

Background: The progressive dysfunction of the immune system during aging appears to be involved in the pathogenesis of several age-related disorders. However, regular physical exercise can present "antiaging" effects on several physiological systems. Methods: A narrative review of studies investigating the chronic effects of exercise and physical activity on the immune system and its association with age-related chronic diseases was carried out according to the guidelines for writing a narrative review. Results: There is compelling evidence suggesting that age-related immune system alterations play a key role on the pathophysiology of atherosclerosis, hypertension, chronic heart failure, type 2 diabetes, obesity, arthritis, and chronic obstructive pulmonary disease. On the other hand, the regular practice of physical activity appears to improve most of the inflammatory/immunological processes involved in these diseases. Conclusion: Epidemiological, experimental, and clinical studies permit us to affirm that regular physical activity improves immunomodulation and may play a key role in the prevention and treatment of several age-related chronic diseases. However, further studies are needed to better describe the prophylactic and therapeutic effects of physical exercise in specific organs of older individuals, as well as the mechanisms involved in such response. [ABSTRACT FROM AUTHOR]

Bladder cancer ranks as the 9th most common malignancy worldwide within the urinary system. Urothelial carcinoma stands as the predominant histologic type in the United States and Western Europe, constituting approximately 90% of bladder cancer cases. While common sites of metastasis for urothelial carcinoma typically involve regional and distinct lymph nodes, the liver, lungs, and bones, instances of metastasis to the pericardium are rare. Roughly 10% of urothelial carcinoma cases exhibit cardiac metastasis, often remaining clinically asymptomatic. Hereby, the authors present a rare case of symptomatic pericardial infiltration originating from urothelial carcinoma in a 32-year-old male. The patient initially presented with a two-week history of progressive dyspnoea on exertion and had been previously diagnosed with high-grade transitional cell carcinoma with squamous differentiation upon histopathological examination and urothelial carcinoma on a Positron Emission Tomography (PET) scan 12 months earlier. Following neoadjuvant chemotherapy and radiotherapy, the patient exhibited a partial response to the treatment. However, despite the effectiveness of the therapies, he developed dyspnoea and pericardial effusion. Although pericardial involvement in advanced malignancies is not uncommon, symptomatic cardiac metastasis from urothelial carcinoma remains rare. Radiographic studies revealed right-sided pleural effusion, while a Computed Tomography (CT) scan of the thorax and upper abdomen (plain and contrast) displayed severe bilateral pleural effusion, pericardial effusion, and metastatic deposits in the mediastinal lymph nodes. Electrocardiography indicated sinus tachycardia, inverted T-waves in leads V1 to V5, and flattening of the T-wave in V6. The patient underwent pericardial tapping, yielding approximately 50 cc of pericardial fluid. A 10 cc of the pericardial fluid was subsequently sent for examination in the Pathology Department, with fluid cytology results indicating the presence of malignant cells. [ABSTRACT FROM AUTHOR]

This work deals with the automatic 3D reconstruction of objects from frontal RGB images. This aims at a better understanding of the reconstruction of 3D objects from RGB images and their use in immersive virtual environments. We propose a complete workflow that can be easily adapted to almost any other family of rigid objects. To explain and validate our method, we focus on guitars. First, we detect and segment the guitars present in the image using semantic segmentation methods based on convolutional neural networks. In a second step, we perform the final 3D reconstruction of the guitar by warping the rendered depth maps of a fitted 3D template in 2D image space to match the input silhouette. We validated our method by obtaining guitar reconstructions from real input images and renders of all guitar models available in the ShapeNet database. Numerical results for different object families were obtained by computing standard mesh evaluation metrics such as Intersection over Union, Chamfer Distance, and the F-score. The results of this study show that our method can automatically generate high-quality 3D object reconstructions from frontal images using various segmentation and 3D reconstruction techniques. [ABSTRACT FROM AUTHOR]

Turner syndrome (TS) leads to a characteristic phenotype, including premature ovarian insufficiency and infertility. Ovarian tissue cryopreservation (OTC) is becoming an established fertility preservation strategy for both pre- and post-pubertal females and may offer the chance of having a biological family to selected patients with TS. To date, women with TS have had ovarian tissue cryopreserved but there are few reports of autologous re-implantation and none of pregnancy. We herein report, to our knowledge, the first clinical pregnancy in a patient with TS, conceived naturally following re-implantation of cryopreserved ovarian tissue which had been removed soon after spontaneous puberty. This provides proof of concept for OTC as a means of fertility preservation in TS. [ABSTRACT FROM AUTHOR]

