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Coronary artery disease and the risk of life-threatening cardiac events after age 40 in long QT syndrome

Authors :
Alon Barsheshet
Ilan Goldenberg
Milica Bjelic
Kirill Buturlin
Aharon Erez
Gustavo Goldenberg
Anita Y. Chen
Bronislava Polonsky
Scott McNitt
Mehmet Aktas
Wojciech Zareba
Gregory Golovchiner
Source :
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

Background and aimsLong QT syndrome (LQTS) and coronary artery disease (CAD) are both associated with increased risk of ventricular tachyarrhythmia. However, there are limited data on the incremental risk conferred by CAD in adult patients with congenital LQTS. We aimed to investigate the risk associated with CAD and life threatening events (LTEs) in patients with LQTS after age 40 years.MethodsThe risk of LTEs (comprising aborted cardiac arrest, sudden cardiac death, or appropriate defibrillator shock) from age 40 through 75 years was examined in 1,020 subjects from the Rochester LQTS registry, categorized to CAD (n = 137) or no-CAD (n = 883) subgroups.ResultsSurvival analysis showed that patients with CAD had a significantly higher cumulative event rate of LTEs from 40 to 75 years (35%) compared with those without CAD (7%; p 4-fold (p = 0.008) increased risk of LTEs among LQTS patients with a lower-range QTc (

Details

Language :
English
ISSN :
2297055X
Volume :
11
Database :
Directory of Open Access Journals
Journal :
Frontiers in Cardiovascular Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.3ec41955d364468fafde4fbbbd4965fc
Document Type :
article
Full Text :
https://doi.org/10.3389/fcvm.2024.1418428