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1. An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.

Author

Naoto Watamura, Kaori Sato, Gen Shiihashi, Ayami Iwasaki, Naoko Kamano, Mika Takahashi, Misaki Sekiguchi, Naomi Mihira, Ryo Fujioka, Kenichi Nagata, Shoko Hashimoto, Takashi Saito, Toshio Ohshima, Saido, Takaomi C., and Hiroki Sasaguri

Subjects
*AMYLOID plaque, *PRESENILINS, *AMYLOID beta-protein precursor, *LABORATORY mice, *ANIMAL disease models
Abstract

The article presents a study which explores the isogenic panel of App knock-in mouse models, profiling beta secretase inhibition and endosomal abnormalities. It mentions that experimental comparisons between different isogenic App, knockin mouse lines will provide previously unidentified insights into the understanding of the etiology of Alzheimer's disease.

Published
2022
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