Excessive cost, insufficient optical modulation, and limited functionality are major drawbacks that presently exist in electrochromic smart windows (ECSWs) that are the backbone of zero‐energy buildings. Herein, a solution toward this niche is provided by optimizing various deposition conditions for WO3 sputtering on crackle lithographically fabricated, cost‐effective Al‐mesh overlayed with SnO2. Ultra‐high switching contrast of 90% is accomplished by a decisive choice of parameters i.e., deposition power (5 W cm−2), oxygen flowrate (46 sccm), pressure (2.7 × 10−2 mbar), and film thickness (530 nm) that are imperative for achieving enhanced oxygen deficiency and film porosity. The ECSW displays fast switching with response and recovery time of 11 and 5 s, respectively, which are nearly twice as fast as control ITO‐based device. Additionally, the film holds good cyclic stability with an excellent coloration efficiency of 47 cm2 C−1. As the state‐of‐the‐art, a large‐area smart window (10 × 10 cm2) operable at 2 V is devised engaging WO3 coated Al_SnO2 electrode. The dual‐functionality is demonstrated by employing four series‐connected (5 × 4 cm2, charging time ≈1.5 min) devices to operate a display for 70 min. A device with a quasi‐solid electrolyte is also fabricated, exhibiting improved cyclic stability beyond 2000 cycles. [ABSTRACT FROM AUTHOR]

STUDY QUESTION Should we perform oocyte accumulation to preserve fertility in women with Turner syndrome (TS)? SUMMARY ANSWER The oocyte cryopreservation strategy is not well adapted for all TS women as their combination of high basal FSH with low basal AMH and low percentage of 46,XX cells in the karyotype significantly reduces the chances of freezing sufficient mature oocytes for fertility preservation. WHAT IS KNOWN ALREADY An oocyte cryopreservation strategy requiring numerous stimulation cycles is needed to preserve fertility in TS women, to compensate for the low ovarian response, the possible oocyte genetic alterations, the reduced endometrial receptivity, and the increased rate of miscarriage, observed in this specific population. The validation of reliable predictive biomarkers of ovarian response to hormonal stimulation in TS patients is necessary to help practitioners and patients choose the best-personalized fertility preservation strategy. STUDY DESIGN, SIZE, DURATION A retrospective bicentric study was performed from 1 January 2011 to 1 January 2023. Clinical and biological data from all TS women who have received from ovarian stimulation for fertility preservation were collected. A systematic review of the current literature on oocyte retrieval outcomes after ovarian stimulation in TS women was also performed (PROSPERO registration number: CRD42022362352). PARTICIPANTS/MATERIALS, SETTING, METHODS A total of 14 TS women who had undergone ovarian stimulation for fertility preservation were included, representing the largest cohort of TS patients published to date (n = 14 patients, 24 cycles). The systematic review of the literature identified 34 additional TS patients with 47 oocyte retrieval outcomes after ovarian stimulation in 14 publications (n = 48 patients, n = 71 cycles in total). MAIN RESULTS AND THE ROLE OF CHANCE The number of cryopreserved mature oocytes on the first cycle for TS patients was low (4.0 ± 3.7). Oocyte accumulation was systematically proposed to increase fertility potential and was accepted by 50% (7/14) of patients (2.4 ± 0.5 cycles), leading to an improved total number of 10.9 ± 7.2 cryopreserved mature oocytes per patient. In the group who refused the oocyte accumulation strategy, only one patient exceeded the threshold of 10 mature cryopreserved oocytes. In contrast, 57.1% (4/7) and 42.9% (3/7) of patients who have underwent the oocyte accumulation strategy reached the threshold of 10 and 15 mature cryopreserved oocytes, respectively (OR = 8 (0.6; 107.0), P  = 0.12; OR= 11 (0.5; 282.1), P  = 0.13). By analyzing all the data published to date and combining it with our data (n = 48 patients, n = 71 cycles), low basal FSH and high AMH concentrations as well as a higher percentage of 46,XX cells in the karyotype were significantly associated with a higher number of cryopreserved oocytes after the first cycle. Moreover, the combination of low basal FSH concentration (<5.9 IU/l), high AMH concentration (>1.13 ng/ml), and the presence of 46,XX cells (>1%) was significantly predictive of obtaining at least six cryopreserved oocytes in the first cycle, representing objective criteria for identifying patients with real chances of preserving an adequate fertility potential by oocyte cryopreservation. LIMITATIONS, REASONS FOR CAUTION Our results should be analyzed with caution, as the optimal oocyte number needed for successful live birth in TS patients is still unknown due to the low number of reports their oocyte use in the literature to date. WIDER IMPLICATIONS OF THE FINDINGS TS patients should benefit from relevant clinical evaluation, genetic counseling and psychological support to make an informed choice regarding their fertility preservation technique, as numerous stimulation cycles would be necessary to preserve a high number of oocytes. STUDY FUNDING/COMPETING INTEREST(S) This research received no external funding. The authors declare no conflict of interest. TRIAL REGISTRATION NUMBER N/A. [ABSTRACT FROM AUTHOR]