An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.

The article presents a study which explores the isogenic panel of App knock-in mouse models, profiling beta secretase inhibition and endosomal abnormalities. It mentions that experimental comparisons between different isogenic App, knockin mouse lines will provide previously unidentified insights into the understanding of the etiology of Alzheimer's disease.