1. Coronary artery disease and the risk of life-threatening cardiac events after age 40 in long QT syndrome
- Author
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Alon Barsheshet, Ilan Goldenberg, Milica Bjelic, Kirill Buturlin, Aharon Erez, Gustavo Goldenberg, Anita Y. Chen, Bronislava Polonsky, Scott McNitt, Mehmet Aktas, Wojciech Zareba, and Gregory Golovchiner
- Subjects
long QT syndrome ,coronary artery disease ,sudden cardiac death ,ventricular arrhythmia ,risk factors ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background and aimsLong QT syndrome (LQTS) and coronary artery disease (CAD) are both associated with increased risk of ventricular tachyarrhythmia. However, there are limited data on the incremental risk conferred by CAD in adult patients with congenital LQTS. We aimed to investigate the risk associated with CAD and life threatening events (LTEs) in patients with LQTS after age 40 years.MethodsThe risk of LTEs (comprising aborted cardiac arrest, sudden cardiac death, or appropriate defibrillator shock) from age 40 through 75 years was examined in 1,020 subjects from the Rochester LQTS registry, categorized to CAD (n = 137) or no-CAD (n = 883) subgroups.ResultsSurvival analysis showed that patients with CAD had a significantly higher cumulative event rate of LTEs from 40 to 75 years (35%) compared with those without CAD (7%; p 4-fold (p = 0.008) increased risk of LTEs among LQTS patients with a lower-range QTc (
- Published
- 2024
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